-
1
-
-
84922466451
-
A roadmap for natural product discovery based on large-scale genomics and metabolomics
-
Doroghazi, J. R. et al. A roadmap for natural product discovery based on large-scale genomics and metabolomics. Nat. Chem. Biol. 10, 963-968 (2014).
-
(2014)
Nat. Chem. Biol.
, vol.10
, pp. 963-968
-
-
Doroghazi, J.R.1
-
2
-
-
84893460683
-
Challenges and triumphs to genomics-based natural product discovery
-
Jensen, P. R., Chavarria, K. L., Fenical, W., Moore, B. S. & Ziemert, N. Challenges and triumphs to genomics-based natural product discovery. J. Ind. Microbiol. Biotechnol. 41, 203-209 (2014).
-
(2014)
J. Ind. Microbiol. Biotechnol.
, vol.41
, pp. 203-209
-
-
Jensen, P.R.1
Chavarria, K.L.2
Fenical, W.3
Moore, B.S.4
Ziemert, N.5
-
3
-
-
84937253653
-
Discovery of microbial natural products by activation of silent biosynthetic gene clusters
-
Rutledge, P. J. & Challis, G. L. Discovery of microbial natural products by activation of silent biosynthetic gene clusters. Nat. Rev. Microbiol. 13, 509-523 (2015).
-
(2015)
Nat. Rev. Microbiol.
, vol.13
, pp. 509-523
-
-
Rutledge, P.J.1
Challis, G.L.2
-
4
-
-
0025275007
-
Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea
-
Weber, J. M. et al. Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea. J. Bacteriol. 172, 2372-2383 (1990).
-
(1990)
J. Bacteriol.
, vol.172
, pp. 2372-2383
-
-
Weber, J.M.1
-
5
-
-
84939557642
-
Minimum Information about a Biosynthetic Gene cluster
-
Medema, M. H. et al. Minimum Information about a Biosynthetic Gene cluster. Nat. Chem. Biol. 11, 625-631 (2015).
-
(2015)
Nat. Chem. Biol.
, vol.11
, pp. 625-631
-
-
Medema, M.H.1
-
6
-
-
33748631825
-
Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic, machinery, and mechanisms
-
Fischbach, M. A. & Walsh, C. T. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem. Rev. 106, 3468-3496 (2006).
-
(2006)
Chem. Rev.
, vol.106
, pp. 3468-3496
-
-
Fischbach, M.A.1
Walsh, C.T.2
-
7
-
-
69249202590
-
The biosynthetic logic of polyketide diversity
-
Hertweck, C. The biosynthetic logic of polyketide diversity. Angew. Chem. Int. Ed. Engl. 48, 4688-4716 (2009).
-
(2009)
Angew. Chem. Int. Ed. Engl.
, vol.48
, pp. 4688-4716
-
-
Hertweck, C.1
-
8
-
-
84880149568
-
Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds
-
Walsh, C. T., O'Brien, R. V. & Khosla, C. Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds. Angew. Chem. Int. Ed. Engl. 52, 7098-7124 (2013).
-
(2013)
Angew. Chem. Int. Ed. Engl.
, vol.52
, pp. 7098-7124
-
-
Walsh, C.T.1
O'Brien, R.V.2
Khosla, C.3
-
9
-
-
84942761231
-
An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products
-
Johnston, C. W. et al. An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products. Nat. Commun. 6, 8421 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 8421
-
-
Johnston, C.W.1
-
10
-
-
84928549042
-
The colibactin warhead crosslinks DNA
-
Vizcaino, M. I. & Crawford, J. M. The colibactin warhead crosslinks DNA. Nat. Chem. 7, 411-417 (2015).
-
(2015)
Nat. Chem.
, vol.7
, pp. 411-417
-
-
Vizcaino, M.I.1
Crawford, J.M.2
-
11
-
-
77949363508
-
Closthioamide: An unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum
-
Lincke, T., Behnken, S., Ishida, K., Roth, M. & Hertweck, C. Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum. Angew. Chem. Int. Ed. Engl. 49, 2011-2013 (2010).
-
(2010)
Angew. Chem. Int. Ed. Engl.
