-
1
-
-
34248359578
-
Natural history of multiple sclerosis: Risk factors and prognostic indicators
-
Vukusic S, Confavreaux C. Natural history of multiple sclerosis: risk factors and prognostic indicators. Curr Opin Neurol. 2007;20(3): 369-374.
-
(2007)
Curr Opin Neurol.
, vol.20
, Issue.3
, pp. 369-374
-
-
Vukusic, S.1
Confavreaux, C.2
-
2
-
-
0024504359
-
The natural history of multiple sclerosis: A geographically based study. I. Clinical course and disability
-
Weinshenker BG, Rice GP, Noseworthy JH, Carriere W, Baskerville J, Ebers GC. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain. 1989;112: 133-146.
-
(1989)
Brain.
, vol.112
, pp. 133-146
-
-
Weinshenker, B.G.1
Rice, G.P.2
Noseworthy, J.H.3
Carriere, W.4
Baskerville, J.5
Ebers, G.C.6
-
3
-
-
84930218860
-
-
Medscape Medical News, Accessed April 9, 2015
-
Jeffrey S. FDA approval for alemtuzumab (Lemtrada) in MS. Medscape Medical News, 2014. Available from: http://www.medscape.com/viewarticle/834994. Accessed April 9, 2015.
-
(2014)
FDA approval for alemtuzumab (Lemtrada) in MS
-
-
Jeffrey, S.1
-
4
-
-
84900471238
-
New management algorithms in multiple sclerosis
-
Sorensen P. New management algorithms in multiple sclerosis. Curr Opin Neurol. 2014;27(3):246-259.
-
(2014)
Curr Opin Neurol.
, vol.27
, Issue.3
, pp. 246-259
-
-
Sorensen, P.1
-
5
-
-
84903217919
-
An update on new and emerging therapies for relapsing-remitting multiple sclerosis
-
Weinstock-Guttman B. An update on new and emerging therapies for relapsing-remitting multiple sclerosis. Am J Manag Care. 2013; 19(17 Suppl):343-354.
-
(2013)
Am J Manag Care.
, vol.19
, Issue.17
, pp. 343-354
-
-
Weinstock-Guttman, B.1
-
6
-
-
84865690684
-
Emerging disease-modifying therapies in multiple sclerosis
-
Perumal J, Khan O. Emerging disease-modifying therapies in multiple sclerosis. Curr Treat Options Neurol. 2012;14(3):256-263.
-
(2012)
Curr Treat Options Neurol.
, vol.14
, Issue.3
, pp. 256-263
-
-
Perumal, J.1
Khan, O.2
-
7
-
-
84930212767
-
2014 Multiple sclerosis therapeutic update
-
Cree BA. 2014 Multiple sclerosis therapeutic update. Neurohospitalist. 2014;4(2):63-65.
-
(2014)
Neurohospitalist.
, vol.4
, Issue.2
, pp. 63-65
-
-
Cree, B.A.1
-
8
-
-
84905382558
-
Impact of diagnosis and early treatment on the course of multiple sclerosis
-
Noyes K, Weinstock-Guttman B. Impact of diagnosis and early treatment on the course of multiple sclerosis. Am J Manag Care. 2013; 19(17 Suppl):321-333.
-
(2013)
Am J Manag Care.
, vol.19
, Issue.17
, pp. 321-333
-
-
Noyes, K.1
Weinstock-Guttman, B.2
-
9
-
-
33846833929
-
Glatiramer acetate in primary progressive multiple sclerosis: Results of a multinational, multicenter, double-blind, placebo-controlled trial
-
Wolinsky JS, Narayana PA, O'Connor P, et al. Glatiramer acetate in primary progressive multiple sclerosis: results of a multinational, multicenter, double-blind, placebo-controlled trial. Ann Neurol. 2007;61(1): 14-24.
-
(2007)
Ann Neurol.
, vol.61
, Issue.1
, pp. 14-24
-
-
Wolinsky, J.S.1
Narayana, P.A.2
O'Connor, P.3
-
10
-
-
70449418132
-
Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial
-
Hawker K, O'Connor P, Freedman MS, et al. Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial. Ann Neurol. 2009; 66(4):460-471.
-
(2009)
Ann Neurol.
, vol.66
, Issue.4
, pp. 460-471
-
-
Hawker, K.1
O'Connor, P.2
Freedman, M.S.3
-
11
-
-
84893856323
-
Treatment options for patients with multiple sclerosis who have a suboptimal response to interferon beta therapy
-
Freedman MS. Treatment options for patients with multiple sclerosis who have a suboptimal response to interferon beta therapy. Eur J Neurol. 2013;21(3):377-387.
