Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens

Journal of Immunology Research

Volumn 2016, Issue , 2016, Pages

  Lee, Wai Ping ^a   Willekens, Barbara ^b   Cras, Patrick ^b,c   Goossens, Herman ^a   Martínez Cáceres, Eva ^d   Berneman, Zwi N ^a,b   Cools, Nathalie ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CD209 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; GLATIRAMER; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; LYMPHOTOXIN; MYELIN; NATALIZUMAB; RECOMBINANT BETA INTERFERON; TUMOR NECROSIS FACTOR; 1,25-DIHYDROXYVITAMIN D; ANTIGEN; CYTOKINE; VITAMIN D;

ADULT; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; CYTOKINE RELEASE; DENDRITIC CELL; FEMALE; FREEZE THAWING; HUMAN; HUMAN CELL; IMMUNOMODULATION; MALE; MEMBRANE MARKER; MIXED LYMPHOCYTE REACTION; MONOCYTE; MULTIPLE SCLEROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; T LYMPHOCYTE; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MIXED LYMPHOCYTE CULTURE; MYELIN SHEATH; PHENOTYPE;

ADULT; ANTIGENS; CELL DIFFERENTIATION; CRYOPRESERVATION; CYTOKINES; DENDRITIC CELLS; FEMALE; HUMANS; IMMUNE TOLERANCE; LYMPHOCYTE CULTURE TEST, MIXED; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; MYELIN SHEATH; PHENOTYPE; T-LYMPHOCYTES; VITAMIN D;

EID: 84989958890     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2016/5392623     Document Type: Article

References (53)

