Intracellular Na+ concentration ([Na+]i) is elevated in diabetic hearts due to enhanced Na+-glucose cotransport

Journal of the American Heart Association

Volumn 4, Issue 9, 2015, Pages

  Lambert, Rebekah ^a   Srodulskic, Sarah ^a   Peng, Xiaoli ^a   Margulies, Kenneth B ^b   Despa, Florin ^a   Despa, Sanda ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Heart; Intracellular Na+ concentration; Na+ glucose cotransporter; Type 2 diabetes

Indexed keywords

PHLORIZIN; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2; SODIUM ION; SLC5A1 PROTEIN, HUMAN; SLC5A1 PROTEIN, RAT; SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIAC MUSCLE CELL; DIABETIC CARDIOMYOPATHY; DOWN REGULATION; ELECTROSTIMULATION; GLUCOSE TRANSPORT; HEART MUSCLE CONTRACTILITY; HUMAN; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SODIUM CELL LEVEL; SODIUM TRANSPORT; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; CARDIAC MUSCLE; COMPLICATION; DIABETIC CARDIOMYOPATHIES; DISEASE MODEL; DRUG EFFECTS; FEMALE; HEART FAILURE; MALE; METABOLISM; MIDDLE AGED; SPRAGUE DAWLEY RAT; TIME FACTOR; UPREGULATION;

AGED; ANIMALS; DIABETES MELLITUS, TYPE 2; DIABETIC CARDIOMYOPATHIES; DISEASE MODELS, ANIMAL; FEMALE; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; MYOCYTES, CARDIAC; PHLORHIZIN; RATS, SPRAGUE-DAWLEY; SODIUM; SODIUM-GLUCOSE TRANSPORTER 1; TIME FACTORS; UP-REGULATION;

EID: 84991521037     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.115.002183     Document Type: Article

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