Development and optimization of ultra-high performance supercritical fluid chromatography mass spectrometry method for high-throughput determination of tocopherols and tocotrienols in human serum

Analytica Chimica Acta

Volumn 934, Issue , 2016, Pages 252-265

  Pilařová, Veronika ^a   Gottvald, Tomáš ^a   Svoboda, Pavel ^a   Novák, Ondřej ^b   Benešová, Karolína ^c   Běláková, Sylvie ^c   Nováková, Lucie ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b INSTITUTE OF EXPERIMENTAL BOTANY   (Czech Republic)

^c Research Institute of Brewing and Malting   (Czech Republic)

Author keywords

Human serum; Liquid liquid extraction; Mass spectrometry; Tocopherols; Tocotrienols; Ultra high performance supercritical fluid chromatography

Indexed keywords

BODY FLUIDS; CARBON DIOXIDE; CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; EFFLUENT TREATMENT; GAS CHROMATOGRAPHY; ISOMERS; LIQUIDS; MASS SPECTROMETRY; POSITIVE IONS; PRECIPITATION (CHEMICAL); SOLVENT EXTRACTION; SUPERCRITICAL FLUIDS; THROUGHPUT;

HUMAN SERUM; LIQUID-LIQUID EXTRACTION; SUPER CRITICAL FLUID CHROMATOGRAPHY; TOCOPHEROLS; TOCOTRIENOLS;

LIQUID CHROMATOGRAPHY;

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; TOCOPHEROL;

ARTICLE; CONTROLLED STUDY; FLOW RATE; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; SENSITIVITY ANALYSIS; SUPERCRITICAL FLUID CHROMATOGRAPHY; TEMPERATURE SENSITIVITY; ULTRA HIGH PERFORMANCE SUPERCRITICAL FLUID CHROMATOGRAPHY; VITAMIN BLOOD LEVEL; BLOOD; CHEMISTRY; CONFORMATION; HUMAN;

CHROMATOGRAPHY, SUPERCRITICAL FLUID; HUMANS; LIQUID-LIQUID EXTRACTION; MASS SPECTROMETRY; MOLECULAR CONFORMATION; TOCOPHEROLS; TOCOTRIENOLS;

EID: 84989808828     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2016.06.008     Document Type: Article

References (49)

