Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice

Journal of Proteomics

Volumn 145, Issue , 2016, Pages 237-245

  Elamin, Ashraf ^a   Titz, Bjoern ^a   Dijon, Sophie ^a   Merg, Celine ^a   Geertz, Marcel ^a,c   Schneider, Thomas ^a   Martin, Florian ^a   Schlage, Walter K ^b   Frentzel, Stefan ^a   Talamo, Fabio ^a   Phillips, Blaine ^a   Veljkovic, Emilija ^a   Ivanov, Nikolai V ^a   Vanscheeuwijck, Patrick ^a   Peitsch, Manuel C ^a   Hoeng, Julia ^a  

^a PHILIP MORRIS PRODUCTS S A   (Switzerland)

^b Biology Consultant   (Germany)

^c BAYER AG   (Germany)

Author keywords

2D PAGE; Data integration; Inhalation toxicology; Modified risk tobacco product; Quantitative proteomics; RPPA; Systems toxicology

Indexed keywords

CIGARETTE SMOKE; PROTEOME; SURFACTANT; ACTIN; PROTEASOME;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HEALTH HAZARD; LIQUID CHROMATOGRAPHY MASS SPECTROMETRY; LUNG; MASS SPECTROMETRY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN MICROARRAY; PROTEOMICS; QUANTITATIVE ANALYSIS; SECONDARY ORGANIC AEROSOL; SMOKING; TOBACCO; TWO DIMENSIONAL GEL ELECTROPHORESIS; AEROSOL; ANIMAL; C57BL MOUSE; CHEMISTRY; COMPARATIVE STUDY; CYTOSKELETON; DRUG EFFECTS; EXPOSURE; LIQUID CHROMATOGRAPHY; PATHOLOGY; PROCEDURES; SMOKE; TANDEM MASS SPECTROMETRY;

ACTINS; AEROSOLS; ANIMALS; CHROMATOGRAPHY, LIQUID; CYTOSKELETON; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; INHALATION EXPOSURE; LUNG; MICE; MICE, INBRED C57BL; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOME; PROTEOMICS; SMOKE; TANDEM MASS SPECTROMETRY; TOBACCO PRODUCTS;

EID: 84990857187     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2016.05.037     Document Type: Article

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