Stereotactic radiosurgery for melanoma brain metastases in patients receiving ipilimumab: Safety profile and efficacy of combined treatment

International Journal of Radiation Oncology Biology Physics

Volumn 92, Issue 2, 2015, Pages 368-375

  Kiess, Ana P ^a,b   Wolchok, Jedd D ^b   Barker, Christopher A ^b   Postow, Michael A ^b   Tabar, Viviane ^b   Huse, Jason T ^b   Chan, Timothy A ^b   Yamada, Yoshiya ^b   Beal, Kathryn ^b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCURRENCY CONTROL; DERMATOLOGY; MAGNETIC RESONANCE IMAGING; MONOCLONAL ANTIBODIES; PATHOLOGY; PATIENT MONITORING; RADIOTHERAPY;

COMMON TERMINOLOGY CRITERIA; CYTOTOXIC T LYMPHOCYTE ANTIGEN-4; IMMUNOMODULATORY EFFECTS; KAPLAN-MEIER METHOD; LOCOREGIONAL CONTROL; METASTATIC MELANOMA; METHODS AND MATERIALS; STEREOTACTIC RADIOSURGERY;

ONCOLOGY;

CISPLATIN; DEXAMETHASONE; INTERLEUKIN 2; IPILIMUMAB; LACTATE DEHYDROGENASE; TEMOZOLOMIDE; VINBLASTINE; MONOCLONAL ANTIBODY;

ADULT; AGED; ARTICLE; BRAIN METASTASIS; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CARDIOPULMONARY DISEASE; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM BLEEDING; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL ARTICLE; COGNITIVE DEFECT; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; ENTEROCOLITIS; FATIGUE; FEMALE; FOLLOW UP; HEADACHE; HEPATITIS; HUMAN; INTERMETHOD COMPARISON; LACTATE DEHYDROGENASE BLOOD LEVEL; LUNG DISEASE; MALE; METASTATIC MELANOMA; MULTIMODALITY CANCER THERAPY; NAUSEA; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSTIC ASSESSMENT; PRURITUS; RASH; RECURRENCE FREE SURVIVAL; SEIZURE; STEREOTACTIC RADIOSURGERY; ADVERSE EFFECTS; BRAIN NEOPLASMS; DRUG ADMINISTRATION; IMMUNOTHERAPY; MELANOMA; MIDDLE AGED; MORTALITY; PROCEDURES; RADIATION DOSE; RADIOSURGERY; REGRESSION ANALYSIS; RETROSPECTIVE STUDY; SECONDARY; TUMOR RECURRENCE;

ADULT; AGED; ANTIBODIES, MONOCLONAL; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; DRUG ADMINISTRATION SCHEDULE; HUMANS; IMMUNOTHERAPY; MALE; MELANOMA; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; RADIOSURGERY; RADIOTHERAPY DOSAGE; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES;

EID: 84928938600     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2015.01.004     Document Type: Article

References (29)