-
(2013)
Eur J Neurol.
, vol.21
, Issue.3
, pp. 377-387
-
-
Freedman, M.S.1
-
12
-
-
31544467633
-
The window of therapeutic opportunity in multiple sclerosis: Evidence from monoclonal antibody therapy
-
Coles AJ, Cox A, Le Page E, et al. The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy. J Neurol. 2006;253(1):98-108.
-
(2006)
J Neurol.
, vol.253
, Issue.1
, pp. 98-108
-
-
Coles, A.J.1
Cox, A.2
Le Page, E.3
-
13
-
-
84893506450
-
The clinical course of multiple sclerosis
-
Confavreaux C, Vukusic S. The clinical course of multiple sclerosis. Handb Clin Neurol. 2014;122:343-369.
-
(2014)
Handb Clin Neurol.
, vol.122
, pp. 343-369
-
-
Confavreaux, C.1
Vukusic, S.2
-
14
-
-
84897574115
-
Multiple sclerosis: Current and emerging disease-modifying therapies and treatment strategies
-
Wingerchuk D, Carter J. Multiple sclerosis: current and emerging disease-modifying therapies and treatment strategies. Mayo Clin Proc. 2014;89(2):225-240.
-
(2014)
Mayo Clin Proc.
, vol.89
, Issue.2
, pp. 225-240
-
-
Wingerchuk, D.1
Carter, J.2
-
15
-
-
39749200152
-
Disability and T2 MRI lesions: A 20-year follow-up of patients with relapse onset of multiple sclerosis
-
Fisniku LK, Brex PA, Altmann DR, et al. Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis. Brain. 2008;131 Pt 3:808-817.
-
(2008)
Brain.
, vol.131
, pp. 808-817
-
-
Fisniku, L.K.1
Brex, P.A.2
Altmann, D.R.3
-
16
-
-
0037069230
-
Eight-year follow-up study of brain atrophy in patients with MS
-
Fisher E, Rudick RA, Simon JH, et al. Eight-year follow-up study of brain atrophy in patients with MS. Neurology. 2002;59(9):1412-1420.
-
(2002)
Neurology.
, vol.59
, Issue.9
, pp. 1412-1420
-
-
Fisher, E.1
Rudick, R.A.2
Simon, J.H.3
-
17
-
-
0034743332
-
Ring-enhancement in multiple sclerosis: Marker of disease severity
-
Morgen K, Jeffries NO, Stone R, et al. Ring-enhancement in multiple sclerosis: marker of disease severity. Mult Scler. 2001;7(3):167-171.
-
(2001)
Mult Scler.
, vol.7
, Issue.3
, pp. 167-171
-
-
Morgen, K.1
Jeffries, N.O.2
Stone, R.3
-
18
-
-
84878638136
-
Drugs in development for relapsing multiple sclerosis
-
Ali R, Nicholas RS, Muraro PA. Drugs in development for relapsing multiple sclerosis. Drugs. 2013;73(7):625-650.
-
(2013)
Drugs.
, vol.73
, Issue.7
, pp. 625-650
-
-
Ali, R.1
Nicholas, R.S.2
Muraro, P.A.3
-
20
-
-
84889635309
-
Impact of alemtuzumab treatment on the survival and function of human regulatory T cells in vitro
-
Havari E, Turner MJ, Campos-Rivera J, et al. Impact of alemtuzumab treatment on the survival and function of human regulatory T cells in vitro. Immunology. 2014;141(1):123-131.
-
(2014)
Immunology.
, vol.141
, Issue.1
, pp. 123-131
-
-
Havari, E.1
Turner, M.J.2
Campos-Rivera, J.3
-
21
-
-
84878344070
-
Alemtuzumab treatment of multiple sclerosis
-
Coles A. Alemtuzumab treatment of multiple sclerosis. Semin Neurol. 2013;33(1):66-73.
-
(2013)
Semin Neurol.
, vol.33
, Issue.1
, pp. 66-73
-
-
Coles, A.1
-
22
-
-
77951757865
-
Abnormal B-cell cytokine responses a trigger of T-cell mediated disease in MS?
-
Bar-Or A, Fawaz L, Fan B, et al. Abnormal B-cell cytokine responses a trigger of T-cell mediated disease in MS? Ann Neurol. 2010;67(4): 452-461.
-
(2010)
Ann Neurol.
