Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior

Cell

Volumn 167, Issue 2, 2016, Pages 341-354.e12

  Doan, Ryan N ^a   Bae, Byoung Il ^a,l   Cubelos, Beatriz ^b,c   Chang, Cindy ^a   Hossain, Amer A ^a   Al Saad, Samira ^d   Mukaddes, Nahit M ^e   Oner, Ozgur ^f   Al Saffar, Muna ^a,g   Balkhy, Soher ^h   Gascon, Generoso G ⁱ   Nieto, Marta ^c   Walsh, Christopher A ^a,j,k  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^d Kuwait Center for Autism   (Kuwait)

^e Child and Adolescent Psychiatry   (Turkey)

^f BAHCESEHIR UNIVERSITY   (Turkey)

^g UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^h KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

ⁱ MASSACHUSETTS GENERAL HOSPITAL   (United States)

^j BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^k HARVARD MEDICAL SCHOOL   (United States)

^l YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

ASD; Autism; Brain Evolution; HARs; Human Accelerated regions; noncoding

Indexed keywords

CDKL5 PROTEIN; CUX1 PROTEIN; GLYPICAN; GLYPICAN 4; PTBP2 PROTEIN; UNCLASSIFIED DRUG; UNTRANSLATED RNA; CUX1 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; NUCLEAR PROTEIN; REPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; AUTISM; COGNITIVE DEFECT; ENHANCER REGION; EVOLUTION; GENE SEQUENCE; GENETIC RISK; GENETIC VARIABILITY; GENOMICS; HUMAN; HUMAN ACCELERATED REGION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PSEUDOGENE; SOCIAL BEHAVIOR; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; ALLELE; ANIMAL; BRAIN CORTEX; COGNITION; GENE DOSAGE; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; HUMAN GENOME; INTRON; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; QUANTITATIVE TRAIT LOCUS; REGULATORY SEQUENCE;

ALLELES; ANIMALS; AUTISM SPECTRUM DISORDER; CEREBRAL CORTEX; COGNITION; GENE DOSAGE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME, HUMAN; HOMEODOMAIN PROTEINS; HUMANS; INTRONS; MICE; MICE, TRANSGENIC; NEUROGENESIS; NUCLEAR PROTEINS; POINT MUTATION; QUANTITATIVE TRAIT LOCI; REGULATORY ELEMENTS, TRANSCRIPTIONAL; REPRESSOR PROTEINS; SOCIAL BEHAVIOR;

EID: 84990861958     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.08.071     Document Type: Article

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