, vol.49
, pp. 2011-2013
-
-
Lincke, T.1
Behnken, S.2
Ishida, K.3
Roth, M.4
Hertweck, C.5
-
12
-
-
77957709176
-
Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant
-
Ishida, K., Lincke, T., Behnken, S. & Hertweck, C. Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant. J. Am. Chem. Soc. 132, 13966-13968 (2010).
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 13966-13968
-
-
Ishida, K.1
Lincke, T.2
Behnken, S.3
Hertweck, C.4
-
13
-
-
84979859096
-
AntiSMASH 3. 0 - A comprehensive resource for the genome mining of biosynthetic gene clusters
-
Weber, T. et al. antiSMASH 3. 0-a comprehensive resource for the genome mining of biosynthetic gene clusters. Nucleic Acids Res. 43, W237-W243 (2015).
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. W237-W243
-
-
Weber, T.1
-
14
-
-
84949999706
-
Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)
-
Skinnider, M. A. et al. Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM). Nucleic Acids Res. 43, 9645-9662 (2015).
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. 9645-9662
-
-
Skinnider, M.A.1
-
15
-
-
77952517931
-
Biosynthesis: Is it time to go retro?
-
Bachmann, B. O. Biosynthesis: is it time to go retro? Nat. Chem. Biol. 6, 390-393 (2010).
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 390-393
-
-
Bachmann, B.O.1
-
16
-
-
64249084052
-
Complex enzymes in microbial natural product biosynthesis, part A: Overview articles and peptides
-
Academic Press
-
Bachmann, B. O. & Ravel, J. Complex enzymes in microbial natural product biosynthesis, part A: overview articles and peptides. in Methods in Enzymology 458, 181-217 (Academic Press, 2009).
-
(2009)
Methods in Enzymology
, vol.458
, pp. 181-217
-
-
Bachmann, B.O.1
Ravel, J.2
-
17
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul, S. F. et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389-3402 (1997).
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
-
18
-
-
84876340080
-
Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models
-
Khayatt, B. I., Overmars, L., Siezen, R. J. & Francke, C. Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models. PLoS One 8, e62136 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e62136
-
-
Khayatt, B.I.1
Overmars, L.2
Siezen, R.J.3
Francke, C.4
-
20
-
-
33745135773
-
Recent developments of the chemistry development kit (CDK)-an open-source Java library for chemo-and bioinformatics
-
Steinbeck, C. et al. Recent developments of the chemistry development kit (CDK)-an open-source java library for chemo-and bioinformatics. Curr. Pharm. Des. 12, 2111-2120 (2006).
-
(2006)
Curr. Pharm. Des.
, vol.12
, pp. 2111-2120
-
-
Steinbeck, C.1
-
21
-
-
74049089230
-
Small Molecule Subgraph Detector (SMSD) toolkit
-
Rahman, S. A., Bashton, M., Holliday, G. L., Schrader, R. & Thornton, J. M. Small Molecule Subgraph Detector (SMSD) toolkit. J. Cheminform. 1, 12 (2009).
-
(2009)
J. Cheminform.
, vol.1
, pp. 12
-
-
Rahman, S.A.1
Bashton, M.2
Holliday, G.L.3
Schrader, R.4
Thornton, J.M.5
-
22
-
-
73349126460
-
Emergent gene order in a model of modular polyketide synthases
-
Callahan, B., Thattai, M. & Shraiman, B. I. Emergent gene order in a model of modular polyketide synthases. Proc. Natl. Acad. Sci. USA 106, 19410-19415 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 19410-19415
-
-
Callahan, B.1
Thattai, M.2
Shraiman, B.I.3
-
23
-
-
9944250036
-
Structural aspects of non-ribosomal peptide biosynthesis
-
Challis, G. L. & Naismith, J. H. Structural aspects of non-ribosomal peptide biosynthesis. Curr. Opin. Struct. Biol. 14, 748-756 (2004).
-
(2004)
Curr. Opin. Struct. Biol.
