-
1
-
-
0032542364
-
Genetic instabilities in human cancers
-
Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature. 1998; 396(6712):643-649.
-
(1998)
Nature
, vol.396
, Issue.6712
, pp. 643-649
-
-
Lengauer, C.1
Kinzler, K.W.2
Vogelstein, B.3
-
2
-
-
84901199614
-
Molecular profiling and the reclassification of cancer: Divide and conquer
-
Munoz J, Swanton C, Kurzrock R. Molecular profiling and the reclassification of cancer: divide and conquer. Am Soc Clin Oncol Educ Book. 2013; 127-34.
-
(2013)
Am Soc Clin Oncol Educ Book
, pp. 127-134
-
-
Munoz, J.1
Swanton, C.2
Kurzrock, R.3
-
3
-
-
84865134914
-
Passenger deletions generate therapeutic vulnerabilities in cancer
-
Muller FL, Colla S, Aquilanti E, et al. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012; 488(7411):337-342.
-
(2012)
Nature
, vol.488
, Issue.7411
, pp. 337-342
-
-
Muller, F.L.1
Colla, S.2
Aquilanti, E.3
-
4
-
-
74449093973
-
A comprehensive catalogue of somatic mutations from a human cancer genome
-
Pleasance ED, Cheetham RK, Stephens PJ, et al. A comprehensive catalogue of somatic mutations from a human cancer genome. Nature. 2010; 463(7278):191-196.
-
(2010)
Nature
, vol.463
, Issue.7278
, pp. 191-196
-
-
Pleasance, E.D.1
Cheetham, R.K.2
Stephens, P.J.3
-
5
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
Greenman C, Stephens P, Smith R, et al. Patterns of somatic mutation in human cancer genomes. Nature. 2007; 446(7132):153-158.
-
(2007)
Nature
, vol.446
, Issue.7132
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
-
7
-
-
80051599317
-
Proinvasion metastasis drivers in early-stage melanoma are oncogenes
-
Scott KL, Nogueira C, Heffernan TP, et al. Proinvasion metastasis drivers in early-stage melanoma are oncogenes. Cancer Cell. 2011; 20(1):92-103.
-
(2011)
Cancer Cell
, vol.20
, Issue.1
, pp. 92-103
-
-
Scott, K.L.1
Nogueira, C.2
Heffernan, T.P.3
-
8
-
-
0026793986
-
Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer
-
Allred DC, Clark GM, Molina R, et al. Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer. Hum Pathol. 1992; 23(9):974-979.
-
(1992)
Hum Pathol
, vol.23
, Issue.9
, pp. 974-979
-
-
Allred, D.C.1
Clark, G.M.2
Molina, R.3
-
9
-
-
0036210281
-
P16 inactivation by methylation of the CDKN2A promoter occurs early during neoplastic progression in Barrett's esophagus
-
Bian YS, Osterheld MC, Fontolliet C, et al. p16 inactivation by methylation of the CDKN2A promoter occurs early during neoplastic progression in Barrett's esophagus. Gastroenterology. 2002; 122(4):1113-1121.
-
(2002)
Gastroenterology
, vol.122
, Issue.4
, pp. 1113-1121
-
-
Bian, Y.S.1
Osterheld, M.C.2
Fontolliet, C.3
-
10
-
-
19944432471
-
Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps
-
Petko Z, Ghiassi M, Shuber A, et al. Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res. 2005; 11(3):1203-1209.
-
(2005)
Clin Cancer Res.
, vol.11
, Issue.3
, pp. 1203-1209
-
-
Petko, Z.1
Ghiassi, M.2
Shuber, A.3
-
11
-
-
77954255681
-
Integrative genomic profiling of human prostate cancer
-
Taylor BS, Schultz N, Hieronymus H, et al. Integrative genomic profiling of human prostate cancer. Cancer Cell. 2010; 18(1):11-22.
-
(2010)
Cancer Cell
, vol.18
, Issue.1
, pp. 11-22
-
-
Taylor, B.S.1
Schultz, N.2
Hieronymus, H.3
-
12
-
-
84858285120
-
HER2/neu and Ki-67 expression predict non-invasive recurrence following breast-conserving therapy for ductal carcinoma in situ
-
Rakovitch E, Nofech-Mozes S, Hanna W, et al. HER2/neu and Ki-67 expression predict non-invasive recurrence following breast-conserving therapy for ductal carcinoma in situ. Br J Cancer. 2012; 106(6):1160-1165.
-
(2012)
Br J Cancer
, vol.106
, Issue.6
, pp. 1160-1165
-
-
Rakovitch, E.1
Nofech-Mozes, S.2
Hanna, W.3
-
13
-
-
84899485568
-
BRAF mutational epidemiology in dysplastic nevi: Does different solar UV radiation exposure matter?
-
Saroufim M, Novy M, Taraif S, et al. BRAF mutational epidemiology in dysplastic nevi: does different solar UV radiation exposure matter? J Eur Acad Dermatol Venereol. 2014; 28(5):615-625.
-
(2014)
J Eur Acad Dermatol Venereol
, vol.28
, Issue.5
, pp. 615-625
-
-
Saroufim, M.1
Novy, M.2
Taraif, S.3
-
14
-
-
84923197605
-
Cancer Genome Atlas N. Comprehensive genomic characterization of head and neck squamous cell carcinomas
-
Cancer Genome Atlas N. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015; 517(7536):576-582.
-
(2015)
Nature
, vol.517
, Issue.7536
, pp. 576-582
-
-
-
15
-
-
84943327713
-
CDKN2B loss promotes progression from benign melanocytic nevus to melanoma
-
McNeal AS, Liu K, Nakhate V, et al. CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma. Cancer Discov. 2015; 5(10):1072-1085.
-
(2015)
Cancer Discov
, vol.5
, Issue.10
, pp. 1072-1085
-
-
McNeal, A.S.1
Liu, K.2
Nakhate, V.3
-
16
-
-
84946887722
-
The genetic evolution of melanoma from precursor lesions
-
Shain AH, Yeh I, Kovalyshyn I, et al. The Genetic Evolution of Melanoma from Precursor Lesions. N Engl J Med. 2015; 373(20):1926-1936.
-
(2015)
N Engl J Med
, vol.373
, Issue.20
, pp. 1926-1936
-
-
Shain, A.H.1
Yeh, I.2
Kovalyshyn, I.3
-
17
-
-
84941006304
-
Clinicopathological significance of CDKN2A promoter hypermethylation frequency with pancreatic cancer
-
Tang B, Li Y, Qi G, et al. Clinicopathological Significance of CDKN2A Promoter Hypermethylation Frequency with Pancreatic Cancer. Sci Rep. 2015; 5:13563.
-
(2015)
Sci Rep
, vol.5
-
-
Tang, B.1
Li, Y.2
Qi, G.3
-
18
-
-
84929072738
-
Molecular phenotypes of DCIS predict overall and invasive recurrence
-
Williams KE, Barnes NL, Cramer A, et al. Molecular Phenotypes of DCIS predict overall and invasive recurrence. Ann Oncol. 2015; 26(5):1019-1025.
-
(2015)
Ann Oncol
, vol.26
, Issue.5
, pp. 1019-1025
-
-
Williams, K.E.1
Barnes, N.L.2
Cramer, A.3
-
19
-
-
84869223443
-
Personalized medicine in a phase I clinical trials program: The MD anderson cancer center initiative
-
Tsimberidou AM, Iskander NG, Hong DS, et al. Personalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative. Clin Cancer Res. 2012; 18(22):6373-6383.
-
(2012)
Clin Cancer Res.
, vol.18
, Issue.22
, pp. 6373-6383
-
-
Tsimberidou, A.M.1
Iskander, N.G.2
Hong, D.S.3
-
20
-
-
66049145392
-
Genetic subgrouping of melanomareveals new opportunities for targeted therapy
-
Smalley KS, Nathanson KL, Flaherty KT. Genetic subgrouping of melanomareveals new opportunities for targeted therapy. Cancer Res. 2009; 69(8):3241-3244.
-
(2009)
Cancer Res.
, vol.69
, Issue.8
, pp. 3241-3244
-
-
Smalley, K.S.1
Nathanson, K.L.2
Flaherty, K.T.3
-
21
-
-
84877590959
-
MAP kinase signaling and inhibition in melanoma
-
Sullivan RJ, Flaherty K. MAP kinase signaling and inhibition in melanoma. Oncogene. 2013; 32(19):2373-2379.
-
(2013)
Oncogene
, vol.32
, Issue.19
, pp. 2373-2379
-
-
Sullivan, R.J.1
Flaherty, K.2
-
22
-
-
18444374405
-
Mutations of the BRAF geneinhuman cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF geneinhuman cancer. Nature. 2002; 417(6892):949-954.
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
23
-
-
84948716195
-
The role of BRAF mutations in primary melanoma growth rate and survival
-
Mar VJ, Liu W, Devitt B, et al. The role of BRAF mutations in primary melanoma growth rate and survival. Br J Dermatol. 2015; 173(1):76-82.
-
(2015)
Br J Dermatol
, vol.173
, Issue.1
, pp. 76-82
-
-
Mar, V.J.1
Liu, W.2
Devitt, B.3
-
24
-
-
84941361474
-
Feasibility of large-scale genomic testing to facilitate enrollment onto genomically matched clinical trials
-
Meric-Bernstam F, Brusco L, Shaw K, et al. Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials. J Clin Oncol. 2015; 33(25):2753-2762.
