메뉴 건너뛰기




Volumn 49, Issue 6, 2016, Pages 311-318

MiR-146 and miR-125 in the regulation of innate immunity and inflammation

Author keywords

Inflammation; Innate immune; MicroRNA; MiR 125; MiR 146

Indexed keywords

MICRORNA; TOLL LIKE RECEPTOR;

EID: 84991338031     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2016.49.6.056     Document Type: Review
Times cited : (136)

References (80)
  • 1
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 2
    • 77953629046 scopus 로고    scopus 로고
    • Regulation of mRNA translation and stability by microRNAs
    • Fabian MR, Sonenberg N and Filipowicz W (2010) Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem 79, 351-379.
    • (2010) Annu Rev Biochem , vol.79 , pp. 351-379
    • Fabian, M.R.1    Sonenberg, N.2    Filipowicz, W.3
  • 3
    • 69249088165 scopus 로고    scopus 로고
    • MicroRNAs: critical mediators of differentiation, development and disease
    • Friedman JM and Jones PA (2009) MicroRNAs: critical mediators of differentiation, development and disease. Swiss Med Wkly 139, 466-472.
    • (2009) Swiss Med Wkly , vol.139 , pp. 466-472
    • Friedman, J.M.1    Jones, P.A.2
  • 4
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • Guo H, Ingolia NT, Weissman JS and Bartel DP (2010) Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466, 835-840.
    • (2010) Nature , vol.466 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 5
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 6
    • 75649139134 scopus 로고    scopus 로고
    • Physiological and pathological roles for microRNAs in the immune system
    • O'Connell RM, Rao DS, Chaudhuri AA and Baltimore D (2010) Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 10, 111-122.
    • (2010) Nat Rev Immunol , vol.10 , pp. 111-122
    • O'Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3    Baltimore, D.4
  • 7
    • 84863723933 scopus 로고    scopus 로고
    • MicroRNAs regulatory networks in myeloid lineage development and differentiation: regulators of the regulators
    • El Gazzar M and McCall CE (2012) MicroRNAs regulatory networks in myeloid lineage development and differentiation: regulators of the regulators. Immunol Cell Biol 90, 587-593.
    • (2012) Immunol Cell Biol , vol.90 , pp. 587-593
    • El Gazzar, M.1    McCall, C.E.2
  • 8
    • 84897129420 scopus 로고    scopus 로고
    • MicroRNA circuits regulate the cancer-inflammation link
    • Iliopoulos D (2014) MicroRNA circuits regulate the cancer-inflammation link. Sci Signal 7, pe8.
    • (2014) Sci Signal , vol.7
    • Iliopoulos, D.1
  • 10
    • 67349273027 scopus 로고    scopus 로고
    • MicroRNA in autoimmunity and autoimmune diseases
    • Pauley KM, Cha S and Chan EK (2009) MicroRNA in autoimmunity and autoimmune diseases. J Autoimmun 32, 189-194.
    • (2009) J Autoimmun , vol.32 , pp. 189-194
    • Pauley, K.M.1    Cha, S.2    Chan, E.K.3
  • 11
    • 79952779639 scopus 로고    scopus 로고
    • MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases
    • Dai R and Ahmed SA (2011) MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases. Transl Res 157, 163-179.
    • (2011) Transl Res , vol.157 , pp. 163-179
    • Dai, R.1    Ahmed, S.A.2
  • 12
    • 84900419023 scopus 로고    scopus 로고
    • Effect of aging on microRNAs and regulation of pathogen recognition receptors
    • Olivieri F, Procopio AD and Montgomery RR (2014) Effect of aging on microRNAs and regulation of pathogen recognition receptors. Curr Opin Immunol 29, 29-37.
    • (2014) Curr Opin Immunol , vol.29 , pp. 29-37
    • Olivieri, F.1    Procopio, A.D.2    Montgomery, R.R.3
  • 13
    • 79952186298 scopus 로고    scopus 로고
    • MicroRNAs: the fine-tuners of Toll-like receptor signalling
    • O'Neill LA, Sheedy FJ and McCoy CE (2011) MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nat Rev Immunol 11, 163-175.
