Spatiotemporal dynamics of dexmedetomidine-induced electroencephalogram oscillations

PLoS ONE

Volumn 11, Issue 10, 2016, Pages

  Akeju, Oluwaseun ^a   Kim, Seong Eun ^b   Vazquez, Rafael ^a   Rhee, James ^a   Pavone, Kara J ^a   Hobbs, Lauren E ^a   Purdon, Patrick L ^a   Brown, Emery N ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE;

ADULT; ALPHA RHYTHM; AROUSAL; ARTICLE; BETA RHYTHM; DELTA RHYTHM; ELECTROENCEPHALOGRAM; FEEDBACK SYSTEM; FEMALE; FRONTAL CORTEX; GLOBAL COHERENCE ANALYSIS; HUMAN; HUMAN EXPERIMENT; MALE; MATHEMATICAL ANALYSIS; NEUROPHYSIOLOGY; NORMAL HUMAN; OCCIPITAL CORTEX; SLEEP; SPATIOTEMPORAL ANALYSIS; SPINDLE OSCILLATION; THETA RHYTHM; BRAIN; CLINICAL TRIAL; DRUG EFFECTS; ELECTROENCEPHALOGRAPHY; PHYSIOLOGY; YOUNG ADULT;

ADULT; BRAIN; DEXMEDETOMIDINE; ELECTROENCEPHALOGRAPHY; FEMALE; HEALTHY VOLUNTEERS; HUMANS; MALE; SPATIO-TEMPORAL ANALYSIS; YOUNG ADULT;

EID: 84990983983     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0163431     Document Type: Article

References (58)