-
(2015)
J Clin Oncol
, vol.33
, Issue.25
, pp. 2753-2762
-
-
Meric-Bernstam, F.1
Brusco, L.2
Shaw, K.3
-
25
-
-
84978034236
-
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
-
Long GV, Menzies AM, Nagrial AM, et al. Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol. 2011; 29(10):1239-1246.
-
(2011)
J Clin Oncol
, vol.29
, Issue.10
, pp. 1239-1246
-
-
Long, G.V.1
Menzies, A.M.2
Nagrial, A.M.3
-
26
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011; 364(26):2507-2516.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
27
-
-
84861083983
-
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial
-
Falchook GS, Long GV, Kurzrock R, et al. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. Lancet. 2012; 379(9829):1893-1901.
-
(2012)
Lancet
, vol.379
, Issue.9829
, pp. 1893-1901
-
-
Falchook, G.S.1
Long, G.V.2
Kurzrock, R.3
-
28
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild A, Grob JJ, Demidov LV, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012; 380(9839):358-365.
-
(2012)
Lancet
, vol.380
, Issue.9839
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
-
29
-
-
84881221698
-
Melanoma patients in a phase I clinic: Molecular aberrations, targeted therapy and outcomes
-
Henary H, Hong DS, Falchook GS, et al. Melanoma patients in a phase I clinic: molecular aberrations, targeted therapy and outcomes. Ann Oncol. 2013; 24(8):2158-2165.
-
(2013)
Ann Oncol
, vol.24
, Issue.8
, pp. 2158-2165
-
-
Henary, H.1
Hong, D.S.2
Falchook, G.S.3
-
30
-
-
84939864059
-
Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations
-
Hyman DM, Puzanov I, Subbiah V, et al. Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations. N Engl J Med. 2015; 373(8):726-736.
-
(2015)
N Engl J Med
, vol.373
, Issue.8
, pp. 726-736
-
-
Hyman, D.M.1
Puzanov, I.2
Subbiah, V.3
-
31
-
-
84863116743
-
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
-
Sosman JA, Kim KB, Schuchter L, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med. 2012; 366(8):707-714.
-
(2012)
N Engl J Med
, vol.366
, Issue.8
, pp. 707-714
-
-
Sosman, J.A.1
Kim, K.B.2
Schuchter, L.3
-
32
-
-
84864371119
-
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: A phase 1 dose-escalation trial
-
Falchook GS, Lewis KD, Infante JR, et al. Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. Lancet Oncol. 2012; 13(8):782-789.
-
(2012)
Lancet Oncol
, vol.13
, Issue.8
, pp. 782-789
-
-
Falchook, G.S.1
Lewis, K.D.2
Infante, J.R.3
-
33
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010; 362(25):2380-2388.
-
(2010)
N Engl J Med
, vol.362
, Issue.25
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
34
-
-
84857502654
-
Erlotinib versus standard chemotherapy asfirst-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, openlabel, randomised phase 3 trial
-
Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy asfirst-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, openlabel, randomised phase 3 trial. Lancet Oncol. 2012; 13(3):239-246.
-
(2012)
Lancet Oncol
, vol.13
, Issue.3
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
35
-
-
84903482432
-
Ceritinib in ALK-rearranged non-smallcell lung cancer
-
Shaw AT, Kim DW, Mehra R, et al. Ceritinib in ALK-rearranged non-smallcell lung cancer. N Engl J Med. 2014; 370(13):1189-1197.
-
(2014)
N Engl J Med
, vol.370
, Issue.13
, pp. 1189-1197
-
-
Shaw, A.T.1
Kim, D.W.2
Mehra, R.3
-
36
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-smallcell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
-
Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-smallcell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011; 12(8):735-742.
-
(2011)
Lancet Oncol
, vol.12
, Issue.8
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
37
-
-
1442323605
-
BRAF mutations are common somatic events in melanocytic nevi
-
Kumar R, Angelini S, Snellman E, et al. BRAF mutations are common somatic events in melanocytic nevi. J Invest Dermatol. 2004; 122(2):342-348.
-
(2004)
J Invest Dermatol
, vol.122
, Issue.2
, pp. 342-348
-
-
Kumar, R.1
Angelini, S.2
Snellman, E.3
-
38
-
-
0037228055
-
High frequency of BRAF mutations in nevi
-
Pollock PM, Harper UL, Hansen KS, et al. High frequency of BRAF mutations in nevi. Nat Genet. 2003; 33(1):19-20.
-
(2003)
Nat Genet
, vol.33
, Issue.1
, pp. 19-20
-
-
Pollock, P.M.1
Harper, U.L.2
Hansen, K.S.3
-
39
-
-
84883040772
-
Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia
-
Yeh I, von Deimling A, Bastian BC. Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia. J Natl Cancer Inst. 2013; 105(12):917-919.
-
(2013)
J Natl Cancer Inst
, vol.105
, Issue.12
, pp. 917-919
-
-
Yeh, I.1
Von Deimling, A.2
Bastian, B.C.3
-
40
-
-
0037339671
-
The transformation rate of moles (melanocytic nevi) into cutaneous melanoma: A population-based estimate
-
Tsao H, Bevona C, Goggins W, et al. The transformation rate of moles (melanocytic nevi) into cutaneous melanoma: a population-based estimate. Arch Dermatol. 2003; 139(3):282-288.
-
(2003)
Arch Dermatol
, vol.139
, Issue.3
, pp. 282-288
-
-
Tsao, H.1
Bevona, C.2
Goggins, W.3
-
41
-
-
0026065802
-
Prospective follow-up for Malignant melanoma in patients with atypical-mole (dysplastic-nevus) syndrome
-
Tiersten AD, Grin CM, Kopf AW, et al. Prospective follow-up for malignant melanoma in patients with atypical-mole (dysplastic-nevus) syndrome. J Dermatol Surg Oncol. 1991; 17(1):44-48.
-
(1991)
J Dermatol Surg Oncol
, vol.17
, Issue.1
, pp. 44-48
-
-
Tiersten, A.D.1
Grin, C.M.2
Kopf, A.W.3
-
42
-
-
84867649483
-
Dynamic changes in nevi of a patient with melanoma treated with vemurafenib: Importance of sequential dermoscopy
-
Haenssle HA, Kraus SL, Brehmer F, et al. Dynamic changes in nevi of a patient with melanoma treated with vemurafenib: importance of sequential dermoscopy. Arch Dermatol. 2012; 148(10):1183-1185.
-
(2012)
Arch Dermatol
, vol.148
, Issue.10
, pp. 1183-1185
-
-
Haenssle, H.A.1
Kraus, S.L.2
Brehmer, F.3
-
43
-
-
84878775551
-
Appearance of new vemurafenib-associated melanocytic nevi on normal-appearing skin: Case series and a review of changing or new pigmented lesions in patients with metastatic Malignant melanoma after initiating treatment with vemurafenib
-
Cohen PR, Bedikian AY, Kim KB. Appearance of New Vemurafenib-associated Melanocytic Nevi on Normal-appearing Skin: Case Series and a Review of Changing or New Pigmented Lesions in Patients with Metastatic Malignant Melanoma After Initiating Treatment with Vemurafenib. J Clin Aesthet Dermatol. 2013; 6(5):27-37.
-
(2013)
J Clin Aesthet Dermatol
, vol.6
, Issue.5
, pp. 27-37
-
-
Cohen, P.R.1
Bedikian, A.Y.2
Kim, K.B.3
-
44
-
-
84862908097
-
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
-
Su F, Viros A, Milagre C, et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med. 2012; 366(3):207-215.
-
(2012)
N Engl J Med
, vol.366
, Issue.3
, pp. 207-215
-
-
Su, F.1
Viros, A.2
Milagre, C.3
-
45
-
-
84863463901
-
Atypical melanocytic proliferations and new primary melanomas in patients with advanced melanoma undergoing selective BRAF inhibition
-
Zimmer L, Hillen U, Livingstone E, et al. Atypical melanocytic proliferations and new primary melanomas in patients with advanced melanoma undergoing selective BRAF inhibition. J Clin Oncol. 2012; 30(19):2375-2383.
-
(2012)
J Clin Oncol
, vol.30
, Issue.19
, pp. 2375-2383
-
-
Zimmer, L.1
Hillen, U.2
Livingstone, E.3
-
46
-
-
44349127222
-
In melanocytic lesions the fraction of BRAF V600E alleles is associated with sun exposure but unrelated to ERK phosphorylation
-
Venesio T, Chiorino G, Balsamo A, et al. In melanocytic lesions the fraction of BRAF V600E alleles is associated with sun exposure but unrelated to ERK phosphorylation. Mod Pathol. 2008; 21(6):716-726.
-
(2008)
Mod Pathol
, vol.21
, Issue.6
, pp. 716-726
-
-
Venesio, T.1
Chiorino, G.2
Balsamo, A.3
-
47
-
-
13444258032
-
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
-
Patton EE, Widlund HR, Kutok JL, et al. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol. 2005; 15(3):249-254.
-
(2005)
Curr Biol.
, vol.15
, Issue.3
, pp. 249-254
-
-
Patton, E.E.1
Widlund, H.R.2
Kutok, J.L.3
-
48
-
-
84958729616
-
A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation
-
Kaufman CK, Mosimann C, Fan ZP, et al. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. 2016; 351(6272): aad2197.
