Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients

Journal of Neuroinflammation

Volumn 13, Issue 1, 2016, Pages

  Mansilla, María José ^a,b   Contreras Cardone, Raian ^a   Navarro Barriuso, Juan ^a,b   Cools, Nathalie ^c   Berneman, Zwi ^c   Ramo Tello, Cristina ^a   Martínez Cáceres, Eva María ^a,b  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Breg; EAE; Multiple sclerosis; NK cells; NKT cells; Tolerogenic dendritic cells; Treg

Indexed keywords

AUTOANTIGEN; COLECALCIFEROL; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN[40-55]; UNCLASSIFIED DRUG; CYTOKINE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); PEPTIDE FRAGMENT; POLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BONE MARROW DERIVED DENDRITIC CELL; CONTROLLED STUDY; CRYOPRESERVATION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; FREEZE THAWING; MOUSE; MULTIPLE SCLEROSIS; NATURAL KILLER CELL; NONHUMAN; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TOLEROGENIC DENDRITIC CELL; ANIMAL; C57BL MOUSE; CELL TRANSPLANTATION; DENDRITIC CELL; DISEASE MODEL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FOLLOW UP; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PROCEDURES; TIME FACTOR; TRANSPLANTATION;

ANIMALS; AUTOANTIGENS; CELL TRANSPLANTATION; CHOLECALCIFEROL; CRYOPRESERVATION; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FOLLOW-UP STUDIES; KILLER CELLS, NATURAL; MICE; MICE, INBRED C57BL; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; PEPTIDE FRAGMENTS; POLYSACCHARIDES; TIME FACTORS;

EID: 84974575595     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0584-9     Document Type: Article

References (25)

1. Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372(9648):1502-17. doi: 10.1016/S0140-6736(08)61620-7.
2. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG. Multiple sclerosis. N Engl J Med. 2000;343(13):938-52. doi: 10.1056/NEJM200009283431307.
3. Fletcher JM, Lalor SJ, Sweeney CM, Tubridy N, Mills KH. T cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Clin Exp Immunol. 2010;162(1):1-11. doi: 10.1111/j.1365-2249.2010.04143.x.
4. Rostami A, Ciric B. Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination. J Neurol Sci. 2013;333(1-2):76-87. doi: 10.1016/j.jns.2013.03.002.
5. Hilkens CM, Isaacs JD, Thomson AW. Development of dendritic cell-based immunotherapy for autoimmunity. Int Rev Immunol. 2010;29(2):156-83. doi: 10.3109/08830180903281193.
6. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol. 2003;21:685-711. doi: 10.1146/annurev.immunol.21.120601.141040.
7. 3-treated tolerogenic dendritic cells. Front Immunol. 2013;4:113. doi: 10.3389/fimmu.2013.00113.
8. Raiotach-Regue D, Grau-Lopez L, Naranjo-Gomez M, Ramo-Tello C, Pujol-Borrell R, Martinez-Caceres E, et al. Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients. Eur J Immunol. 2012;42(3):771-82. doi: 10.1002/eji.201141835.
9. Mansilla MJ, Selles-Moreno C, Fabregas-Puig S, Amoedo J, Navarro-Barriuso J, Teniente-Serra A, et al. Beneficial effect of tolerogenic dendritic cells pulsed with MOG autoantigen in experimental autoimmune encephalomyelitis. CNS Neurosci Ther. 2015;21(3):222-30. doi: 10.1111/cns.12342.
10. Radhakrishnan AK, Sim GC, Cheong SK. Comparing the ability of freshly generated and cryopreserved dendritic cell vaccines to inhibit growth of breast cancer in a mouse model. BioResearch open access. 2012;1(5):239-46. doi: 10.1089/biores.2012.0229.
11. Giannoukakis N, Phillips B, Finegold D, Harnaha J, Trucco M. Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care. 2011;34(9):2026-32. doi: 10.2337/dc11-0472.
12. Moreau A, Varey E, Beriou G, Hill M, Bouchet-Delbos L, Segovia M, et al. Tolerogenic dendritic cells and negative vaccination in transplantation: from rodents to clinical trials. Front Immunol. 2012;3:218. doi: 10.3389/fimmu.2012.00218.
13. Thomson AW, Robbins PD. Tolerogenic dendritic cells for autoimmune disease and transplantation. Ann Rheum Dis. 2008;67 Suppl 3:iii90-6. doi: 10.1136/ard.2008.099176.
14. Benham H, Nel HJ, Law SC, Mehdi AM, Street S, Ramnoruth N, et al. Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients. Sci Transl Med. 2015;7(290):290ra87. doi: 10.1126/scitranslmed.aaa9301.
15. Jauregui-Amezaga A, Cabezon R, Ramirez-Morros A, Espana C, Rimola J, Bru C, et al. Intraperitoneal administration of autologous tolerogenic dendritic cells for refractory Crohn's disease: a phase I study. J Crohns Colitis. 2015;9(12):1071-8. doi: 10.1093/ecco-jcc/jjv144.
16. Bell G, Anderson A, Diboll J, Reece R, Eltherington O, Harry RA et al. Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis (AuToDeCRA). Ann Rheum Dis. 2016. In press.
17. Ten Brinke A, Hilkens CM, Cools N, Geissler EK, Hutchinson JA, Lombardi G, et al. Clinical use of tolerogenic dendritic cells-harmonization approach in European collaborative effort. Mediat Inflamm. 2015;2015:471719. doi: 10.1155/2015/471719.
18. Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity. 2008;28(5):639-50. doi: 10.1016/j.immuni.2008.03.017.
19. Mauri C. Regulation of immunity and autoimmunity by B cells. Curr Opin Immunol. 2010;22(6):761-7. doi: 10.1016/j.coi.2010.10.009.
20. Di Caro V, Phillips B, Engman C, Harnaha J, Trucco M, Giannoukakis N. Retinoic acid-producing, ex-vivo-generated human tolerogenic dendritic cells induce the proliferation of immunosuppressive B lymphocytes. Clin Exp Immunol. 2013;174(2):302-17. doi: 10.1111/cei.12177.
21. Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol. 2007;25:297-336. doi: 10.1146/annurev.immunol.25.022106.141711.
22. Caielli S, Sorini C, Falcone M. The dangerous liaison between iNKT cells and dendritic cells: does it prevent or promote autoimmune diseases? Autoimmunity. 2011;44(1):11-22. doi: 10.3109/08916931003782130.
23. Novak J, Lehuen A. Mechanism of regulation of autoimmunity by iNKT cells. Cytokine. 2011;53(3):263-70. doi: 10.1016/j.cyto.2010.11.001.
24. Hayakawa Y, Smyth MJ. CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J Immunol. 2006;176(3):1517-24.
25. Hayakawa Y, Huntington ND, Nutt SL, Smyth MJ. Functional subsets of mouse natural killer cells. Immunol Rev. 2006;214:47-55. doi: 10.1111/j.1600-065X.2006.00454.x.