NF-κB p65 recruited SHP regulates PDCD5-mediated apoptosis in cancer cells

Apoptosis

Volumn 19, Issue 3, 2014, Pages 506-517

  Murshed, Farhan ^a   Farhana, Lulu ^a,b,c   Dawson, Marcia I ^d   Fontana, Joseph A ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

^d BURNHAM INSTITUTE   (United States)

Author keywords

Apoptosis; Breast cancer; p65 NF B; PDCD5; Prostate cancer; RelA; SHP

Indexed keywords

ADAMANTANE; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CINNAMATES; HUMANS; NEOPLASM PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTOR RELA;

EID: 84894439095     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0939-y     Document Type: Article

References (48)

1. Hinz M, Broemer M, Arslan SC, Otto A, Mueller E-C, Dettmer R, Scheidereit C (2007) Signal responsiveness of IκB kinases is determined by Cdc37-assisted transient interaction with HSP90. J Biol Chem 282(44):32311-32319
2. Baldwin AS (2012) Regulation of cell death and autophagy by IKK and NF-κB: critical Mechanisms in immune function and cancer. Immunol Rev 246(1):327-345
3. Janssens S, Tschopp J (2006) Signals from within: the DNA-damage-induced NF-kappaB response. Cell Death Differ 13(5):773-784
4. Liu ZG, Hsu H, Goeddel DV, Karin M (1996) Dissection of the TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87(3):565-576
5. Kim HJ, Hawke N, Baldwin AS (2006) NF-κB and IKK as the therapeutic targets in cancer. Cell Death Differ 13(5):238-247
6. Chen X, Kandasamy K, Srivastava RK (2003) Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand signaling. Cancer Res 63(5):1059-1066
7. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of the NF-κB. Nature 376(3536):167-170
8. Farhana L, Dawson MI, Fontana JA (2005) Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-κB activation. Cancer Res 65(11):4909-4917
9. Bednarski BK, Baldwin AS Jr, Kim HJ (2009) Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin. PLoS 4(9):e6992
10. Jin F, Liu X, Zhou Z, Yue P, Lotan R, Khuri FR, Chung LW, Sun SY (2005) Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res 65(14):6354-6363
11. Delhase M, Hayakawa M, Chen Y, Karin M (1999) Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284(5412):309-313
12. Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A (2006) NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell 21(4):467-480
13. Ho JQ, Asagiri M, Hoffmann A, Ghosh G (2011) NF-κB potentiates caspase-independent hydrogen peroxidase-induced cell death. PLoS One 6(2):e16815
14. Campbell KJ, Rocha S, Perkins ND (2004) Active repression of antiapoptotic genes expression by RelA/NF-κB. Mol Cell 13(6):853-865
15. Jennewein C, Karl S, Baumann B, Micheau O, Debatin KM, Fulda S (2012) Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. Oncogene 31(11):1468-1474
16. Dawson MI, Hobbs PD, Peterson VJ, Leid M, Lange CW, Feng KC, Chen Gq, Gu J, Li H, Kolluri SK, Xk Zhang, Zhang Y, Fontana JA (2001) Apoptosis induction in cancer cells b a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2- naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity. Cancer Res 61(12):4723-4730
17. Zhang Y, Dawson MI, Ning Y, Polin L, Parchment RE, Corbett T, Mohamed AN, Feng KC, Farhana L, Rishi AK, Hogge D, Leid M, Peterson VJ, Zhang XK, Mohammad R, Lu JS, Willman C, VanBuren E, Biggar S, Edelstein M, Eilender D, Fontana JA (2003) Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog. Blood 102(10):3743-3752
18. Farhana L, Dawson MI, Murshed F, Fontana JA (2011) Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF-κB noncanonical and canonical pathway activation. Cell Death Differ 18(1):164-173
19. Liu H, Wang Y, Zhang Y, Song Q, Di C, Chen G, Tang J, Ma D (1999) TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biophys Res Commun 254:203-210
20. Chen C, Zhou H, Xu L, Xu D, Wang Y, Zhang Y, Liu X, Liu Z, Ma D, Ma Q, Chen Y (2010) Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo. Apoptosis 15(7):805-813
21. Wang Y, Li X, Wang L, Ding P, Zhang Y, Han W, Ma D (2004) An alternative form of paraptosis-like cell death, triggered by TAJ/TROY and enhanced by PDCD5 overexpression. J Cell Sci 117(8):1525-1532
22. Xu M, Cheng N, Gui L, Lai M, Wang Y, Xia D, Rui M, Zhang Y, Ma D (2004) The 5′-upstream region of human programmed cell death 5 gene contains a highly active TATA-less promoter that is up-regulated by etoposide. Gene 329:39-49
23. Kim YS, Han CY, Kim SW, Kim JH, Lee SK, Jung DJ, Park SY, Kang H, Choi HS, Lee JW, Pak YK (2001) The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear receptor-κB in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7. J Biol Chem 276(36):33736-33740
24. Farhana L, Dawson MI, Leid M, Wang L, Moore DD, Liu G, Xia Z, Fontana JA (2007) Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor. Cancer Res 67(1):313-325