-
(2016)
Science
, vol.351
, Issue.6272
-
-
Kaufman, C.K.1
Mosimann, C.2
Fan, Z.P.3
-
49
-
-
84861163796
-
Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
-
Vredeveld LC, Possik PA, Smit MA, et al. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. Genes Dev. 2012; 26(10):1055-1069.
-
(2012)
Genes Dev
, vol.26
, Issue.10
, pp. 1055-1069
-
-
Vredeveld, L.C.1
Possik, P.A.2
Smit, M.A.3
-
50
-
-
33747192833
-
Cellular senescence in naevi and immortalisation in melanoma: A role for p16?
-
Gray-Schopfer VC, Cheong SC, Chong H, et al. Cellular senescence in naevi and immortalisation in melanoma: a role for p16? Br J Cancer. 2006; 95(4):496-505.
-
(2006)
Br J Cancer
, vol.95
, Issue.4
, pp. 496-505
-
-
Gray-Schopfer, V.C.1
Cheong, S.C.2
Chong, H.3
-
51
-
-
77952479288
-
IGFBP7 is not required for B-RAF-induced melanocyte senescence
-
Scurr LL, Pupo GM, Becker TM, et al. IGFBP7 is not required for B-RAF-induced melanocyte senescence. Cell. 2010; 141(4):717-727.
-
(2010)
Cell
, vol.141
, Issue.4
, pp. 717-727
-
-
Scurr, L.L.1
Pupo, G.M.2
Becker, T.M.3
-
52
-
-
41549149451
-
Cellular senescence in vivo: A Barrier to tumorigenesis
-
Prieur A, Peeper DS. Cellular senescence in vivo: a barrier to tumorigenesis. Curr Opin Cell Biol. 2008; 20(2):150-155.
-
(2008)
Curr Opin Cell Biol.
, vol.20
, Issue.2
, pp. 150-155
-
-
Prieur, A.1
Peeper, D.S.2
-
53
-
-
42949129074
-
Many roads lead to oncogene-induced senescence
-
Courtois-Cox S, Jones SL, Cichowski K. Many roads lead to oncogene-induced senescence. Oncogene. 2008; 27(20):2801-2809.
-
(2008)
Oncogene
, vol.27
, Issue.20
, pp. 2801-2809
-
-
Courtois-Cox, S.1
Jones, S.L.2
Cichowski, K.3
-
54
-
-
79551683487
-
Cellular senescence: Putting the paradoxes in perspective
-
Campisi J. Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev. 2011; 21(1):107-112.
-
(2011)
Curr Opin Genet Dev
, vol.21
, Issue.1
, pp. 107-112
-
-
Campisi, J.1
-
55
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 2001; 11(11):S27-S31.
-
(2001)
Trends Cell Biol.
, vol.11
, Issue.11
, pp. S27-S31
-
-
Campisi, J.1
-
56
-
-
84975464501
-
Genetics of melanoma progression: The rise and fall of cell senescence
-
in press
-
Bennett DC Genetics of melanoma progression: the rise and fall of cell senescence. Pigment Cell Melanoma Res. 2015; in press.
-
(2015)
Pigment Cell Melanoma Res.
-
-
Bennett, D.C.1
-
57
-
-
38849168162
-
Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
-
Wajapeyee N, Serra RW, Zhu X, et al. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell. 2008; 132(3):363-374.
-
(2008)
Cell
, vol.132
, Issue.3
, pp. 363-374
-
-
Wajapeyee, N.1
Serra, R.W.2
Zhu, X.3
-
58
-
-
76649101414
-
Lack of correlation between IGFBP7 expression and BRAF mutational status in melanoma
-
Schrama D, Kneitz H, Willmes C, et al. Lack of correlation between IGFBP7 expression and BRAF mutational status in melanoma. J Invest Dermatol. 2010; 130(3):897-898.
-
(2010)
J Invest Dermatol
, vol.130
, Issue.3
, pp. 897-898
-
-
Schrama, D.1
Kneitz, H.2
Willmes, C.3
-
59
-
-
34848920124
-
Differential gene expression in melanocytic nevi with the V600E BRAF mutation
-
Bloethner S, Snellman E, Bermejo JL, et al. Differential gene expression in melanocytic nevi with the V600E BRAF mutation. Genes Chromosomes Cancer. 2007; 46(11):1019-1027.
-
(2007)
Genes Chromosomes Cancer
, vol.46
, Issue.11
, pp. 1019-1027
-
-
Bloethner, S.1
Snellman, E.2
Bermejo, J.L.3
-
60
-
-
84902535383
-
Near-genomewide RNAi screening for regulators of BRAF(V600E)-induced senescence identifies RASEF, a gene epigenetically silenced in melanoma
-
Kaplon J, Homig-Holzel C, Gao L, et al. Near-genomewide RNAi screening for regulators of BRAF(V600E)-induced senescence identifies RASEF, a gene epigenetically silenced in melanoma. Pigment Cell Melanoma Res. 2014; 27(4):640-652.
-
(2014)
Pigment Cell Melanoma Res.
, vol.27
, Issue.4
, pp. 640-652
-
-
Kaplon, J.1
Homig-Holzel, C.2
Gao, L.3
-
61
-
-
84860214530
-
From genes to drugs: Targeted strategies for melanoma
-
Flaherty KT, Hodi FS, Fisher DE. From genes to drugs: targeted strategies for melanoma. Nat Rev Cancer. 2012; 12(5):349-361.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.5
, pp. 349-361
-
-
Flaherty, K.T.1
Hodi, F.S.2
Fisher, D.E.3
-
62
-
-
84908491115
-
Drugging the undruggable RAS: Mission possible?
-
Cox AD, Fesik SW, Kimmelman AC, et al. Drugging the undruggable RAS: Mission possible? Nat Rev Drug Discov. 2014; 13(11):828-851.
-
(2014)
Nat Rev Drug Discov
, vol.13
, Issue.11
, pp. 828-851
-
-
Cox, A.D.1
Fesik, S.W.2
Kimmelman, A.C.3
-
63
-
-
84863116014
-
Effect of KRAS oncogene substitutions on protein behavior: Implications for signaling and clinical outcome
-
Ihle NT, Byers LA, Kim ES, et al. Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome. J Natl Cancer Inst. 2012; 104(3):228-239.
-
(2012)
J Natl Cancer Inst
, vol.104
, Issue.3
, pp. 228-239
-
-
Ihle, N.T.1
Byers, L.A.2
Kim, E.S.3
-
65
-
-
24944497744
-
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
-
Eberhard DA, Johnson BE, Amler LC, et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol. 2005; 23(25):5900-5909.
-
(2005)
J Clin Oncol
, vol.23
, Issue.25
, pp. 5900-5909
-
-
Eberhard, D.A.1
Johnson, B.E.2
Amler, L.C.3
-
66
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008; 359(17):1757-1765.
-
(2008)
N Engl J Med
, vol.359
, Issue.17
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
68
-
-
77951755278
-
Pancreatic cancer
-
Hidalgo M. Pancreatic cancer. N Engl J Med. 2010; 362(17):1605-1617.
-
(2010)
N Engl J Med
, vol.362
, Issue.17
, pp. 1605-1617
-
-
Hidalgo, M.1
-
69
-
-
84943230198
-
Colon tumors with the simultaneous induction of driver mutations in APC, KRAS, and PIK3CA still progress through the adenoma-to-carcinoma sequence
-
Hadac JN, Leystra AA, Paul Olson TJ, et al. Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence. Cancer Prev Res (Phila). 2015; 8(10):952-961.
-
(2015)
Cancer Prev Res (Phila)
, vol.8
, Issue.10
, pp. 952-961
-
-
Hadac, J.N.1
Leystra, A.A.2
Paul Olson, T.J.3
-
70
-
-
0037047057
-
Mutations in APC, kirsten-ras, and p53-alternative genetic pathways to colorectal cancer
-
Smith G, Carey FA, Beattie J, et al. Mutations in APC, Kirsten-ras, and p53-alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci U S A. 2002; 99(14):9433-9438.
-
(2002)
Proc Natl Acad Sci U.S.A
, vol.99
, Issue.14
, pp. 9433-9438
-
-
Smith, G.1
Carey, F.A.2
Beattie, J.3
-
71
-
-
33746263912
-
BRAF and NRAS mutations in melanoma and melanocytic nevi
-
Poynter JN, Elder JT, Fullen DR, et al. BRAF and NRAS mutations in melanoma and melanocytic nevi. Melanoma Res. 2006; 16(4):267-273.
-
(2006)
Melanoma Res.
, vol.16
, Issue.4
, pp. 267-273
-
-
Poynter, J.N.1
Elder, J.T.2
Fullen, D.R.3
-
72
-
-
84879952154
-
NRAS and BRAF mutations in melanoma-associated nevi and uninvolved nevi
-
Tschandl P, Berghoff AS, Preusser M, et al. NRAS and BRAF mutations in melanoma-associated nevi and uninvolved nevi. PLoS One. 2013; 8(7):e69639.
-
(2013)
PLoS One
, vol.8
, Issue.7
-
-
Tschandl, P.1
Berghoff, A.S.2
Preusser, M.3
-
73
-
-
33845726945
-
Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations
-
Bauer J, Curtin JA, Pinkel D, et al. Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations. J Invest Dermatol. 2007; 127(1):179-182.
