Stimulation of transforming growth factor-β1-induced endothelial-to-mesenchymal transition and tissue fibrosis by endothelin-1 (ET-1): A novel profibrotic effect of ET-1

PLoS ONE

Volumn 11, Issue 9, 2016, Pages

  Wermuth, Peter J ^a   Li, Zhaodong ^a   Mendoza, Fabian A ^a   Jimenez, Sergio A ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD31 ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; ENDOTHELIN 1; INTERCELLULAR ADHESION MOLECULE 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAI1; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; ACTIN; ALPHA-SMOOTH MUSCLE ACTIN, MOUSE; FIBRINOGEN RECEPTOR; VON WILLEBRAND FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CAPILLARY ENDOTHELIAL CELL; CELL TRANSFORMATION; CONTROLLED STUDY; ENDOTHELIAL TO MESENCHYMAL TRANSITION; FIBROSIS; GENE EXPRESSION; IN VIVO STUDY; LUNG FIBROSIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SKIN FIBROSIS; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; DRUG INTERACTION; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; LUNG; MESODERM; METABOLISM; MICROVASCULATURE; PATHOLOGY; SKIN; VASCULARIZATION;

ACTINS; ANIMALS; COLLAGEN TYPE I; COLLAGEN TYPE III; DRUG INTERACTIONS; ENDOTHELIAL CELLS; ENDOTHELIN-1; FIBROSIS; GENE EXPRESSION REGULATION; LUNG; MESODERM; MICE; MICE, INBRED C57BL; MICROVESSELS; PLATELET MEMBRANE GLYCOPROTEINS; SKIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84990935091     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0161988     Document Type: Article

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