메뉴 건너뛰기




Volumn 7, Issue 1, 2014, Pages 150-160

Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulations

Author keywords

Barley extract; Blood plasma; Human oral bioavailability; Tocotrienol composition; Urinary metabolites; Vitamin E

Indexed keywords

HORDEUM;

EID: 84898047698     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2014.01.001     Document Type: Article
Times cited : (27)

References (46)
  • 1
    • 84863716186 scopus 로고    scopus 로고
    • Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: In vitro, in situ and in vivo studies
    • Abuasal B.S., Qosa H., Sylvester P.W., Kaddoumi A. Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: In vitro, in situ and in vivo studies. Biopharmaceutics & Drug Disposition 2012, 33:246-256.
    • (2012) Biopharmaceutics & Drug Disposition , vol.33 , pp. 246-256
    • Abuasal, B.S.1    Qosa, H.2    Sylvester, P.W.3    Kaddoumi, A.4
  • 2
    • 77957909450 scopus 로고    scopus 로고
    • Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases
    • Aggarwal B.B., Sundaram C., Prasad S., Kannappan R. Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases. Biochemical Pharmacology 2010, 80:1613-1631.
    • (2010) Biochemical Pharmacology , vol.80 , pp. 1613-1631
    • Aggarwal, B.B.1    Sundaram, C.2    Prasad, S.3    Kannappan, R.4
  • 4
    • 79957648820 scopus 로고    scopus 로고
    • Functional foods development in the European market: A consumer perspective
    • Annunziata A., Vecchio R. Functional foods development in the European market: A consumer perspective. Journal of Functional Foods 2011, 3:223-228.
    • (2011) Journal of Functional Foods , vol.3 , pp. 223-228
    • Annunziata, A.1    Vecchio, R.2
  • 5
    • 22844454988 scopus 로고    scopus 로고
    • Effect of vitamin C supplementation on concentrations of vitamins C and E in fasting plasma
    • Benzie I., Strain J.J. Effect of vitamin C supplementation on concentrations of vitamins C and E in fasting plasma. Asia Pacific Journal of Clinical Nutrition 1999, 8:207-210.
    • (1999) Asia Pacific Journal of Clinical Nutrition , vol.8 , pp. 207-210
    • Benzie, I.1    Strain, J.J.2
  • 6
    • 0036791124 scopus 로고    scopus 로고
    • Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells
    • Birringer M., Pfluger P., Kluth D., Landes N., Brigelius-Flohé R. Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells. Journal of Nutrition 2002, 132:3113-3118.
    • (2002) Journal of Nutrition , vol.132 , pp. 3113-3118
    • Birringer, M.1    Pfluger, P.2    Kluth, D.3    Landes, N.4    Brigelius-Flohé, R.5
  • 8
    • 84895070725 scopus 로고    scopus 로고
    • Nutraceutical-based therapeutics and formulation strategies augmenting their efficiency to complement modern medicine: An overview
    • Braithwaite M.C., Tyagi C., Tomar L.K., Kumar P., Choonara Y.E., Pillay V. Nutraceutical-based therapeutics and formulation strategies augmenting their efficiency to complement modern medicine: An overview. Journal of Functional Foods 2013, http://dx.doi.org/10.1016/j.jff.2013.09.022.
    • (2013) Journal of Functional Foods
    • Braithwaite, M.C.1    Tyagi, C.2    Tomar, L.K.3    Kumar, P.4    Choonara, Y.E.5    Pillay, V.6
  • 12
    • 33644860047 scopus 로고    scopus 로고
    • Supplementation with mixed tocopherols increases serum and blood cell γ-tocopherol but does not alter biomarkers, of platelet activation in subjects with type 2 diabetes
    • Clarke M.W., Ward N.C., Wu J.H.Y., Hodgson J.M., Puddey I.B., Croft K.D. Supplementation with mixed tocopherols increases serum and blood cell γ-tocopherol but does not alter biomarkers, of platelet activation in subjects with type 2 diabetes. American Journal of Clinical Nutrition 2006, 83:95-102.
    • (2006) American Journal of Clinical Nutrition , vol.83 , pp. 95-102
    • Clarke, M.W.1    Ward, N.C.2    Wu, J.H.Y.3    Hodgson, J.M.4    Puddey, I.B.5    Croft, K.D.6
  • 13
    • 33845906092 scopus 로고    scopus 로고
    • Functional diversity of tocochromanols in plants
    • Dörmann P. Functional diversity of tocochromanols in plants. Planta 2007, 225:269-276.
    • (2007) Planta , vol.225 , pp. 269-276