1. Purdon PL, Sampson A, Pavone KJ, Brown EN. Clinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures. Anesthesiology. 2015; 123(4):937-60. Epub 2015/08/15. doi: 10.1097/ALN.0000000000000841 PMID: 26275092; PubMed Central PMCID: PMC4573341.
2. Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. 2003; 98(2):428-36. Epub 2003/01/29. doi: 10.1097/00000542-200302000-00024 PMID: 12552203.
3. Correa-Sales C, Rabin BC, Maze M. A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology. 1992; 76(6):948-52. Epub 1992/06/01. doi: 10.1097/00000542-199206000-00013 PMID: 1350889.
4. Chiu TH, Chen MJ, Yang YR, Yang JJ, Tang FI. Action of dexmedetomidine on rat locus coeruleus neurones: intracellular recording in vitro. European journal of pharmacology. 1995; 285(3):261-8. Epub 1995/10/24. doi: 10.1016/0014-2999(95)00417-j PMID: 8575512.
5. Mizobe T, Maghsoudi K, Sitwala K, Tianzhi G, Ou J, Maze M. Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat. The Journal of clinical investigation. 1996; 98 (5):1076-80. Epub 1996/09/01. doi: 10.1172/JCI118887 PMID: 8787667; PubMed Central PMCID: PMC507526.
6. Jorm CM, Stamford JA. Actions of the hypnotic anaesthetic, dexmedetomidine, on noradrenaline release and cell firing in rat locus coeruleus slices. British journal of anaesthesia. 1993; 71(3):447-9. Epub 1993/09/01. doi: 10.1093/bja/71.3.447 PMID: 8104450.
7. Nacif-Coelho C, Correa-Sales C, Chang LL, Maze M. Perturbation of ion channel conductance alters the hypnotic response to the alpha 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat. Anesthesiology. 1994; 81(6):1527-34. Epub 1994/12/01. doi: 10.1097/00000542-199412000-00029 PMID: 7992922.
8. Saper CB, Fuller PM, Pedersen NP, Lu J, Scammell TE. Sleep state switching. Neuron. 2010; 68 (6):1023-42. Epub 2010/12/22. doi: 10.1016/j.neuron.2010.11.032 PMID: 21172606; PubMed Central PMCID: PMC3026325.
9. Huupponen E, Maksimow A, Lapinlampi P, Sarkela M, Saastamoinen A, Snapir A, et al. Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta anaesthesiologica Scandinavica. 2008; 52(2):289-94. Epub 2007/11/17. doi: 10.1111/j.1399-6576.2007. 01537.x PMID: 18005372.
10. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, et al. A comparison of propofol-and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014; 121(5):978-89. Epub 2014/09/05. doi: 10.1097/ALN. 0000000000000419 PMID: 25187999; PubMed Central PMCID: PMC4304638.
11. Ozgoren M, Bayazit O, Gokmen N, Oniz A. Spectral pattern analysis of propofol induced spindle oscillations in the presence of auditory stimulations. The open neuroimaging journal. 2010; 4:121-9. Epub 2010/01/01. doi: 10.2174/1874440001004010121 PMID: 21792383; PubMed Central PMCID: PMC3141347.
12. Wolter S, Friedel C, Bohler K, Hartmann U, Kox WJ, Hensel M. Presence of 14Hz spindle oscillations in the human EEG during deep anesthesia. Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology. 2006; 117(1):157-68. Epub 2005/12/06. doi: 10.1016/j.clinph. 2005.08.031 PMID: 16326139.
13. Huotari AM, Koskinen M, Suominen K, Alahuhta S, Remes R, Hartikainen KM, et al. Evoked EEG patterns during burst suppression with propofol. British journal of anaesthesia. 2004; 92(1):18-24. Epub 2003/12/11. doi: 10.1093/bja/aeh022 PMID: 14665548.
14. Marzano C, Moroni F, Gorgoni M, Nobili L, Ferrara M, De Gennaro L. How we fall asleep: regional and temporal differences in electroencephalographic synchronization at sleep onset. Sleep medicine. 2013; 14(11):1112-22. Epub 2013/09/21. doi: 10.1016/j.sleep.2013.05.021 PMID: 24051119.
15. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, et al. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. eLife. 2014; 3: e04499. Epub 2014/11/29. doi: 10.7554/eLife.04499 PMID: 25432022; PubMed Central PMCID: PMC4280551.
16. Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KF, et al. Electroencephalogram Signatures of Loss and Recovery of Consciousness from Propofol. PNAS. 2013;Epub March 4. doi: 10. 1073/pnas.1221180110 PMID: 23487781
17. Babadi B, Brown EN. A review of multitaper spectral analysis. IEEE transactions on bio-medical engineering. 2014; 61(5):1555-64. Epub 2014/04/25. doi: 10.1109/TBME.2014.2311996 PMID: 24759284.
18. Delorme A, Makeig S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Journal of neuroscience methods. 2004; 134(1):9-21. Epub 2004/04/23. doi: 10.1016/j.jneumeth.2003.10.009 PMID: 15102499.
19. Cimenser A, Purdon PL, Pierce ET, Walsh JL, Salazar-Gomez AF, Harrell PG, et al. Tracking brain states under general anesthesia by using global coherence analysis. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(21):8832-7. Epub 2011/05/11. doi: 10.1073/pnas.1017041108 PMID: 21555565; PubMed Central PMCID: PMC3102391.
