Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury

Toxicology Letters

Volumn 262, Issue , 2016, Pages 80-91

  Yang, Yong ^a,c   Bai, Ting ^b   Yao, You Li ^a   Zhang, De Quan ^a   Wu, Yan Ling ^a   Lian, Li Hua ^a   Nan, Ji Xing ^a,d  

^a YANBIAN UNIVERSITY   (China)

^b UNIVERSITY OF JINAN   (China)

^c DALIAN UNIVERSITY   (China)

^d TONGHUA NORMAL UNIVERSITY   (China)

Author keywords

AMP activated protein kinase; Hepatic stellate cells; Liver injury; Thymoquinone

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ALANINE AMINOTRANSFERASE; ALCOHOL; ALPHA SMOOTH MUSCLE ACTIN; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COLLAGEN TYPE 1; COLLAGENASE 3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SIRTUIN 1; THYMOQUINONE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRIACYLGLYCEROL; ADENYLATE KINASE; BENZOQUINONE DERIVATIVE; PROTEIN SERINE THREONINE KINASE; SIRT1 PROTEIN, HUMAN; STK11 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL LIVER CIRRHOSIS; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; GENE DELETION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STELLATE CELL; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ALCOHOLISM; ANIMAL; BINGE DRINKING; BIOSYNTHESIS; C57BL MOUSE; CHEMICAL AND DRUG INDUCED LIVER INJURY; DRUG EFFECTS; HEPATIC STELLATE CELL; LIVER FUNCTION TEST; METABOLISM; PATHOLOGY;

ADENYLATE KINASE; ALCOHOLISM; ANIMALS; BENZOQUINONES; BINGE DRINKING; CHEMICAL AND DRUG INDUCED LIVER INJURY; HEPATIC STELLATE CELLS; HUMANS; LIVER FUNCTION TESTS; MALE; MICE; MICE, INBRED C57BL; PPAR GAMMA; PROTEIN-SERINE-THREONINE KINASES; SIRTUIN 1; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84990067662     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2016.09.014     Document Type: Article

References (35)