    • Dörmann, P.1
  • 14
    • 33750620058 scopus 로고    scopus 로고
    • Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of α-tocopherol
    • Fairus S., Nor R.M., Cheng H.M., Sundram K. Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of α-tocopherol. American Journal of Clinical Nutrition 2006, 84:835-842.
    • (2006) American Journal of Clinical Nutrition , vol.84 , pp. 835-842
    • Fairus, S.1    Nor, R.M.2    Cheng, H.M.3    Sundram, K.4
  • 15
    • 84855766685 scopus 로고    scopus 로고
    • Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation
    • Fairus S., Nor R.M., Cheng H.M., Sundram K. Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation. Nutrition Journal 2012, 11(5):1-11.
    • (2012) Nutrition Journal , vol.11 , Issue.5 , pp. 1-11
    • Fairus, S.1    Nor, R.M.2    Cheng, H.M.3    Sundram, K.4
  • 16
    • 0032318592 scopus 로고    scopus 로고
    • Identification and estimation of tocotrienols in the annatto lipid fraction by gas chromatography mass spectrometry
    • Frega N., Mozzon M., Bocci F. Identification and estimation of tocotrienols in the annatto lipid fraction by gas chromatography mass spectrometry. Journal of the American Oil Chemists Society 1998, 75:1723-1727.
    • (1998) Journal of the American Oil Chemists Society , vol.75 , pp. 1723-1727
    • Frega, N.1    Mozzon, M.2    Bocci, F.3
  • 17
    • 65349107677 scopus 로고    scopus 로고
    • Γ-Tocotrienol and γ-tocopherol are primarily metabolized to conjugated 2-(β-carboxyethyl)-6-hydroxy-2,7,8-trimethylchroman and sulfated long-chain carboxychromanols in rats
    • Freiser H., Jiang Q. Γ-Tocotrienol and γ-tocopherol are primarily metabolized to conjugated 2-(β-carboxyethyl)-6-hydroxy-2,7,8-trimethylchroman and sulfated long-chain carboxychromanols in rats. Journal of Nutrition 2009, 139:884-889.
    • (2009) Journal of Nutrition , vol.139 , pp. 884-889
    • Freiser, H.1    Jiang, Q.2
  • 18
    • 0037082352 scopus 로고    scopus 로고
    • Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of α- and γ-tocopherol in human plasma
    • Galli F., Lee R., Dunster C., Kelly F.J. Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of α- and γ-tocopherol in human plasma. Free Radical Biology & Medicine 2002, 32:333-340.
    • (2002) Free Radical Biology & Medicine , vol.32 , pp. 333-340
    • Galli, F.1    Lee, R.2    Dunster, C.3    Kelly, F.J.4
  • 19
    • 0037082352 scopus 로고    scopus 로고
    • Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of α- and γ-tocopherol in human plasma.
    • (785-785)
    • Galli F., Lee R., Dunster C., Kelly F.J. Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of α- and γ-tocopherol in human plasma. Free Radical Biology & Medicine 2002, 32:333. (785-785).
    • (2002) Free Radical Biology & Medicine , vol.32 , pp. 333
    • Galli, F.1    Lee, R.2    Dunster, C.3    Kelly, F.J.4
  • 20
    • 79952624643 scopus 로고    scopus 로고
    • Unleashing the untold and misunderstood observations on vitamin E
    • Gee P.T. Unleashing the untold and misunderstood observations on vitamin E. Genes and Nutrition 2011, 6:5-16.
    • (2011) Genes and Nutrition , vol.6 , pp. 5-16
    • Gee, P.T.1
  • 21
    • 0030949103 scopus 로고    scopus 로고
    • Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs
    • Hosomi A., Arita M., Sato Y., Kiyose C., Ueda T., Igarashi O., Arai H., Inoue K. Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Letters 1997, 409:105-108.
    • (1997) FEBS Letters , vol.409 , pp. 105-108
    • Hosomi, A.1    Arita, M.2    Sato, Y.3    Kiyose, C.4    Ueda, T.5    Igarashi, O.6    Arai, H.7    Inoue, K.8
  • 22
    • 0037317112 scopus 로고    scopus 로고
    • Dietary α-tocopherol decreases α-tocotrienol but not γ-tocotrienol concentration in rats
    • Ikeda S., Tohyama T., Yoshimura H., Hamamura K., Abe K., Yamashita K. Dietary α-tocopherol decreases α-tocotrienol but not γ-tocotrienol concentration in rats. Journal of Nutrition 2003, 133:428-434.
    • (2003) Journal of Nutrition , vol.133 , pp. 428-434
    • Ikeda, S.1    Tohyama, T.2    Yoshimura, H.3    Hamamura, K.4    Abe, K.5    Yamashita, K.6
