메뉴 건너뛰기




Volumn 120, Issue 2, 2016, Pages 185-194

Immune modulation by hypofractionated stereotactic radiation therapy: Therapeutic implications

Author keywords

Abscopal effect; Checkpoint blockade; SBRT; SRS

Indexed keywords

CANCER VACCINE; CHEMOKINE; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; DOCETAXEL; IPILIMUMAB; NIVOLUMAB; PEMBROLIZUMAB; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 2;

EID: 84991085089     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2016.07.013     Document Type: Review
Times cited : (95)

References (118)
  • 1
    • 0024552564 scopus 로고
    • Immunosuppression in irradiated breast cancer patients: in vitro effect of cyclooxygenase inhibitors
    • [1] Wasserman, J., Blomgren, H., Rotstein, S., Petrini, B., Hammarström, S., Immunosuppression in irradiated breast cancer patients: in vitro effect of cyclooxygenase inhibitors. Bull N Y Acad Med 65 (1989), 36–44.
    • (1989) Bull N Y Acad Med , vol.65 , pp. 36-44
    • Wasserman, J.1    Blomgren, H.2    Rotstein, S.3    Petrini, B.4    Hammarström, S.5
  • 2
    • 7444258053 scopus 로고    scopus 로고
    • Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes
    • [2] Garnett, C.T., Palena, C., Chakraborty, M., Tsang, K.Y., Schlom, J., Hodge, J.W., Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes. Cancer Res 64 (2004), 7985–7994.
    • (2004) Cancer Res , vol.64 , pp. 7985-7994
    • Garnett, C.T.1    Palena, C.2    Chakraborty, M.3    Tsang, K.Y.4    Schlom, J.5    Hodge, J.W.6
  • 3
    • 70149113060 scopus 로고    scopus 로고
    • Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
    • [3] Lee, Y., Auh, S.L., Wang, Y., et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood 114 (2009), 589–595.
    • (2009) Blood , vol.114 , pp. 589-595
    • Lee, Y.1    Auh, S.L.2    Wang, Y.3
  • 4
    • 45449090985 scopus 로고    scopus 로고
    • Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity
    • [4] Lugade, A.A., Sorensen, E.W., Gerber, S.A., Moran, J.P., Frelinger, J.G., Lord, E.M., Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity. J Immunol 180 (2008), 3132–3139.
    • (2008) J Immunol , vol.180 , pp. 3132-3139
    • Lugade, A.A.1    Sorensen, E.W.2    Gerber, S.A.3    Moran, J.P.4    Frelinger, J.G.5    Lord, E.M.6
  • 5
    • 84899150225 scopus 로고    scopus 로고
    • Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated γ-irradiation
    • [5] Hennel, R., Brix, N., Seidl, K., et al. Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated γ-irradiation. Radiat Oncol, 9, 2014, 85.
    • (2014) Radiat Oncol , vol.9 , pp. 85
    • Hennel, R.1    Brix, N.2    Seidl, K.3
  • 6
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • [6] Postow, M.A., Callahan, M.K., Barker, C.A., et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 366 (2012), 925–931.
    • (2012) N Engl J Med , vol.366 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3
  • 7
    • 85003053854 scopus 로고    scopus 로고
    • An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer
    • [7] Golden, E.B., Demaria, S., Schiff, P.B., Chachoua, A., Formenti, S.C., An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res 1 (2013), 365–372.
    • (2013) Cancer Immunol Res , vol.1 , pp. 365-372
    • Golden, E.B.1    Demaria, S.2    Schiff, P.B.3    Chachoua, A.4    Formenti, S.C.5
  • 8
    • 20944441967 scopus 로고    scopus 로고
    • Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer
    • [8] Gulley, J.L., Arlen, P.M., Bastian, A., et al. Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer. Clin Cancer Res 11 (2005), 3353–3362.
    • (2005) Clin Cancer Res , vol.11 , pp. 3353-3362
    • Gulley, J.L.1    Arlen, P.M.2    Bastian, A.3
  • 9
    • 84942915875 scopus 로고    scopus 로고
    • Ablative tumor radiation can change the tumor immune cell microenvironment to induce durable complete remissions
    • [9] Filatenkov, A., Baker, J., Mueller, A.M., et al. Ablative tumor radiation can change the tumor immune cell microenvironment to induce durable complete remissions. Clin Cancer Res 21 (2015), 3727–3739.
    • (2015) Clin Cancer Res , vol.21 , pp. 3727-3739
    • Filatenkov, A.1    Baker, J.2    Mueller, A.M.3
  • 10
    • 0242468607 scopus 로고    scopus 로고
    • Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer
    • [10] Timmerman, R., Papiez, L., McGarry, R., et al. Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer. Chest 124 (2003), 1946–1955.
    • (2003) Chest , vol.124 , pp. 1946-1955
    • Timmerman, R.1    Papiez, L.2    McGarry, R.3
  • 11
    • 63749100778 scopus 로고    scopus 로고
    • Multi-institutional phase I/II trial of stereotactic body radiation therapy for lung metastases
    • [11] Rusthoven, K.E., Kavanagh, B.D., Burri, S.H., et al. Multi-institutional phase I/II trial of stereotactic body radiation therapy for lung metastases. J Clin Oncol 27 (2009), 1579–1584.
    • (2009) J Clin Oncol , vol.27 , pp. 1579-1584
    • Rusthoven, K.E.1    Kavanagh, B.D.2    Burri, S.H.3
  • 12
    • 63749100778 scopus 로고    scopus 로고
    • Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases
    • [12] Rusthoven, K.E., Kavanagh, B.D., Cardenes, H., et al. Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases. J Clin Oncol 27 (2009), 1572–1578.
    • (2009) J Clin Oncol , vol.27 , pp. 1572-1578
    • Rusthoven, K.E.1    Kavanagh, B.D.2    Cardenes, H.3
  • 13
    • 34547699263 scopus 로고    scopus 로고
    • Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure
    • [13] Chang, E.L., Shiu, A.S., Mendel, E., et al. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine 7 (2007), 151–160.
