Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1-mediated lipogenesis

Clinical Cancer Research

Volumn 22, Issue 21, 2016, Pages 5337-5348

  Geng, Feng ^a   Cheng, Xiang ^a   Wu, Xiaoning ^a   Yoo, Ji Young ^a   Cheng, Chunming ^a   Guo, Jeffrey Yunhua ^a   Mo, Xiaokui ^a   Ru, Peng ^a   Hurwitz, Brian ^a   Kim, Sung Hak ^b   Otero, Jose ^a   Puduvalli, Vinay ^a   Lefai, Etienne ^c   Ma, Jianjie ^a   Nakano, Ichiro ^b   Horbinski, Craig ^d   Kaur, Balveen ^a   Chakravarti, Arnab ^a   Guo, Deliang ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITÉ LYON 1   (France)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ACYLTRANSFERASE; FAT DROPLET; SHORT HAIRPIN RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; ANTINEOPLASTIC AGENT; CHOLESTEROL; SREBF1 PROTEIN, HUMAN; STEROL O-ACYLTRANSFERASE 1;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SURVIVAL; CANCER TISSUE; CHOLESTEROL ESTERIFICATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTRON MICROSCOPY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; GENE SILENCING; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; LIPOGENESIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOUSE; NEUROSURGERY; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GROWTH; TUMOR XENOGRAFT; VERY ELDERLY; WESTERN BLOTTING; YOUNG ADULT; ADOLESCENT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GLIOMA; LIPID METABOLISM; METABOLISM; NUDE MOUSE; TUMOR CELL LINE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLESTEROL; ENDOPLASMIC RETICULUM; FEMALE; GENE EXPRESSION REGULATION; GLIOBLASTOMA; GLIOMA; HUMANS; LIPID METABOLISM; LIPOGENESIS; MALE; MICE; MICE, NUDE; MIDDLE AGED; STEROL O-ACYLTRANSFERASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; YOUNG ADULT;

EID: 84989777905     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-15-2973     Document Type: Article

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