  • 23
    • 0034529484 scopus 로고    scopus 로고
    • Effects of administration of α-tocopherol and tocotrienols on serum lipids and liver HMG CoA reductase activity
    • Khor H.T., Ng T.T. Effects of administration of α-tocopherol and tocotrienols on serum lipids and liver HMG CoA reductase activity. International Journal of Food Sciences and Nutrition 2000, 51:S3-S11.
    • (2000) International Journal of Food Sciences and Nutrition , vol.51
    • Khor, H.T.1    Ng, T.T.2
  • 24
    • 0034972661 scopus 로고    scopus 로고
    • α-Tocopherol affects the urinary and biliary excretion of 2,7,8-trimethyl-2(2'-carboxyethyl)-6-hydroxychroman, γ-tocopherol metabolite, in rats
    • Kiyose C., Saito H., Kaneko K., Hamamura K., Tomioka M., Ueda T., Igarashi O. α-Tocopherol affects the urinary and biliary excretion of 2,7,8-trimethyl-2(2'-carboxyethyl)-6-hydroxychroman, γ-tocopherol metabolite, in rats. Lipids 2001, 36:467-472.
    • (2001) Lipids , vol.36 , pp. 467-472
    • Kiyose, C.1    Saito, H.2    Kaneko, K.3    Hamamura, K.4    Tomioka, M.5    Ueda, T.6    Igarashi, O.7
  • 25
    • 34250693717 scopus 로고    scopus 로고
    • Comparison of reversed-phase liquid chromatography-mass spectrometry with electrospray and atmospheric pressure chemical ionization for analysis of dietary tocopherols
    • Lanina S.A., Toledo P., Sampels S., Kamal-Eldin A., Jastrebova J.A. Comparison of reversed-phase liquid chromatography-mass spectrometry with electrospray and atmospheric pressure chemical ionization for analysis of dietary tocopherols. Journal of Chromatography A 2007, 1157:159-170.
    • (2007) Journal of Chromatography A , vol.1157 , pp. 159-170
    • Lanina, S.A.1    Toledo, P.2    Sampels, S.3    Kamal-Eldin, A.4    Jastrebova, J.A.5
  • 27
    • 0035113436 scopus 로고    scopus 로고
    • α- and γ-Tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine
    • Lodge J.K., Ridlington J., Leonard S., Vaule H., Traber M.G. α- and γ-Tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine. Lipids 2001, 36:43-48.
    • (2001) Lipids , vol.36 , pp. 43-48
    • Lodge, J.K.1    Ridlington, J.2    Leonard, S.3    Vaule, H.4    Traber, M.G.5
  • 29
    • 68249146268 scopus 로고    scopus 로고
    • Vitamin E-modulated gene expression associated with ROS generation
    • Nakamura Y.K., Omaye S.T. Vitamin E-modulated gene expression associated with ROS generation. Journal of Functional Foods 2009, 1:241-252.
    • (2009) Journal of Functional Foods , vol.1 , pp. 241-252
    • Nakamura, Y.K.1    Omaye, S.T.2
  • 32
    • 0036188413 scopus 로고    scopus 로고
    • Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans
    • Qureshi A.A., Sami S.A., Salser W.A., Khan F.A. Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis 2002, 161:199-207.
    • (2002) Atherosclerosis , vol.161 , pp. 199-207
    • Qureshi, A.A.1    Sami, S.A.2    Salser, W.A.3    Khan, F.A.4
  • 34
    • 0028858639 scopus 로고
    • Novel urinary metabolite of α-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin-E supply?
    • Schultz M., Leist M., Petrzika M., Gassmann B., Brigelius-Flohé R. Novel urinary metabolite of α-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin-E supply?. American Journal of Clinical Nutrition 1995, 62:S1527-S1534.
    • (1995) American Journal of Clinical Nutrition , vol.62
    • Schultz, M.1    Leist, M.2    Petrzika, M.3    Gassmann, B.4    Brigelius-Flohé, R.5
  • 35
    • 0025761230 scopus 로고
    • Free-radical recycling and intramembrane mobility in the antioxidant properties of α-tocopherol and α-tocotrienol
    • Serbinova E., Kagan V., Han D., Packer L. Free-radical recycling and intramembrane mobility in the antioxidant properties of α-tocopherol and α-tocotrienol. Free Radical Biology & Medicine 1991, 10:263-275.
    • (1991) Free Radical Biology & Medicine , vol.10 , pp. 263-275
    • Serbinova, E.1    Kagan, V.2    Han, D.3    Packer, L.4
  • 36
    • 34248198290 scopus 로고    scopus 로고
    • Influence of major structural features of tocopherols and tocotrienols on their ω-oxidation by tocopherol-ω-hydroxylase
