High serum interleukin-6 level is associated with increased risk of delirium in elderly patients after noncardiac surgery: A prospective cohort study

Chinese Medical Journal

Volumn 126, Issue 19, 2013, Pages 3621-3627

  Liu, Pei ^a   Li, Ya Wei ^a   Wang, Xiao Shan ^b   Zou, Xi ^a   Zhang, Da Zhi ^c   Wang, Dong Xin ^a   Li, Shi Zhong ^c  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b Peking University Civil Aviation School of Clinical Medicine   (China)

^c Jishuitan Orthopaedic College of Tsinghua University   (China)

Author keywords

Delirium; Elderly; Interleukin 6; Operative; Postoperative complications; Surgical procedures

Indexed keywords

INTERLEUKIN 6;

ACUTE HEART INFARCTION; AGED; ARTICLE; COHORT ANALYSIS; DELIRIUM; ECHOCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART ARRHYTHMIA; HEART FAILURE; HEART SURGERY; HOSPITALIZATION; HUMAN; INTESTINE OBSTRUCTION; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MORTALITY; PREVALENCE; PROSPECTIVE STUDY; RESPIRATORY FAILURE; RICHMOND AGITATION SEDATION SCALE; SEPSIS; SURVIVAL; VISUAL ANALOG SCALE;

AGED; COHORT STUDIES; DELIRIUM; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RISK;

EID: 84884855701     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20130211     Document Type: Article

References (30)

1. Inouye S. Delirium in older persons. N Engl J Med 2006; 354: 1157-1165.
2. Dasgupta M, Dumbrell AC. Preoperative risk assessment for delirium after noncardiac surgery: a systematic review. J Am Geriatr Soc 2006; 54: 1578-1589.
3. Young J, Inouye SK. Delirium in older people. BMJ 2007; 334: 842-846.
4. Franco K, Litaker D, Locala J, Bronson D.The cost of delirium in the surgical patient. Psychosomatics 2001; 42: 68-73.
5. Brooks PB. Postoperative delirium in elderly patients. Am J Nurs 2012; 112: 38-49.
6. Loponen P, Luther M, Wistbacka JO, Nissinen J, Sintonen H, Huhtala H, et al. Postoperative delirium and health related quality of life after coronary artery bypass grafting. Scand Cardiovasc J 2008; 42: 337-344.
7. Saczynski JS, Marcantonio ER, Quach L, Fong TG, Gross A, Inouye SK, et al. Cognitive trajectories after postoperative delirium. N Engl J Med 2012; 367: 30-39.
8. Lin Y, Chen J, Wang Z. Meta-analysis of factors which influence delirium following cardiac surgery. J Card Surg 2012; 27: 481-492.
9. Steiner LA. Postoperative delirium. Part 1: pathophysiology and risk factors. Eur J Anaesthesiol 2011; 28: 628-636.
10. Simone MJ, Tan ZS. The role of inflammation in the pathogenesis of delirium and dementia in older adults: a review. CNS Neurosci Ther 2011; 17: 506-513.
11. Sparkman NL, Johnson RW. Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation 2008; 15: 323-330.
12. van Munster BC, Korevaar JC, Zwinderman AH, Levi M, Wiersinga WJ, De Rooij SE. Time-course of cytokines during delirium in elderly patients with hip fractures. J Am Geriatr Soc 2008; 56: 1704-1709.
13. Kudoh A, Takase H, Katagai H, Takazawa T. Postoperative interleukin-6 and cortisol concentrations in elderly patients with postoperative confusion. Neuroimmunomodulation 2005; 12: 60-66.
14. Plaschke K, Fichtenkamm P, Schramm C, Hauth S, Martin E, Verch M, et al. Early postoperative delirium after open-heart cardiac surgery is associated with decreased bispectral EEG and increased cortisol and interleukin-6. Intensive Care Med 2010; 36: 2081-2089.
15. Lemstra AW, Kalisvaart KJ, Vreeswijk R, van Gool WA, Eikelenboom P. Pre-operative inflammatory markers and the risk of postoperative delirium in elderly patients. Int J Geriatr Psychiatry 2008; 23: 943-948.
16. Adamis D, Lunn M, Martin FC, Treloar A, Gregson N, Hamilton G, et al. Cytokines and IGF-I in delirious and non-delirious acutely ill older medical inpatients. Age Ageing 2009; 38: 326-332; discussion 251.
17. Adamis D, Treloar A, Martin FC, Gregson N, Hamilton G, Macdonald AJ. APOE and cytokines as biological markers for recovery of prevalent delirium in elderly medical inpatients. Int J Geriatr Psychiatry 2007; 22: 688-694.
18. Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, et al. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med 2001; 29: 1370-1379.
19. Ohzato H, Yoshizaki K, Nishimoto N, Ogat A, Tagoh H, Monden M, et al. Interleukin-6 as a new indicator of inflammatory status: detection of serum levels of interleukin-6 and C-reactive protein after surgery. Surgery 1992; 111: 201-209.
20. Mahdy AM, Galley HF, Abdel-Wahed MA, El-Korny KF, Sheta SA, Webster NR. Differential modulation of interleukin-6 and interleukin-10 by diclofenac in patients undergoing major surgery. Br J Anaesth 2002; 88: 797-802.
21. Uchikado H, Akiyama H, Kondo H, Ikeda K, Tsuchiya K, Kato M, et al. Activation of vascular endothelial cells and perivascular cells by systemic inflammation-an immunohistochemical study of postmortem human brain tissues. Acta Neuropathol 2004; 107: 341-351.
22. Wilson CJ, Finch CE, Cohen HJ. Cytokines and cognition-the case for a head-to-toe inflammatory paradigm. J Am Geriatr Soc 2002; 50: 2041-2056.
23. Maclullich AM, Ferguson KJ, Miller T, de Rooij SE, Cunningham C. Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res 2008; 65: 229-238.
24. Kronfol Z, Remick DG. Cytokines and the brain: implications for clinical psychiatry. Am J Psychiatry 2000; 157: 683-694.
25. Jawa RS, Anillo S, Huntoon K, Baumann H, Kulaylat M. Analytic review: Interleukin-6 in surgery, trauma, and critical care: part I: basic science. J Intensive Care Med 2011; 26: 3-12.
26. vonBernhardi R, Tichauer JE, Eugenin J. Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders. J Neurochem 2010; 112: 1099-1114.
27. Dilger RN, Johnson RW. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol 2008; 84: 932-939.
28. Simen AA, Bordner KA, Martin MP, Moy LA, Barry LC. Cognitive dysfunction with aging and the role of inflammation. Ther Adv Chronic Dis 2011; 2: 175-195.
29. Vaurio LE, Sands LP, Wang Y, Mullen EA, Leung JM. Postoperative delirium: the importance of pain and pain management. Anesth Analg 2006; 102: 1267-1273.
30. Morrison RS, Magaziner J, Gilbert M, Koval KJ, McLaughlin MA, Orosz G, et al. Relationship between pain and opioid analgesics on the development of delirium following hip fracture. J Gerontol A Biol Sci Med Sci 2003; 58: 76-81.