, vol.14
, pp. 748-756
-
-
Challis, G.L.1
Naismith, J.H.2
-
25
-
-
0019887799
-
Identification of common molecular subsequences
-
Smith, T. F. & Waterman, M. S. Identification of common molecular subsequences. J. Mol. Biol. 147, 195-197 (1981).
-
(1981)
J. Mol. Biol.
, vol.147
, pp. 195-197
-
-
Smith, T.F.1
Waterman, M.S.2
-
26
-
-
0014757386
-
A general method applicable to the search for similarities in the amino acid sequence of two proteins
-
Needleman, S. B. & Wunsch, C. D. A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol. 48, 443-453 (1970).
-
(1970)
J. Mol. Biol.
, vol.48
, pp. 443-453
-
-
Needleman, S.B.1
Wunsch, C.D.2
-
27
-
-
0001008029
-
An efficient method for finding the minimum of a function of several variables without calculating derivatives
-
Powell, M. J. D. An efficient method for finding the minimum of a function of several variables without calculating derivatives. Comput. J. 7, 155-162 (1964).
-
(1964)
Comput. J.
, vol.7
, pp. 155-162
-
-
Powell, M.J.D.1
-
28
-
-
0014420924
-
The structure of telomycin
-
Sheehan, J. C., Mania, D., Nakamura, S., Stock, J. A. & Maeda, K. The structure of telomycin. J. Am. Chem. Soc. 90, 462-470 (1968).
-
(1968)
J. Am. Chem. Soc.
, vol.90
, pp. 462-470
-
-
Sheehan, J.C.1
Mania, D.2
Nakamura, S.3
Stock, J.A.4
Maeda, K.5
-
29
-
-
84862999012
-
Mass spectral molecular networking of living microbial colonies
-
Watrous, J. et al. Mass spectral molecular networking of living microbial colonies. Proc. Natl. Acad. Sci. USA 109, E1743-E1752 (2012).
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E1743-E1752
-
-
Watrous, J.1
-
30
-
-
0013927106
-
The structure of lucensomycin. Part i
-
Gaudiano, G., Bravo, P. & Qiulico, A. The structure of lucensomycin. Part I. Tetrahedr. Lett. 7, 3559-3565 (1966).
-
(1966)
Tetrahedr. Lett.
, vol.7
, pp. 3559-3565
-
-
Gaudiano, G.1
Bravo, P.2
Qiulico, A.3
-
31
-
-
0023743260
-
Novel antifungal antibiotics octacosamicins A and B. II. the structure elucidation using various NMR spectroscopic methods
-
Dobashi, K., Naganawa, H., Takahashi, Y., Takita, T. & Takeuchi, T. Novel antifungal antibiotics octacosamicins A and B. II. The structure elucidation using various NMR spectroscopic methods. J. Antibiot. (Tokyo) 41, 1533-1541 (1988).
-
(1988)
J. Antibiot. (Tokyo)
, vol.41
, pp. 1533-1541
-
-
Dobashi, K.1
Naganawa, H.2
Takahashi, Y.3
Takita, T.4
Takeuchi, T.5
-
32
-
-
0035825748
-
Bogorol A produced in culture by a marine Bacillus sp. Reveals a novel template for cationic peptide antibiotics
-
Barsby, T., Kelly, M. T., Gagné, S. M. & Andersen, R. J. Bogorol A produced in culture by a marine Bacillus sp. reveals a novel template for cationic peptide antibiotics. Org. Lett. 3, 437-440 (2001).
-
(2001)
Org. Lett.
, vol.3
, pp. 437-440
-
-
Barsby, T.1
Kelly, M.T.2
Gagné, S.M.3
Andersen, R.J.4
-
33
-
-
38349061819
-
Tauramamide, a lipopeptide antibiotic produced in culture by Brevibacillus laterosporus isolated from a marine habitat: Structure elucidation and synthesis
-
Desjardine, K. et al. Tauramamide, a lipopeptide antibiotic produced in culture by Brevibacillus laterosporus isolated from a marine habitat: structure elucidation and synthesis. J. Nat. Prod. 70, 1850-1853 (2007).
-
(2007)
J. Nat. Prod.
, vol.70
, pp. 1850-1853
-
-
Desjardine, K.1
|