20. Finelli LA, Achermann P, Borbely AA. Individual fingerprints in human sleep EEG topography. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology. 2001; 25(5 Suppl):S57-62. Epub 2001/10/30. doi: 10.1016/S0893-133X(01)00320-7 PMID: 11682275.
21. De Gennaro L, Marzano C, Veniero D, Moroni F, Fratello F, Curcio G, et al. Neurophysiological correlates of sleepiness: a combined TMS and EEG study. NeuroImage. 2007; 36(4):1277-87. Epub 2007/ 05/26. doi: 10.1016/j.neuroimage.2007.04.013 PMID: 17524675.
22. Wright KP Jr., Badia P, Wauquier A. Topographical and temporal patterns of brain activity during the transition from wakefulness to sleep. Sleep. 1995; 18(10):880-9. Epub 1995/12/01. PMID: 8746396.
23. Buzsaki G, Moser EI. Memory, navigation and theta rhythm in the hippocampal-entorhinal system. Nature neuroscience. 2013; 16(2):130-8. Epub 2013/01/29. doi: 10.1038/nn.3304 PMID: 23354386; PubMed Central PMCID: PMC4079500.
24. Buzsaki G. Theta oscillations in the hippocampus. Neuron. 2002; 33(3):325-40. Epub 2002/02/08. doi: 10.1016/s0896-6273(02)00586-x PMID: 11832222.
25. Jacobs J. Hippocampal theta oscillations are slower in humans than in rodents: implications for models of spatial navigation and memory. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2014; 369(1635):20130304. Epub 2013/12/25. doi: 10.1098/rstb.2013.0304 PMID: 24366145; PubMed Central PMCID: PMC3866455.
26. Alexopoulou C, Kondili E, Diamantaki E, Psarologakis C, Kokkini S, Bolaki M, et al. Effects of dexmedetomidine on sleep quality in critically ill patients: a pilot study. Anesthesiology. 2014; 121(4):801-7. Epub 2014/07/06. doi: 10.1097/ALN.0000000000000361 PMID: 24988068.
27. Oto J, Yamamoto K, Koike S, Onodera M, Imanaka H, Nishimura M. Sleep quality of mechanically ventilated patients sedated with dexmedetomidine. Intensive care medicine. 2012; 38(12):1982-9. Epub 2012/09/11. doi: 10.1007/s00134-012-2685-y PMID: 22961436.
28. Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. Jama. 2012; 307(11):1151-60. Epub 2012/03/23. doi: 10.1001/jama.2012.304 PMID: 22436955.
29. Riker RR, Shehabi Y, Bokesch PM, Ceraso D, WisemandleW, Koura F, et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. Jama. 2009; 301(5):489-99. Epub 2009/02/04. doi: 10.1001/jama.2009.56 PMID: 19188334.
30. Reade MC, Eastwood GM, Bellomo R, Bailey M, Bersten A, Cheung B, et al. Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial. Jama. 2016. Epub 2016/03/16. doi: 10.1001/jama.2016.2707 PMID: 26975647.
31. Reade MC, O'Sullivan K, Bates S, Goldsmith D, Ainslie WR, Bellomo R. Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial. Critical care. 2009; 13 (3):R75. Epub 2009/05/21. doi: 10.1186/cc7890 PMID: 19454032; PubMed Central PMCID: PMC2717438.
32. Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. Jama. 2007; 298(22):2644-53. Epub 2007/12/13. doi: 10.1001/ jama.298.22.2644 PMID: 18073360.
33. Li B, Li Y, Tian S, Wang H, Wu H, Zhang A, et al. Anti-inflammatory Effects of Perioperative Dexmedetomidine Administered as an Adjunct to General Anesthesia: A Meta-analysis. Scientific reports. 2015; 5:12342. Epub 2015/07/22. doi: 10.1038/srep12342 PMID: 26196332; PubMed Central PMCID: PMC4508837.
34. Siami S, Annane D, Sharshar T. The encephalopathy in sepsis. Critical care clinics. 2008; 24(1):67-82, viii. doi: 10.1016/j.ccc.2007.10.001 PMID: 18241779.
35. O'Keeffe ST, Ni Chonchubhair A. Postoperative delirium in the elderly. British journal of anaesthesia. 1994; 73(5):673-87. doi: 10.1093/bja/73.5.673 PMID: 7826799.
36. Lenz A, Franklin GA, Cheadle WG. Systemic inflammation after trauma. Injury. 2007; 38(12):1336-45. doi: 10.1016/j.injury.2007.10.003 PMID: 18048040.
37. Shimaoka M, Park EJ. Advances in understanding sepsis. European journal of anaesthesiology Supplement. 2008; 42:146-53. doi: 10.1017/S0265021507003389 PMID: 18289433; PubMed Central PMCID: PMC2490719.
38. Weichhart T, Haidinger M, Horl WH, Saemann MD. Current concepts of molecular defence mechanisms operative during urinary tract infection. European journal of clinical investigation. 2008; 38 Suppl 2:29-38. doi: 10.1111/j.1365-2362.2008.02006.x PMID: 18826479.
39. Bjornsson GL, Thorsteinsson L, Gudmundsson KO, Jonsson H Jr., Gudmundsson S, Gudbjornsson B. Inflammatory cytokines in relation to adrenal response following total hip replacement. Scandinavian journal of immunology. 2007; 65(1):99-105. doi: 10.1111/j.1365-3083.2006.01872.x PMID: 17212773.
