Comparison between male and female sprague-dawley rats in the response of urinary biomarkers to injury induced by gentamicin

Toxicologic Pathology

Volumn 42, Issue 7, 2014, Pages 1105-1116

  Gautier, Jean Charles ^a   Gury, Thierry ^a   Guffroy, Magali ^b   Masson, Régis ^c   Khan Malek, Richard ^a   Hoffman, David ^a   Pettit, Syril ^d   Harpur, Ernie ^e  

^a SANOFI   (France)

^b PFIZER INC   (United States)

^c Covance Laboratory SAS ^*  (France)

^d ILSI HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE   (United States)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

assay platforms; gentamicin nephrotoxicity; kidney; sex differences; Sprague Dawley rats.; urinary biomarkers

Indexed keywords

ALBUMIN; ANTIGEN; BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CALBINDIN; CLUSTERIN; CREATININE; CYSTATIN C; EPIDERMAL GROWTH FACTOR; GENTAMICIN; GLUTATHIONE TRANSFERASE ALPHA; HYALIN; KIDNEY INJURY MOLECULE 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OSTEOPONTIN; PROTEIN; RENAL PAPILLARY ANTIGEN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BETA 2 MICROGLOBULIN URINE LEVEL; CELL DEGENERATION; CELL INFILTRATION; CELL REGENERATION; CONTROLLED STUDY; CREATININE URINE LEVEL; DIAGNOSTIC VALUE; DRUG INDUCED DISEASE; DRUG TOLERABILITY; FEMALE; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INJURY SEVERITY; KIDNEY CONCENTRATING CAPACITY; KIDNEY DISTAL TUBULE; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MALE; MONONUCLEAR CELL; NEPHROTOXICITY; NONHUMAN; ORGAN WEIGHT; RAT; REVIEW; SEX DIFFERENCE; UREA NITROGEN BLOOD LEVEL; URINALYSIS; WEIGHT CHANGE; ANIMAL; CHEMICALLY INDUCED; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; KIDNEY; KIDNEY DISEASE; PATHOLOGY; SPRAGUE DAWLEY RAT; URINE;

ANIMALS; BETA 2-MICROGLOBULIN; BIOLOGICAL MARKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENTAMICINS; KIDNEY; KIDNEY DISEASES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS;

EID: 84907501172     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623314524489     Document Type: Review

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