1. Adachi, M., Brenner, D.A., High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology 47 (2008), 677–685.
2. Ajmo, J.M., Liang, X., Rogers, C.Q., Pennock, B., You, M., Resveratrol alleviates alcoholic fatty liver in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 295 (2008), G833–842.
3. Ali, B.H., Blunden, G., Pharmacological and toxicological properties of Nigella sativa. Phytother. Res. PTR 17 (2003), 299–305.
4. Bai, T., Lian, L.H., Wu, Y.L., Wan, Y., Nan, J.X., Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells. Int. Immunopharmacol. 15 (2013), 275–281.
5. Bai, T., Yang, Y., Wu, Y.L., Jiang, S., Lee, J.J., Lian, L.H., Nan, J.X., Thymoquinone alleviates thioacetamide-induced hepatic fibrosis and inflammation by activating LKB1-AMPK signaling pathway in mice. Int. Immunopharmacol. 19 (2014), 351–357.
6. Bai, T., Yang, Y., Yao, Y.L., Sun, P., Lian, L.H., Wu, Y.L., Nan, J.X., Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway. Pharmacol. Res. 105 (2016), 1–12.
7. Bertola, A., Mathews, S., Ki, S.H., Wang, H., Gao, B., Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat. Protoc. 8 (2013), 627–637.
8. Ceni, E., Mello, T., Galli, A., Pathogenesis of alcoholic liver disease: role of oxidative metabolism. World J. Gastroenterol. 20 (2014), 17756–17772.
9. Chung, S., Park, C.W., Role of peroxisome proliferator-activated receptor alpha in diabetic nephropathy. Diabetes Metab. J. 35 (2011), 327–336.
10. Crispe, I.N., The liver as a lymphoid organ. Annu. Rev. Immunol. 27 (2009), 147–163.
11. Darakhshan, S., Bidmeshki Pour, A., Hosseinzadeh Colagar, A., Sisakhtnezhad, S., Thymoquinone and its therapeutic potentials. Pharmacol. Res. 95–96 (2015), 138–158.
12. Gao, B., Bataller, R., Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141 (2011), 1572–1585.
13. Green, A.S., Chapuis, N., Lacombe, C., Mayeux, P., Bouscary, D., Tamburini, J., LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology. Cell Cycle 10 (2011), 2115–2120.
14. Gressner, A.M., Weiskirchen, R., Breitkopf, K., Dooley, S., Roles of TGF-beta in hepatic fibrosis. Front. Biosci. 7 (2002), d793–807.
15. Haffar, T., Berube-Simard, F.A., Bousette, N., Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs. Biochem. Biophys. Res. Commun. 459 (2015), 54–59.
16. Hernandez-Gea, V., Friedman, S.L., Pathogenesis of liver fibrosis. Annu. Rev. Pathol. 6 (2011), 425–456.
17. Iredale, J.P., Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J. Clin. Invest. 117 (2007), 539–548.
18. Jin, Z., Sun, R., Wei, H., Gao, X., Chen, Y., Tian, Z., Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. Hepatology 53 (2011), 219–229.
19. Johnson-Ajinwo, O.R., Li, W.W., Stable isotope dilution gas chromatography-mass spectrometry for quantification of thymoquinone in black cumin seed oil. J. Agric. Food Chem. 62 (2014), 5466–5471.
20. Kuno, A., Horio, Y., SIRT1: a novel target for the treatment of muscular dystrophies. Oxid. Med. Cell. Longev., 2016, 2016, 6714686.
21. Luo, J., Wu, S., Liu, J., Li, Y., Yang, H., Kim, T., Zhelyabovska, O., Ding, G., Zhou, Y., Yang, Y., Yang, Q., Conditional PPARgamma knockout from cardiomyocytes of adult mice impairs myocardial fatty acid utilization and cardiac function. Am. J. Transl. Res. 3 (2010), 61–72.
22. Ma, J., Shi, H., Mi, C., Li, H.L., Lee, J.J., Jin, X., Malloapelta B suppresses LPS-induced NF-kappaB activation and NF-kappaB-regulated target gene products. Int. Immunopharmacol. 24 (2015), 147–152.
23. Nolan, J.P., The role of intestinal endotoxin in liver injury: a long and evolving history. Hepatology 52 (2010), 1829–1835.
24. Purushotham, A., Schug, T.T., Xu, Q., Surapureddi, S., Guo, X., Li, X., Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 9 (2009), 327–338.
25. Rahimian, R., Masih-Khan, E., Lo, M., van Breemen, C., McManus, B.M., Dube, G.P., Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus. Mol. Cell. Biochem. 224 (2001), 29–37.
26. Rana, S., Blowers, E.C., Natarajan, A., Small molecule adenosine 5′-monophosphate activated protein kinase (AMPK) modulators and human diseases. J. Med. Chem. 58 (2015), 2–29.
27. Ruderman, N.B., Xu, X.J., Nelson, L., Cacicedo, J.M., Saha, A.K., Lan, F., Ido, Y., AMPK and SIRT1: a long-standing partnership?. Am. J. Physiol. Endocrinol. Metab. 298 (2010), E751–760.
28. Tu, C., Gao, D., Li, X.F., Li, C.Y., Li, R.S., Zhao, Y.L., Li, N., Jia, G.L., Pang, J.Y., Cui, H.R., Ma, Z.J., Xiao, X.H., Wang, J.B., Inflammatory stress potentiates emodin-induced liver injury in rats. Front. Pharmacol., 6, 2015, 233.
29. Wang, C., Kemp-Harper, B.K., Kocan, M., Ang, S.Y., Hewitson, T.D., Samuel, C.S., The anti-fibrotic actions of relaxin are mediated through a NO-sGC-cGMP-dependent pathway in renal myofibroblasts in vitro and enhanced by the NO donor, diethylamine NONOate. Front. Pharmacol., 7, 2016, 91.
30. Wilfred de Alwis, N.M., Day, C.P., Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. Semin. Liver Dis. 27 (2007), 44–54.
31. Wu, C.H., Ou, T.T., Chang, C.H., Chang, X.Z., Yang, M.Y., Wang, C.J., The polyphenol extract from Sechium edule shoots inhibits lipogenesis and stimulates lipolysis via activation of AMPK signals in HepG2 cells. J. Agric. Food Chem. 62 (2014), 750–759.
32. Xu, J., Liu, X., Koyama, Y., Wang, P., Lan, T., Kim, I.G., Kim, I.H., Ma, H.Y., Kisseleva, T., The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies. Front. Pharmacol., 5, 2014, 167.
33. You, M., Jogasuria, A., Taylor, C., Wu, J., Sirtuin 1 signaling and alcoholic fatty liver disease. Hepatobiliary Surg. Nutr. 4 (2015), 88–100.
34. Zhan, S.S., Jiang, J.X., Wu, J., Halsted, C., Friedman, S.L., Zern, M.A., Torok, N.J., Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo. Hepatology 43 (2006), 435–443.
35. Zhou, Y., Zheng, S., Lin, J., Zhang, Q.J., Chen, A., The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro. Lab. Invest. 87 (2007), 488–498.