, vol.67
, Issue.4
, pp. 452-461
-
-
Bar-Or, A.1
Fawaz, L.2
Fan, B.3
-
23
-
-
34249655671
-
Alemtuzumab (Campath-1H) in the treatment of chronic lymphocytic leukemia
-
Lapalombella R, Andritsos L, Baiocchi RA, Lin TS, Byrd JC. Alemtuzumab (Campath-1H) in the treatment of chronic lymphocytic leukemia. Oncogene. 2007;26(25):3644-3653.
-
(2007)
Oncogene.
, vol.26
, Issue.25
, pp. 3644-3653
-
-
Lapalombella, R.1
Andritsos, L.2
Baiocchi, R.A.3
Lin, T.S.4
Byrd, J.C.5
-
24
-
-
84904020925
-
Alemtuzumab: The advantages and challenges of a novel therapy in MS
-
Menge T, Stüve O, Kieseier BC, Hartung HP. Alemtuzumab: the advantages and challenges of a novel therapy in MS. Neurology. 2014;83(1): 87-97.
-
(2014)
Neurology.
, vol.83
, Issue.1
, pp. 87-97
-
-
Menge, T.1
Stüve, O.2
Kieseier, B.C.3
Hartung, H.P.4
-
25
-
-
84907260470
-
Alemtuzumab for the treatment of relapsing-remitting multiple sclerosis: A review of its clinical pharmacology, efficacy and safety
-
Jones D, Goldman M. Alemtuzumab for the treatment of relapsing-remitting multiple sclerosis: a review of its clinical pharmacology, efficacy and safety. Expert Rev Clin Immunol. 2014;10(10):1281-1291.
-
(2014)
Expert Rev Clin Immunol.
, vol.10
, Issue.10
, pp. 1281-1291
-
-
Jones, D.1
Goldman, M.2
-
26
-
-
84922924306
-
Alemtuzumab: A new therapy for active relapsing-remitting multiple sclerosis
-
Hartung H, Aktas O, Boyko AN. Alemtuzumab: a new therapy for active relapsing-remitting multiple sclerosis. Mult Scler. 2015;21(1):22-34.
-
(2015)
Mult Scler.
, vol.21
, Issue.1
, pp. 22-34
-
-
Hartung, H.1
Aktas, O.2
Boyko, A.N.3
-
27
-
-
77957044257
-
Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity
-
Jones JL, Anderson JM, Phuah CL, et al. Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity. Brain. 2010;133 Pt 8:2232-2247.
-
(2010)
Brain.
, vol.133
, pp. 2232-2247
-
-
Jones, J.L.1
Anderson, J.M.2
Phuah, C.L.3
-
28
-
-
84868525833
-
B cells and antibodies in multiple sclerosis pathogenesis and therapy
-
Krumbholz M, Derfuss T, Hohlfeld R, Meinl E. B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat Rev Neurol. 2012;8(11):613-623.
-
(2012)
Nat Rev Neurol.
, vol.8
, Issue.11
, pp. 613-623
-
-
Krumbholz, M.1
Derfuss, T.2
Hohlfeld, R.3
Meinl, E.4
-
29
-
-
84861556651
-
Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis
-
Elliot C, Lindner M, Arthur A, et al. Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain. 2012;135(6):1819-1833.
-
(2012)
Brain.
, vol.135
, Issue.6
, pp. 1819-1833
-
-
Elliot, C.1
Lindner, M.2
Arthur, A.3
-
30
-
-
23744454283
-
Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange
-
Keegan M, König F, McClelland R, et al. Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange. Lancet. 2005;366(9485):579-582.
-
(2005)
Lancet.
, vol.366
, Issue.9485
, pp. 579-582
-
-
Keegan, M.1
König, F.2
McClelland, R.3
-
31
-
-
84872852405
-
Immunoadsorption in steroid-refractory multiple sclerosis: Clincial experience in 60 patients
-
Heigl F, Hettich R, Arendt R, Durner J, Koehler J, Mauch E. Immunoadsorption in steroid-refractory multiple sclerosis: clincial experience in 60 patients. Atheroscler Suppl. 2013;14(1):167-173.
-
(2013)
Atheroscler Suppl.
, vol.14
, Issue.1
, pp. 167-173
-
-
Heigl, F.1
Hettich, R.2
Arendt, R.3
Durner, J.4
Koehler, J.5
Mauch, E.6
-
32
-
-
55149110100
-
Rituximab induces clinical stabilization in a patient with fulminant multiple sclerosis not responding to natalizumab: Evidence for disease heterogeneity
-
Leussink VI, Lehmann HC, Meyer zu Hörste G, Hartung HP, Stüve O, Kieseier BC. Rituximab induces clinical stabilization in a patient with fulminant multiple sclerosis not responding to natalizumab: evidence for disease heterogeneity. J Neurol. 2008;255(9):1436-1438.