1. [1] Colombo, M.L., An update on vitamin E, tocopherol and tocotrienol – perspectives. Molecules 15 (2010), 2103–2113.
2. [2] Clemente, H.A., Ramalho, H.M.M., Lima, M.S.R., Grilo, E.C., Dimensteinn, R., Maternal supplementation with natural or synthetic vitamin E and its levels in human colostrum. JPGN 60 (2015), 535–537.
3. n),. Food Chem. 134 (2012), 559–563.
4. [4] Paz San Andrés, M., Otero, J., Vera, S., High performance liquid chromatography method for the simultaneous determination of α-, γ- and δ-tocopherol in vegetable oils in presence of hexaseyltrimethylammonium bromide/n-propanol in mobile phase. Food. Chem. 126 (2011), 1470–1474.
5. [5] Drotleff, A.M., Bohnsack, C., Schneider, I., Hahn, A., Ternes, W., Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocotrienol-low) barely oil and palm oil formulations. J. Funct. Foods 7 (2014), 150–160.
6. [6] Huang, H.-Y., Appel, L.J., Supplementation of diets with α- tocopherol reduces serum concentration of γ- and δ- tocopherol in humans. J. Nutr. 133 (2003), 3137–3140.
7. [7] Sen, C.K., Khanna, S., Roy, S., Tocotrienols in health and disease: the other half of the natural vitamin E family,. Mol. Asp. Med. 28 (2007), 692–728.
8. [8] Aggarwal, B.B., Sundaram, C., Prasad, S., Kannappan, R., Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem. Pharmacol. 80 (2010), 1613–1631.
9. [9] Pinheiro-Sant'Ana, H.M., Guinazi, M., da Silva Oliviera, D., Della Lucia, C.M., de Lazzari Reis, B., Cardoso Brandão, S.C., Method for simultaneous analysis of eight vitamin E isomers in various foods by high performance liquid chromatography and fluorescence detection. J. Chromatogr. A 1218 (2011), 8496–8502.
10. [10] Krinsky, N.I., Human requirements for fat-soluble vitamins, and other things concerning these nutrients. Mol. Asp. Med. 24 (2003), 317–324.
11. [11] Podsedek, A., Natural antioxidants and antioxidant capacity of Brassica vegetables: a review. LWT 40 (2007), 1–11.
12. [12] Eitenmiller, R., Lee, J., VITAMIN E: Food Chemistry, Composition and Analysis. 2004, Marcel Dekker Inc., New York, 438–493.
13. [13] Blatt, D.H., Leonard, S.W., Traber, M.G., Vitamin E kinetics and the function of tocopherol regulatory proteins. Nutrition 17 (2001), 799–805.
14. [14] Dutta-Roy, A.K., Molecular mechanism of cellula uptake and intracellular translocation of α-tocopherol: role of tocopherol-binding proteins. Food Chem. Toxicol. 37 (1999), 967–971.
15. [15] Packer, L., Fuchs, J., VITAMIN E in Health and Disease: Biochemistry and Clinical Applications. 1993, Marcel Dekker Inc., New York, 861–862.
16. [16] Traber, M.G., Manor, D., Vitamin E. Adv. Nutr. 3 (2012), 330–331.
17. [17] Traber, M.G., Atkinson, J., Vitamin E, antioxidant and nothing more. J. Free Rad. BioL. Med. 43 (2007), 4–15.
18. [18] Traber, M.G., Mechanisms for the prevention of vitamin E excess. J. Lipid Res. 54 (2013), 2295–2306.
19. [19] Rupérez, F.J., Martín, D., Herrera, E., Barbas, C., Chromatographic analysis of α-tocopherol and related compounds in various matrices. J. Chromatogr A 935 (2001), 45–69.
20. [20] Ibanez, E., Palacios, J., Reglero, G., Analysis of tocopherols by on-line coupling supercritical fluid extraction - supercritical fluid chromatography. J. Microcolumn Sep. 11 (1999), 605–611.
21. [21] Manninen, P., Laakso, P., Kallio, H., Method for characterization of triacylglycerols ad fat-soluble vitamins in edible oils and fats by supercritical fluid chromatography. J. Am. Oil Chem. Soc. 72 (1995), 1001–1008.
22. [22] Galuba, G., Gogolewski, M., Separation of tocopherols and sterols in soybean oil condensate utilizing supercritical fluid chromatography. Chem. Anal. Wars. 42 (1997), 245–248.
23. [23] Méjean, M., Brunelle, A., Touboul, D., Quantification of tocopherols and tocotrienols in soybean oil by supercritical-fluid chromatography coupled to high-resolution mass spectrometry. Anal. Bioanal. Chem. 407 (2015), 5133–5142.
24. [24] Gee, P.T., Liew, C.Y., Thong, M.C., Gaym, M.C.L., Vitamin E analysis by ultra-performance convergence chromatography and structural elucidation of novel α-tocodienol by high-resolution mass spectrometry. Food Chem. 196 (2016), 367–373.
25. [25] Andrés, M.P.S., Otero, J., Vera, S., High performance liquid chromatography method for the simultaneous determination of α-, γ- and δ-tocopherol in vegetable oils in presence of hexadecyltrimethylammonium bromide/n-propanol in mobile phase. Food Chem. 126 (2011), 1470–1474.
26. [26] Pinheiro-Sant'Ana, H.M., Guinazi, M., da Silva Oliviera, D., Lucia, C.M.D., de Lazzari Reis, B., Brandao, S.C.C., Method for simultaneous analysis of eight vitamin E isomers in various foods by high performance liquid chromatography and fluorescence detection. J. Chromatogr. A 1218 (2011), 8496–8502.
27. [27] Grebenstein, N., Frank, J., Rapid baseline-separation of all eight tocopherols and tocotrienols by reversed-phase liquid chromatography with a solid-core pentafluorophenyl column and their sensitive quantification in plasma and liver. J. Chromatogr. A 1243 (2012), 39–46.
