Atorvastatin reduces endotoxin-induced microvascular inflammation via NOSII

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 388, Issue 5, 2015, Pages 557-564

  McGown, Caroline C ^a   Brookes, Zoë L S ^a   Hellewell, Paul G ^a   Ross, Jonathan J ^a   Brown, Nicola J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Leucocyte adhesion; Macromolecular extravasation; Nitric oxide; NOSII; Sepsis; Statins

Indexed keywords

ANTIINFLAMMATORY AGENT; ATORVASTATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTOXIN; LIPOPOLYSACCHARIDE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) NITROARGININE METHYL ESTER; INDUCIBLE NITRIC OXIDE SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; NOS2 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENDOTOXIN INDUCED MICROVASCULAR INFLAMMATION; FLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; LEUKOCYTE ADHERENCE; LIPOPOLYSACCHARIDE-INDUCED HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ARTERY; MICROANGIOPATHY; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; CAPILLARY PERMEABILITY; CELL ADHESION; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECTS; ENDOTOXEMIA; ENZYMOLOGY; GENE EXPRESSION; GENETICS; INTRAVITAL MICROSCOPY; LEUKOCYTE; METABOLISM; MICROCIRCULATION; MICROVASCULATURE; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM; VASCULITIS; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ATORVASTATIN CALCIUM; CAPILLARY PERMEABILITY; CELL ADHESION; ENDOTHELIUM, VASCULAR; ENDOTOXEMIA; GENE EXPRESSION; INTRAVITAL MICROSCOPY; LEUKOCYTES; LIPOPOLYSACCHARIDES; MALE; MICROCIRCULATION; MICROVESSELS; NITRIC OXIDE SYNTHASE TYPE II; RATS, WISTAR; VASCULITIS;

EID: 84939417625     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-015-1100-y     Document Type: Article

References (39)

