-
1
-
-
0036791359
-
Furin at the cutting edge: From protein traffic to embryogenesis and disease
-
Thomas, G. Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol 3, 753-766 (2002).
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 753-766
-
-
Thomas, G.1
-
3
-
-
84881238159
-
The multifaceted proprotein convertases: Their unique, redundant, complementary, and opposite functions
-
Seidah, N. G, Sadr, M. S, Chretien, M. & Mbikay, M. The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. J Biol Chem 288, 21473-21481 (2013).
-
(2013)
J Biol Chem
, vol.288
, pp. 21473-21481
-
-
Seidah, N.G.1
Sadr, M.S.2
Chretien, M.3
Mbikay, M.4
-
4
-
-
0037743535
-
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity
-
Henrich, S. et al. The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nat Struct Biol 10, 520-526 (2003).
-
(2003)
Nat Struct Biol
, vol.10
, pp. 520-526
-
-
Henrich, S.1
-
5
-
-
0027375104
-
Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis
-
Creemers, J. W, Siezen, R. J, Roebroek, A. J, Ayoubi, T. A, Huylebroeck, D. & Van de Ven, W. J. Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis. J Biol Chem 268, 21826-21834 (1993).
-
(1993)
J Biol Chem
, vol.268
, pp. 21826-21834
-
-
Creemers, J.W.1
Siezen, R.J.2
Roebroek, A.J.3
Ayoubi, T.A.4
Huylebroeck, D.5
Van De Ven, W.J.6
-
6
-
-
84860383419
-
The biology and therapeutic targeting of the proprotein convertases
-
Seidah, N. G. & Prat, A. The biology and therapeutic targeting of the proprotein convertases. Nat Rev Drug Discov 11, 367-383 (2012).
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 367-383
-
-
Seidah, N.G.1
Prat, A.2
-
7
-
-
27744541223
-
Inhibitors of proprotein convertases
-
Basak, A. Inhibitors of proprotein convertases. J Mol Med 83, 844-855 (2005).
-
(2005)
J Mol Med
, vol.83
, pp. 844-855
-
-
Basak, A.1
-
8
-
-
41649118952
-
A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness
-
Coppola, J. M, Bhojani, M. S, Ross, B. D. & Rehemtulla, A. A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness. Neoplasia 10, 363-370 (2008).
-
(2008)
Neoplasia
, vol.10
, pp. 363-370
-
-
Coppola, J.M.1
Bhojani, M.S.2
Ross, B.D.3
Rehemtulla, A.4
-
9
-
-
20144371230
-
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin
-
Lopez de Cicco, R, Bassi, D. E, Zucker, S, Seidah, N. G. & Klein-Szanto, A. J. Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin. Cancer research 65, 4162-4171 (2005).
-
(2005)
Cancer Research
, vol.65
, pp. 4162-4171
-
-
Lopez De Cicco, R.1
Bassi, D.E.2
Zucker, S.3
Seidah, N.G.4
Klein-Szanto, A.J.5
-
10
-
-
0026716831
-
Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160
-
Hallenberger, S, Bosch, V, Angliker, H, Shaw, E, Klenk, H. D. & Garten, W. Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160. Nature 360, 358-361 (1992).
-
(1992)
Nature
, vol.360
, pp. 358-361
-
-
Hallenberger, S.1
Bosch, V.2
Angliker, H.3
Shaw, E.4
Klenk, H.D.5
Garten, W.6
-
11
-
-
84933502451
-
Novel Furin Inhibitors with Potent Anti-infectious Activity
-
Hardes, K. et al. Novel Furin Inhibitors with Potent Anti-infectious Activity. ChemMedChem (2015).
-
(2015)
ChemMedChem
-
-
Hardes, K.1
-
12
-
-
84860380797
-
On the cutting edge of proprotein convertase pharmacology: From molecular concepts to clinical applications
-
Couture, F, D'Anjou, F. & Day, R. On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications. Biomolecular concepts 2, 421-438 (2011).
-
(2011)
Biomolecular Concepts
, vol.2
, pp. 421-438
-
-
Couture, F.1
D'Anjou, F.2
Day, R.3
-
13
-
-
9644281041
-
Proprotein convertase models based on the crystal structures of furin and kexin: Explanation of their specificity
-
Henrich, S, Lindberg, I, Bode, W. & Than, M. E. Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity. J Mol Biol 345, 211-227 (2005).