28. [28] Knecht, K., Sandfuchs, K., Kulling, S.E., Bunzel, D., Tocopherol and tocotrienol analysis in raw and cooked vegetables: a validated method with emphasis on sample preparation. Food Chem. 169 (2015), 20–27.
29. [29] Vinas, P., Bravo-Bravo, M., Lopez-García, I., Pastor-Belda, M., Hernandéz-Córdoba, M., Pressurized liquid extraction and dispersive liquid-liquid microextraction for determination of tocopherols and tocotrienols in plant foods by liquid chromatography with fluorescence and atmospheric pressure chemical ionization-mass spectrometry detection. Talanta 119 (2014), 98–114.
30. [30] Shammugasamy, B., Ramakrishnan, Y., Ghazali, H.M., Muhammad, K., Combination of saponification and dispersive liquid-liquid microextraction for the determination of tocopherols and tocotrienols in cereals by reversed-phase high-performance liquid chromatography. J. Chromatogr. A 1300 (2013), 31–37.
31. [31] Chávez-Servín, J.L., Castellote, A.I., Lopéz-Sabater, M.C., Simultaneous analysis of Vitamins A and E in infant milk-based formulae by normal-phase high performance liquid chromatography-diode array detection using a short narrow-bore column. J. Chromatogr. A 1122 (2006), 138–143.
32. [32] Huang, S.-H., Ng, L.-T., An improved high-performance liquid chromatographic method for simultaneous determination of tocopherols, tocotrienols and γ-oryzanol in rice. J. Chromatogr. A 1218 (2011), 4709–4713.
33. [33] Yuan, C., Burgyan, M., Bunch, D.R., Reineks, E., Jackson, R., Steinle, R., Wang, S., Fast, simple, and sensitive high-performance liquid chromatography method for measuring vitamins A and E in human blood plasma. J. Sep. Sci. 37 (2014), 2293–2299.
34. [34] Richellle, M., Tavazzi, I., Fay, L.B., Simultaneous determination of deuterated and non-deuterated α-tocopherol in human plasma by high-performance liquid chromatography. J. Chromatogr. B 794 (2003), 1–8.
35. [35] Chatzimichalakis, P.F., Samanidou, V.F., Papadoyannis, I.N., Development of a validated liquid chromatography method for the simultaneous determination of eight fat-soluble vitamins in biological fluids after solid-phase extraction. J. Chromatogr. B 805 (2004), 289–296.
36. [36] Desfontaine, V., Guillarme, D., Francotte, E., Nováková, L., Supercritical fluid chromatography in pharmaceutical analysis. J. Pharm. Biomed. Anal. 113 (2015), 56–71.
37. [37] Taylor, L.T., Supercritical fluid chromatography for the 21st century. J. Supercrit. Fluids 47 (2009), 566–573.
38. [38] Kalíková, K., Šlechtová, T., Vozka, J., Tesařová, E., Supercritical fluid chromatography as a tool for enantioselective separation; A review. Anal. Chim. Acta 821 (2014), 1–33.
39. [39] Spaggiari, D., Mehl, F., Desfontaine, V., Grand-Guillaume Perrenoud, A., Fekete, S., Rudaz, S., Guillarme, D., Comparison of liquid chromatography and supercritical fluid chromatography coupled to compact single quadrupole mass spectrometer for targeted in vitro metabolism assay. J. Chromatogr. A 1371 (2014), 244–256.
40. [40] Grand-Guillaume Perrenoud, A., Veuthey, J.-L., Guillarme, D., The use of columns packed with sub-2 μm particles in supercritical fluid chromatography. Trends Anal. Chem. 63 (2014), 44–54.
41. [41] Nováková, L., Grand-Guillaume Perrenoud, A., Francois, I., West, C., Lesellier, E., Guillarme, D., Modern analytical supercritical fluid chromatography using columns packed with sub-2 μm particles: a tutorial. Anal. Chim. Acta 824 (2014), 18–35.
42. [42] Grand-Guillaume Perrenoud, A., Veuthey, J.-L., Guillarme, D., Comparison of ultra-high performance supercritical fluid chromatography and ultra-high performance liquid chromatography for the analysis of pharmaceutical compound. J. Chromatogr. A 1266 (2012), 158–167.
43. [43] Nováková, L., Grand-Guillaume Perrenoud, A., Nicoli, R., Saugy, M., Veuthey, J.-L., Guillarme, D., Ultra-high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. I: investigation of mobile phase and MS conditions. Anal. Chim. Acta 853 (2015), 637–646.
44. [44] Grand-Guillaume Perrenoud, A., Veuthey, J.-L., Guillarme, D., Coupling state-of-the-art supercritical fluid chromatography and mass spectrometry: from hyphenation interface optimization to high-sensitivity analysis of pharmaceutical compounds. J. Chromatogr. A 1339 (2014), 174–184.
45. [45] http://www.chemicalize.org/10th March 2016.
46. [46] EMA Guideline on bioanalytical method validation online available 10th March 2016.
47. [47] Matuszewski, B.K., Constanzer, M.L., Chavez-Eng, C.M., Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 75 (2003), 3019–3030.
48. [48] Lesellier, E., West, C., The many faces of packed column supercritical fluid chromatography – a review. J. Chromatogr. A 1382 (2015), 2–46.
49. [49] Tarafder, A., Guiochon, G., Unexpected retention behaviour of supercritical fluid chromatography at the low density near critical region of carbon dioxide. J. Chromatogr. A 1229 (2012), 249–259.