A Feedback Inhibition between miRNA-127 and TGFβ/c-Jun Cascade in HCC Cell Migration via MMP13

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Yang, Zhihong ^a   Zhang, Yuxia ^a   Wang, Li ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; MICRORNA; MICRORNA 127; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C JUN; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; MIGRATION INHIBITION; MOLECULAR INTERACTION; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; ONCOGENE C JUN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; TRANSACTIVATION; TUMOR SUPPRESSOR GENE; UPREGULATION;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; FEEDBACK, PHYSIOLOGICAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 13; MICE; MICE, NUDE; MICRORNAS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-JUN; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

MUS MUSCULUS;

EID: 84878750954     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065256     Document Type: Article

References (35)

1. Kircher M, Bock C, Paulsen M, (2008) Structural conservation versus functional divergence of maternally expressed microRNAs in the Dlk1/Gtl2 imprinting region. BMC Genomics 9: 346.
2. Song G, Wang L, (2008) MiR-433 and miR-127 arise from independent overlapping primary transcripts encoded by the miR-433-127 locus. PLoS One 3: e3574.
3. Song G, Wang L, (2008) Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma. Nucleic Acids Res 36: 5727-5735.
4. Song G, Wang L, (2009) A conserved gene structure and expression regulation of miR-433 and miR-127 in mammals. PLoS One 4: e7829.
5. Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, et al. (2006) Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9: 435-443.
6. Lee JW, Choi CH, Choi JJ, Park YA, Kim SJ, et al. (2008) Altered MicroRNA expression in cervical carcinomas. Clin Cancer Res 14: 2535-2542.
7. Dixon-McIver A, East P, Mein CA, Cazier JB, Molloy G, et al. (2008) Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia. PLoS One 3: e2141.
8. Robertus JL, Harms G, Blokzijl T, Booman M, de Jong D, et al. (2009) Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma. Mod Pathol 22: 547-555.
9. Yan LX, Huang XF, Shao Q, Huang MY, Deng L, et al. (2008) MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. Rna 14: 2348-2360.
10. Tryndyak VP, Ross SA, Beland FA, Pogribny IP, (2009) Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Mol Carcinog 48: 479-487.
11. Mosakhani N, Sarhadi VK, Borze I, Karjalainen-Lindsberg ML, Sundstrom J, et al. (2012) MicroRNA profiling differentiates colorectal cancer according to KRAS status. Genes Chromosomes Cancer 51: 1-9.
12. Xie T, Liang J, Liu N, Wang Q, Li Y, et al. (2012) MicroRNA-127 inhibits lung inflammation by targeting IgG Fcgamma receptor I. J Immunol. 188: 2437-2444.
13. Li Y, Tang ZY, Ye SL, Liu YK, Chen J, et al. (2001) Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97. World J Gastroenterol 7: 630-636.
14. Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, et al. (2010) Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol 30: 1341-1356.
15. Yang Z, Zhang Y, Kemper JK, Wang L, (2012) Cross-Regulation of Protein Stability by p53 and Nuclear Receptor SHP. PLoS One 7: e39789.
16. Song G, Zhang Y, Wang L, (2009) MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation. J Biol Chem 284: 31921-31927.
17. Zhang Y, Xu P, Park K, Choi Y, Moore DD, et al. (2008) Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology 48: 289-298.
18. Zhang Y, Yang Z, Whitby R, Wang L, (2011) Regulation of miR-200c by nuclear receptors PPARalpha, LRH-1 and SHP. Biochem Biophys Res Commun 416: 135-139.
19. Zhou T, Zhang Y, Macchiarulo A, Yang Z, Cellanetti M, et al. (2010) Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes. J Biol Chem 285: 24871-24881.
20. Lee CF, Ling ZQ, Zhao T, Fang SH, Chang WC, et al. (2009) Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma. World J Gastroenterol 15: 356-365.
21. Leivonen SK, Ala-Aho R, Koli K, Grenman R, Peltonen J, et al. (2006) Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells. Oncogene 25: 2588-2600.
22. Sume SS, Kantarci A, Lee A, Hasturk H, Trackman PC, (2010) Epithelial to mesenchymal transition in gingival overgrowth. Am J Pathol 177: 208-218.
23. Fransvea E, Angelotti U, Antonaci S, Giannelli G, (2008) Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology 47: 1557-1566.
24. Yang Z, Zhang Y, Wang L, (2012) Mdm2 is a novel activator of ApoCIII promoter which is antagonized by p53 and SHP inhibition. Biochem Biophys Res Commun 417: 744-746.
25. Mulder KM, (2000) Role of Ras and Mapks in TGFbeta signaling. Cytokine Growth Factor Rev 11: 23-35.
26. Padua D, Massague J, (2009) Roles of TGFbeta in metastasis. Cell Res 19: 89-102.
27. He N, Park K, Zhang Y, Huang J, Lu S, et al. (2008) Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth. Gastroenterology 134: 793-802.
28. Yang ZF, Ho DW, Ng MN, Lau CK, Yu WC, et al. (2008) Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell 13: 153-166.
29. Llovet JM, Chen Y, Wurmbach E, Roayaie S, Fiel MI, et al. (2006) A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology 131: 1758-1767.
30. Roessler S, Jia HL, Budhu A, Forgues M, Ye QH, et al. (2010) A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. Cancer Res 70: 10202-10212.
31. Yang JD, Nakamura I, Roberts LR, (2011) The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets. Semin Cancer Biol 21: 35-43.
32. Coulouarn C, Factor VM, Andersen JB, Durkin ME, Thorgeirsson SS, (2009) Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene 28: 3526-3536.
33. Bianchi ME, Agresti A, (2005) HMG proteins: dynamic players in gene regulation and differentiation. Curr Opin Genet Dev 15: 496-506.
34. Lopez-Bergami P, Huang C, Goydos JS, Yip D, Bar-Eli M, et al. (2007) Rewired ERK-JNK signaling pathways in melanoma. Cancer Cell 11: 447-460.
35. Johnson GL, Lapadat R, (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298: 1911-1912.