Correlation of an epigenetic mitotic clock with cancer risk

Genome Biology

Volumn 17, Issue 1, 2016, Pages

  Yang, Zhen ^a   Wong, Andrew ^b   Kuh, Diana ^b   Paul, Dirk S ^c   Rakyan, Vardhman K ^d   Leslie, R David ^d   Zheng, Shijie C ^a   Widschwendter, Martin ^b   Beck, Stephan ^c   Teschendorff, Andrew E ^a,b,c  

^a MAX PLANCK INSTITUTE   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Ageing; Cancer; DNA methylation; Epigenetic clock; Mitotic; Stem cells

Indexed keywords

AGING; ARTICLE; CANCER RISK; CELL DIVISION; CELL HETEROGENEITY; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETIC MITOTIC CLOCK MODEL; EPIGENETICS; GENE EXPRESSION; GENE LOCATION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; MITOSIS INDEX; RNA SEQUENCE; SMOKING; SYSTEMATIC ERROR; TRANSCRIPTION INITIATION SITE; VALIDATION PROCESS; BIOSYNTHESIS; CANCER STEM CELL; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HIGH THROUGHPUT SEQUENCING; MITOSIS; NEOPLASMS; PATHOLOGY; PROMOTER REGION; THEORETICAL MODEL;

POLYCOMB GROUP PROTEIN;

AGING; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MITOSIS; MITOTIC INDEX; MODELS, THEORETICAL; NEOPLASMS; NEOPLASTIC STEM CELLS; POLYCOMB-GROUP PROTEINS; PROMOTER REGIONS, GENETIC;

EID: 84989345511     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-016-1064-3     Document Type: Article

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