HIF-1α inhibition ameliorates an allergic airway disease via VEGF suppression in bronchial epithelium

European Journal of Immunology

Volumn 40, Issue 10, 2010, Pages 2858-2869

  Kim, So Ri ^a   Lee, Kyung Sun ^a   Park, Hee Sun ^b   Park, Seoung Ju ^a   Min, Kyung Hoon ^a   Moon, Hee ^a   Puri, Kamal D ^c   Lee, Yong Chul ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Chungnam National University   (South Korea)

^c Calistoga Pharmaceuticals   (United States)

Author keywords

Allergic airway disease; Hypoxia inducible factor 1 ; PI3K ; RNA interference; Vascular endothelial growth factor

Indexed keywords

2 METHOXYESTRADIOL; CBO P11; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PHOSPHOTRANSFERASE; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BRONCHUS MUCOSA; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FEMALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; SIGNAL TRANSDUCTION; TRACHEA MUCOSA;

ADENINE; AIRWAY REMODELING; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; ENDOTHELIAL GROWTH FACTORS; EPITHELIAL CELLS; ESTRADIOL; FEMALE; HISTOCYTOCHEMISTRY; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, INBRED C57BL; OVALBUMIN; PEPTIDES, CYCLIC; PHOSPHATIDYLINOSITOL 3-KINASES; QUINAZOLINES; RESPIRATORY FUNCTION TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77957102906     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939948     Document Type: Article

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