-
(2007)
J Invest Dermatol
, vol.127
, Issue.1
, pp. 179-182
-
-
Bauer, J.1
Curtin, J.A.2
Pinkel, D.3
-
74
-
-
84896672554
-
NRAS mutation is the sole recurrent somatic mutation in large congenital melanocytic nevi
-
Charbel C, Fontaine RH, Malouf GG, et al. NRAS mutation is the sole recurrent somatic mutation in large congenital melanocytic nevi. J Invest Dermatol. 2014; 134(4):1067-1074.
-
(2014)
J Invest Dermatol
, vol.134
, Issue.4
, pp. 1067-1074
-
-
Charbel, C.1
Fontaine, R.H.2
Malouf, G.G.3
-
75
-
-
33745027181
-
Melanoma risk in congenital melanocytic naevi: A systematic review
-
Krengel S, Hauschild A, Schafer T. Melanoma risk in congenital melanocytic naevi: a systematic review. Br J Dermatol. 2006; 155(1):1-8.
-
(2006)
Br J Dermatol
, vol.155
, Issue.1
, pp. 1-8
-
-
Krengel, S.1
Hauschild, A.2
Schafer, T.3
-
76
-
-
20144375230
-
Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background
-
Ackermann J, Frutschi M, Kaloulis K, et al. Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. Cancer Res. 2005; 65(10):4005-4011.
-
(2005)
Cancer Res.
, vol.65
, Issue.10
, pp. 4005-4011
-
-
Ackermann, J.1
Frutschi, M.2
Kaloulis, K.3
-
77
-
-
85027948290
-
Costello syndrome: A ras/mitogen activated protein kinase pathway syndrome (rasopathy) resulting from HRAS germline mutations
-
Gripp KW, Lin AE. Costello syndrome: a Ras/mitogen activated protein kinase pathway syndrome (rasopathy) resulting from HRAS germline mutations. Genet Med. 2012; 14(3):285-292.
-
(2012)
Genet Med
, vol.14
, Issue.3
, pp. 285-292
-
-
Gripp, K.W.1
Lin, A.E.2
-
78
-
-
84928583796
-
A RASopathy gene commonly mutated in cancer: The neurofibromatosis type 1 tumour suppressor
-
Ratner N, Miller SJ. A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nat Rev Cancer. 2015; 15(5):290-301.
-
(2015)
Nat Rev Cancer
, vol.15
, Issue.5
, pp. 290-301
-
-
Ratner, N.1
Miller, S.J.2
-
80
-
-
68649121646
-
The RASopathies: Developmental syndromes of ras/MAPK pathway dysregulation
-
Tidyman WE, Rauen KA. The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation. Curr Opin Genet Dev. 2009; 19(3):230-236.
-
(2009)
Curr Opin Genet Dev
, vol.19
, Issue.3
, pp. 230-236
-
-
Tidyman, W.E.1
Rauen, K.A.2
-
81
-
-
84928205738
-
Cancer spectrum and frequency among children with noonan, costello, and cardio-facio-cutaneous syndromes
-
Kratz CP, Franke L, Peters H, et al. Cancer spectrum and frequency among children with Noonan, Costello, and cardio-facio-cutaneous syndromes. Br J Cancer. 2015; 112(8):1392-1397.
-
(2015)
Br J Cancer
, vol.112
, Issue.8
, pp. 1392-1397
-
-
Kratz, C.P.1
Franke, L.2
Peters, H.3
-
82
-
-
79955043471
-
Cancer in noonan, costello, cardiofaciocutaneous and LEOPARD syndromes
-
Kratz CP, Rapisuwon S, Reed H, et al. Cancer in Noonan, Costello, cardiofaciocutaneous and LEOPARD syndromes. Am J Med Genet C Semin Med Genet. 2011; 157C(2):83-89.
-
(2011)
Am J Med Genet C Semin Med Genet
, vol.157 C
, Issue.2
, pp. 83-89
-
-
Kratz, C.P.1
Rapisuwon, S.2
Reed, H.3
-
83
-
-
84877957142
-
Sturge-weber syndrome and portwine stains caused by somatic mutation in GNAQ
-
Shirley MD, Tang H, Gallione CJ, et al. Sturge-Weber syndrome and portwine stains caused by somatic mutation in GNAQ. N Engl J Med. 2013; 368(21):1971-1979.
-
(2013)
N Engl J Med
, vol.368
, Issue.21
, pp. 1971-1979
-
-
Shirley, M.D.1
Tang, H.2
Gallione, C.J.3
-
85
-
-
84899948353
-
HER2 aberrations in cancer: Implications for therapy
-
Yan M, Parker BA, Schwab R, et al. HER2 aberrations in cancer: implications for therapy. Cancer Treat Rev. 2014; 40(6):770-780.
-
(2014)
Cancer Treat Rev
, vol.40
, Issue.6
, pp. 770-780
-
-
Yan, M.1
Parker, B.A.2
Schwab, R.3
-
86
-
-
84925382907
-
HER2 expression status in diverse cancers: Review of results from 37,992 patients
-
Yan M, Schwaederle M, Arguello D, et al. HER2 expression status in diverse cancers: review of results from 37,992 patients. Cancer Metastasis Rev. 2015; 34(1):157-164.
-
(2015)
Cancer Metastasis Rev
, vol.34
, Issue.1
, pp. 157-164
-
-
Yan, M.1
Schwaederle, M.2
Arguello, D.3
-
87
-
-
84873830350
-
Non-small-cell lung cancer with HER2 exon 20 mutation: Regression with dual HER2 inhibition and anti-VEGF combination treatment
-
Falchook GS, Janku F, Tsao AS, et al. Non-small-cell lung cancer with HER2 exon 20 mutation: regression with dual HER2 inhibition and anti-VEGF combination treatment. J Thorac Oncol. 2013; 8(2):e19-e20.
-
(2013)
J Thorac Oncol
, vol.8
, Issue.2
, pp. e19-e20
-
-
Falchook, G.S.1
Janku, F.2
Tsao, A.S.3
-
88
-
-
76349106646
-
Ductal carcinoma in situ of the breast: A systematic review of incidence, treatment, and outcomes
-
Virnig BA, Tuttle TM, Shamliyan T, et al. Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes. J Natl Cancer Inst. 2010; 102(3):170-178.
-
(2010)
J Natl Cancer Inst
, vol.102
, Issue.3
, pp. 170-178
-
-
Virnig, B.A.1
Tuttle, T.M.2
Shamliyan, T.3
-
89
-
-
0026472124
-
Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
-
Guy CT, Webster MA, Schaller M, et al. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci U S A. 1992; 89(22):10578-10582.
-
(1992)
Proc Natl Acad Sci U.S.A
, vol.89
, Issue.22
, pp. 10578-10582
-
-
Guy, C.T.1
Webster, M.A.2
Schaller, M.3
-
90
-
-
0023430930
-
Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells
-
Hudziak RM, Schlessinger J, Ullrich A. Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc Natl Acad Sci U S A. 1987; 84(20):7159-7163.
-
(1987)
Proc Natl Acad Sci U.S.A
, vol.84
, Issue.20
, pp. 7159-7163
-
-
Hudziak, R.M.1
Schlessinger, J.2
Ullrich, A.3
-
91
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987; 235(4785):177-182.
-
(1987)
Science
, vol.235
, Issue.4785
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
92
-
-
85022193993
-
Prognostic and predictive relevance of HER2 status in ductal carcinoma in situ: Results from the UK/ANZ DCIS trial
-
(December)
-
Thorat M, Wagner S, Jones LJ, et al. Prognostic and predictive relevance of HER2 status in ductal carcinoma in situ: Results from the UK/ANZ DCIS trial. San Antonio Breast Cancer Symposium (December). 2015; P3-07-02.
-
(2015)
San Antonio Breast Cancer Symposium
, pp. P30702
-
-
Thorat, M.1
Wagner, S.2
Jones, L.J.3
-
93
-
-
84888646015
-
Tyrosine kinase gene rearrangements in epithelial Malignancies
-
Shaw AT, Hsu PP, Awad MM, et al. Tyrosine kinase gene rearrangements in epithelial malignancies. Nat Rev Cancer. 2013; 13(11):772-787.
-
(2013)
Nat Rev Cancer
, vol.13
, Issue.11
, pp. 772-787
-
-
Shaw, A.T.1
Hsu, P.P.2
Awad, M.M.3
-
94
-
-
84897022815
-
Cancer Genome Atlas Research N. Comprehensive molecular characterization of urothelial bladder carcinoma
-
Cancer Genome Atlas Research N. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014; 507(7492):315-322.
-
(2014)
Nature
, vol.507
, Issue.7492
, pp. 315-322
-
-
-
95
-
-
0032841519
-
Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas
-
Cappellen D, De Oliveira C, Ricol D, et al. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nat Genet. 1999; 23(1):18-20.
-
(1999)
Nat Genet
, vol.23
, Issue.1
, pp. 18-20
-
-
Cappellen, D.1
De Oliveira, C.2
Ricol, D.3
-
96
-
-
84954469968
-
The FGFR landscape in cancer: Analysis of 4853 tumors by next generation sequencing
-
Helsten T, Elkin S, Arthur E, et al. The FGFR Landscape in Cancer: Analysis of 4853 Tumors by Next Generation Sequencing. Clin Cancer Res. 2016; 22(1):259-267.