    • (2007) J Neurosurg Spine , vol.7 , pp. 151-160
    • Chang, E.L.1    Shiu, A.S.2    Mendel, E.3
  • 14
    • 84858708179 scopus 로고    scopus 로고
    • Tumor control outcomes after hypofractionated and single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases from renal cell carcinoma
    • [14] Zelefsky, M.J., Greco, C., Motzer, R., et al. Tumor control outcomes after hypofractionated and single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases from renal cell carcinoma. Int J Radiat Oncol Biol Phys 82 (2012), 1744–1748.
    • (2012) Int J Radiat Oncol Biol Phys , vol.82 , pp. 1744-1748
    • Zelefsky, M.J.1    Greco, C.2    Motzer, R.3
  • 15
    • 84855825726 scopus 로고    scopus 로고
    • Long-term outcomes from a prospective trial of stereotactic body radiotherapy for low-risk prostate cancer
    • [15] King, C.R., Brooks, J.D., Gill, H., Presti, J.C. Jr., Long-term outcomes from a prospective trial of stereotactic body radiotherapy for low-risk prostate cancer. Int J Radiat Oncol Biol Phys 82 (2012), 877–882.
    • (2012) Int J Radiat Oncol Biol Phys , vol.82 , pp. 877-882
    • King, C.R.1    Brooks, J.D.2    Gill, H.3    Presti, J.C.4
  • 16
    • 84930340525 scopus 로고    scopus 로고
    • Stereotactic body radiotherapy (SBRT) in the management of extracranial oligometastatic (OM) disease
    • [16] Bhattacharya, I.S., Woolf, D.K., Hughes, R.J., et al. Stereotactic body radiotherapy (SBRT) in the management of extracranial oligometastatic (OM) disease. Br J Radiol, 1048, 2015, 20140712.
    • (2015) Br J Radiol , vol.1048 , pp. 20140712
    • Bhattacharya, I.S.1    Woolf, D.K.2    Hughes, R.J.3
  • 17
    • 64049110827 scopus 로고    scopus 로고
    • Dose-response relationship for image-guided stereotactic body radiotherapy of pulmonary tumors: relevance of 4D dose calculation
    • [17] Guckenberger, M., Wulf, J., Mueller, G., et al. Dose-response relationship for image-guided stereotactic body radiotherapy of pulmonary tumors: relevance of 4D dose calculation. Int J Radiat Oncol Biol Phys 74 (2009), 47–54.
    • (2009) Int J Radiat Oncol Biol Phys , vol.74 , pp. 47-54
    • Guckenberger, M.1    Wulf, J.2    Mueller, G.3
  • 18
    • 65649120797 scopus 로고    scopus 로고
    • Local surgical, ablative, and radiation treatment of metastases
    • [18] Timmerman, R.D., Bizekis, C.S., Pass, H.I., et al. Local surgical, ablative, and radiation treatment of metastases. CA Cancer J Clin 59 (2009), 145–170.
    • (2009) CA Cancer J Clin , vol.59 , pp. 145-170
    • Timmerman, R.D.1    Bizekis, C.S.2    Pass, H.I.3
  • 19
    • 0013071190 scopus 로고
    • Whole body irradiation; radiobiology or medicine?
    • [19] Mole, R.H., Whole body irradiation; radiobiology or medicine?. Br J Radiol 26 (1953), 234–241.
    • (1953) Br J Radiol , vol.26 , pp. 234-241
    • Mole, R.H.1
  • 20
    • 84912558665 scopus 로고    scopus 로고
    • Abscopal effects of radiation therapy: a clinical review for the radiobiologist
    • [20] Siva, S., MacManus, M.P., Martin, R.F., Martin, O.A., Abscopal effects of radiation therapy: a clinical review for the radiobiologist. Cancer Lett 356 (2015), 82–90.
    • (2015) Cancer Lett , vol.356 , pp. 82-90
    • Siva, S.1    MacManus, M.P.2    Martin, R.F.3    Martin, O.A.4
  • 22
    • 84874693196 scopus 로고    scopus 로고
    • The tumor microenvironment at a glance
    • [22] Balkwill, F.R., Capasso, M., Hagemann, T., The tumor microenvironment at a glance. J Cell Sci 125 (2012), 5591–5596.
    • (2012) J Cell Sci , vol.125 , pp. 5591-5596
    • Balkwill, F.R.1    Capasso, M.2    Hagemann, T.3
  • 24
    • 0028846648 scopus 로고
    • Radiation-induced apoptosis: relevance to radiotherapy
    • [24] Dewey, W.C., Ling, C.C., Meyn, R.E., Radiation-induced apoptosis: relevance to radiotherapy. Int J Radiat Oncol Biol Phys 33 (1995), 781–796.
    • (1995) Int J Radiat Oncol Biol Phys , vol.33 , pp. 781-796
    • Dewey, W.C.1    Ling, C.C.2    Meyn, R.E.3
  • 25
    • 0027423615 scopus 로고
    • Radiation-induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay
    • [25] Olive, P.L., Frazer, G., Banáth, J.P., Radiation-induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay. Radiat Res 136 (1993), 130–136.
    • (1993) Radiat Res , vol.136 , pp. 130-136
    • Olive, P.L.1    Frazer, G.2    Banáth, J.P.3
  • 26
    • 0032982136 scopus 로고    scopus 로고
    • Increase in the fraction of necrotic, not apoptotic, cells in SiHa xenograft tumours shortly after irradiation
    • [26] Olive, P.L., Vikse, C.M., Vanderbyl, S., Increase in the fraction of necrotic, not apoptotic, cells in SiHa xenograft tumours shortly after irradiation. Radiother Oncol 50 (1999), 113–119.
