Atorvastatin ameliorates inflammatory hyperalgesia in rat model of monoarticular arthritis

Pharmacological Research

Volumn 61, Issue 4, 2010, Pages 329-333

  Wahane, V D ^a   Kumar, V L ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Anti arthritic drugs; Arthritis; Atorvastatin; Hyperalgesia; Inflammation

Indexed keywords

ATORVASTATIN; DICLOFENAC; FREUND ADJUVANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLIMBING; CONTROLLED STUDY; DISABILITY; DRUG EFFICACY; FEMALE; HISTOPATHOLOGY; HYPERALGESIA; LOCOMOTION; MALE; MONARTHRITIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; DICLOFENAC; FEMALE; FREUND'S ADJUVANT; HEPTANOIC ACIDS; HYPERALGESIA; INFLAMMATION; JOINTS; LOWER EXTREMITY; MALE; MOTOR ACTIVITY; PYRROLES; RATS; RATS, WISTAR;

EID: 77649342579     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.11.006     Document Type: Article

References (34)

1. Downs J.R., Clearfield M., Weis S., Whitney E., Shapiro D.R., Beere P.A., et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 279 (1998) 1615-1622
2. Nasu K., Tsuchikane E., Katoh O., Tanaka N., Kimura M., Ehara M., et al. Effect of fluvastatin on progression of coronary atherosclerotic plaque evaluated by virtual histology intravascular ultrasound. JACC Cardiovasc Interv 2 (2009) 689-696
3. Sawara Y., Takei T., Uchida K., Ogawa T., Yoshida T., Tsuchiya K., et al. Effects of lipid-lowering therapy with rosuvastatin on atherosclerotic burden in patients with chronic kidney disease. Intern Med 47 (2008) 1505-1510
4. Amarenco P., Benavente O., Goldstein L.B., Callahan III A., Sillesen H., Hennerici M.G., et al. Results of the stroke prevention by aggressive reduction in cholesterol levels (SPARCL) trial by stroke subtypes. Stroke 40 (2009) 1405-1409
5. Xie RQ, Cui W, Liu F, Yang C, Pei WN, Lu JC. Statin therapy shortens QTc, QTcd, and improves cardiac function in patients with chronic heart failure. Int J Cardiol 2008; in press
6. Garjani A., Andalib S., Ziaee M., and Maleki-Dizaji N. Biphasic effects of atorvastatin on inflammation. Pak J Pharm Sci 21 (2008) 125-130
7. Niwa S., Totsuka T., and Hayashi S. Inhibitory effect of fluvastatin, an HMG-CoA reductase inhibitor, on the expression of adhesion molecules on human monocyte cell line. Int J Immunopharmacol 18 (1996) 669-675
8. Ikeda U., and Shimada K. Statins and monocytes. Lancet 353 (1999) 2070
9. Dichtl W., Dulak J., Frick M., Alber H.F., Schwarzacher S.P., Ares M.P., et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 23 (2003) 58-63
10. Leung B.P., Sattar N., Crilly A., Prach M., McCarey D.W., Payne H., et al. A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J Immunol 170 (2003) 1524-1530
11. Barsante M.M., Roffê E., Yokoro C.M., Tafuri W.L., Souza D.G., Pinho V., et al. Anti-inflammatory and analgesic effects of atorvastatin in a rat model of adjuvant-induced arthritis. Eur J Pharmacol 516 (2005) 282-289
12. Funk J.L., Chen J., Downey K.J., and Clark R.A. Bone protective effect of simvastatin in experimental arthritis. J Rheumatol 35 (2008) 1083-1091
13. Yamagata T., Kinoshita K., Nozaki Y., Sugiyama M., Ikoma S., and Funauchi M. Effects of pravastatin in murine collagen-induced arthritis. Rheumatol Int 27 (2007) 631-639
14. Butler S.H., Godefroy F., Besson J.M., and Weil-Fugazza J. A limited arthritic model for chronic pain studies in the rat. Pain 48 (1992) 73-81
15. De Castro Costa M., De Sutter P., Gybels J., and Van Hees J. Adjuvant induced arthritis in rats: a possible animal model of chronic pain. Pain 10 (1981) 173-185
16. Wang Y., Huang C., Cao Y., and Han J.S. Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat. Life Sci 67 (2000) 261-267