1. A. H. Beecham, N. A. Patsopoulos, D. K. Xifara et al., "Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis, " Nature Genetics, vol. 45, pp. 1353-1360, 2013.
2. G. C. Ebers, "Environmental factors andmultiple sclerosis, " The Lancet Neurology, vol. 7, no. 3, pp. 268-277, 2008.
3. J. M. Fletcher, S. J. Lalor, C. M. Sweeney, N. Tubridy, and K. H. G. Mills, "T cells in multiple sclerosis and experimental autoimmune encephalomyelitis, " Clinical and Experimental Immunology, vol. 162, no. 1, pp. 1-11, 2010.
4. V. Brucklacher-Waldert, K. Stuerner, M. Kolster, J. Wolthausen, and E. Tolosa, "Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis, " Brain, vol. 132, no. 12, pp. 3329-3341, 2009.
5. J. S. Tzartos, M. A. Friese, M. J. Craner et al., "Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis, " American Journal of Pathology, vol. 172, no. 1, pp. 146-155, 2008.
6. M. Montes, X. Zhang, L. Berthelot et al., "Oligoclonal myelinreactive T-cell infiltrates derived from multiple sclerosis lesions are enriched inTh17 cells, " Clinical Immunology, vol. 130, no. 2, pp. 133-144, 2009.
7. S. Skurkovich, A. Boiko, I. Beliaeva et al., "Randomized study of antibodies to IFN- and TNF- in secondary progressive multiple sclerosis, " Multiple Sclerosis, vol. 7, no. 5, pp. 277-284, 2001.
8. N. Cools, A. Petrizzo, E. Smits et al., "Dendritic cells in thepathogenesis and treatment of human diseases: A Janus Bifrons?" Immunotherapy, vol. 3, no. 10, pp. 1203-1222, 2011.
9. R. M. Steinman, D. Hawiger, and M. C. Nussenzweig, "Tolerogenic dendritic cells, " Annual Review of Immunology, vol. 21, pp. 685-711, 2003.
10. I. Van Brussel, W. P. Lee, M. Rombouts et al., "Tolerogenic dendritic cell vaccines to treat autoimmune diseases: can the unattainable dream turn into reality?" Autoimmunity Reviews, vol. 13, no. 2, pp. 138-150, 2014.
11. N. Cools, P. Ponsaerts, V. F. I. Van Tendeloo, and Z. N. Berneman, "Balancing between immunity and tolerance: An interplay between dendritic cells, regulatory T cells, and effector T cells, " Journal of Leukocyte Biology, vol. 82, no. 6, pp. 1365-1374, 2007.
12. G. Penna and L. Adorini, "1?, 25-dihydroxyVitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation, " Journal of Immunology, vol. 164, no. 5, pp. 2405-2411, 2000.
13. L. Piemonti, P. Monti, M. Sironi et al., "Vitamin D3 affects differentiation, maturation, and function of human monocytederived dendritic cells, " Journal of Immunology, vol. 164, no. 9, pp. 4443-4451, 2000.
14. D. Ra?c? h-Regué, L. Grau-López, M. Naranjo-Gómez et al., "Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients, " European Journal of Immunology, vol. 42, no. 3, pp. 771-782, 2012.
15. J. N. Stoop, R. A. Harry, A. Von Delwig, J. D. Isaacs, J. H. Robinson, and C. M. U. Hilkens, "Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses, " Arthritis Care and Research, vol. 62, no. 12, pp. 3656-3665, 2010.
16. E. Peelen, S. Knippenberg, A.-H. Muris et al., "Effects of VitaminDon the peripheral adaptive immune system: A review, " Autoimmunity Reviews, vol. 10, no. 12, pp. 733-743, 2011.
17. M. Hewison, "Vitamin D and innate and adaptive immunity, " Vitamins and Hormones, vol. 86, pp. 23-62, 2011.
18. W. W. J. Unger, S. Laban, F. S. Kleijwegt, A. R. Van Der Slik, and B. O. Roep, "Induction of Treg by monocyte-derived DC modulated by Vitamin D3 or dexamethasone: differential role for PD-L1, " European Journal of Immunology, vol. 39, no. 11, pp. 3147-3159, 2009.
19. E. Martin, C. Capini, E. Duggan et al., "Antigen-specific suppression of established arthritis in mice by dendritic cells deficient in NF-B, " Arthritis and Rheumatism, vol. 56, no. 7, pp. 2255-2266, 2007.
20. M. Menges, S. Rossner, C. Voigtländer et al., "Repetitive injections of dendritic cells matured with tumor necrosis factor induce antigen-specific protection of mice fromautoimmunity, " Journal of ExperimentalMedicine, vol. 195, no. 1, pp. 15-21, 2002.
21. J. Machen, J. Harnaha, R. Lakomy, A. Styche, M. Trucco, and N. Giannoukakis, "Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells, " Journal of Immunology, vol. 173, no. 7, pp. 4331-4341, 2004.
22. N. Giannoukakis, B. Phillips, D. Finegold, J. Harnaha, and M. Trucco, "Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients, " Diabetes Care, vol. 34, no. 9, pp. 2026-2032, 2011.
23. H. Benham, H. J. Nel, S. C. Law et al., "Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients, " Science Translational Medicine, vol. 7, no. 290, Article ID 290ra87, 2015.
24. A. Jauregui-Amezaga, R. Cabezón, A. Ramírez-Morros et al., "Intraperitoneal administration of autologous tolerogenic dendritic cells for refractory Crohn's disease: A phase I study, " Journal of Crohn's and Colitis, vol. 9, no. 12, pp. 1071-1078, 2015.
25. G. M. Bell, A. E. Anderson, J. Diboll et al., "Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis, " Annals of the Rheumatic Diseases, 2016.
26. M. J. Mansilla, C. Sellès-Moreno, S. Fàbregas-Puig et al., "Beneficial effect of tolerogenic dendritic cells pulsed with MOG autoantigen in experimental autoimmune encephalomyelitis, " CNS Neuroscience and Therapeutics, vol. 21, no. 3, pp. 222-230, 2015.
27. C. H. Polman, S. C. Reingold, B. Banwell et al., "Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria, " Annals of Neurology, vol. 69, no. 2, pp. 292-302, 2011.
28. S. Janetzki, K. S. Panageas, L. Ben-Porat et al., "Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI), " Cancer Immunology, Immunotherapy, vol. 57, no. 3, pp. 303-315, 2008.
29. A. H. Nuyts, P. Ponsaerts, V. F. I. Van Tendeloo et al., "Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells frompatients withmultiple sclerosis are functionally comparable to those of healthy controls, " Cytotherapy, vol. 16, no. 7, pp. 1024-1030, 2014.
