IFN-Υ synergistically enhances LPS signalling in alveolar macrophages from COPD patients and controls by corticosteroid-resistant STAT1 activation

British Journal of Pharmacology

Volumn 166, Issue 7, 2012, Pages 2070-2083

  Southworth, T ^a   Metryka, A ^a   Lea, S ^a   Farrow, S ^b   Plumb, J ^a   Singh, D ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

alveolar macrophage; COPD; corticosteroid insensitivity; IFN priming; IL 6; IP 10; JAK STAT; TNF ; toll like receptors

Indexed keywords

DEXAMETHASONE; FLUDARABINE; GAMMA INTERFERON; INTERLEUKIN 6; JANUS KINASE; JANUS KINASE INHIBITOR; STAT1 PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; CORTICOSTEROID; CYTOKINE; DRUG DERIVATIVE; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEIN KINASE INHIBITOR; STAT1 PROTEIN, HUMAN; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; VIDARABINE;

ADULT; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; AGED; CELL CULTURE; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; GENETICS; METABOLISM; MIDDLE AGED; SIGNAL TRANSDUCTION;

ADRENAL CORTEX HORMONES; AGED; ANTI-INFLAMMATORY AGENTS; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DEXAMETHASONE; DRUG RESISTANCE; FEMALE; HUMANS; INTERFERON-GAMMA; JANUS KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MALE; MIDDLE AGED; PROTEIN KINASE INHIBITORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; VIDARABINE;

EID: 84863643134     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01907.x     Document Type: Article

References (56)