1. F.S. Hodi, S.J. O'Day, and D.F. McDermott Improved survival with ipilimumab in patients with metastatic melanoma N Engl J Med 363 2010 711 723
2. C. Robert, L. Thomas, and I. Bondarenko Ipilimumab plus dacarbazine for previously untreated metastatic melanoma N Engl J Med 364 2011 2517 2526
3. T. Gupta Stereotactic radiosurgery for brain oligometastases: Good for some, better for all? Ann Oncol 16 2005 1749 1754
4. P.W. Sperduto, N. Kased, and D. Roberge Summary report on the graded prognostic assessment: An accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases J Clin Oncol 30 2012 419 425
5. J.P. Knisely, J.B. Yu, and J. Flanigan Radiosurgery for melanoma brain metastases in the ipilimumab era and the possibility of longer survival J Neurosurg 117 2012 227 233
6. D.N. Liew, H. Kano, and D. Kondziolka Outcome predictors of Gamma Knife surgery for melanoma brain metastases. Clinical article J Neurosurg 114 2011 769 779
7. W.E. Samlowski, G.A. Watson, and M. Wang Multimodality treatment of melanoma brain metastases incorporating stereotactic radiosurgery (SRS) Cancer 109 2007 1855 1862
8. K. Margolin, M.S. Ernstoff, and O. Hamid Ipilimumab in patients with melanoma and brain metastases: An open-label, phase 2 trial Lancet Oncol 13 2012 459 465
9. S. Demaria, B. Ng, and M.L. Devitt Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated Int J Radiat Oncol Biol Phys 58 2004 862 870
10. M.Z. Dewan, A.E. Galloway, and N. Kawashima Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody Clin Cancer Res 15 2009 5379 5388
11. M.A. Postow, M.K. Callahan, and C.A. Barker Immunologic correlates of the abscopal effect in a patient with melanoma N Engl J Med 366 2012 925 931
12. E.B. Golden, S. Demaria, and P.B. Schiff An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer Cancer Immunol Res 1 2013 365 372
13. S.M. Hiniker, D.S. Chen, and S.J. Knox Abscopal effect in a patient with melanoma N Engl J Med 366 2012 2035 author reply 2035-2036
14. E.F. Stamell, J.D. Wolchok, and S. Gnjatic The abscopal effect associated with a systemic anti-melanoma immune response Int J Radiat Oncol Biol Phys 85 2013 293 295
15. J. Schoenfeld, M. Dyer, and B. Alexander Melanoma brain metastases treated with brain-directed radiation followed by ipilimumab [ASTRO abstract 2181] Int J Rad Oncol Biol Phys 84 suppl 2012 S287
16. M. Mathew, M. Tam, and P.A. Ott Ipilimumab in melanoma with limited brain metastases treated with stereotactic radiosurgery Melanoma Res 23 2013 191 195
17. K. Tazi, C. Chiuzan, and K. Shirai Survival of melanoma patients with brain metastases treated with ipilimumab combined with stereotactic radiosurgery [ASCO abstract e20019] J Clin Oncol 31 suppl 2013
18. S. Shoukat, D. Marcus, and M. Rizzo Outcome with stereotactic radiosurgery (SRS) and ipilimumab (Ipi) for malignant melanoma brain metastases [ASCO abstract 3032] J Clin Oncol 31 suppl 2013
19. E. Shaw, R. Kline, and M. Gillin Radiation Therapy Oncology Group: Radiosurgery quality assurance guidelines Int J Radiat Oncol Biol Phys 27 1993 1231 1239
20. M.A. Davies, P. Liu, and S. McIntyre Prognostic factors for survival in melanoma patients with brain metastases Cancer 117 2011 1687 1696
21. K.M. Fife, M.H. Colman, and G.N. Stevens Determinants of outcome in melanoma patients with cerebral metastases J Clin Oncol 22 2004 1293 1300
22. J.H. Sampson, J.H. Carter Jr., and A.H. Friedman Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma J Neurosurg 88 1998 11 20
23. F.S. Hodi, D.A. Oble, and J. Drappatz CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS Nat Clin Pract Oncol 5 2008 557 561
24. A. Hoos, A.M. Eggermont, and S. Janetzki Improved endpoints for cancer immunotherapy trials J Natl Cancer Inst 102 2010 1388 1397
25. J.D. Wolchok, A. Hoos, and S. O'Day Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria Clin Cancer Res 15 2009 7412 7420
26. P.E. Huber, H. Hawighorst, and M. Fuss Transient enlargement of contrast uptake on MRI after linear accelerator (linac) stereotactic radiosurgery for brain metastases Int J Radiat Oncol Biol Phys 49 2001 1339 1349
27. J.S. Weber, A. Amin, and D. Minor Safety and clinical activity of ipilimumab in melanoma patients with brain metastases: Retrospective analysis of data from a phase 2 trial Melanoma Res 21 2011 530 534
28. S. Demaria, and S.C. Formenti Radiation as an immunological adjuvant: Current evidence on dose and fractionation Front Oncol 2 2012 153
29. K.A. Pilones, N. Kawashima, and A.M. Yang Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade Clin Cancer Res 15 2009 597 606