1. Andrew P, Deng Y, Kaufman S (2000) Fluid extravasation from spleen reduces blood volume in endotoxemia. Am J Physiol Regul Integr Comp Physiol 278:60-65
2. Bagnall NM, Dent PC, Walkowska A, Sadowski J, Johns EJ (2005) Nitric oxide inhibition and the impact on renal nerve-mediated antinatriuresis and antidiuresis in the anaesthetized rat. J Physiol 569:849-856
3. Birnbaum J, Lehmann C, Klotz E, Hein OV, Blume A, Jubin F, Polze N, Luther D, Spies CD (2008) Effects of N-acetylcysteine and tirilazad mesylate on intestinal functional capillary density, leukocyte adherence, mesenteric plasma extravasation and cytokine levels in experimental endotoxemia in rats. Clin Hemorheol Microcirc 39:99-111
4. Brookes ZL, Kaufman S (2005) Effects of atrial natriuretic peptide on the extrasplenic microvasculature and lymphatics in the rat in vivo. J Physiol 565:269-277
5. Brookes ZL, Brown NJ, Reilly CS (2002) Response of the rat cremaster microcirculation to hemorrhage in vivo: differential effects of intravenous anesthetic agents. Shock 18:542-548
6. Brookes ZL, McGown CC, Reilly CS (2009) Statins for all: the new premed? Br J Anaesth 103(1):99-107. doi: 10.1093/bja/aep149
7. Calisto KL, Carvalho Bde M, Ropelle ER, Mittestainer FC, Camacho AC, Guadagnini D, Carvalheira JB, Saad MJ (2010) Atorvastatin improves survival in septic rats: effect on tissue inflammatory pathway and on insulin signaling. PLoS One 5(12):e14232
8. Clough GF, L'Esperance V, Turzyniecka M, Walter L, Chipperfield AJ, Gamble J, Krentz AJ, Byrne CD (2011) Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity and is not improved by high dose statin treatment. Microcirculation 18:74-84
9. Dobesh PP, Klepser DG, McGuire TR, Morgan CW, Olsen KM (2009) Reduction in mortality associated with statin therapy in patients with severe sepsis. Pharmacotherapy 29:621-630. doi: 10.1592/phco.29.6.621
10. Endres M, Laufs U, Huang Z, Nakamura T, Huang P, Moskowitz MA, Liao JK (1998) Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease. Proc Natl Acad Sci U S A 95:8880-8885
11. Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD (2005) Metformin and reduced risk of cancer in diabetic patients. BMJ 330:1304-1305
12. Filep JG, Delalandre A, Beauchamp M (1997) Dual role for nitric oxide in the regulation of plasma volume and albumin escape during endotoxin shock in conscious rats. Circ Res 81:840-847
13. Fox SB, Leek RD, Weekes MP, Whitehouse RM, Gatter KC, Harris AL (1995) Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis. J Pathol 177:275-283
14. Gardiner SM, Kemp PA, March JE, Bennett T (1995) Cardiac and regional haemodynamics, inducible nitric oxide synthase (NOS) activity, and the effects of NOS inhibitors in conscious, endotoxaemic rats. Br J Pharmacol 116:2005-2016
15. Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJ, Knowles RG (1997) 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272:4959-4963
16. Giusti-Paiva A, Martinez MR, Felix JV, da Rocha MJ, Carnio EC, Elias LL (2004) Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats. Shock 21:271-275
17. Gong X, Ma Y, Ruan Y, Fu G, Wu S (2014) Long-term atorvastatin improves age-related endothelial dysfunction by ameliorating oxidative stress and normalizing eNOS/iNOS imbalance in rat aorta. Exp Gerontol 52:9-17
18. Grover R, Zaccardelli D, Colice G, Guntupalli K, Watson D, Vincent JL (1999) An open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. Crit Care Med 27:913-922
19. Hickey MJ, Sharkey KA, Sihota EG (1997) Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. FASEB J 11:955-964
20. Hollenberg SM, Guglielmi M, Parrillo JE (2007) Discordance between microvascular permeability and leukocyte dynamics in septic inducible nitric oxide synthase deficient mice. Crit Care 11:125
21. Kandasamy K, Prawez S, Choudhury S, More AS, AHanger AA, Singh TU, Parida S, Mishra SK (2011) Atorvastatin prevents vascular hyporeactivity to norepinephrine in sepsis: role of nitric oxide and α-adrenoceptor mRNA expression. Shock 36(1):76-82. doi: 10.1097/SHK.0b013e31821a4002
22. Kruger P, Bailey M, Bellomo R, Cooper DJ, Harward M, Higgins A, Howe B, Jones D, Joyce C, Kostner K, McNeil J, Nichol A, Roberts MS, Syres G, Venkatesh B, ANZ-STATInS Investigators-ANZICS Clinical Trials Group (2013) A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis. Am J Respir Crit Care Med 187(7):743-750. doi: 10.1164/rccm.201209-1718OC
23. G-nitro-L-arginine methyl ester on renal function and blood pressure. Renal Fluid Electrolyte Physiol 30:1033-F1037
24. Madonna R, Di Napoli P, Massaro M, Grilli A, Felaco M, De Caterina A, Tang D, De Caterina R, Geng YJ (2005) Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. J Biol Chem 280:13503-13511
25. Matsuda N, Hayashi Y, Takahashi Y, Hattori Y (2006) Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy. J Pharmacol Exp Ther 319:1348-1354
26. McGown CC, Brookes ZL (2007) Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide. Br J Anaesth 98:163-175
27. McGown CC, Brown NJ, Hellewell PG, Reilly CS, Brookes ZL (2010) Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve NOSIII. Br J Anaesth 104:183-190. doi: 10.1093/bja/aep361
28. Merx MW, Liehn EA, Janssens U, Lütticken R, Schrader J, Hanrath P, Weber C (2004) HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis. Circulation 109(21):2560-2565
29. Merx MW, Liehn EA, Graf J, van de Sandt A, Schaltenbrand M, Schrader J, Hanrath P, Weber C (2005) Statin treatment after onset of sepsis in a murine model improves survival. Circulation 112:117-124
30. Miller FN, Joshua IG, Anderson GL (1982) Quantitation of vasodilator-induced macromolecular leakage by in vivo fluorescent microscopy. Microvasc Res 24:56-67
31. NICE (2008) NICE Implementation Uptake Report: statins for the prevention of cardiovascular events. National Institute for Health and Clinical Excellence. http://www.nice.org.uk/proxy/?sourceUrl=http%3a%2f%2fwww.nice.org.uk%2fmedia%2f919%2fC6%2fTA94UptakeReport.pdf. Accessed 23 Aug 2014
32. O'Neal HR Jr, Koyama T, Koehler EA, Siew E, Curtis BR, Fremonth RD, May AK, Bernard GR, Ware LB (2011) Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit Care Med 39(6):1343-1350. doi: 10.1097/CCM.0b013e3182120992
33. Patel JM, Snaith C, Thickett DR, Linhartova L, Melody T, Hawkey P, Barnett AH, Jones A, Hong T, Cooke MW, Perkins GD, Gao F (2012) Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial). Crit Care 16(6):R231. doi: 10.1186/cc11895
34. Scalia R, Stalker TJ (2002) Microcirculation as a target for the anti-inflammatory properties of Statins. Microcirculation 9:431-442
35. Simpson RJ Jr, Signorovitch J, Birnbaum H, Ivanova J, Connolly C, Kidolezi Y, Kuznik A (2009) Cardiovascular and economic outcomes after initiation of lipid-lowering therapy with atorvastatin vs simvastatin in an employed population. Mayo Clin Proc 84:1065-1072. doi: 10.4065/mcp.2009.0298
36. Subramani J, Kathirvel K, Leo MD, Kuntamallappanavar G, Uttam Singh T, Mishra SK (2009) Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. J Cardiovasc Pharmacol 54:526-534. doi: 10.1097/FJC.0b013e3181bfafd6
37. Walther A, Weihrauch M, Schmidt W, Gebhard MM, Martin E, Schmidt H (2000) Leukocyte-independent plasma extravasation during endotoxemia. Crit Care Med 28:2943-2948
38. Wang L, Taneja R, Razavi HM, Law C, Gillis C, Mehta S (2012) Specific role of neutrophil inducible nitric oxide synthase in murine sepsis-induced lung injury in vivo. Shock 37(5):539-547. doi: 10.1097/SHK.0b013e31824dcb5a
39. Xiao H, Qin X, Ping D, Zuo K (2013) Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. PLoS One 8(3):e59233