Amelioration of renal inflammation, endoplasmic reticulum stress and apoptosis underlies the protective effect of low dosage of atorvastatin in gentamicin-induced nephrotoxicity

PLoS ONE

Volumn 11, Issue 10, 2016, Pages

  Jaikumkao, Krit ^a   Pongchaidecha, Anchalee ^a   Thongnak, La Ongdao ^a   Wanchai, Keerati ^a,b   Arjinajarn, Phatchawan ^c   Chatsudthipong, Varanuj ^d   Chattipakorn, Nipon ^a   Lungkaphin, Anusorn ^a  

^a Faculty of Medicine Chiang Mai University   (Thailand)

^b MAE FAH LUANG UNIVERSITY   (Thailand)

^c CHIANG MAI UNIVERSITY   (Thailand)

^d MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CALPAIN; CASPASE 12; CASPASE 3; CREATININE; GENTAMICIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; PROTEIN BAX; PROTEIN BCL 2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; UREA; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; PROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DRUG EFFICACY; ENDOPLASMIC RETICULUM STRESS; KIDNEY FIBROSIS; KIDNEY HYPERTROPHY; KIDNEY MASS; LONG TERM EXPOSURE; LOW DRUG DOSE; MALE; NEPHRITIS; NEPHROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; SPRAGUE DAWLEY RAT; THERAPY DELAY; TREATMENT RESPONSE; TUNEL ASSAY; UREA NITROGEN BLOOD LEVEL; ANIMAL; BLOOD; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECTS; KIDNEY; METABOLISM; PATHOLOGY;

ANIMALS; APOPTOSIS; ATORVASTATIN CALCIUM; BCL-2-ASSOCIATED X PROTEIN; BLOOD UREA NITROGEN; CASPASE 12; CREATININE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENDOPLASMIC RETICULUM STRESS; GENTAMICINS; HEAT-SHOCK PROTEINS; INTERLEUKIN-6; KIDNEY; MALE; NEPHRITIS; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84991451286     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0164528     Document Type: Article

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