-
(2008)
J Neurol.
, vol.255
, Issue.9
, pp. 1436-1438
-
-
Leussink, V.I.1
Lehmann, H.C.2
Meyer zu Hörste, G.3
Hartung, H.P.4
Stüve, O.5
Kieseier, B.C.6
-
33
-
-
26444598492
-
Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis
-
Stüve O, Cepok S, Elias B, et al. Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis. Arch Neurol. 2005;62(10):1620-1623.
-
(2005)
Arch Neurol.
, vol.62
, Issue.10
, pp. 1620-1623
-
-
Stüve, O.1
Cepok, S.2
Elias, B.3
-
34
-
-
60549116884
-
Long-term B-lymphocyte depletion with rituximab in patients with relapsing-remitting multiple sclerosis
-
Stüve O, Leussink VI, Fröhlich R, et al. Long-term B-lymphocyte depletion with rituximab in patients with relapsing-remitting multiple sclerosis. Arch Neurol. 2009;66(2):259-261.
-
(2009)
Arch Neurol.
, vol.66
, Issue.2
, pp. 259-261
-
-
Stüve, O.1
Leussink, V.I.2
Fröhlich, R.3
-
35
-
-
77249114139
-
B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis
-
Thompson S, Jones JL, Cox AL, Compston DA, Coles AJ. B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis. J Clin Immunol. 2010;30(1):99-105.
-
(2010)
J Clin Immunol.
, vol.30
, Issue.1
, pp. 99-105
-
-
Thompson, S.1
Jones, J.L.2
Cox, A.L.3
Compston, D.A.4
Coles, A.J.5
-
36
-
-
33644584352
-
A randomized placebo-controlled trial of natalizumab for relapsing multiple sclerosis
-
Polman CH, O'Connor PW, Havrdova E, et al. A randomized placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med. 2006;354(9):899-891.
-
(2006)
N Engl J Med.
, vol.354
, Issue.9
-
-
Polman, C.H.1
O'Connor, P.W.2
Havrdova, E.3
-
37
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
Kappos L, Radue EW, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010; 362(5):387-401.
-
(2010)
N Engl J Med.
, vol.362
, Issue.5
, pp. 387-401
-
-
Kappos, L.1
Radue, E.W.2
O'Connor, P.3
-
38
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010; 362(5): 402-415.
-
(2010)
N Engl J Med.
, vol.362
, Issue.5
, pp. 402-415
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
-
39
-
-
80053533877
-
Randomized trial of oral teriflunomide for relapsing multiple sclerosis
-
O'Connor P, Wolinsky JS, Confavreux C, et al. Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med. 2011; 365(14):1293-1303.
-
(2011)
N Engl J Med.
, vol.365
, Issue.14
, pp. 1293-1303
-
-
O'Connor, P.1
Wolinsky, J.S.2
Confavreux, C.3
-
40
-
-
84884339141
-
Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: Subgroup analyses of the DEFINE study
-
Bar-Or A, Gold R, Kappos L, et al. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the DEFINE study. J Neurol. 2013;260(9): 2297-2305.
-
(2013)
J Neurol.
, vol.260
, Issue.9
, pp. 2297-2305
-
-
Bar-Or, A.1
Gold, R.2
Kappos, L.3
-
41
-
-
84866355653
-
Placebo-controlled Phase 3 study of oral BG-12 or glatiramer in multiple sclerosis
-
Fox RJ, Miller DH, Phillips JT, et al. Placebo-controlled Phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med. 2012;367(12):1087-1097.
-
(2012)
N Engl J Med.
, vol.367
, Issue.12
, pp. 1087-1097
-
-
Fox, R.J.1
Miller, D.H.2
Phillips, J.T.3
-
42
-
-
84869492471
-
Alemtuzumab versus interferon beta-1a as a first-line treatment for patients with relapsing-remitting multiple sclerosis: A randomized controlled phase 3 trial
-
Cohen JA, Coles AJ, Arnold DL, et al. Alemtuzumab versus interferon beta-1a as a first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomized controlled phase 3 trial. Lancet. 2012; 380(9856):1819-1828.
-
(2012)
Lancet.
