NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: Biologic mechanisms and clinical associations

Oncotarget

Volumn 5, Issue 1, 2014, Pages 67-77

  Schroeder, Rebecca Dunbar ^a,b   Angelo, Laura S ^a   Kurzrock, Razelle ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Merlin; Mutation; Neurofibromatosis 2; Schwannoma

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CURCUMIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EVEROLIMUS; FOCAL ADHESION KINASE; KNK 437; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MERLIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NILOTINIB; PAXILLIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; PTC 299; SALIRASIB; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG;

ACOUSTIC NEURINOMA; ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CARCINOGENESIS; CLINICAL FEATURE; DRUG TARGETING; ENDOMETRIUM CANCER; EPENDYMOMA; FRAMESHIFT MUTATION; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GLIOBLASTOMA; HUMAN; INTRACELLULAR SIGNALING; LIVER CANCER; LUNG CANCER; MALIGNANT MENINGIOMA; MALIGNANT NEOPLASTIC DISEASE; MENINGIOMA; MESOTHELIOMA; NEURILEMOMA; NEUROFIBROMATOSIS; NF2 GENE; OVERALL SURVIVAL; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PLEURA MESOTHELIOMA; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SOMATIC MUTATION; THYROID CANCER; ANIMAL; GENETICS; GERMLINE MUTATION; NERVOUS SYSTEM TUMOR; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALS; GENES, NEUROFIBROMATOSIS 2; GERM-LINE MUTATION; HUMANS; NERVOUS SYSTEM NEOPLASMS; NEUROFIBROMATOSIS 2; SIGNAL TRANSDUCTION;

EID: 84893870298     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1557     Document Type: Review

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