Treg cell function in rheumatoid arthritis is compromised by CTLA-4 promoter methylation resulting in a failure to activate the indoleamine 2,3-dioxygenase pathway

Arthritis and Rheumatology

Volumn 66, Issue 9, 2014, Pages 2344-2354

  Cribbs, Adam P ^a   Kennedy, Alan ^a   Penn, Henry ^b   Read, Jordan E ^a   Amjadi, Parisa ^a   Green, Patricia ^a   Syed, Khaja ^a   Manka, Szymon W ^a   Brennan, Fionula M ^c   Gregory, Bernard ^a   Williams, Richard O ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NORTHWICK PARK HOSPITAL   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BISULFITE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE; TRANSCRIPTION FACTOR NFAT; TRYPTOPHAN;

ANTIGEN PRESENTING CELL; ARTICLE; AUTOLOGOUS MIXED LYMPHOCYTE REACTION; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; METHYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS;

ARTHRITIS, RHEUMATOID; CTLA-4 ANTIGEN; DNA METHYLATION; DOWN-REGULATION; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY;

EID: 84907398809     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38715     Document Type: Article

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