, vol.380
, Issue.9856
, pp. 1819-1828
-
-
Cohen, J.A.1
Coles, A.J.2
Arnold, D.L.3
-
43
-
-
84869507357
-
Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: A randomised controlled phase 3 trial
-
Coles AJ, Twyman CL, Arnold DL, et al. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet. 2012;380(9856): 1829-1839.
-
(2012)
Lancet.
, vol.380
, Issue.9856
, pp. 1829-1839
-
-
Coles, A.J.1
Twyman, C.L.2
Arnold, D.L.3
-
44
-
-
84874920634
-
Alemtuzumab: Evidence for its potential in relapsing-remitting multiple sclerosis
-
Brown JW, Coles AJ. Alemtuzumab: evidence for its potential in relapsing-remitting multiple sclerosis. Drug Des Devel Ther. 2013;7: 131-138.
-
(2013)
Drug Des Devel Ther.
, vol.7
, pp. 131-138
-
-
Brown, J.W.1
Coles, A.J.2
-
45
-
-
54949143968
-
Alemtuzumab vs interferon beta-1a in early multiple sclerosis: The CAMMS223 trial investigators
-
CAMMS223 Trial Investigators, Coles AJ, Compston DA, Selmaj KW, et al. Alemtuzumab vs interferon beta-1a in early multiple sclerosis: the CAMMS223 trial investigators. N Engl J Med. 2008; 359(17): 1786-1801.
-
(2008)
N Engl J Med.
, vol.359
, Issue.17
, pp. 1786-1801
-
-
Coles, A.J.1
Compston, D.A.2
Selmaj, K.W.3
CAMMS223 Trial Investigators4
-
46
-
-
84860780657
-
Alemtuzumab more effective than interferon b-1a at 5-year follow up of CAMMS223 trial
-
Coles A, Coles AJ, Fox E, Vladic A, et al. Alemtuzumab more effective than interferon b-1a at 5-year follow up of CAMMS223 trial. Neurology. 2012;78(14):1069-1078.
-
(2012)
Neurology.
, vol.78
, Issue.14
, pp. 1069-1078
-
-
Coles, A.1
Coles, A.J.2
Fox, E.3
Vladic, A.4
-
47
-
-
77956209762
-
A novel strategy to reduce the immunogenicity of biological therapies
-
Somerfield J, Hill-Cawthorne GA, Lin A, et al. A novel strategy to reduce the immunogenicity of biological therapies. J Immunol. 2010; 185(1):763-768.
-
(2010)
J Immunol.
, vol.185
, Issue.1
, pp. 763-768
-
-
Somerfield, J.1
Hill-Cawthorne, G.A.2
Lin, A.3
-
48
-
-
84921319094
-
Alemtuzumab treatment of multiple sclerosis: Long-term safety and efficacy
-
Tuohy O, Costelloe L, Hill-Cawthorne G, et al. Alemtuzumab treatment of multiple sclerosis: long-term safety and efficacy. J Neurol Neurosurg Psychiatry. 2015;86(2):208-215.
-
(2015)
J Neurol Neurosurg Psychiatry.
, vol.86
, Issue.2
, pp. 208-215
-
-
Tuohy, O.1
Costelloe, L.2
Hill-Cawthorne, G.3
-
49
-
-
84880440010
-
Alemtuzumab in multiple sclerosis: Latest evidence and clinical prospects
-
Kousin-Ezewu O, Coles A. Alemtuzumab in multiple sclerosis: latest evidence and clinical prospects. Ther Adv Chronic Dis. 2013;4(3): 97-103.
-
(2013)
Ther Adv Chronic Dis.
, vol.4
, Issue.3
, pp. 97-103
-
-
Kousin-Ezewu, O.1
Coles, A.2
-
50
-
-
49449108196
-
Anti-glomerular basement membrane disease after alemtuzumab
-
Clatworthy MR, Wallin EF, Jayne DR. Anti-glomerular basement membrane disease after alemtuzumab. N Engl J Med. 2008;359(7): 768-769.
-
(2008)
N Engl J Med.
, vol.359
, Issue.7
, pp. 768-769
-
-
Clatworthy, M.R.1
Wallin, E.F.2
Jayne, D.R.3
-
51
-
-
84876473109
-
Randomized study combining interferon and glatiramer acetate in multiple sclerosis
-
Lublin FD, Cofield SS, Cutter GR, et al. Randomized study combining interferon and glatiramer acetate in multiple sclerosis. Ann Neurol. 2013;73(3):327-340.
-
(2013)
Ann Neurol.
, vol.73
, Issue.3
, pp. 327-340
-
-
Lublin, F.D.1
Cofield, S.S.2
Cutter, G.R.3
|