    • (1999) Radiother Oncol , vol.50 , pp. 113-119
    • Olive, P.L.1    Vikse, C.M.2    Vanderbyl, S.3
  • 27
    • 0033380292 scopus 로고    scopus 로고
    • Apoptosis or necrosis for tumor immunotherapy: What's in a name?
    • [27] Melcher, A., Gough, M., Todryk, S., Vile, R., Apoptosis or necrosis for tumor immunotherapy: What's in a name?. J Mol Med (Berl) 77 (1999), 824–833.
    • (1999) J Mol Med (Berl) , vol.77 , pp. 824-833
    • Melcher, A.1    Gough, M.2    Todryk, S.3    Vile, R.4
  • 28
    • 0034614897 scopus 로고    scopus 로고
    • Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
    • [28] Sauter, B., Albert, M.L., Francisco, L., Larsson, M., Somersan, S., Bhardwaj, N., Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 191 (2000), 423–434.
    • (2000) J Exp Med , vol.191 , pp. 423-434
    • Sauter, B.1    Albert, M.L.2    Francisco, L.3    Larsson, M.4    Somersan, S.5    Bhardwaj, N.6
  • 29
    • 0033179274 scopus 로고    scopus 로고
    • Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake
    • [29] Todryk, S., Melcher, A.A., Hardwick, N., et al. Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake. J Immunol 163 (1999), 1398–1408.
    • (1999) J Immunol , vol.163 , pp. 1398-1408
    • Todryk, S.1    Melcher, A.A.2    Hardwick, N.3
  • 30
    • 5944233768 scopus 로고    scopus 로고
    • Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    • [30] Holler, N., Zaru, R., Micheau, O., et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1 (2000), 489–495.
    • (2000) Nat Immunol , vol.1 , pp. 489-495
    • Holler, N.1    Zaru, R.2    Micheau, O.3
  • 31
    • 0036155773 scopus 로고    scopus 로고
    • Defective death receptor signaling as a cause of tumor immune escape
    • [31] French, L.E., Tschopp, J., Defective death receptor signaling as a cause of tumor immune escape. Semin Cancer Biol 12 (2002), 51–55.
    • (2002) Semin Cancer Biol , vol.12 , pp. 51-55
    • French, L.E.1    Tschopp, J.2
  • 32
    • 24144443517 scopus 로고    scopus 로고
    • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    • [32] Gasser, S., Orsulic, S., Brown, E.J., Raulet, D.H., The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436 (2005), 1186–1190.
    • (2005) Nature , vol.436 , pp. 1186-1190
    • Gasser, S.1    Orsulic, S.2    Brown, E.J.3    Raulet, D.H.4
  • 33
    • 84885696103 scopus 로고    scopus 로고
    • Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+ T-cell activation events
    • [33] Schouppe, E., Mommer, C., Movahedi, K., et al. Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+ T-cell activation events. Eur J Immunol 43 (2013), 2930–2942.
    • (2013) Eur J Immunol , vol.43 , pp. 2930-2942
    • Schouppe, E.1    Mommer, C.2    Movahedi, K.3
  • 34
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • [34] Mantovani, A., Sozzani, S., Locati, M., Allavena, P., Sica, A., Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23 (2002), 549–555.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 35
    • 84914096079 scopus 로고    scopus 로고
    • Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors
    • [35] Beury, D.W., Parker, K.H., Nyandjo, M., Sinha, P., Carter, K.A., Ostrand-Rosenberg, S., Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors. J Leukoc Biol 96 (2014), 1109–1118.
    • (2014) J Leukoc Biol , vol.96 , pp. 1109-1118
    • Beury, D.W.1    Parker, K.H.2    Nyandjo, M.3    Sinha, P.4    Carter, K.A.5    Ostrand-Rosenberg, S.6
  • 36
    • 48549085973 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    • [36] Serafini, P., Mgebroff, S., Noonan, K., Borrello, I., Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res 68 (2008), 5439–5449.
    • (2008) Cancer Res , vol.68 , pp. 5439-5449
    • Serafini, P.1    Mgebroff, S.2    Noonan, K.3    Borrello, I.4
  • 37
    • 84875024405 scopus 로고    scopus 로고
    • Irradiation promotes an m2 macrophage phenotype in tumor hypoxia
    • [37] Chiang, C.S., Fu, S.Y., Wang, S.C., et al. Irradiation promotes an m2 macrophage phenotype in tumor hypoxia. Front Oncol, 2, 2012, 89.
    • (2012) Front Oncol , vol.2 , pp. 89
    • Chiang, C.S.1    Fu, S.Y.2    Wang, S.C.3
  • 38
    • 63449083667 scopus 로고    scopus 로고
    • Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors
    • [38] Chen, F.H., Chiang, C.S., Wang, C.C., et al. Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors. Clin Cancer Res 15 (2009), 1721–1729.
    • (2009) Clin Cancer Res , vol.15 , pp. 1721-1729
    • Chen, F.H.1    Chiang, C.S.2    Wang, C.C.3
  • 39
    • 79953295544 scopus 로고    scopus 로고
    • The efficacy of radiotherapy relies upon induction of type I interferon-dependent innate and adaptive immunity
    • [39] Burnette, B.C., Liang, H., Lee, Y., et al. The efficacy of radiotherapy relies upon induction of type I interferon-dependent innate and adaptive immunity. Cancer Res 71 (2011), 2488–2496.
    • (2011) Cancer Res , vol.71 , pp. 2488-2496
    • Burnette, B.C.1    Liang, H.2    Lee, Y.3
  • 40
    • 42649099297 scopus 로고    scopus 로고
    • Mechanisms involved in radiation enhancement of intratumoral dendritic cell therapy
    • [40] Teitz-Tennenbaum, S., Li, Q., Okuyama, R., et al. Mechanisms involved in radiation enhancement of intratumoral dendritic cell therapy. J Immunother 31 (2008), 345–358.