-
(2016)
Clin Cancer Res.
, vol.22
, Issue.1
, pp. 259-267
-
-
Helsten, T.1
Elkin, S.2
Arthur, E.3
-
97
-
-
84942194341
-
Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: Biologic and clinical implications
-
Helsten T, Schwaederle M, Kurzrock R. Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications. Cancer Metastasis Rev. 2015; 34(3):479-496.
-
(2015)
Cancer Metastasis Rev
, vol.34
, Issue.3
, pp. 479-496
-
-
Helsten, T.1
Schwaederle, M.2
Kurzrock, R.3
-
98
-
-
84943737092
-
Fibroblast growth factor family aberrations in cancers: Clinical and molecular characteristics
-
Parish A, Schwaederle M, Daniels G, et al. Fibroblast Growth Factor Family Aberrations in Cancers: Clinical and Molecular Characteristics. Cell Cycle. 2015; 14(13):2121-2128.
-
(2015)
Cell Cycle
, vol.14
, Issue.13
, pp. 2121-2128
-
-
Parish, A.1
Schwaederle, M.2
Daniels, G.3
-
99
-
-
0034676335
-
Somatic mutations of fibroblast growth factor receptor 3 (FGFR3) are uncommon in carcinomas of the uterine cervix
-
Wu R, Connolly D, Ngelangel C, et al. Somatic mutations of fibroblast growth factor receptor 3 (FGFR3) are uncommon in carcinomas of the uterine cervix. Oncogene. 2000; 19(48):5543-5546.
-
(2000)
Oncogene
, vol.19
, Issue.48
, pp. 5543-5546
-
-
Wu, R.1
Connolly, D.2
Ngelangel, C.3
-
100
-
-
84857433085
-
Mechanisms of FGFR-mediated carcinogenesis
-
Ahmad I, Iwata T, Leung HY. Mechanisms of FGFR-mediated carcinogenesis. Biochim Biophys Acta. 2012; 1823(4):850-860.
-
(2012)
Biochim Biophys Acta
, vol.1823
, Issue.4
, pp. 850-860
-
-
Ahmad, I.1
Iwata, T.2
Leung, H.Y.3
-
101
-
-
33747079040
-
Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas
-
Hernandez S, Lopez-Knowles E, Lloreta J, et al. Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas. J Clin Oncol. 2006; 24(22):3664-3671.
-
(2006)
J Clin Oncol
, vol.24
, Issue.22
, pp. 3664-3671
-
-
Hernandez, S.1
Lopez-Knowles, E.2
Lloreta, J.3
-
102
-
-
34447576555
-
FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization
-
Hafner C, Hartmann A, van Oers JM, et al. FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization. Mod Pathol. 2007; 20(8):895-903.
-
(2007)
Mod Pathol
, vol.20
, Issue.8
, pp. 895-903
-
-
Hafner, C.1
Hartmann, A.2
Van Oers, J.M.3
-
103
-
-
34548069945
-
Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern
-
Hafner C, Lopez-Knowles E, Luis NM, et al. Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. Proc Natl Acad Sci U S A. 2007; 104(33):13450-13454.
-
(2007)
Proc Natl Acad Sci U.S.A
, vol.104
, Issue.33
, pp. 13450-13454
-
-
Hafner, C.1
Lopez-Knowles, E.2
Luis, N.M.3
-
104
-
-
33750039697
-
High frequency of FGFR3 mutations in adenoid seborrheic keratoses
-
Hafner C, van Oers JM, Hartmann A, et al. High frequency of FGFR3 mutations in adenoid seborrheic keratoses. J Invest Dermatol. 2006; 126(11):2404-2407.
-
(2006)
J Invest Dermatol
, vol.126
, Issue.11
, pp. 2404-2407
-
-
Hafner, C.1
Van Oers, J.M.2
Hartmann, A.3
-
105
-
-
66149123020
-
Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours
-
Hida Y, Kubo Y, Arase S. Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours. Br J Dermatol. 2009; 160(6):1258-1263.
-
(2009)
Br J Dermatol
, vol.160
, Issue.6
, pp. 1258-1263
-
-
Hida, Y.1
Kubo, Y.2
Arase, S.3
-
106
-
-
33746754183
-
Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi
-
Hafner C, van Oers JM, Vogt T, et al. Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi. J Clin Invest. 2006; 116(8):2201-2207.
-
(2006)
J Clin Invest
, vol.116
, Issue.8
, pp. 2201-2207
-
-
Hafner, C.1
Van Oers, J.M.2
Vogt, T.3
-
107
-
-
77953363228
-
FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes
-
Hafner C, Di Martino E, Pitt E, et al. FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes. Exp Cell Res. 2010; 316(12):2008-2016.
-
(2010)
Exp Cell Res.
, vol.316
, Issue.12
, pp. 2008-2016
-
-
Hafner, C.1
Di Martino, E.2
Pitt, E.3
-
108
-
-
0028872752
-
Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3
-
Tavormina PL, Shiang R, Thompson LM, et al. Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3. Nat Genet. 1995; 9(3):321-328.
-
(1995)
Nat Genet
, vol.9
, Issue.3
, pp. 321-328
-
-
Tavormina, P.L.1
Shiang, R.2
Thompson, L.M.3
-
109
-
-
0029937714
-
Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1)
-
Rousseau F, el Ghouzzi V, Delezoide AL, et al. Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1). Hum Mol Genet. 1996; 5(4):509-512.
-
(1996)
Hum Mol Genet
, vol.5
, Issue.4
, pp. 509-512
-
-
Rousseau, F.1
El Ghouzzi, V.2
D'Elezoide, A.L.3
-
110
-
-
0036926992
-
Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in nonlethal skeletal disorders
-
van Rhijn BW, van Tilborg AA, Lurkin I, et al. Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in nonlethal skeletal disorders. Eur J Hum Genet. 2002; 10(12):819-824.
-
(2002)
Eur J Hum Genet
, vol.10
, Issue.12
, pp. 819-824
-
-
Van Rhijn, B.W.1
Van Tilborg, A.A.2
Lurkin, I.3
-
111
-
-
84856332741
-
A novel tyrosine kinase inhibitor restores chondrocyte differentiation and promotes bone growth in a gain-of-function fgfr3 mouse model
-
Jonquoy A, Mugniery E, Benoist-Lasselin C, et al. A novel tyrosine kinase inhibitor restores chondrocyte differentiation and promotes bone growth in a gain-of-function Fgfr3 mouse model. Hum Mol Genet. 2012; 21(4):841-851.
-
(2012)
Hum Mol Genet
, vol.21
, Issue.4
, pp. 841-851
-
-
Jonquoy, A.1
Mugniery, E.2
Benoist-Lasselin, C.3
-
112
-
-
35848939418
-
Mortality in achondroplasia study: A 42-year follow-up
-
Wynn J, King TM, Gambello MJ, et al. Mortality in achondroplasia study: a 42-year follow-up. Am J Med Genet A. 2007; 143A(21):2502-2511.
-
(2007)
Am J Med Genet A
, vol.143 A
, Issue.21
, pp. 2502-2511
-
-
Wynn, J.1
King, T.M.2
Gambello, M.J.3
-
113
-
-
33344462540
-
Mutation of the PIK3CA oncogene in human cancers
-
Karakas B, Bachman KE, Park BH. Mutation of the PIK3CA oncogene in human cancers. Br J Cancer. 2006; 94(4):455-459.
-
(2006)
Br J Cancer
, vol.94
, Issue.4
, pp. 455-459
-
-
Karakas, B.1
Bachman, K.E.2
Park, B.H.3
-
114
-
-
84895906492
-
Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors
-
Janku F, Hong DS, Fu S, et al. Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors. Cell Rep. 2014; 6(2):377-387.
-
(2014)
Cell Rep
, vol.6
, Issue.2
, pp. 377-387
-
-
Janku, F.1
Hong, D.S.2
Fu, S.3
-
115
-
-
84863338519
-
PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic Malignancies harboring PIK3CA mutations
-
Janku F, Wheler JJ, Westin SN, et al. PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol. 2012; 30(8):777-782.
-
(2012)
J Clin Oncol
, vol.30
, Issue.8
, pp. 777-782
-
-
Janku, F.1
Wheler, J.J.2
Westin, S.N.3
-
116
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, et al. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 2005; 4(12):988-1004.
-
(2005)
Nat Rev Drug Discov
, vol.4
, Issue.12
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
-
117
-
-
79951834210
-
PIK3CA mutations May be discordant between primary and corresponding metastatic disease in breast cancer
-
Dupont Jensen J, Laenkholm AV, Knoop A, et al. PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer. Clin Cancer Res. 2011; 17(4):667-677.
-
(2011)
Clin Cancer Res.
, vol.17
, Issue.4
, pp. 667-677
-
-
Dupont Jensen, J.1
Laenkholm, A.V.2
Knoop, A.3
-
118
-
-
84864409793
-
Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA
-
Lindhurst MJ, Parker VE, Payne F, et al. Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA. Nat Genet. 2012; 44(8):928-933.
-
(2012)
Nat Genet
, vol.44
, Issue.8
, pp. 928-933
-
-
Lindhurst, M.J.1
Parker, V.E.2
Payne, F.3
-
119
-
-
84864402732
-
De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly
-
Lee JH, Huynh M, Silhavy JL, et al. De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly. Nat Genet. 2012; 44(8):941-945.