    • (2011) Nat Rev Immunol , vol.11 , pp. 163-175
    • O'Neill, L.A.1    Sheedy, F.J.2    McCoy, C.E.3
  • 14
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar H, Kawai T and Akira S (2011) Pathogen recognition by the innate immune system. Int Rev Immunol 30, 16-34.
    • (2011) Int Rev Immunol , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 15
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • Kawai T and Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11, 373-384.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 16
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • Kawai T and Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34, 637-650.
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 17
    • 44649132540 scopus 로고    scopus 로고
    • Host innate immune receptors and beyond: making sense of microbial infections
    • Ishii KJ, Koyama S, Nakagawa A, Coban C and Akira S (2008) Host innate immune receptors and beyond: making sense of microbial infections. Cell Host Microbe 3, 352-363.
    • (2008) Cell Host Microbe , vol.3 , pp. 352-363
    • Ishii, K.J.1    Koyama, S.2    Nakagawa, A.3    Coban, C.4    Akira, S.5
  • 18
    • 84886442156 scopus 로고    scopus 로고
    • Molecular control of the NEMO family of ubiquitin-binding proteins
    • Clark K, Nanda S and Cohen P (2013) Molecular control of the NEMO family of ubiquitin-binding proteins. Nat Rev Mol Cell Biol 14, 673-685.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 673-685
    • Clark, K.1    Nanda, S.2    Cohen, P.3
  • 19
    • 36049033394 scopus 로고    scopus 로고
    • Signaling to NF-kappaB by Toll-like receptors
    • Kawai T and Akira S (2007) Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med 13, 460-469.
    • (2007) Trends Mol Med , vol.13 , pp. 460-469
    • Kawai, T.1    Akira, S.2
  • 20
    • 84883199752 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in innate immunity
    • Arthur JS and Ley SC (2013) Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol 13, 679-692.
    • (2013) Nat Rev Immunol , vol.13 , pp. 679-692
    • Arthur, J.S.1    Ley, S.C.2
  • 21
    • 77956025260 scopus 로고    scopus 로고
    • New insights into the regulation of signalling by toll-like receptors and nod-like receptors
    • Coll RC and O'Neill LA (2010) New insights into the regulation of signalling by toll-like receptors and nod-like receptors. J Innate Immun 2, 406-421.
    • (2010) J Innate Immun , vol.2 , pp. 406-421
    • Coll, R.C.1    O'Neill, L.A.2
  • 22
    • 30544439770 scopus 로고    scopus 로고
    • MAP kinase kinase kinases and innate immunity
    • Symons A, Beinke S and Ley SC (2006) MAP kinase kinase kinases and innate immunity. Trends Immunol 27, 40-48.
    • (2006) Trends Immunol , vol.27 , pp. 40-48
    • Symons, A.1    Beinke, S.2    Ley, S.C.3
  • 23
    • 84901807090 scopus 로고    scopus 로고
    • The TLR and IL-1 signalling network at a glance
    • Cohen P (2014) The TLR and IL-1 signalling network at a glance. J Cell Sci 127, 2383-2390.
    • (2014) J Cell Sci , vol.127 , pp. 2383-2390
    • Cohen, P.1
  • 25
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by micro-RNAs: are the answers in sight?
    • Filipowicz W, Bhattacharyya SN and Sonenberg N (2008) Mechanisms of post-transcriptional regulation by micro-RNAs: are the answers in sight? Nat Rev Genet 9, 102-114.
    • (2008) Nat Rev Genet , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 26
    • 84858379476 scopus 로고    scopus 로고
    • MicroRNAs in stress signaling and human disease
    • Mendell JT and Olson EN (2012) MicroRNAs in stress signaling and human disease. Cell 148, 1172-1187.
    • (2012) Cell , vol.148 , pp. 1172-1187
    • Mendell, J.T.1    Olson, E.N.2
  • 27
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL and Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 28
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B, Ha I and Ruvkun G (1993) Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75, 855-862.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 29
    • 84924971782 scopus 로고    scopus 로고
    • Outside the coding genome, mammalian microRNAs confer structural and functional complexity
    • Olive V, Minella AC and He L (2015) Outside the coding genome, mammalian microRNAs confer structural and functional complexity. Sci Signal 8, re2.
