A novel small molecule activator of nuclear receptor SHP inhibits HCC cell migration via suppressing Ccl2

Molecular Cancer Therapeutics

Volumn 15, Issue 10, 2016, Pages 2294-2301

  Yang, Zhihong ^a,b   Koehler, Angela N ^c,d   Wang, Li ^a,b,e,f  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c Massachusetts Institute of Technology   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 (DIETHYLSULFAMOYL) 3 HYDROXYNAPHTHALENE 2 CARBOXYLIC ACID; ANTIMETASTATIC AGENT; CARBOXYLIC ACID DERIVATIVE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; ORPHAN NUCLEAR RECEPTOR; SMALL HETERODIMER PARTNER; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CELL RECEPTOR; NUCLEAR RECEPTOR SUBFAMILY 0, GROUP B, MEMBER 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; DRUG ANTAGONISM; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; GENETIC DATABASE; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; METASTASIS; METASTASIS INHIBITION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN TARGETING; RECEPTOR BINDING ASSAY; RNA SEQUENCE; TRANSCRIPTION INITIATION; TUMOR INVASION; UBIQUITINATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MOTION; DRUG DEVELOPMENT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; KAPLAN MEIER METHOD; KNOCKOUT MOUSE; LIVER TUMOR; METABOLISM; MORTALITY; PATHOLOGY; PROGNOSIS; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; CHEMOKINE CCL2; DRUG DISCOVERY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASM METASTASIS; PROGNOSIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION, GENETIC;

EID: 84990957228     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-16-0153     Document Type: Article

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