-
(2012)
Nat Genet
, vol.44
, Issue.8
, pp. 941-945
-
-
Lee, J.H.1
Huynh, M.2
Silhavy, J.L.3
-
120
-
-
33745209647
-
PI3-kinase subunits are infrequent somatic targets in melanoma
-
Curtin JA, Stark MS, Pinkel D, et al. PI3-kinase subunits are infrequent somatic targets in melanoma. J Invest Dermatol. 2006; 126(7):1660-1663.
-
(2006)
J Invest Dermatol
, vol.126
, Issue.7
, pp. 1660-1663
-
-
Curtin, J.A.1
Stark, M.S.2
Pinkel, D.3
-
121
-
-
33745888704
-
Mutations of PIK3CA are rare in cutaneous melanoma
-
Omholt K, Krockel D, Ringborg U, et al. Mutations of PIK3CA are rare in cutaneous melanoma. Melanoma Res. 2006; 16(2):197-200.
-
(2006)
Melanoma Res.
, vol.16
, Issue.2
, pp. 197-200
-
-
Omholt, K.1
Krockel, D.2
Ringborg, U.3
-
122
-
-
77954838442
-
Activation of the PI3K/AKT signalling pathway in non-melanoma skin cancer is not mediated by oncogenic PIK3CA and AKT1 hotspot mutations
-
Hafner C, Landthaler M, Vogt T. Activation of the PI3K/AKT signalling pathway in non-melanoma skin cancer is not mediated by oncogenic PIK3CA and AKT1 hotspot mutations. Exp Dermatol. 2010; 19(8):e222-227.
-
(2010)
Exp Dermatol
, vol.19
, Issue.8
, pp. e222-e227
-
-
Hafner, C.1
Landthaler, M.2
Vogt, T.3
-
123
-
-
84856071447
-
Phase I, dose-escalation study of BKM120, an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors
-
Bendell JC, Rodon J, Burris HA, et al. Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol. 2012; 30(3):282-290.
-
(2012)
J Clin Oncol
, vol.30
, Issue.3
, pp. 282-290
-
-
Bendell, J.C.1
Rodon, J.2
Burris, H.A.3
-
124
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten JD, Faber AL, Horn C, et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature. 2007; 448(7152):439-444.
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
-
125
-
-
78650582977
-
Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors
-
Hafner C, Toll A, Fernandez-Casado A, et al. Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors. Proc Natl Acad Sci U S A. 2010; 107(48):20780-20785.
-
(2010)
Proc Natl Acad Sci U.S.A
, vol.107
, Issue.48
, pp. 20780-20785
-
-
Hafner, C.1
Toll, A.2
Fernandez-Casado, A.3
-
126
-
-
77952987104
-
Airway PI3K pathway activation is an early and reversible event in lung cancer development
-
Gustafson AM, Soldi R, Anderlind C, et al. Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci Transl Med. 2010; 2(26):26ra25.
-
(2010)
Sci Transl Med
, vol.2
, Issue.26
-
-
Gustafson, A.M.1
Soldi, R.2
Anderlind, C.3
-
127
-
-
84884549747
-
Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
-
Hallberg B, Palmer RH. Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. Nat Rev Cancer. 2013; 13(10):685-700.
-
(2013)
Nat Rev Cancer
, vol.13
, Issue.10
, pp. 685-700
-
-
Hallberg, B.1
Palmer, R.H.2
-
128
-
-
78049428879
-
Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor
-
Butrynski JE, D'Adamo DR, Hornick JL, et al. Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor. N Engl J Med. 2010; 363(18):1727-1733.
-
(2010)
N Engl J Med
, vol.363
, Issue.18
, pp. 1727-1733
-
-
Butrynski, J.E.1
D'Adamo, D.R.2
Hornick, J.L.3
-
129
-
-
0033890820
-
TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors
-
Lawrence B, Perez-Atayde A, Hibbard MK, et al. TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol. 2000; 157(2):377-384.
-
(2000)
Am J Pathol
, vol.157
, Issue.2
, pp. 377-384
-
-
Lawrence, B.1
Perez-Atayde, A.2
Hibbard, M.K.3
-
130
-
-
79955755025
-
Targeting oncogenic ALK: A promising strategy for cancer treatment
-
Grande E, Bolos MV, Arriola E. Targeting oncogenic ALK: a promising strategy for cancer treatment. Mol Cancer Ther. 2011; 10(4):569-579.
-
(2011)
Mol Cancer Ther
, vol.10
, Issue.4
, pp. 569-579
-
-
Grande, E.1
Bolos, M.V.2
Arriola, E.3
-
131
-
-
84897109567
-
Crizotinib in advanced, chemoresistant anaplastic lymphoma kinase-positive lymphoma patients
-
Gambacorti Passerini C, Farina F, Stasia A, et al. Crizotinib in advanced, chemoresistant anaplastic lymphoma kinase-positive lymphoma patients. J Natl Cancer Inst. 2014; 106(2): djt378.
-
(2014)
J Natl Cancer Inst
, vol.106
, Issue.2
-
-
Gambacorti Passerini, C.1
Farina, F.2
Stasia, A.3
-
132
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013; 368(25):2385-2394.
-
(2013)
N Engl J Med
, vol.368
, Issue.25
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
134
-
-
84885735554
-
Mutational landscape and significance across 12 major cancer types
-
Kandoth C, McLellan MD, Vandin F, et al. Mutational landscape and significance across 12 major cancer types. Nature. 2013; 502(7471):333-339.
-
(2013)
Nature
, vol.502
, Issue.7471
, pp. 333-339
-
-
Kandoth, C.1
McLellan, M.D.2
Vandin, F.3
-
135
-
-
84896098750
-
Mutant p53 in cancer: New functions and therapeutic opportunities
-
Muller PA, Vousden KH. Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell. 2014; 25(3):304-317.
-
(2014)
Cancer Cell
, vol.25
, Issue.3
, pp. 304-317
-
-
Muller, P.A.1
Vousden, K.H.2
-
136
-
-
84880321253
-
P53 mutations in advanced cancers: Clinical characteristics, outcomes, and correlation between progression-free survival and bevacizumab-containing therapy
-
Said R, Hong DS, Warneke CL, et al. P53 mutations in advanced cancers: clinical characteristics, outcomes, and correlation between progression-free survival and bevacizumab-containing therapy. Oncotarget. 2013; 4(5):705-714.
-
(2013)
Oncotarget
, vol.4
, Issue.5
, pp. 705-714
-
-
Said, R.1
Hong, D.S.2
Warneke, C.L.3
-
137
-
-
0031911731
-
Mutations of the p53 tumour suppressor gene in erosive rheumatoid synovial tissue
-
Reme T, Travaglio A, Gueydon E, et al. Mutations of the p53 tumour suppressor gene in erosive rheumatoid synovial tissue. Clin Exp Immunol. 1998; 111(2):353-358.
-
(1998)
Clin Exp Immunol
, vol.111
, Issue.2
, pp. 353-358
-
-
Reme, T.1
Travaglio, A.2
Gueydon, E.3
-
138
-
-
0030886724
-
Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium
-
Firestein GS, Echeverri F, Yeo M, et al. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. Proc Natl Acad Sci U S A. 1997; 94(20):10895-10900.
-
(1997)
Proc Natl Acad Sci U.S.A
, vol.94
, Issue.20
, pp. 10895-10900
-
-
Firestein, G.S.1
Echeverri, F.2
Yeo, M.3
-
139
-
-
34248379012
-
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database
-
Petitjean A, Mathe E, Kato S, et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mutat. 2007; 28(6):622-629.
-
(2007)
Hum Mutat
, vol.28
, Issue.6
, pp. 622-629
-
-
Petitjean, A.1
Mathe, E.2
Kato, S.3
-
140
-
-
0142157701
-
Li-fraumeni and related syndromes: Correlation between tumor type, family structure, and TP53 genotype
-
Olivier M, Goldgar DE, Sodha N, et al. Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype. Cancer Res. 2003; 63(20):6643-6650.
-
(2003)
Cancer Res.
, vol.63
, Issue.20
, pp. 6643-6650
-
-
Olivier, M.1
Goldgar, D.E.2
Sodha, N.3
-
141
-
-
0036232968
-
P53, proto-oncogene and rheumatoid arthritis
-
Sun Y, Cheung HS. p53, proto-oncogene and rheumatoid arthritis. Semin Arthritis Rheum. 2002; 31(5):299-310.
-
(2002)
Semin Arthritis Rheum
, vol.31
, Issue.5
, pp. 299-310
-
-
Sun, Y.1
Cheung, H.S.2
-
142
-
-
0036469114
-
Autocrine interleukin-6 production in renal cell carcinoma: Evidence for the involvement of p53
-
Angelo LS, Talpaz M, Kurzrock R. Autocrine interleukin-6 production in renal cell carcinoma: evidence for the involvement of p53. Cancer Res. 2002; 62(3):932-940.
-
(2002)
Cancer Res.
, vol.62
, Issue.3
, pp. 932-940
-
-
Angelo, L.S.1
Talpaz, M.2
Kurzrock, R.3
-
143
-
-
84859449924
-
The roles of Interleukin-6 in the pathogenesis of rheumatoid arthritis
-
Hashizume M, Mihara M. The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis. Arthritis. 2011; 2011:765624.