    • (2008) J Immunother , vol.31 , pp. 345-358
    • Teitz-Tennenbaum, S.1    Li, Q.2    Okuyama, R.3
  • 41
    • 84866467129 scopus 로고    scopus 로고
    • Molecular mechanisms of treg-mediated T cell suppression
    • [41] Schmidt, A., Oberle, N., Krammer, P.H., Molecular mechanisms of treg-mediated T cell suppression. Front Immunol, 3, 2012, 51.
    • (2012) Front Immunol , vol.3 , pp. 51
    • Schmidt, A.1    Oberle, N.2    Krammer, P.H.3
  • 43
    • 84894489353 scopus 로고    scopus 로고
    • Type I interferons induced by radiation therapy mediate recruitment and effector function of CD8(+) T cells
    • [43] Lim, J.Y., Gerber, S.A., Murphy, S.P., Lord, E.M., Type I interferons induced by radiation therapy mediate recruitment and effector function of CD8(+) T cells. Cancer Immunol Immunother 63 (2014), 259–271.
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 259-271
    • Lim, J.Y.1    Gerber, S.A.2    Murphy, S.P.3    Lord, E.M.4
  • 44
    • 84983353116 scopus 로고    scopus 로고
    • Stereotactic radiation therapy augments antigen-specific PD-1-mediated antitumor immune responses via cross-presentation of tumor antigen
    • [44] Sharabi, A.B., Nirschl, C.J., Kochel, C.M., et al. Stereotactic radiation therapy augments antigen-specific PD-1-mediated antitumor immune responses via cross-presentation of tumor antigen. Cancer Immunol Res 3 (2015), 345–355.
    • (2015) Cancer Immunol Res , vol.3 , pp. 345-355
    • Sharabi, A.B.1    Nirschl, C.J.2    Kochel, C.M.3
  • 45
    • 51549088023 scopus 로고    scopus 로고
    • Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells
    • [45] Matsumura, S., Wang, B., Kawashima, N., et al. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol 181 (2008), 3099–3107.
    • (2008) J Immunol , vol.181 , pp. 3099-3107
    • Matsumura, S.1    Wang, B.2    Kawashima, N.3
  • 46
    • 77955965216 scopus 로고    scopus 로고
    • OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology
    • [46] Ishii, N., Takahashi, T., Soroosh, P., Sugamura, K., OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology. Adv Immunol 105 (2010), 63–98.
    • (2010) Adv Immunol , vol.105 , pp. 63-98
    • Ishii, N.1    Takahashi, T.2    Soroosh, P.3    Sugamura, K.4
  • 47
    • 19544374904 scopus 로고    scopus 로고
    • The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells
    • [47] Maçon-Lemaître, L., Triebel, F., The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells. Immunology 115 (2005), 170–178.
    • (2005) Immunology , vol.115 , pp. 170-178
    • Maçon-Lemaître, L.1    Triebel, F.2
  • 48
    • 44349150012 scopus 로고    scopus 로고
    • Inhibitory B7-family molecules in the tumour microenvironment
    • [48] Zou, W., Chen, L., Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol 8 (2008), 467–477.
    • (2008) Nat Rev Immunol , vol.8 , pp. 467-477
    • Zou, W.1    Chen, L.2
  • 49
    • 79955977180 scopus 로고    scopus 로고
    • Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
    • [49] Zhou, Q., Munger, M.E., Veenstra, R.G., et al. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood 117 (2011), 4501–4510.
    • (2011) Blood , vol.117 , pp. 4501-4510
    • Zhou, Q.1    Munger, M.E.2    Veenstra, R.G.3
  • 50
    • 20444406500 scopus 로고    scopus 로고
    • Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor
    • [50] Lugade, A.A., Moran, J.P., Gerber, S.A., Rose, R.C., Frelinger, J.G., Lord, E.M., Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J Immunol 174 (2005), 7516–7523.
    • (2005) J Immunol , vol.174 , pp. 7516-7523
    • Lugade, A.A.1    Moran, J.P.2    Gerber, S.A.3    Rose, R.C.4    Frelinger, J.G.5    Lord, E.M.6
  • 51
    • 39749126854 scopus 로고    scopus 로고
    • Enhancement of antitumor radiation efficacy and consistent induction of the abscopal effect in mice by ECI301, an active variant of macrophage inflammatory protein-1alpha
    • [51] Shiraishi, K., Ishiwata, Y., Nakagawa, K., et al. Enhancement of antitumor radiation efficacy and consistent induction of the abscopal effect in mice by ECI301, an active variant of macrophage inflammatory protein-1alpha. Clin Cancer Res 14 (2008), 1159–1166.
    • (2008) Clin Cancer Res , vol.14 , pp. 1159-1166
    • Shiraishi, K.1    Ishiwata, Y.2    Nakagawa, K.3
  • 52
    • 12244289275 scopus 로고    scopus 로고
    • Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers
    • [52] Khan, M.A., Van Dyk, J., Yeung, I.W., Hill, R.P., Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiother Oncol 66 (2003), 95–102.
    • (2003) Radiother Oncol , vol.66 , pp. 95-102
    • Khan, M.A.1    Van Dyk, J.2    Yeung, I.W.3    Hill, R.P.4
  • 53
    • 1242315588 scopus 로고    scopus 로고
    • Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
    • [53] Demaria, S., Ng, B., Devitt, M.L., et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys 58 (2004), 862–870.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 862-870
    • Demaria, S.1    Ng, B.2    Devitt, M.L.3
  • 54
    • 12244252335 scopus 로고    scopus 로고
    • Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    • [54] Demaria, S., Kawashima, N., Yang, A.M., et al. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res 11 (2005), 728–734.
    • (2005) Clin Cancer Res , vol.11 , pp. 728-734
    • Demaria, S.1    Kawashima, N.2    Yang, A.M.3
  • 55
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • [55] Dewan, M.Z., Galloway, A.E., Kawashima, N., et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res 15 (2009), 5379–5388.
