Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients

Respiratory Research

Volumn 17, Issue 1, 2016, Pages

  Southworth, Thomas ^a   Plumb, Jonathan ^a   Gupta, Vandana ^a   Pearson, James ^a   Ramis, Isabel ^b   Lehner, Martin D ^b   Miralpeix, Montserrat ^b   Singh, Dave ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Almirall R and D Center ^*  (Spain)

Author keywords

Asthma; Bronchoscopy; JAK STAT; Phosphatidylinositol 3 kinase delta; T cell cytokines

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; JANUS KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PIK 294; PROTEIN KINASE B; STAT PROTEIN; T LYMPHOCYTE RECEPTOR; TOFACITINIB; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; AUTACOID; CD3 ANTIGEN; IFNG PROTEIN, HUMAN; INTERLEUKIN-13, HUMAN; JANUS KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CD PROTEIN, HUMAN; PIPERIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BRONCHUS BIOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG LAVAGE; MALE; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; ANTAGONISTS AND INHIBITORS; BRONCHOALVEOLAR LAVAGE FLUID; CASE CONTROL STUDY; CELL CULTURE; COMBINATION DRUG THERAPY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; IMMUNOLOGY; LUNG; LYMPHOCYTE ACTIVATION; METABOLISM; MIDDLE AGED; MOLECULARLY TARGETED THERAPY; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ADULT; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; CD3 COMPLEX; CELLS, CULTURED; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; INTERLEUKIN-13; INTERLEUKIN-17; JANUS KINASE INHIBITORS; JANUS KINASES; LUNG; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MOLECULAR TARGETED THERAPY; PIPERIDINES; PYRIMIDINES; PYRROLES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84990049974     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-016-0436-2     Document Type: Article

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