-
(2011)
Arthritis
, vol.2011
-
-
Hashizume, M.1
Mihara, M.2
-
144
-
-
52149099504
-
IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
-
Emery P, Keystone E, Tony HP, et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis. 2008; 67(11):1516-1523.
-
(2008)
Ann Rheum Dis
, vol.67
, Issue.11
, pp. 1516-1523
-
-
Emery, P.1
Keystone, E.2
Tony, H.P.3
-
145
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-674.
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
146
-
-
60749109846
-
Cell cycle, CDKs and cancer: A changing paradigm
-
Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer. 2009; 9(3):153-166.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.3
, pp. 153-166
-
-
Malumbres, M.1
Barbacid, M.2
-
147
-
-
33645802169
-
Cyclin-dependent kinase pathways as targets for cancer treatment
-
Shapiro GI Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol. 2006; 24(11):1770-1783.
-
(2006)
J Clin Oncol
, vol.24
, Issue.11
, pp. 1770-1783
-
-
Shapiro, G.I.1
-
148
-
-
84928014990
-
Cyclin-dependent kinase pathway aberrations in diverse Malignancies: Clinical and molecular characteristics
-
Kato S, Schwaederle M, Daniels GA, et al. Cyclin-dependent kinase pathway aberrations in diverse malignancies: clinical and molecular characteristics. Cell Cycle. 2015; 14(8):1252-1259.
-
(2015)
Cell Cycle
, vol.14
, Issue.8
, pp. 1252-1259
-
-
Kato, S.1
Schwaederle, M.2
Daniels, G.A.3
-
149
-
-
84943780413
-
Next generation sequencing demonstrates association between tumor suppressor gene aberrations and poor outcome in patients with cancer
-
Schwaederle M, Daniels GA, Piccioni DE, et al. Next generation sequencing demonstrates association between tumor suppressor gene aberrations and poor outcome in patients with cancer. Cell Cycle. 2015; 14(11):1730-1737.
-
(2015)
Cell Cycle
, vol.14
, Issue.11
, pp. 1730-1737
-
-
Schwaederle, M.1
Daniels, G.A.2
Piccioni, D.E.3
-
150
-
-
84867634662
-
Familial atypical multiple mole melanoma syndrome
-
DL, Riegert-Johnson LA, Boardman T, Hefferon et al., eds. Bethesda, MD
-
Eckerle Mize D, Bishop M, Resse E, et al. Familial Atypical Multiple Mole Melanoma Syndrome. In: DL, Riegert-Johnson LA, Boardman T, Hefferon et al., eds. Cancer Syndromes. Bethesda, MD; 2009.
-
(2009)
Cancer Syndromes
-
-
Eckerle Mize, D.1
Bishop, M.2
Resse, E.3
-
151
-
-
33847282821
-
Features associated with germline CDKN2A mutations: A GenoMEL study of melanoma-prone families from three continents
-
Goldstein AM, Chan M, Harland M, et al. Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. J Med Genet. 2007; 44(2):99-106.
-
(2007)
J Med Genet
, vol.44
, Issue.2
, pp. 99-106
-
-
Goldstein, A.M.1
Chan, M.2
Harland, M.3
-
152
-
-
84928727401
-
Prevalence and predictors of germline CDKN2A mutations for melanoma cases from Australia, Spain and the United Kingdom
-
Harland M, Cust AE, Badenas C, et al. Prevalence and predictors of germline CDKN2A mutations for melanoma cases from Australia, Spain and the United Kingdom. Hered Cancer Clin Pract. 2014; 12(1):20.
-
(2014)
Hered Cancer Clin Pract
, vol.12
, Issue.1
, pp. 20
-
-
Harland, M.1
Cust, A.E.2
Badenas, C.3
-
153
-
-
84878886596
-
Melanoma prone families with CDK4 germline mutation: Phenotypic profile and associations with MC1R variants
-
Puntervoll HE, Yang XR, Vetti HH, et al. Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants. J Med Genet. 2013; 50(4):264-270.
-
(2013)
J Med Genet
, vol.50
, Issue.4
, pp. 264-270
-
-
Puntervoll, H.E.1
Yang, X.R.2
Vetti, H.H.3
-
154
-
-
0036895738
-
CDKN2A germline mutations in familial pancreatic cancer
-
Bartsch DK, Sina-Frey M, Lang S, et al. CDKN2A germline mutations in familial pancreatic cancer. Ann Surg. 2002; 236(6):730-737.
-
(2002)
Ann Surg
, vol.236
, Issue.6
, pp. 730-737
-
-
Bartsch, D.K.1
Sina-Frey, M.2
Lang, S.3
-
155
-
-
0036143702
-
Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanomapancreatic carcinoma-prone families: The familial atypical mole melanoma-pancreatic carcinoma syndrome
-
Lynch HT, Brand RE, Hogg D, et al. Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanomapancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome. Cancer. 2002; 94(1):84-96.
-
(2002)
Cancer
, vol.94
, Issue.1
, pp. 84-96
-
-
Lynch, H.T.1
Brand, R.E.2
Hogg, D.3
-
156
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008; 321(5897):1807-1812.
-
(2008)
Science
, vol.321
, Issue.5897
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
-
157
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
-
Verhaak RG, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010; 17(1):98-110.
-
(2010)
Cancer Cell
, vol.17
, Issue.1
, pp. 98-110
-
-
Verhaak, R.G.1
Hoadley, K.A.2
Purdom, E.3
-
158
-
-
84940611736
-
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas
-
Krauthammer M, Kong Y, Bacchiocchi A, et al. Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas. Nat Genet. 2015; 47(9):996-1002.
-
(2015)
Nat Genet
, vol.47
, Issue.9
, pp. 996-1002
-
-
Krauthammer, M.1
Kong, Y.2
Bacchiocchi, A.3
-
159
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008; 455(7216):1069-1075.
-
(2008)
Nature
, vol.455
, Issue.7216
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
-
160
-
-
84872546604
-
Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic Malignant peripheral nerve sheath tumors
-
Endo M, Yamamoto H, Setsu N, et al. Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors. Clin Cancer Res. 2013; 19(2):450-461.
-
(2013)
Clin Cancer Res.
, vol.19
, Issue.2
, pp. 450-461
-
-
Endo, M.1
Yamamoto, H.2
Setsu, N.3
-
161
-
-
84899513979
-
Loss of NF1 incutaneous melanoma is associated with RAS activation and MEK dependence
-
Nissan MH, Pratilas CA, Jones AM, et al. Loss of NF1 incutaneous melanoma is associated with RAS activation and MEK dependence. Cancer Res. 2014; 74(8):2340-2350.
-
(2014)
Cancer Res.
, vol.74
, Issue.8
, pp. 2340-2350
-
-
Nissan, M.H.1
Pratilas, C.A.2
Jones, A.M.3
-
162
-
-
84906906663
-
Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers
-
Malone CF, Fromm JA, Maertens O, et al. Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers. Cancer Discov. 2014; 4(9):1062-1073.
-
(2014)
Cancer Discov
, vol.4
, Issue.9
, pp. 1062-1073
-
-
Malone, C.F.1
Fromm, J.A.2
Maertens, O.3
-
163
-
-
84903516924
-
Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity
-
Watson AL, Anderson LK, Greeley AD, et al. Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity. Oncotarget. 2014; 5(6):1502-1514.
-
(2014)
Oncotarget
, vol.5
, Issue.6
, pp. 1502-1514
-
-
Watson, A.L.1
Anderson, L.K.2
Greeley, A.D.3
-
165
-
-
84873809147
-
MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors
-
Jessen WJ, Miller SJ, Jousma E, et al. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. J Clin Invest. 2013; 123(1):340-347.
-
(2013)
J Clin Invest
, vol.123
, Issue.1
, pp. 340-347
-
-
Jessen, W.J.1
Miller, S.J.2
Jousma, E.3
-
166
-
-
84893870298
-
NF2/merlin in hereditary neurofibromatosis 2 versus cancer: Biologic mechanisms and clinical associations
-
Schroeder RD, Angelo LS, Kurzrock R. NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations. Oncotarget. 2014; 5(1):67-77.
-
(2014)
Oncotarget
, vol.5
, Issue.1
, pp. 67-77
-
-
Schroeder, R.D.1
Angelo, L.S.2
Kurzrock, R.3
-
167
-
-
14844355090
-
The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression
-
Xiao GH, Gallagher R, Shetler J, et al. The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol. 2005; 25(6):2384-2394.
-
(2005)
Mol Cell Biol.
, vol.25
, Issue.6
, pp. 2384-2394
-
-
Xiao, G.H.1
Gallagher, R.2
Shetler, J.3
-
168
-
-
68149150655
-
Neurofibromatosis type 2 (NF2): A clinical and molecular review
-
Evans DG Neurofibromatosis type 2 (NF2): a clinical and molecular review. Orphanet J Rare Dis. 2009; 4:16.
-
(2009)
Orphanet J Rare Dis
, vol.4
, pp. 16
-
-
Evans, D.G.1
-
169
-
-
33845946249
-
Mutational spectrum of the NF2 gene: A meta-analysis of 12 years of research and diagnostic laboratory findings
-
Ahronowitz I, Xin W, Kiely R, et al. Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings. Hum Mutat. 2007; 28(1):1-12.
