MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 4, 2014, Pages 836-847.e11

  Rebane, Ana ^a,b   Runnel, Toomas ^a,b   Aab, Alar ^a,b   Maslovskaja, Julia ^a,b   Rückert, Beate ^a   Zimmermann, Maya ^a   Plaas, Mario ^b   Kärner, Jaanika ^a,b   Treis, Angela ^a   Pihlap, Maire ^b   Haljasorg, Uku ^b   Hermann, Helen ^b   Nagy, Nikoletta ^c,d   Kemeny, Lajos ^c,d   Erm, Triin ^e   Kingo, Külli ^b,e   Li, Mei ^f   Boldin, Mark P ^g   Akdis, Cezmi A ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF TARTU   (Estonia)

^c UNIVERSITY OF SZEGED   (Hungary)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^e TARTU UNIVERSITY HOSPITAL   (Estonia)

^f UNIVERSITÉ DE STRASBOURG   (France)

^g CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Allergy; atopic eczema; gene therapy; noncoding RNA

Indexed keywords

CALCIPOTRIOL; CARRIER PROTEINS AND BINDING PROTEINS; CASPASE RECRUITMENT DOMAIN PROTEIN 10; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1BETA; MESSENGER RNA; MICRORNA 146A; MONOCYTE CHEMOTACTIC PROTEIN 2; RANTES; RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; CALCITRIOL; CYTOKINE; MICRORNA; MIRN146 MICRORNA, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; BIOACCUMULATION; CELL STIMULATION; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CONTROLLED STUDY; DERMIS; EPIDERMIS; FEMALE; GENE; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; KERATINOCYTE; LUCIFERASE ASSAY; MALE; MONOCYTE CHEMOTACTIC GENE 2; MOUSE; MOUSE MODEL; NONHUMAN; PRIMARY CELL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; RANTES GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BIOPSY; TISSUE CULTURE; UBIQUITIN D GENE; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL MOTION; CHEMICALLY INDUCED; CHRONIC DISEASE; DISEASE MODEL; GENETICS; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SKIN; UPREGULATION;

ANIMALS; CALCITRIOL; CELL MOVEMENT; CELLS, CULTURED; CHRONIC DISEASE; CYTOKINES; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; HUMANS; IMMUNITY, INNATE; IMMUNOSUPPRESSION; INFLAMMATION; INFLAMMATION MEDIATORS; KERATINOCYTES; MICE; MICE, INBRED C57BL; MICRORNAS; NF-KAPPA B; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SKIN; UP-REGULATION;

EID: 84908123687     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.05.022     Document Type: Article

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