1. Adcock IM, Ito K, Barnes PJ, (2004). Glucocorticoids: effects on gene transcription. Proc Am Thorac Soc 1: 247-254.
2. Armstrong J, Sargent C, Singh D, (2009). Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages. Clin Exp Immunol 158: 74-83.
3. Armstrong J, Harbron C, Lea S, Booth G, Cadden P, Wreggett K, et al,. (2011). Synergistic effects of p38 MAPK inhibition with a corticosteroid in alveolar macrophages from COPD patients. J Pharmacol Exp Ther 338: 732-740.
4. Barnes PJ, (2000). Chronic obstructive pulmonary disease. N Engl J Med 343: 269-280.
5. Barnes PJ, (2004). Alveolar macrophages as orchestrators of COPD. COPD 1: 59-70.
6. Barnes PJ, (2010). Inhaled corticosteroids in COPD: a controversy. Respiration 80: 89-95.
7. Bosisio D, Polentarutti N, Sironi M, Bernasconi S, Miyake K, Webb GR, et al,. (2002). Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide. Blood 99: 3427-3431.
8. Brown GP, Iwamoto GK, Monick MM, Hunninghake GW, (1989). Cigarette smoking decreases interleukin 1 release by human alveolar macrophages. Am J Physiol 256 (2 Pt 1): C260-C264.
9. Chen H, Cowan MJ, Hasday JD, Vogel SN, Medvedev AE, (2007). Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonists. J Immunol 179: 6097-6106.
10. Clarke DL, Clifford RL, Jindarat S, Proud D, Pang L, Belvisi M, et al,. (2010). TNFalpha and IFNgamma synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-kappaB, and the transcriptional coactivator CREB-binding protein. J Biol Chem 285: 29101-29110.
11. Coombs JH, Bloom BJ, Breedveld FC, Fletcher MP, Gruben D, Kremer JM, et al,. (2010). Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 69: 413-416.
12. Cosio BG, Tsaprouni L, Ito K, Jazrawi E, Adcock IM, Barnes PJ, (2004). Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med 200: 689-695.
13. Darnell JE, Jr, Kerr IM, Stark GR, (1994). Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415-1421.
14. Dendorfer U, Oettgen P, Libermann TA, (1994). Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Mol Cell Biol 14: 4443-4454.
15. Di Stefano A, Capelli A, Lusuardi M, Balbo P, Vecchio C, Maestrelli P, et al,. (1998). Severity of airflow limitation is associated with severity of airway inflammation in smokers. Am J Respir Crit Care Med 158: 1277-1285.
16. Doyle I, Ratcliffe M, Walding A, Vanden Bon E, Dymond M, Tomlinson W, et al,. (2010). Differential gene expression analysis in human monocyte-derived macrophages: impact of cigarette smoke on host defence. Mol Immunol 47: 1058-1065.
17. Droemann D, Goldmann T, Tiedje T, Zabel P, Dalhoff K, Schaaf B, (2005). Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients. Respir Res 6: 68.
18. Gough DJ, Levy DE, Johnstone RW, Clarke CJ, (2008). IFNgamma signaling-does it mean JAK-STAT? Cytokine Growth Factor Rev 19: 383-394.
19. Grumelli S, Corry DB, Song LZ, Song L, Green L, Huh J, et al,. (2004). An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med 1: e8.
20. Hens G, Vanaudenaerde BM, Bullens DM, Piessens M, Decramer M, Dupont LJ, et al,. (2008). Sinonasal pathology in nonallergic asthma and COPD: 'united airway disease' beyond the scope of allergy. Allergy 63: 261-267.
21. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al,. (2004). The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350: 2645-2653.
22. Hu X, Li WP, Meng C, Ivashkiv LB, (2003). Inhibition of IFN-gamma signaling by glucocorticoids. J Immunol 170: 4833-4839.
23. Hu X, Chakravarty SD, Ivashkiv LB, (2008). Regulation of interferon and toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms. Immunol Rev 226: 41-56.
24. Kelsen SG, Aksoy MO, Georgy M, Hershman R, Ji R, Li X, et al,. (2009). Lymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3. Am J Respir Crit Care Med 179: 799-805.
25. Kent L, Smyth L, Clayton C, Scott L, Cook T, Stephens R, et al,. (2008). Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages. Cytokine 42: 205-216.
26. Knobloch J, Hag H, Jungck D, Urban K, Koch A, (2011). Resveratrol impairs the release of steroid-resistant cytokines from bacterial endotoxin-exposed alveolar macrophages in chronic obstructive pulmonary disease. Basic Clin Pharmacol Toxicol 109: 138-143.
27. Kovarik P, Stoiber D, Novy M, Decker T, (1998). Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation. EMBO J 17: 3660-3668.
28. Laan M, Palmberg L, Larsson K, Linden A, (2002). Free, soluble interleukin-17 protein during severe inflammation in human airways. Eur Respir J 19: 534-537.
29. Lethbridge MW, Kemeny DM, Ratoff JC, O'Connor BJ, Hawrylowicz CM, Corrigan CJ, (2010). A novel technique to explore the functions of bronchial mucosal T cells in chronic obstructive pulmonary disease: application to cytotoxicity and cytokine immunoreactivity. Clin Exp Immunol 161: 560-569.
30. Libermann TA, Baltimore D, (1990). Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol 10: 2327-2334.
31. Makris D, Lazarou S, Alexandrakis M, Kourelis TV, Tzanakis N, Kyriakou D, et al,. (2008). Tc2 response at the onset of COPD exacerbations. Chest 134: 483-488.
32. Mita Y, Dobashi K, Shimizu Y, Nakazawa T, Mori M, (2001). Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-gamma and macrophage colony-stimulating factor. Immunol Lett 78: 97-101.
33. Panzner P, Lafitte JJ, Tsicopoulos A, Hamid Q, Tulic MK, (2003). Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients with chronic bronchitis with obstruction. Chest 124: 1909-1915.
34. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al,. (2007). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 176: 532-555.
35. Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, et al,. (2010). IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J Immunol 184: 1642-1652.
36. Russell RE, Culpitt SV, DeMatos C, Donnelly L, Smith M, Wiggins J, et al,. (2002). Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 26: 602-609.
37. Saetta M, Mariani M, Panina-Bordignon P, Turato G, Buonsanti C, Baraldo S, et al,. (2002). Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 165: 1404-1409.
38. Saha B, Jyothi Prasanna S, Chandrasekar B, Nandi D, (2010). Gene modulation and immunoregulatory roles of interferon gamma. Cytokine 50: 1-14.
39. Sanceau J, Kaisho T, Hirano T, Wietzerbin J, (1995). Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors. J Biol Chem 270: 27920-27931.
40. von Scheele I, Larsson K, Palmberg L, (2010). Budesonide enhances toll-like receptor 2 expression in activated bronchial epithelial cells. Inhal Toxicol 22: 493-499.
41. Schoenborn JR, Wilson CB, (2007). Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol 96: 41-101.
42. Schroder K, Hertzog PJ, Ravasi T, Hume DA, (2004). Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75: 163-189.
43. Schroder K, Sweet MJ, Hume DA, (2006). Signal integration between IFNgamma and TLR signalling pathways in macrophages. Immunobiology 211: 511-524.
44. Sethi S, Murphy TF, (2008). Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med 359: 2355-2365.
45. Shaykhiev R, Krause A, Salit J, Strulovici-Barel Y, Harvey BG, O'Connor TP, et al,. (2009). Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. J Immunol 183: 2867-2883.
46. Singh M, Lee SH, Porter P, Xu C, Ohno A, Atmar RL, et al,. (2010). Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 125: 1369-1378 e1362.
47. Soliman DM, Twigg HL, 3rd, (1992). Cigarette smoking decreases bioactive interleukin-6 secretion by alveolar macrophages. Am J Physiol 263 (4 Pt 1): L471-L478.
48. Srinivasan S, Ito M, Kajiya H, Key LL, Jr, Johnson-Pais TL, Reddy SV, (2006). Functional characterization of human osteoclast inhibitory peptide-1 (OIP-1/hSca) gene promoter. Gene 371: 16-24.
49. Stark GR, (2007). How cells respond to interferons revisited: from early history to current complexity. Cytokine Growth Factor Rev 18: 419-423.
50. Tudhope SJ, Catley MC, Fenwick PS, Russell RE, Rumsey WL, Newton R, et al,. (2007). The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells. J Immunol 179: 6237-6245.
51. Vanden Berghe W, Vermeulen L, De Wilde G, De Bosscher K, Boone E, Haegeman G, (2000). Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6. Biochem Pharmacol 60: 1185-1195.
52. Wilkinson TM, Hurst JR, Perera WR, Wilks M, Donaldson GC, Wedzicha JA, (2006). Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD. Chest 129: 317-324.
53. William AD, Lee AC, Blanchard S, Poulsen A, Teo E, Nagaraj H, et al,. (2011). Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5, 7,26-triaza-tetracyclo[19.3.1. 1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10, 12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/Fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lymphoma. J Med Chem 54: 4368-4658.
54. Yamaguchi E, Okazaki N, Itoh A, Abe S, Kawakami Y, Okuyama H, (1989). Interleukin 1 production by alveolar macrophages is decreased in smokers. Am Rev Respir Dis 140: 397-402.
55. Yamaguchi E, Itoh A, Furuya K, Miyamoto H, Abe S, Kawakami Y, (1993). Release of tumor necrosis factor-alpha from human alveolar macrophages is decreased in smokers. Chest 103: 479-483.
56. Zhu X, Gadgil AS, Givelber R, George MP, Stoner MW, Sciurba FC, et al,. (2009). Peripheral T cell functions correlate with the severity of chronic obstructive pulmonary disease. J Immunol 182: 3270-3277.