40. Kragsbjerg P, Holmberg H, Vikerfors T. Serum concentrations of interleukin-6, tumour necrosis factoralpha, and C-reactive protein in patients undergoing major operations. The European journal of surgery = Acta chirurgica. 1995; 161(1):17-22. PMID: 7727600.
41. Keck M, Herndon DH, Kamolz LP, Frey M, Jeschke MG. Pathophysiology of burns. Wiener medizinische Wochenschrift. 2009; 159(13-14):327-36. doi: 10.1007/s10354-009-0651-2 PMID: 19652939.
42. Marx N, Neumann FJ, Ott I, Gawaz M, Koch W, Pinkau T, et al. Induction of cytokine expression in leukocytes in acute myocardial infarction. Journal of the American College of Cardiology. 1997; 30 (1):165-70. doi: 10.1016/s0735-1097(97)00116-2 PMID: 9207638.
43. Asimakopoulos G. Mechanisms of the systemic inflammatory response. Perfusion. 1999; 14(4):269-77. doi: 10.1177/026765919901400406 PMID: 10456781.
44. Sun Y, Tawara I, Toubai T, Reddy P. Pathophysiology of acute graft-versus-host disease: recent advances. Translational research: the journal of laboratory and clinical medicine. 2007; 150(4):197-214. doi: 10.1016/j.trsl.2007.06.003 PMID: 17900507; PubMed Central PMCID: PMC2084257.
45. Stinghen AE, Goncalves SM, Martines EG, Nakao LS, Riella MC, Aita CA, et al. Increased plasma and endothelial cell expression of chemokines and adhesion molecules in chronic kidney disease. Nephron Clinical practice. 2009; 111(2):c117-26. doi: 10.1159/000191205 PMID: 19147993.
46. Shawcross DL, Shabbir SS, Taylor NJ, Hughes RD. Ammonia and the neutrophil in the pathogenesis of hepatic encephalopathy in cirrhosis. Hepatology. 2010; 51(3):1062-9. doi: 10.1002/hep.23367 PMID: 19890967.
47. van Munster BC, Korevaar JC, Zwinderman AH, Levi M, Wiersinga WJ, De Rooij SE. Time-course of cytokines during delirium in elderly patients with hip fractures. Journal of the American Geriatrics Society. 2008; 56(9):1704-9. doi: 10.1111/j.1532-5415.2008.01851.x PMID: 18691278.
48. Culley DJ, Snayd M, Baxter MG, Xie Z, Lee IH, Rudolph J, et al. Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. Frontiers in aging neuroscience. 2014; 6:107. doi: 10.3389/fnagi.2014.00107 PMID: 24959140; PubMed Central PMCID: PMC4050637.
49. Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, et al. Cytokine-associated emotional and cognitive disturbances in humans. Archives of general psychiatry. 2001; 58(5):445-52. doi: 10. 1001/archpsyc.58.5.445 PMID: 11343523.
50. Brydon L, Harrison NA, Walker C, Steptoe A, Critchley HD. Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans. Biological psychiatry. 2008; 63 (11):1022-9. doi: 10.1016/j.biopsych.2007.12.007 PMID: 18242584; PubMed Central PMCID: PMC2885493.
51. Sparkman NL, Buchanan JB, Heyen JR, Chen J, Beverly JL, Johnson RW. Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2006; 26(42):10709-16. doi: 10.1523/JNEUROSCI.3376-06.2006 PMID: 17050710.
52. Krzyszton CP, Sparkman NL, Grant RW, Buchanan JB, Broussard SR, Woods J, et al. Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation. American journal of physiology Regulatory, integrative and comparative physiology. 2008; 295(4):R1109-14. doi: 10.1152/ajpregu.90302.2008 PMID: 18650318; PubMed Central PMCID: PMC2576089.
53. Richwine AF, Sparkman NL, Dilger RN, Buchanan JB, Johnson RW. Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide. Brain, behavior, and immunity. 2009; 23(6):794-802. doi: 10.1016/j.bbi.2009.02.020 PMID: 19272439; PubMed Central PMCID: PMC2881543.
54. Capri M, Yani SL, Chattat R, Fortuna D, Bucci L, Lanzarini C, et al. Pre-Operative, High-IL-6 Blood Level is a Risk Factor of Post-Operative Delirium Onset in Old Patients. Frontiers in endocrinology. 2014; 5:173. doi: 10.3389/fendo.2014.00173 PMID: 25368603; PubMed Central PMCID: PMC4201145.
55. Liu P, Li YW, Wang XS, Zou X, Zhang DZ, Wang DX, et al. High serum interleukin-6 level is associated with increased risk of delirium in elderly patients after noncardiac surgery: a prospective cohort study. Chinese medical journal. 2013; 126(19):3621-7. PMID: 24112153.
56. Ingiosi AM, Opp MR, Krueger JM. Sleep and immune function: glial contributions and consequences of aging. Current opinion in neurobiology. 2013; 23(5):806-11. Epub 2013/03/05. doi: 10.1016/j.conb. 2013.02.003 PMID: 23452941; PubMed Central PMCID: PMC3695049.
57. Vacas S, Degos V, Feng X, Maze M. The neuroinflammatory response of postoperative cognitive decline. British medical bulletin. 2013; 106:161-78. Epub 2013/04/06. doi: 10.1093/bmb/ldt006 PMID: 23558082.
58. Garrity AG, Botta S, Lazar SB, Swor E, Vanini G, Baghdoyan HA, et al. Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat. Sleep. 2015; 38(1):73-84. Epub 2014/10/18. doi: 10.5665/sleep.4328 PMID: 25325438; PubMed Central PMCID: PMC4262959.