    • (2015) Sci Signal , vol.8
    • Olive, V.1    Minella, A.C.2    He, L.3
  • 30
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J, Getz G, Miska EA et al (2005) MicroRNA expression profiles classify human cancers. Nature 435, 834-838.
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 31
    • 34250841756 scopus 로고    scopus 로고
    • MicroRNAs in human cancer: from research to therapy
    • Negrini M, Ferracin M, Sabbioni S and Croce CM (2007) MicroRNAs in human cancer: from research to therapy. J Cell Sci 120, 1833-1840.
    • (2007) J Cell Sci , vol.120 , pp. 1833-1840
    • Negrini, M.1    Ferracin, M.2    Sabbioni, S.3    Croce, C.M.4
  • 32
    • 79958121735 scopus 로고    scopus 로고
    • microRNAs in the regulation of adipogenesis and obesity
    • McGregor RA and Choi MS (2011) microRNAs in the regulation of adipogenesis and obesity. Curr Mol Med 11, 304-316.
    • (2011) Curr Mol Med , vol.11 , pp. 304-316
    • McGregor, R.A.1    Choi, M.S.2
  • 33
    • 66149138833 scopus 로고    scopus 로고
    • MicroRNAs in cancer
    • Lee YS and Dutta A (2009) MicroRNAs in cancer. Annu Rev Pathol 4, 199-227.
    • (2009) Annu Rev Pathol , vol.4 , pp. 199-227
    • Lee, Y.S.1    Dutta, A.2
  • 34
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Lee Y, Ahn C, Han J et al (2003) The nuclear RNase III Drosha initiates microRNA processing. Nature 425, 415-419.
    • (2003) Nature , vol.425 , pp. 415-419
    • Lee, Y.1    Ahn, C.2    Han, J.3
  • 35
    • 10644234841 scopus 로고    scopus 로고
    • The Drosha-DGCR8 complex in primary microRNA processing
    • Han J, Lee Y, Yeom KH, Kim YK, Jin H and Kim VN (2004) The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 18, 3016-3027.
    • (2004) Genes Dev , vol.18 , pp. 3016-3027
    • Han, J.1    Lee, Y.2    Yeom, K.H.3    Kim, Y.K.4    Jin, H.5    Kim, V.N.6
  • 37
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Yi R, Qin Y, Macara IG and Cullen BR (2003) Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 17, 3011-3016.
    • (2003) Genes Dev , vol.17 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    Macara, I.G.3    Cullen, B.R.4
  • 38
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein E, Caudy AA, Hammond SM and Hannon GJ (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 39
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvágner G, McLachlan J, Pasquinelli AE, Bálint E, Tuschl T and Zamore PD (2001) A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293, 834-838.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvágner, G.1    McLachlan, J.2    Pasquinelli, A.E.3    Bálint, E.4    Tuschl, T.5    Zamore, P.D.6
  • 40
    • 36348979175 scopus 로고    scopus 로고
    • P68 RNA helicase unwinds the human let-7 microRNA precursor duplex and is required for let-7-directed silencing of gene expression
    • Salzman DW, Shubert-Coleman J and Furneaux H (2007) P68 RNA helicase unwinds the human let-7 microRNA precursor duplex and is required for let-7-directed silencing of gene expression. J Biol Chem 282, 32773-32779.
    • (2007) J Biol Chem , vol.282 , pp. 32773-32779
    • Salzman, D.W.1    Shubert-Coleman, J.2    Furneaux, H.3
  • 41
    • 23644433363 scopus 로고    scopus 로고
    • TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
    • Chendrimada TP, Gregory RI and Kumaraswamy E et al (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436, 740-744.
    • (2005) Nature , vol.436 , pp. 740-744
    • Chendrimada, T.P.1    Gregory, R.I.2    Kumaraswamy, E.3
  • 44
    • 40449098091 scopus 로고    scopus 로고
    • MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation
    • Sonkoly E, Ståhle M and Pivarcsi A (2008) MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Semin Cancer Biol 18, 131-140.
    • (2008) Semin Cancer Biol , vol.18 , pp. 131-140
    • Sonkoly, E.1    Ståhle, M.2    Pivarcsi, A.3
  • 45
    • 45549103746 scopus 로고    scopus 로고
    • microRNAs and the immune response
    • Lindsay MA (2008) microRNAs and the immune response. Trends Immunol 29, 343-351.