-
(2007)
Hum Mutat
, vol.28
, Issue.1
, pp. 1-12
-
-
Ahronowitz, I.1
Xin, W.2
Kiely, R.3
-
170
-
-
84856873458
-
Treatment of patients with advanced neurofibromatosis type 2 with novel molecularly targeted therapies: From bench to bedside
-
Subbiah V, Slopis J, Hong DS, et al. Treatment of patients with advanced neurofibromatosis type 2 with novel molecularly targeted therapies: from bench to bedside. J Clin Oncol. 2012; 30(5):e64-e68.
-
(2012)
J Clin Oncol
, vol.30
, Issue.5
, pp. e64-e68
-
-
Subbiah, V.1
Slopis, J.2
Hong, D.S.3
-
171
-
-
84987802495
-
Erlotinib and the risk of oral cancer: The erlotinib prevention of oral cancer (EPOC) randomized clinical trial
-
William WN Jr, Papadimitrakopoulou V, Lee JJ, et al. Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial. JAMA Oncol. 2015; 2(2):209-216.
-
(2015)
JAMA Oncol
, vol.2
, Issue.2
, pp. 209-216
-
-
William, W.N.1
Papadimitrakopoulou, V.2
Lee, J.J.3
-
172
-
-
84976582488
-
Oral cancer chemoprevention - The end of EPOC, the beginning of an epoch of molecular selection
-
Bauman JE, Grandis J. Oral Cancer Chemoprevention-The End of EPOC, the Beginning of an Epoch of Molecular Selection. JAMA Oncol. 2015; 2(2):178-179.
-
(2015)
JAMA Oncol
, vol.2
, Issue.2
, pp. 178-179
-
-
Bauman, J.E.1
Grandis, J.2
-
173
-
-
84955306452
-
Transforming cancer prevention through precision medicine and immune-oncology
-
Kensler TW, Spira A, Garber JE, et al. Transforming Cancer Prevention through Precision Medicine and Immune-oncology. Cancer Prev Res (Phila). 2016; 9(1):2-10.
-
(2016)
Cancer Prev Res (Phila)
, vol.9
, Issue.1
, pp. 2-10
-
-
Kensler, T.W.1
Spira, A.2
Garber, J.E.3
-
174
-
-
24744461722
-
EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients
-
Tang X, Shigematsu H, Bekele BN, et al. EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients. Cancer Res. 2005; 65(17):7568-7572.
-
(2005)
Cancer Res.
, vol.65
, Issue.17
, pp. 7568-7572
-
-
Tang, X.1
Shigematsu, H.2
Bekele, B.N.3
-
175
-
-
33744814638
-
Lung adenocarcinomas induced in mice by mutant EGF receptors foundinhuman lung cancers respond toatyrosine kinase inhibitor or to down-regulation of the receptors
-
Politi K, Zakowski MF, Fan PD, et al. Lung adenocarcinomas induced in mice by mutant EGF receptors foundinhuman lung cancers respond toatyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev. 2006; 20(11):1496-1510.
-
(2006)
Genes Dev
, vol.20
, Issue.11
, pp. 1496-1510
-
-
Politi, K.1
Zakowski, M.F.2
Fan, P.D.3
-
176
-
-
84929991442
-
Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin
-
Martincorena I, Roshan A, Gerstung M, et al. Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science. 2015; 348(6237):880-886.
-
(2015)
Science
, vol.348
, Issue.6237
, pp. 880-886
-
-
Martincorena, I.1
Roshan, A.2
Gerstung, M.3
-
177
-
-
84927628586
-
Notch1 mutations are drivers of oral tumorigenesis
-
Izumchenko E, Sun K, Jones S, et al. Notch1 mutations are drivers of oral tumorigenesis. Cancer Prev Res (Phila). 2015; 8(4):277-286.
-
(2015)
Cancer Prev Res (Phila)
, vol.8
, Issue.4
, pp. 277-286
-
-
Izumchenko, E.1
Sun, K.2
Jones, S.3
-
178
-
-
0037420020
-
Cyclin D1 genotype, response to biochemoprevention, and progression rate to upper aerodigestive tract cancer
-
Izzo JG, Papadimitrakopoulou VA, Liu DD, et al. Cyclin D1 genotype, response to biochemoprevention, and progression rate to upper aerodigestive tract cancer. J Natl Cancer Inst. 2003; 95(3):198-205.
-
(2003)
J Natl Cancer Inst
, vol.95
, Issue.3
, pp. 198-205
-
-
Izzo, J.G.1
Papadimitrakopoulou, V.A.2
Liu, D.D.3
-
179
-
-
84900804116
-
Molecular profiling of Premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis
-
Ooi AT, Gower AC, Zhang KX, et al. Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. Cancer Prev Res (Phila). 2014; 7(5):487-495.
-
(2014)
Cancer Prev Res (Phila)
, vol.7
, Issue.5
, pp. 487-495
-
-
Ooi, A.T.1
Gower, A.C.2
Zhang, K.X.3
-
180
-
-
84942036061
-
Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA
-
Izumchenko E, Chang X, Brait M, et al. Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA. Nat Commun. 2015; 6:8258.
-
(2015)
Nat Commun
, vol.6
, pp. 8258
-
-
Izumchenko, E.1
Chang, X.2
Brait, M.3
-
181
-
-
77958186832
-
Circulating benign nevus cells detected by ISET technique: Warning for melanoma molecular diagnosis
-
De Giorgi V, Pinzani P, Salvianti F, et al. Circulating benign nevus cells detected by ISET technique: warning for melanoma molecular diagnosis. Arch Dermatol. 2010; 146(10):1120-1124.
-
(2010)
Arch Dermatol
, vol.146
, Issue.10
, pp. 1120-1124
-
-
De Giorgi, V.1
Pinzani, P.2
Salvianti, F.3
-
182
-
-
84926216729
-
Germline ETV6 mutations in familial thrombocytopenia and hematologic Malignancy
-
Zhang MY, Churpek JE, Keel SB, et al. Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. Nat Genet. 2015; 47(2):180-185.
-
(2015)
Nat Genet
, vol.47
, Issue.2
, pp. 180-185
-
-
Zhang, M.Y.1
Churpek, J.E.2
Keel, S.B.3
-
183
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter EJ, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005; 365(9464):1054-1061.
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
-
184
-
-
84920024296
-
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
-
Genovese G, Kahler AK, Handsaker RE, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014; 371(26):2477-2487.
-
(2014)
N Engl J Med
, vol.371
, Issue.26
, pp. 2477-2487
-
-
Genovese, G.1
Kahler, A.K.2
Handsaker, R.E.3
-
185
-
-
0023142769
-
A novel c-abl protein product in philadelphia-positive acute Lymphoblastic Leukaemia
-
Kurzrock R, Shtalrid M, Romero P, et al. A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia. Nature. 1987; 325(6105):631-635.
-
(1987)
Nature
, vol.325
, Issue.6105
, pp. 631-635
-
-
Kurzrock, R.1
Shtalrid, M.2
Romero, P.3
-
186
-
-
0023753576
-
The molecular genetics of philadelphia chromosome-positive Leukemias
-
Kurzrock R, Gutterman JU, Talpaz M. The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med. 1988; 319(15):990-998.
-
(1988)
N Engl J Med
, vol.319
, Issue.15
, pp. 990-998
-
-
Kurzrock, R.1
Gutterman, J.U.2
Talpaz, M.3
-
187
-
-
0028786297
-
Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals
-
Biernaux C, Loos M, Sels A, et al. Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals. Blood. 1995; 86(8):3118-3122.
-
(1995)
Blood
, vol.86
, Issue.8
, pp. 3118-3122
-
-
Biernaux, C.1
Loos, M.2
Sels, A.3
-
188
-
-
0032211172
-
The presence of typical and atypical BCR-ABL fusion genes in Leukocytes of normal individuals: Biologic significance and implications for the assessment of minimal residual disease
-
Bose S, Deininger M, Gora-Tybor J, et al. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood. 1998; 92(9):3362-3367.
-
(1998)
Blood
, vol.92
, Issue.9
, pp. 3362-3367
-
-
Bose, S.1
Deininger, M.2
Gora-Tybor, J.3
-
189
-
-
84896515055
-
Incidence of bcrabl fusion transcripts in healthy individuals
-
Ismail SI, Naffa RG, Yousef AM, et al. Incidence of bcrabl fusion transcripts in healthy individuals. Mol Med Rep. 2014; 9(4):1271-1276.
-
(2014)
Mol Med Rep
, vol.9
, Issue.4
, pp. 1271-1276
-
-
Ismail, S.I.1
Naffa, R.G.2
Yousef, A.M.3
-
190
-
-
84881298446
-
European LeukemiaNet recommendations for the management of chronic myeloid Leukemia: 2013
-
Baccarani M, Deininger MW, Rosti G, et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood. 2013; 122(6):872-884.
-
(2013)
Blood
, vol.122
, Issue.6
, pp. 872-884
-
-
Baccarani, M.1
Deininger, M.W.2
Rosti, G.3
-
192
-
-
80055092549
-
Loss-of-function mutations in notch receptors in cutaneous and lung squamous cell carcinoma
-
Wang NJ, Sanborn Z, Arnett KL, et al. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A. 2011; 108(43):17761-17766.
-
(2011)
Proc Natl Acad Sci U.S.A
, vol.108
, Issue.43
, pp. 17761-17766
-
-
Wang, N.J.1
Sanborn, Z.2
Arnett, K.L.3
|