17. Keeble J., Blades M., Pitzalis C., Castro da Rocha F.A., and Brain S.D. The role of substance P in microvascular responses in murine joint inflammation. Br J Pharmacol 144 (2005) 1059-1066
18. Johnston B., Burns A.R., and Kubes P. A role for mast cells in the development of adjuvant-induced vasculitis and arthritis. Am J Pathol 152 (1998) 555-563
19. Burgess G.M., Perkins M.N., Rang H.P., Campbell E.A., Brown M.C., McIntyre P., et al. Bradyzide, a potent non-peptide B(2) bradykinin receptor antagonist with long-lasting oral activity in animal models of inflammatory hyperalgesia. Br J Pharmacol 129 (2000) 77-86
20. Day S.M., Lockhart J.C., Ferrell W.R., and McLean J.S. Divergent roles of nitrergic and prostanoid pathways in chronic joint inflammation. Ann Rheum Dis 63 (2004) 1564-1570
21. Kleinau S., Erlandsson H., and Klareskog L. Percutaneous exposure of adjuvant oil causes arthritis in DA rats. Clin Exp Immunol 96 (1994) 281-284
22. Majlesi Y., Samorapoompichit P., Hauswirth A.W., Schernthaner G.H., Ghannadan M., Baghestanian M., et al. Cerivastatin and atorvastatin inhibit IL-3-dependent differentiation and IgE-mediated histamine release in human basophils and downmodulate expression of the basophil-activation antigen CD203c/E-NPP3. J Leukoc Biol 73 (2003) 107-117
23. Hernández-Presa M.A., Martín-Ventura J.L., Ortego M., Gómez-Hernández A., Tuñón J., Hernández-Vargas P., et al. Atorvastatin reduces the expression of cyclooxygenase-2 in a rabbit model of atherosclerosis and in cultured vascular smooth muscle cells. Atherosclerosis 160 (2002) 49-58
24. Yokota K., Miyazaki T., Hirano M., Akiyama Y., and Mimura T. Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Rheumatol 33 (2006) 463-471
25. Maher B.M., Dhonnchu T.N., Burke J.P., Soo A., Wood A.E., and Watson R.W. Statins alter neutrophil migration by modulating cellular Rho activity-a potential mechanism for statins-mediated pleotropic effects?. J Leukoc Biol 85 (2009) 186-193
26. Zhao D., and Pothoulakis C. Rho GTPases as therapeutic targets for the treatment of inflammatory diseases. Expert Opin Ther Targets 7 (2003) 583-592
27. McCarey D.W., McInnes I.B., Madhok R., Hampson R., Scherbakov O., Ford I., et al. Trial of atorvastatin in rheumatoid arthritis (TARA): double-blind, randomised placebo-controlled trial. Lancet 363 (2004) 2015-2021
28. Van Doornum S., McColl G., and Wicks I.P. Atorvastatin reduces arterial stiffness in patients with rheumatoid arthritis. Ann Rheum Dis 63 (2004) 1571-1575
29. Seed M.P., and Gardner C.R. The modulation of intra-articular inflammation cartilage matrix and bone loss in mono-articular arthritis induced by heat-killed Mycobacterium tuberculosis. Inflammopharmacology 12 (2005) 551-567
30. Pircio A.W., Fedele C.T., and Bierwagen M.E. A new method for the evaluation of analgesic activity using adjuvant-induced arthritis in the rat. Eur J Pharmacol 31 (1975) 207-215
31. Santodomingo-Garzón T., Cunha T.M., Verri Jr. W.A., Valério D.A.R., Parada C.A., Poole S., et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol 149 (2006) 14-22
32. Wu S., Duan S., Zhao S., Cai Y., Chen P., and Fang X. Atorvastatin reduces lipopolysaccharide-induced expression of cyclooxygenase-2 in human pulmonary epithelial cells. Respir Res 6 (2005) 27
33. Attal N., and Guilbaud G. Analgesic action of sodium diclofenac: behavioral and electrophysiological study in normal and polyarthritic rats. Presse Med 17 (1988) 1841-1844
34. Ortiz M.I., Lozano-Cuenca J., Granados-Soto V., and Castañeda-Hernández G. Additive interaction between peripheral and central mechanisms involved in the antinociceptive effect of diclofenac in the formalin test in rats. Pharmacol Biochem Behav 91 (2008) 32-37