    • (2008) Trends Immunol , vol.29 , pp. 343-351
    • Lindsay, M.A.1
  • 46
    • 33747608638 scopus 로고    scopus 로고
    • NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    • T Taganov KD, Boldin MP, Chang KJ and Baltimore D (2006) NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 103, 12481-12486.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12481-12486
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.J.3    Baltimore, D.4
  • 48
    • 34547774686 scopus 로고    scopus 로고
    • Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids
    • Moschos SA, Williams AE, Perry MM, Birrell MA, Belvisi MG and Lindsay MA (2007) Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids. BMC Genomics 8, 240.
    • (2007) BMC Genomics , vol.8 , pp. 240
    • Moschos, S.A.1    Williams, A.E.2    Perry, M.M.3    Birrell, M.A.4    Belvisi, M.G.5    Lindsay, M.A.6
  • 49
    • 38049030287 scopus 로고    scopus 로고
    • Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
    • Tili E, Michaille JJ, Cimino A et al (2007) Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 179, 5082-5089.
    • (2007) J Immunol , vol.179 , pp. 5082-5089
    • Tili, E.1    Michaille, J.J.2    Cimino, A.3
  • 50
    • 84890283575 scopus 로고    scopus 로고
    • miR-125a-5p regulates differential activation of macrophages and inflammation
    • Banerjee S, Cui H, Xie N et al (2013) miR-125a-5p regulates differential activation of macrophages and inflammation. J Biol Chem 288, 35428-35436.
    • (2013) J Biol Chem , vol.288 , pp. 35428-35436
    • Banerjee, S.1    Cui, H.2    Xie, N.3
  • 52
    • 77955924350 scopus 로고    scopus 로고
    • MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation
    • Li T, Morgan MJ, Choksi S, Zhang Y, Kim YS and Liu ZG (2010) MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Nat Immunol 11, 799-805.
    • (2010) Nat Immunol , vol.11 , pp. 799-805
    • Li, T.1    Morgan, M.J.2    Choksi, S.3    Zhang, Y.4    Kim, Y.S.5    Liu, Z.G.6
  • 53
    • 84919674993 scopus 로고    scopus 로고
    • MicroRNA-146a: A Dominant, Negative Regulator of the Innate Immune Response
    • Saba R, Sorensen DL and Booth SA (2014) MicroRNA-146a: A Dominant, Negative Regulator of the Innate Immune Response. Front Immunol 5, 578.
    • (2014) Front Immunol , vol.5 , pp. 578
    • Saba, R.1    Sorensen, D.L.2    Booth, S.A.3
  • 54
    • 45549101837 scopus 로고    scopus 로고
    • Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells
    • Perry MM, Moschos SA, Williams AE, Shepherd NJ, Larner-Svensson HM and Lindsay MA (2008) Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells. J Immunol 180, 5689-5698.
    • (2008) J Immunol , vol.180 , pp. 5689-5698
    • Perry, M.M.1    Moschos, S.A.2    Williams, A.E.3    Shepherd, N.J.4    Larner-Svensson, H.M.5    Lindsay, M.A.6
  • 56
    • 79958257077 scopus 로고    scopus 로고
    • miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
    • Boldin MP, Taganov KD, Rao DS et al (2011) miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med 208, 1189-1201.
    • (2011) J Exp Med , vol.208 , pp. 1189-1201
    • Boldin, M.P.1    Taganov, K.D.2    Rao, D.S.3
  • 58
    • 73849121794 scopus 로고    scopus 로고
    • Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype
    • Starczynowski DT, Kuchenbauer F, Argiropoulos B et al (2010) Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype. Nat Med 16, 49-58.
    • (2010) Nat Med , vol.16 , pp. 49-58
    • Starczynowski, D.T.1    Kuchenbauer, F.2    Argiropoulos, B.3
  • 59
    • 78649863208 scopus 로고    scopus 로고
    • Differential regulation of interleukin-1 receptorassociated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease
    • Cui JG, Li YY, Zhao Y, Bhattacharjee S and Lukiw WJ (2010) Differential regulation of interleukin-1 receptorassociated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease. J Biol Chem 285, 38951-38960.