    • (2009) Clin Cancer Res , vol.15 , pp. 5379-5388
    • Dewan, M.Z.1    Galloway, A.E.2    Kawashima, N.3
  • 56
    • 78049420571 scopus 로고    scopus 로고
    • In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study
    • [56] Brody, J.D., Ai, W.Z., Czerwinski, D.K., et al. In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study. J Clin Oncol 28 (2010), 4324–4332.
    • (2010) J Clin Oncol , vol.28 , pp. 4324-4332
    • Brody, J.D.1    Ai, W.Z.2    Czerwinski, D.K.3
  • 57
    • 67649359533 scopus 로고    scopus 로고
    • Systemic effects of local radiotherapy
    • [57] Formenti, S.C., Demaria, S., Systemic effects of local radiotherapy. Lancet Oncol 10 (2009), 718–726.
    • (2009) Lancet Oncol , vol.10 , pp. 718-726
    • Formenti, S.C.1    Demaria, S.2
  • 58
    • 33744511428 scopus 로고    scopus 로고
    • Radiotherapy-induced lymphocytopenia: changes in total lymphocyte count and in lymphocyte subpopulations under pelvic irradiation in gynecologic neoplasms
    • [58] Lissoni, P., Meregalli, S., Bonetto, E., et al. Radiotherapy-induced lymphocytopenia: changes in total lymphocyte count and in lymphocyte subpopulations under pelvic irradiation in gynecologic neoplasms. J Biol Regul Homeost Agents 19 (2005), 153–158.
    • (2005) J Biol Regul Homeost Agents , vol.19 , pp. 153-158
    • Lissoni, P.1    Meregalli, S.2    Bonetto, E.3
  • 60
    • 33745106605 scopus 로고    scopus 로고
    • Regression of non-irradiated metastases after extracranial stereotactic radiotherapy in metastatic renal cell carcinoma
    • [60] Wersäll, P.J., Blomgren, H., Pisa, P., Lax, I., Kälkner, K.M., Svedman, C., Regression of non-irradiated metastases after extracranial stereotactic radiotherapy in metastatic renal cell carcinoma. Acta Oncol 45 (2006), 493–497.
    • (2006) Acta Oncol , vol.45 , pp. 493-497
    • Wersäll, P.J.1    Blomgren, H.2    Pisa, P.3    Lax, I.4    Kälkner, K.M.5    Svedman, C.6
  • 61
    • 84880911204 scopus 로고    scopus 로고
    • Abscopal [corrected] effects after conventional and stereotactic lung irradiation of non-small-cell lung cancer
    • [61] Siva, S., Callahan, J., MacManus, M.P., Martin, O., Hicks, R.J., Ball, D.L., Abscopal [corrected] effects after conventional and stereotactic lung irradiation of non-small-cell lung cancer. J Thorac Oncol, 2013, e71–e72.
    • (2013) J Thorac Oncol , pp. e71-e72
    • Siva, S.1    Callahan, J.2    MacManus, M.P.3    Martin, O.4    Hicks, R.J.5    Ball, D.L.6
  • 63
    • 84864977831 scopus 로고    scopus 로고
    • Spontaneous regression of thoracic metastases while progression of brain metastases after stereotactic radiosurgery and stereotactic body radiotherapy for metastatic renal cell carcinoma: abscopal effect prevented by the blood-brain barrier?
    • [63] Ishiyama, H., Teh, B.S., Ren, H., et al. Spontaneous regression of thoracic metastases while progression of brain metastases after stereotactic radiosurgery and stereotactic body radiotherapy for metastatic renal cell carcinoma: abscopal effect prevented by the blood-brain barrier?. Clin Genitourin Cancer 10:3 (2012), 196–198.
    • (2012) Clin Genitourin Cancer , vol.10 , Issue.3 , pp. 196-198
    • Ishiyama, H.1    Teh, B.S.2    Ren, H.3
  • 64
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • [64] Topalian, S.L., Hodi, F.S., Brahmer, J.R., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366 (2012), 2443–2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 65
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: moving beyond current vaccines
    • [65] Rosenberg, S.A., Yang, J.C., Restifo, N.P., Cancer immunotherapy: moving beyond current vaccines. Nat Med 10 (2004), 909–915.
    • (2004) Nat Med , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 66
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • [66] Tivol, E.A., Borriello, F., Schweitzer, A.N., Lynch, W.P., Bluestone, J.A., Sharpe, A.H., Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3 (1995), 541–547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 67
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • [67] Waterhouse, P., Penninger, J.M., Timms, E., et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270 (1995), 985–988.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3
  • 69
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • [69] Peggs, K.S., Quezada, S.A., Chambers, C.A., Korman, A.J., Allison, J.P., Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med 206 (2009), 1717–1725.
    • (2009) J Exp Med , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 70
    • 0027362823 scopus 로고
    • B70 antigen is a second ligand for CTLA-4 and CD28
    • [70] Azuma, M., Ito, D., Yagita, H., et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366 (1993), 76–79.
    • (1993) Nature , vol.366 , pp. 76-79
    • Azuma, M.1    Ito, D.2    Yagita, H.3
  • 71
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
    • [71] Qureshi, O.S., Zheng, Y., Nakamura, K., et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 332:6029 (2011), 600–603.
    • (2011) Science , vol.332 , Issue.6029 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3
  • 72
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • [72] Hodi, F.S., O'Day, S.J., McDermott, D.F., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363 (2010), 711–723.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 73
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • [73] Freeman, G.J., Long, A.J., Iwai, Y., et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192 (2000), 1027–1034.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 74
    • 0032736029 scopus 로고    scopus 로고
    • B7–H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    • [74] Dong, H., Zhu, G., Tamada, K., Chen, L., B7–H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 5 (1999), 1365–1369.
    • (1999) Nat Med , vol.5 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3    Chen, L.4
  • 75
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7–H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • [75] Dong, H., Strome, S.E., Salomao, D.R., et al. Tumor-associated B7–H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 8 (2002), 793–800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 76
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • [76] Latchman, Y., Wood, C.R., Chernova, T., et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2 (2001), 261–268.