30. K. Mahnke, T. Bedke, and A. H. Enk, "Regulatory conversation between antigen presenting cells and regulatory T cells enhance immune suppression, " Cellular Immunology, vol. 250, no. 1-2, pp. 1-13, 2007.
31. R. Kushwah, J. Wu, J. R. Oliver et al., "Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg, " European Journal of Immunology, vol. 40, no. 4, pp. 1022-1035, 2010.
32. A. Bar-Or, A. Pachner, F. Menguy-Vacheron, J. Kaplan, and H. Wiendl, "Teriflunomide and its mechanism of action in multiple sclerosis, " Drugs, vol. 74, no. 6, pp. 659-674, 2014.
33. R. Bomprezzi, "Dimethyl fumarate in the treatment of relapsingremittingmultiple sclerosis: An overview, "Therapeutic Advances in Neurological Disorders, vol. 8, no. 1, pp. 20-30, 2015.
34. R. Babij and J. S. Perumal, "Comparative efficacy of alemtuzumab and established treatment in the management of multiple sclerosis, " Neuropsychiatric Disease and Treatment, vol. 11, pp. 1221-1229, 2015.
35. P. T. H. Coates, R. Krishnan, S. Kireta, J. Johnston, and G. R. Russ, "Human myeloid dendritic cells transduced with an adenoviral interleukin-10 gene construct inhibit human skin graft rejection in humanized NOD-scid chimeric mice, " Gene Therapy, vol. 8, no. 16, pp. 1224-1233, 2001.
36. N. Giannoukakis, C. A. Bonham, S. Qian et al., "Prolongation of cardiac allograft survival using dendritic cells treated with NFkB decoy oligodeoxyribonucleotides, " Molecular Therapy, vol. 1, no. 5, pp. 430-437, 2000.
37. K. Thewissen, B. Broux, J. J. Hendriks et al., "Tolerogenic dendritic cells generated by in vitro treatment with SAHA are not stable in vivo, " Cell Transplantation, vol. 25, no. 6, pp. 1207-1218, 2016.
38. H. Bartosik-Psujek, J. Tabarkiewicz, K. Pocinska, Z. Stelmasiak, and J. Rolinski, "Immunomodulatory effects of Vitamin D on monocyte-derived dendritic cells inmultiple sclerosis, "Multiple Sclerosis, vol. 16, no. 12, pp. 1513-1516, 2010.
39. H. Hayden, J. Friedl, M. Dettke et al., "Cryopreservation of monocytes is superior to cryopreservation of immature or semimature dendritic cells for dendritic cell-based immunotherapy, " Journal of Immunotherapy, vol. 32, no. 6, pp. 638-654, 2009.
40. M. Makino and M. Baba, "Acryopreservation method of human peripheral blood mononuclear cells for efficient production of dendritic cells, " Scandinavian Journal of Immunology, vol. 45, no. 6, pp. 618-622, 1997.
41. G. F. Silveira, P. F. Wowk, A. M. B. Machado, C. N. D. dos Santos, and J. Bordignon, "Immature dendritic cells generated from cryopreserved human monocytes show impaired ability to respond to lps and to induce allogeneic lymphocyte proliferation, " PLoS ONE, vol. 8, no. 7, Article ID e71291, 2013.
42. S.-I. Hori, Y. Heike, M. Takei et al., "Freeze-thawing procedures have no influence on the phenotypic and functional development of dendritic cells generated fromperipheral blood CD14+ monocytes, " Journal of Immunotherapy, vol. 27, no. 1, pp. 27-35, 2004.
43. M. Meijerink, D. Ulluwishewa, R. C. Anderson, and J. M. Wells, "Cryopreservation of monocytes or differentiated immature DCs leads to an altered cytokine response to TLR agonists and microbial stimulation, " Journal of Immunological Methods, vol. 373, no. 1-2, pp. 136-142, 2011.
44. B. Feuerstein, T. G. Berger, C. Maczek et al., "A method for the production of cryopreserved aliquots of antigen-preloaded, mature dendritic cells ready for clinical use, " Journal of Immunological Methods, vol. 245, no. 1-2, pp. 15-29, 2000.
45. P. Lewalle, R. Rouas, F. Lehmann, and P. Martiat, "Freezing of dendritic cells, generated from cryopreserved leukaphereses, does not influence their ability to induce antigen-specific immune responses or functionally react to maturation stimuli, " Journal of Immunological Methods, vol. 240, no. 1-2, pp. 69-78, 2000.
46. J. Westermann, I. J. Körner, J. Kopp et al., "Cryopreservation of mature monocyte-derived human dendritic cells for vaccination: influence on phenotype and functional properties, " Cancer Immunology, Immunotherapy, vol. 52, no. 3, pp. 194-198, 2003.
47. D. Gülen, S. Maas, H. Julius et al., "Cryopreservation of adenovirus-transfected dendritic cells (DCs) for clinical use, " International Immunopharmacology, vol. 13, no. 1, pp. 61-68, 2012.
48. J. John, J. Hutchinson, A. Dalgleish, and H. Pandha, "Cryopreservation of immature monocyte-derived dendritic cells results in enhanced cell maturation but reduced endocytic activity and efficiency of adenoviral transduction, " Journal of Immunological Methods, vol. 272, no. 1-2, pp. 35-48, 2003.
49. M. J. Mansilla, R. Contreras-Cardone, J. Navarro-Barriuso et al., "Cryopreserved Vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients, " Journal of Neuroinflammation, vol. 13, no. 1, article 113, 2016.
50. A. G. S. Van Halteren, O. M. Tysma, E. Van Etten, C. Mathieu, and B. O. Roep, "1?, 25-DihydroxyVitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis, " Journal of Autoimmunity, vol. 23, no. 3, pp. 233-239, 2004.
51. F. S. Kleijwegt, S. Laban, G. Duinkerken et al., "Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells, " The Journal of Immunology, vol. 185, no. 3, pp. 1412-1418, 2010.
52. K. Sochorová, V. Budinský, D. Ro?zková et al., "Paricalcitol (19-nor-1, 25-dihydroxyVitamin D2) and calcitriol (1, 25-dihydroxyVitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells, " Clinical Immunology, vol. 133, no. 1, pp. 69-77, 2009.
53. A. T. Brinke, C. M. U. Hilkens, N. Cools et al., "Clinical use of tolerogenic dendritic cells-harmonization approach in european collaborative effort, " Mediators of Inflammation, vol. 2015, Article ID 471719, 8 pages, 2015.