    • (2010) J Biol Chem , vol.285 , pp. 38951-38960
    • Cui, J.G.1    Li, Y.Y.2    Zhao, Y.3    Bhattacharjee, S.4    Lukiw, W.J.5
  • 60
    • 84921932058 scopus 로고    scopus 로고
    • MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins
    • Park H, Huang X, Lu C, Cairo MS and Zhou X (2015) MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins. J Biol Chem 290, 2831-2841.
    • (2015) J Biol Chem , vol.290 , pp. 2831-2841
    • Park, H.1    Huang, X.2    Lu, C.3    Cairo, M.S.4    Zhou, X.5
  • 61
    • 71749096218 scopus 로고    scopus 로고
    • miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY
    • Nahid MA, Pauley KM, Satoh M and Chan EK (2009) miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY. J Biol Chem 284, 34590-34599.
    • (2009) J Biol Chem , vol.284 , pp. 34590-34599
    • Nahid, M.A.1    Pauley, K.M.2    Satoh, M.3    Chan, E.K.4
  • 62
    • 84936764355 scopus 로고    scopus 로고
    • Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression
    • Gao M, Wang X, Zhang X et al (2015) Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression. J Immunol 195, 672-682.
    • (2015) J Immunol , vol.195 , pp. 672-682
    • Gao, M.1    Wang, X.2    Zhang, X.3
  • 63
    • 84938995470 scopus 로고    scopus 로고
    • Poly(I:C) induced microRNA-146a regulates epithelial barrier and secretion of proinflammatory cytokines in human nasal epithelial cells
    • Miyata R, Kakuki T, Nomura K et al (2015) Poly(I:C) induced microRNA-146a regulates epithelial barrier and secretion of proinflammatory cytokines in human nasal epithelial cells. Eur J Pharmacol 761, 375-382.
    • (2015) Eur J Pharmacol , vol.761 , pp. 375-382
    • Miyata, R.1    Kakuki, T.2    Nomura, K.3
  • 64
    • 84908123687 scopus 로고    scopus 로고
    • MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes
    • Rebane A, Runnel T, Aab A et al (2014) MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes. J Allergy Clin Immunol 134, 836-847 e811.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 836-847
    • Rebane, A.1    Runnel, T.2    Aab, A.3
  • 65
    • 84902549323 scopus 로고    scopus 로고
    • MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes
    • Meisgen F, Xu Landén N and Wang A et al (2014) MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes. J Invest Dermatol 134, 1931-1940.
    • (2014) J Invest Dermatol , vol.134 , pp. 1931-1940
    • Meisgen, F.1    Xu Landén, N.2    Wang, A.3
  • 66
    • 84929595790 scopus 로고    scopus 로고
    • Angiopoietin-1 inhibits toll-like receptor 4 signalling in cultured endothelial cells: role of miR-146b-5p
    • Echavarria R, Mayaki D, Neel JC, Harel S, Sanchez V and Hussain SN (2015) Angiopoietin-1 inhibits toll-like receptor 4 signalling in cultured endothelial cells: role of miR-146b-5p. Cardiovasc Res 106, 465-477.
    • (2015) Cardiovasc Res , vol.106 , pp. 465-477
    • Echavarria, R.1    Mayaki, D.2    Neel, J.C.3    Harel, S.4    Sanchez, V.5    Hussain, S.N.6
  • 67
    • 81355135120 scopus 로고    scopus 로고
    • Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response
    • Schnitger AK, Machova A, Mueller RU et al (2011) Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response. PLoS One 6, e27435.
    • (2011) PLoS One , vol.6
    • Schnitger, A.K.1    Machova, A.2    Mueller, R.U.3
  • 68
    • 84929649804 scopus 로고    scopus 로고
    • MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection
    • Kim JK, Yuk JM, Kim SY et al (2015) MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection. J Immunol 194, 5355-5365.
    • (2015) J Immunol , vol.194 , pp. 5355-5365
    • Kim, J.K.1    Yuk, J.M.2    Kim, S.Y.3
  • 69
    • 68649091506 scopus 로고    scopus 로고
    • The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs
    • Androulidaki A, Iliopoulos D, Arranz A et al (2009) The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 31, 220-231.