    • (2001) Nat Immunol , vol.2 , pp. 261-268
    • Latchman, Y.1    Wood, C.R.2    Chernova, T.3
  • 77
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • [77] Francisco, L.M., Salinas, V.H., Brown, K.E., et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 206 (2009), 3015–3029.
    • (2009) J Exp Med , vol.206 , pp. 3015-3029
    • Francisco, L.M.1    Salinas, V.H.2    Brown, K.E.3
  • 78
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
    • [78] Weber, J.S., D'Angelo, S.P., Minor, D., et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 16 (2015), 375–384.
    • (2015) Lancet Oncol , vol.16 , pp. 375-384
    • Weber, J.S.1    D'Angelo, S.P.2    Minor, D.3
  • 79
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
    • [79] Robert, C., Ribas, A., Wolchok, J.D., et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 384 (2014), 1109–1117.
    • (2014) Lancet , vol.384 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3
  • 80
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • [80] Garon, E.B., Rizvi, N.A., Hui, R., et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 372 (2015), 2018–2028.
    • (2015) N Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 81
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer
    • [81] Brahmer, J., Reckamp, K.L., Baas, P., et al. Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. N Engl J Med 373 (2015), 123–135.
    • (2015) N Engl J Med , vol.373 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3
  • 82
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • [82] van Elsas, A., Hurwitz, A.A., Allison, J.P., Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 190 (1999), 355–366.
    • (1999) J Exp Med , vol.190 , pp. 355-366
    • van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 83
    • 63449124514 scopus 로고    scopus 로고
    • Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor–secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors
    • [83] Li, B., Van Roey, M., Wang, C., Chen, T.H., Korman, A., Jooss, K., Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor–secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors. Clin Cancer Res 15 (2009), 1623–1634.
    • (2009) Clin Cancer Res , vol.15 , pp. 1623-1634
    • Li, B.1    Van Roey, M.2    Wang, C.3    Chen, T.H.4    Korman, A.5    Jooss, K.6
  • 84
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • [84] Vanneman, M., Dranoff, G., Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer 12 (2012), 237–251.
    • (2012) Nat Rev Cancer , vol.12 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 86
    • 59449094876 scopus 로고    scopus 로고
    • Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade
    • [86] Pilones, K.A., Kawashima, N., Yang, A.M., Babb, J.S., Formenti, S.C., Demaria, S., Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade. Clin Cancer Res 15 (2009), 597–606.
    • (2009) Clin Cancer Res , vol.15 , pp. 597-606
    • Pilones, K.A.1    Kawashima, N.2    Yang, A.M.3    Babb, J.S.4    Formenti, S.C.5    Demaria, S.6
  • 87
    • 84926525215 scopus 로고    scopus 로고
    • Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
    • [87] Twyman-Saint Victor, C., Rech, A.J., Maity, A., et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 520 (2015), 373–377.
    • (2015) Nature , vol.520 , pp. 373-377
    • Twyman-Saint Victor, C.1    Rech, A.J.2    Maity, A.3
  • 88
    • 84904207094 scopus 로고    scopus 로고
    • Focal radiation therapy combined with 4–1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model
    • [88] Belcaid, Z., Phallen, J.A., Zeng, J., et al. Focal radiation therapy combined with 4–1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model. PLoS ONE, 9, 2014, e101764.
    • (2014) PLoS ONE , vol.9 , pp. e101764
    • Belcaid, Z.1    Phallen, J.A.2    Zeng, J.3
  • 89
    • 84877581852 scopus 로고    scopus 로고
    • Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas
    • [89] Zeng, J., See, A.P., Phallen, J., et al. Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys 86 (2013), 343–349.
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , pp. 343-349
    • Zeng, J.1    See, A.P.2    Phallen, J.3
  • 90
    • 84893876109 scopus 로고    scopus 로고
    • Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
    • [90] Deng, L., Liang, H., Burnette, B., et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest 124 (2014), 687–695.
    • (2014) J Clin Invest , vol.124 , pp. 687-695
    • Deng, L.1    Liang, H.2    Burnette, B.3
  • 91
    • 84863602592 scopus 로고    scopus 로고
    • Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies
    • [91] Verbrugge, I., Hagekyriakou, J., Sharp, L.L., et al. Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies. Cancer Res 72 (2012), 3163–3174.
    • (2012) Cancer Res , vol.72 , pp. 3163-3174
    • Verbrugge, I.1    Hagekyriakou, J.2    Sharp, L.L.3
  • 92
    • 84886090883 scopus 로고    scopus 로고
    • Combined treatment effects of radiation and immunotherapy: studies in an autochthonous prostate cancer model
    • [92] Wada, S., Harris, T.J., Tryggestad, E., et al. Combined treatment effects of radiation and immunotherapy: studies in an autochthonous prostate cancer model. Int J Radiat Oncol Biol Phys 87 (2013), 769–776.
    • (2013) Int J Radiat Oncol Biol Phys , vol.87 , pp. 769-776
    • Wada, S.1    Harris, T.J.2    Tryggestad, E.3
  • 93
    • 38949156782 scopus 로고    scopus 로고
    • Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer
    • [93] Yokouchi, H., Yamazaki, K., Chamoto, K., et al. Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer. Cancer Sci 99 (2008), 361–367.
    • (2008) Cancer Sci , vol.99 , pp. 361-367
    • Yokouchi, H.1    Yamazaki, K.2    Chamoto, K.3
  • 94
    • 33750719582 scopus 로고    scopus 로고
    • Augmented antitumor effects of radiation therapy by 4–1BB antibody (BMS-469492) treatment
    • [94] Shi, W., Siemann, D.W., Augmented antitumor effects of radiation therapy by 4–1BB antibody (BMS-469492) treatment. Anticancer Res 26 (2006), 3445–3453.