25. Lin L, DeMartino GN, Greene WC (2000) Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production. The EMBO J 19:4712-4722
26. Li H, Zhang X, Song X, Zhu F, Wang Q, Guo C, Liu C, Shi Y, Ma C, Wang X, Zhang L (2012) PDCD5 promotes cisplatin-induced apoptosis of glioma cells via activating mitochondrial apoptotic pathway. Cancer Biol Therapy 13(9):822-830
27. Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (1997) CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proc Natl Acad Sci USA 94:6346-6351
28. Blyth K, Cameron ER, Neil JC (2005) The RUNX genes: gain or loss of function in cancer. Nat Rev Cancer 5:376-387
29. Wu D, Ozaki T, Yoshihara Y, Kubo N, Nakagawara A (2012) Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation. J Biol Chem 288:1353-1364
30. Ozaki T, Wu D, Sugimoto H, Nagase H, Nakagawara A (2013) Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage. Cell Death and Dis 4:e610. doi: 10.1038/cddis.2013.127
31. Benschop R, Wei T, Na S (2009) Tumor Necrosis factor receptor superfamily member 21: TNFR-related death receptor-6, DR6. Adv Exp Med Biol 647:186-194
32. Zeng L, Li T, Xu DC, Liu J, Mao G, Cui MZ, Fu X, Xu X (2012) Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein. J Biol Chem 287(34):29125-29133
33. Kasof GM, Lu JJ, Liu D, Speer B, Mongan KN, Gomes BC, Lorenzi MV (2001) Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB. Oncogene 20(55):7965-7975
34. Lin Y, Choksi S, Shen HM, Yang QF, Hur GM, Kim YS, Tran JH, Nedospasov SA, Liu ZG (2004) Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem 279(11):10822-10828
35. Spinola M, Meyer P, Kammerer S, Falvella FS, Boettger MB, Hoyal CR, Pignatiello C, Fischer R, Roth RB, Pastorino U, Haeussinger K, Nelson MR, Dierkesmann R, Dragani TA, Braun A (2006) Association of the PDCD5 locus with lung cancer risk and prognosis in smokers. J Clin Oncol 24(11):1672-1678
36. Yin A, Jiang Y, Zhang X, Zhao J, Luo H (2010) Transfection of PDCD5 sensitizes colorectal cancer cells to cisplatin-induced apoptosis in vitro and in vivo. Eur J Pharmacol 649:120-126
37. Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG (2011) Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Proc. Natl Acad Sci USA 98(26):15089-15094
38. Li H, Wang Q, Gao F, Zhu F, Wang X, Zhou C, Liu C, Chen Y, Ma C, Sun W, Zhang L (2008) Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas. Oncol Rep 20(3):573-579
39. Ruan GR, Zhao HS, Chang Y, Li JL, Qin YZ, Liu YR, Chen SS, Huang XJ (2008) Adenovirus-mediated PDCD5 gene transfer sensitizes K562 cells to apoptosis induced by idarubicin in vitro and in vivo. Apoptosis 13(5):641-648
40. Hedenfalk I, Duggan D, Chen Y, Radmacher M, Bittner M, Simon R, Meltzer P, Gusterson B, Esteller M, Kallioniemi OP, Wilfond B, Borg A, Trent J, Raffeld M, Yakhini Z, Ben-Dor A, Dougherty E, Kononen J, Bubendorf L, Fehrle W, Pittaluga S, Gruvberger S, Loman N, Johannsson O, Olsson H, Sauter G (2001) Gene-expression profiles in hereditary breast cancer. N Eng J Med 344(8):539-548
41. Ma X, Ruan G, Wang Y, Li Q, Zhu P, Qin YZ, Li JL, Liu YR, Ma D, Zhao H (2005) Two single-nucleotide polymorphisms with linkage disequilibrium in the human programmed cell death 5 gene 5′ regulatory region affect promoter activity and the susceptibility of chronic myelogenous leukemia in Chinese population. Clin Cancer Res 11(24):8592-8599
42. Xu HY, Chen ZW, Pan YM, Fan L, Guan J, Lu YY (2012) Transfection of PDCD5 effect on the biological behavior of tumor cells and sensitized gastric cancer cells to cisplatin-induced apoptosis. Diq Dis Sci 57(7):1847-1856
43. Salvi M, Xu D, Chen Y, Cabrelle A, Sarno S, Pinna LA (2009) Programmed cell death protein 5 (PDCD5) is phosphorylated by CK2 in vitro and in 293T cells. Biochem Biophys Res Commun 387:606-610
44. Farhana L, Dawson MI, Dannenberg JH, Xu L, Fontana JA (2009) SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediate nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis. Mol Cancer Ther 8(6):1625-1635
45. Chen F, Castranova V (2007) Nuclear factor-κB, an unappreciated tumor suppressor. Cancer Res 67:11093-11098
46. Ouaaz F, Li M, Beg AA (1999) A critical role for the RelA of nuclear factor κB in regulation of multiple immune-response genes and in Fas-induced cell death. J Exp Med 189:999-1004
47. Lin B, Williams-Skipp C, Tao Y, Schleicher MS, Cano LL, Duke RC, Scheinman RI (1999) NF-κB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type. Cell Death Differ 6(6):570-582
48. Makewicz M, Zeller N, Yilmaz ZB, Weih F (2003) NFκB controls the balance between Fas and tumor necrosis factor cell death pathways during T cell receptor-induced apoptosis via the expression of its target gene A20. J Biol Chem 278:32825-32833