    • (2009) Immunity , vol.31 , pp. 220-231
    • Androulidaki, A.1    Iliopoulos, D.2    Arranz, A.3
  • 70
    • 77954498935 scopus 로고    scopus 로고
    • Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages
    • Murphy AJ, Guyre PM and Pioli PA (2010) Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages. J Immunol 184, 5029-5037.
    • (2010) J Immunol , vol.184 , pp. 5029-5037
    • Murphy, A.J.1    Guyre, P.M.2    Pioli, P.A.3
  • 71
    • 84922574946 scopus 로고    scopus 로고
    • 5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p
    • Busch S, Auth E, Scholl F et al (2015) 5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p. J Immunol 194, 1646-1653.
    • (2015) J Immunol , vol.194 , pp. 1646-1653
    • Busch, S.1    Auth, E.2    Scholl, F.3
  • 72
    • 81455141958 scopus 로고    scopus 로고
    • MicroRNA-125b potentiates macrophage activation
    • Chaudhuri AA, So AY, Sinha N et al (2011) MicroRNA-125b potentiates macrophage activation. J Immunol 187, 5062-5068.
    • (2011) J Immunol , vol.187 , pp. 5062-5068
    • Chaudhuri, A.A.1    So, A.Y.2    Sinha, N.3
  • 73
    • 52249094653 scopus 로고    scopus 로고
    • Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    • Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH and Chan EK (2008) Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther 10, R101.
    • (2008) Arthritis Res Ther , vol.10 , pp. R101
    • Pauley, K.M.1    Satoh, M.2    Chan, A.L.3    Bubb, M.R.4    Reeves, W.H.5    Chan, E.K.6
  • 74
    • 84922561074 scopus 로고    scopus 로고
    • Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network
    • Fang J, Barker B, Bolanos L et al (2014) Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network. Cell Rep 8, 1328-1338.
    • (2014) Cell Rep , vol.8 , pp. 1328-1338
    • Fang, J.1    Barker, B.2    Bolanos, L.3
  • 75
    • 84961221099 scopus 로고    scopus 로고
    • Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling
    • Varney ME, Niederkorn M, Konno H et al (2015) Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. J Exp Med 212, 1967-1985.
    • (2015) J Exp Med , vol.212 , pp. 1967-1985
    • Varney, M.E.1    Niederkorn, M.2    Konno, H.3
  • 76
    • 84928814137 scopus 로고    scopus 로고
    • Upregulation of microRNA-146a by hepatitis B virus X protein contributes to hepatitis development by downregulating complement factor H
    • Li JF, Dai XP, Zhang W et al (2015) Upregulation of microRNA-146a by hepatitis B virus X protein contributes to hepatitis development by downregulating complement factor H. MBio 6, pii: e02459-02414.
    • (2015) MBio , vol.6
    • Li, J.F.1    Dai, X.P.2    Zhang, W.3
  • 77
    • 78149358596 scopus 로고    scopus 로고
    • MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus
    • Zhao X, Tang Y, Qu B et al (2010) MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus. Arthritis Rheum 62, 3425-3435.
    • (2010) Arthritis Rheum , vol.62 , pp. 3425-3435
    • Zhao, X.1    Tang, Y.2    Qu, B.3
  • 78
    • 84876271260 scopus 로고    scopus 로고
    • MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis
    • Reijerkerk A, Lopez-Ramirez MA, van Het Hof B et al (2013) MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis. J Neurosci 33, 6857-6863.
    • (2013) J Neurosci , vol.33 , pp. 6857-6863
    • Reijerkerk, A.1    Lopez-Ramirez, M.A.2    van Het Hof, B.3
  • 79
    • 84929193321 scopus 로고    scopus 로고
    • MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis
    • Pan W, Zhu S, Dai D et al (2015) MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis. Nat Commun 6, 7096.
    • (2015) Nat Commun , vol.6 , pp. 7096
    • Pan, W.1    Zhu, S.2    Dai, D.3
  • 80
    • 84862962818 scopus 로고    scopus 로고
    • Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps
    • Zhang XH, Zhang YN, Li HB et al (2012) Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med 185, 140-151.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 140-151
    • Zhang, X.H.1    Zhang, Y.N.2    Li, H.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.