    • (2006) Anticancer Res , vol.26 , pp. 3445-3453
    • Shi, W.1    Siemann, D.W.2
  • 95
    • 0041737455 scopus 로고    scopus 로고
    • Anti-CD40 monoclonal antibody therapy in combination with irradiation results in a CD8 T-cell-dependent immunity to B-cell lymphoma
    • [95] Honeychurch, J., Glennie, M.J., Johnson, P.W., Illidge, T.M., Anti-CD40 monoclonal antibody therapy in combination with irradiation results in a CD8 T-cell-dependent immunity to B-cell lymphoma. Blood 102:4 (2003), 1449–1457.
    • (2003) Blood , vol.102 , Issue.4 , pp. 1449-1457
    • Honeychurch, J.1    Glennie, M.J.2    Johnson, P.W.3    Illidge, T.M.4
  • 96
    • 84871694504 scopus 로고    scopus 로고
    • A systemic complete response of metastatic melanoma to local radiation and immunotherapy
    • [96] Hiniker, S.M., Chen, D.S., Reddy, S., et al. A systemic complete response of metastatic melanoma to local radiation and immunotherapy. Transl Oncol 5:6 (2012), 404–407.
    • (2012) Transl Oncol , vol.5 , Issue.6 , pp. 404-407
    • Hiniker, S.M.1    Chen, D.S.2    Reddy, S.3
  • 97
    • 84919494209 scopus 로고    scopus 로고
    • Current clinical trials testing combinations of immunotherapy and radiation
    • [97] Crittenden, M., Kohrt, H., Levy, R., et al. Current clinical trials testing combinations of immunotherapy and radiation. Semin Radiat Oncol 25:1 (2015), 54–64.
    • (2015) Semin Radiat Oncol , vol.25 , Issue.1 , pp. 54-64
    • Crittenden, M.1    Kohrt, H.2    Levy, R.3
  • 98
    • 84880508629 scopus 로고    scopus 로고
    • Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study
    • [98] Slovin, S.F., Higano, C.S., Hamid, O., et al. Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study. Ann Oncol 24:7 (2013), 1813–1821.
    • (2013) Ann Oncol , vol.24 , Issue.7 , pp. 1813-1821
    • Slovin, S.F.1    Higano, C.S.2    Hamid, O.3
  • 99
    • 84901641673 scopus 로고    scopus 로고
    • Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial
    • [99] Kwon, E.D., Drake, CG2, Scher, HI, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol 15:7 (2014), 700–712.
    • (2014) Lancet Oncol , vol.15 , Issue.7 , pp. 700-712
    • Kwon, E.D.1    Drake, C.G.2    Scher, H.I.3
  • 100
    • 84941784779 scopus 로고    scopus 로고
    • A systematic evaluation of abscopal responses following radiotherapy in patients with metastatic melanoma treated with ipilimumab
    • [100] Chandra, R.A., Wilhite, T.J., Balboni, T.A., et al. A systematic evaluation of abscopal responses following radiotherapy in patients with metastatic melanoma treated with ipilimumab. Oncoimmunology, 4(11), 2015, e1046028.
    • (2015) Oncoimmunology , vol.4 , Issue.11 , pp. e1046028
    • Chandra, R.A.1    Wilhite, T.J.2    Balboni, T.A.3
  • 101
    • 84952023257 scopus 로고    scopus 로고
    • Ipilimumab and stereotactic radiosurgery versus stereotactic radiosurgery alone for newly diagnosed melanoma brain metastases
    • [Epub ahead of print]
    • [101] Patel, K.R., Shoukat, S., Oliver, D.E., et al. Ipilimumab and stereotactic radiosurgery versus stereotactic radiosurgery alone for newly diagnosed melanoma brain metastases. Am J Clin Oncol, 2015 [Epub ahead of print].
    • (2015) Am J Clin Oncol
    • Patel, K.R.1    Shoukat, S.2    Oliver, D.E.3
  • 102
    • 84928938600 scopus 로고    scopus 로고
    • Stereotactic radiosurgery for melanoma brain metastases in patients receiving ipilimumab: safety profile and efficacy of combined treatment
    • [102] Kiess, A.P., Wolchok, J.D., Barker, C.A., et al. Stereotactic radiosurgery for melanoma brain metastases in patients receiving ipilimumab: safety profile and efficacy of combined treatment. Int J Radiat Oncol Biol Phys 92:2 (2015), 368–375.
    • (2015) Int J Radiat Oncol Biol Phys , vol.92 , Issue.2 , pp. 368-375
    • Kiess, A.P.1    Wolchok, J.D.2    Barker, C.A.3
  • 103
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • [103] Pardoll, D.M., The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12:4 (2012), 252–264.
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 104
    • 77957273591 scopus 로고    scopus 로고
    • Improved endpoints for cancer immunotherapy trials
    • [104] Hoos, A., Eggermont, A.M., Janetzki, S., et al. Improved endpoints for cancer immunotherapy trials. J Natl Cancer Inst 102:18 (2010), 1388–1397.
    • (2010) J Natl Cancer Inst , vol.102 , Issue.18 , pp. 1388-1397
    • Hoos, A.1    Eggermont, A.M.2    Janetzki, S.3
  • 105
    • 84894272707 scopus 로고    scopus 로고
    • Ipilimumab in the treatment of metastatic melanoma: management of adverse events
    • [105] Della Vittoria Scarpati, G., Fusciello, C., Perri, F., et al. Ipilimumab in the treatment of metastatic melanoma: management of adverse events. Onco Targets Ther 7 (2014), 203–209.
    • (2014) Onco Targets Ther , vol.7 , pp. 203-209
    • Della Vittoria Scarpati, G.1    Fusciello, C.2    Perri, F.3
  • 106
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
    • [106] Brahmer, J.R., Drake, C.G., Wollner, I., et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 28:19 (2010), 3167–3175.
    • (2010) J Clin Oncol , vol.28 , Issue.19 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 107
    • 84946226475 scopus 로고    scopus 로고
    • Acute skin reaction suggestive of pembrolizumab-induced radiosensitization
    • [107] Sibaud, V., David, I., Lamant, L., et al. Acute skin reaction suggestive of pembrolizumab-induced radiosensitization. Melanoma Res 25:6 (2015), 555–558.