    • Sontag T.J., Parker R.S. Influence of major structural features of tocopherols and tocotrienols on their ω-oxidation by tocopherol-ω-hydroxylase. Journal of Lipid Research 2007, 48:1090-1098.
    • (2007) Journal of Lipid Research , vol.48 , pp. 1090-1098
    • Sontag, T.J.1    Parker, R.S.2
  • 37
    • 0032933234 scopus 로고    scopus 로고
    • Urinary excretion of 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxychroman is a major route of elimination of γ-tocopherol in humans
    • Swanson J.E., Ben R.N., Burton G.W., Parker R.S. Urinary excretion of 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxychroman is a major route of elimination of γ-tocopherol in humans. Journal of Lipid Research 1999, 40:665-671.
    • (1999) Journal of Lipid Research , vol.40 , pp. 665-671
    • Swanson, J.E.1    Ben, R.N.2    Burton, G.W.3    Parker, R.S.4
  • 38
    • 84857049136 scopus 로고    scopus 로고
    • Tissue distribution of α- and γ-tocotrienol and γ-tocopherol in rats and interference with their accumulation by α-tocopherol
    • Uchida T., Abe C., Nomura S., Ichikawa T., Ikeda S. Tissue distribution of α- and γ-tocotrienol and γ-tocopherol in rats and interference with their accumulation by α-tocopherol. Lipids 2012, 47:129-139.
    • (2012) Lipids , vol.47 , pp. 129-139
    • Uchida, T.1    Abe, C.2    Nomura, S.3    Ichikawa, T.4    Ikeda, S.5
  • 39
    • 84856805385 scopus 로고    scopus 로고
    • Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol
    • Uchida T., Nomura S., Ichikawa T., Abe C., Ikeda S. Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol. Journal of Nutritional Science and Vitaminology 2011, 57:326-332.
    • (2011) Journal of Nutritional Science and Vitaminology , vol.57 , pp. 326-332
    • Uchida, T.1    Nomura, S.2    Ichikawa, T.3    Abe, C.4    Ikeda, S.5
  • 41
    • 84898038009 scopus 로고    scopus 로고
    • Bioavailability and Metabolism of Tocotrienols
    • CRC Press, Boca Raton, B. Tan, R.R. Watson, V.R. Preedy (Eds.)
    • Yang Z., Lee M.-J., Sang S., Yang C.S. Bioavailability and Metabolism of Tocotrienols. Tocotrienols: Vitamin E beyond tocopherols 2013, 37-51. CRC Press, Boca Raton. 2nd ed. B. Tan, R.R. Watson, V.R. Preedy (Eds.).
    • (2013) Tocotrienols: Vitamin E beyond tocopherols , pp. 37-51
    • Yang, Z.1    Lee, M.-J.2    Sang, S.3    Yang, C.S.4
  • 42
    • 0037249854 scopus 로고    scopus 로고
    • Influence of route of administration on the absorption and disposition of α-, γ- and δ-tocotrienols in rats
    • Yap S.P., Yuen K.H., Lim A.B. Influence of route of administration on the absorption and disposition of α-, γ- and δ-tocotrienols in rats. Journal of Pharmacy and Pharmacology 2003, 55:53-58.
    • (2003) Journal of Pharmacy and Pharmacology , vol.55 , pp. 53-58
    • Yap, S.P.1    Yuen, K.H.2    Lim, A.B.3
  • 43
    • 0035140716 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status
    • Yap S.P., Yuen K.H., Wong J.W. Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status. Journal of Pharmacy and Pharmacology 2001, 53:67-71.
    • (2001) Journal of Pharmacy and Pharmacology , vol.53 , pp. 67-71
    • Yap, S.P.1    Yuen, K.H.2    Wong, J.W.3
  • 44
    • 33746941768 scopus 로고    scopus 로고
    • Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens
    • Yu S.G., Thomas A.M., Gapor A., Tan B., Qureshi N., Qureshi A.A. Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens. Lipids 2006, 41:453-461.
    • (2006) Lipids , vol.41 , pp. 453-461
    • Yu, S.G.1    Thomas, A.M.2    Gapor, A.3    Tan, B.4    Qureshi, N.5    Qureshi, A.A.6
  • 45
    • 77952592333 scopus 로고    scopus 로고
    • Plasma vitamin C and tocotrienols changes in response to dietary supplementation among young male adults
    • Zahara A.M., Lee C.C., Fatimah I.S., Poh B.K., Khairul O., Das S., Mohamad J. Plasma vitamin C and tocotrienols changes in response to dietary supplementation among young male adults. Clinica Terapeutica 2010, 161:121-124.
    • (2010) Clinica Terapeutica , vol.161 , pp. 121-124
    • Zahara, A.M.1    Lee, C.C.2    Fatimah, I.S.3    Poh, B.K.4    Khairul, O.5    Das, S.6    Mohamad, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.