    • (2015) Melanoma Res , vol.25 , Issue.6 , pp. 555-558
    • Sibaud, V.1    David, I.2    Lamant, L.3
  • 108
    • 14744275172 scopus 로고    scopus 로고
    • Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma
    • [108] Chi, K.H., Liu, S.J., Li, C.P., Kuo, H.P., Wang, Y.S., Chao, Y., Hsieh, S.L., Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma. J Immunother 28:2 (2005), 129–135.
    • (2005) J Immunother , vol.28 , Issue.2 , pp. 129-135
    • Chi, K.H.1    Liu, S.J.2    Li, C.P.3    Kuo, H.P.4    Wang, Y.S.5    Chao, Y.6    Hsieh, S.L.7
  • 109
    • 84937525789 scopus 로고    scopus 로고
    • Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial
    • [109] Golden, E.B., Chhabra, A., Chachoua, A., et al. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial. Lancet Oncol 16:7 (2015), 795–803.
    • (2015) Lancet Oncol , vol.16 , Issue.7 , pp. 795-803
    • Golden, E.B.1    Chhabra, A.2    Chachoua, A.3
  • 110
    • 84964284182 scopus 로고    scopus 로고
    • Role of radiation therapy as immune activator in the era of modern immunotherapy for metastatic malignant melanoma
    • [110] Okwan-Duodu, D., Pollack, B.P., Lawson, D., Khan, M.K., Role of radiation therapy as immune activator in the era of modern immunotherapy for metastatic malignant melanoma. Am J Clin Oncol 38:1 (2015), 119–125.
    • (2015) Am J Clin Oncol , vol.38 , Issue.1 , pp. 119-125
    • Okwan-Duodu, D.1    Pollack, B.P.2    Lawson, D.3    Khan, M.K.4
  • 111
    • 52649182085 scopus 로고    scopus 로고
    • Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant
    • [111] Lechleider, R.J., Arlen, P.M., Tsang, K.Y., et al. Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant. Clin Cancer Res 14:16 (2008), 5284–5291.
    • (2008) Clin Cancer Res , vol.14 , Issue.16 , pp. 5284-5291
    • Lechleider, R.J.1    Arlen, P.M.2    Tsang, K.Y.3
  • 112
    • 84922214829 scopus 로고    scopus 로고
    • Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions
    • [112] Hato, T., Goyal, L., Greten, T.F., Duda, D.G., Zhu, A.X., Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions. Hepatology 60:5 (2014), 1776–1782.
    • (2014) Hepatology , vol.60 , Issue.5 , pp. 1776-1782
    • Hato, T.1    Goyal, L.2    Greten, T.F.3    Duda, D.G.4    Zhu, A.X.5
  • 113
    • 84940379785 scopus 로고    scopus 로고
    • Cancer and the immune system: basic concepts and targets for intervention
    • [113] Pardoll, D., Cancer and the immune system: basic concepts and targets for intervention. Semin Oncol 42:4 (2015), 523–538.
    • (2015) Semin Oncol , vol.42 , Issue.4 , pp. 523-538
    • Pardoll, D.1
  • 114
    • 84958754046 scopus 로고    scopus 로고
    • Multi-institutional phase II study of high-dose hypofractionated proton beam therapy in patients with localized, unresectable hepatocellular carcinoma and intrahepatic cholangiocarcinoma
    • [114] Hong, T.S., Wo, J.Y., Yeap, B.Y., et al. Multi-institutional phase II study of high-dose hypofractionated proton beam therapy in patients with localized, unresectable hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J Clin Oncol 34:5 (2016), 460–468.
    • (2016) J Clin Oncol , vol.34 , Issue.5 , pp. 460-468
    • Hong, T.S.1    Wo, J.Y.2    Yeap, B.Y.3
  • 115
    • 84958750295 scopus 로고    scopus 로고
    • Outcomes after stereotactic body radiotherapy or radiofrequency ablation for hepatocellular carcinoma
    • [115] Wahl, D.R., Stenmark, M.H., Tao, Y., et al. Outcomes after stereotactic body radiotherapy or radiofrequency ablation for hepatocellular carcinoma. J Clin Oncol 34:5 (2016), 452–459.
    • (2016) J Clin Oncol , vol.34 , Issue.5 , pp. 452-459
    • Wahl, D.R.1    Stenmark, M.H.2    Tao, Y.3
  • 116
    • 34547407250 scopus 로고    scopus 로고
    • Dosimetric feasibility of hypofractionated proton radiotherapy for neoadjuvant pancreatic cancer treatment
    • [116] Kozak, K.R., Kachnic, L.A., Adams, J., et al. Dosimetric feasibility of hypofractionated proton radiotherapy for neoadjuvant pancreatic cancer treatment. Int J Radiat Oncol Biol Phys 68:5 (2007), 1557–1566.
    • (2007) Int J Radiat Oncol Biol Phys , vol.68 , Issue.5 , pp. 1557-1566
    • Kozak, K.R.1    Kachnic, L.A.2    Adams, J.3
  • 117
    • 3042569675 scopus 로고    scopus 로고
    • External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing
    • [117] Chakraborty, M., Abrams, S.I., Coleman, C.N., Camphausen, K., Schlom, J., Hodge, J.W., External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing. Cancer Res 64 (2004), 4328–4337.
    • (2004) Cancer Res , vol.64 , pp. 4328-4337
    • Chakraborty, M.1    Abrams, S.I.2    Coleman, C.N.3    Camphausen, K.4    Schlom, J.5    Hodge, J.W.6
  • 118
    • 33646704729 scopus 로고    scopus 로고
    • Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
    • [118] Reits, E.A., Hodge, J.W., Herberts, C.A., et al. Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med 203 (2006), 1259–1271.
    • (2006) J Exp Med , vol.203 , pp. 1259-1271
    • Reits, E.A.1    Hodge, J.W.2    Herberts, C.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.