-
(2005)
J Mol Biol
, vol.345
, pp. 211-227
-
-
Henrich, S.1
Lindberg, I.2
Bode, W.3
Than, M.E.4
-
14
-
-
84934890156
-
Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells
-
Lu, Y. et al. Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells. Antiviral Res 120, 89-100 (2015).
-
(2015)
Antiviral Res
, vol.120
, pp. 89-100
-
-
Lu, Y.1
-
15
-
-
84900838688
-
X-ray Structures of Human Furin in Complex with Competitive Inhibitors
-
Dahms, S. O, Hardes, K, Becker, G. L, Steinmetzer, T, Brandstetter, H. & Than, M. E. X-ray Structures of Human Furin in Complex with Competitive Inhibitors. ACS Chem Biol 9, 1113-1118 (2014).
-
(2014)
ACS Chem Biol
, vol.9
, pp. 1113-1118
-
-
Dahms, S.O.1
Hardes, K.2
Becker, G.L.3
Steinmetzer, T.4
Brandstetter, H.5
Than, M.E.6
-
16
-
-
1542297713
-
Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases
-
Holyoak, T, Kettner, C. A, Petsko, G. A, Fuller, R. S. & Ringe, D. Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases. Biochemistry 43, 2412-2421 (2004).
-
(2004)
Biochemistry
, vol.43
, pp. 2412-2421
-
-
Holyoak, T.1
Kettner, C.A.2
Petsko, G.A.3
Fuller, R.S.4
Ringe, D.5
-
17
-
-
34249848612
-
Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2
-
Wheatley, J. L. & Holyoak, T. Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc Natl Acad Sci USA 104, 6626-6631 (2007).
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 6626-6631
-
-
Wheatley, J.L.1
Holyoak, T.2
-
18
-
-
77956700490
-
Structural and mechanistic insight into how antibodies inhibit serine proteases
-
Ganesan, R, Eigenbrot, C. & Kirchhofer, D. Structural and mechanistic insight into how antibodies inhibit serine proteases. Biochem J 430, 179-189 (2010).
-
(2010)
Biochem J
, vol.430
, pp. 179-189
-
-
Ganesan, R.1
Eigenbrot, C.2
Kirchhofer, D.3
-
19
-
-
38049174343
-
Structural insight into distinct mechanisms of protease inhibition by antibodies
-
Wu, Y. et al. Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc Natl Acad Sci USA 104, 19784-19789 (2007).
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19784-19789
-
-
Wu, Y.1
-
20
-
-
44949119318
-
Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition
-
Farady, C. J, Egea, P. F, Schneider, E. L, Darragh, M. R. & Craik, C. S. Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition. J Mol Biol 380, 351-360 (2008).
-
(2008)
J Mol Biol
, vol.380
, pp. 351-360
-
-
Farady, C.J.1
Egea, P.F.2
Schneider, E.L.3
Darragh, M.R.4
Craik, C.S.5
-
21
-
-
79955014374
-
Cross-domain inhibition of TACE ectodomain
-
Tape, C. J. et al. Cross-domain inhibition of TACE ectodomain. Proc Natl Acad Sci USA 108, 5578-5583 (2011).
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 5578-5583
-
-
Tape, C.J.1
-
22
-
-
84955478819
-
The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody
-
Ciferri, C. et al. The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody. Biochem J 472, 169-181 (2015).
-
(2015)
Biochem J
, vol.472
, pp. 169-181
-
-
Ciferri, C.1
-
23
-
-
84899473717
-
Nanobody-based products as research and diagnostic tools
-
De Meyer, T, Muyldermans, S. & Depicker, A. Nanobody-based products as research and diagnostic tools. Trends in biotechnology 32, 263-270 (2014).
-
(2014)
Trends in Biotechnology
, vol.32
, pp. 263-270
-
-
De Meyer, T.1
Muyldermans, S.2
Depicker, A.3
-
24
-
-
84857841703
-
Allosteric antibody inhibition of human hepsin protease
-
Koschubs, T. et al. Allosteric antibody inhibition of human hepsin protease. Biochem J 442, 483-494 (2012).
-
(2012)
Biochem J
, vol.442
, pp. 483-494
-
-
Koschubs, T.1
-
25
-
-
71049189254
-
Unraveling the allosteric mechanism of serine protease inhibition by an antibody
-
Ganesan, R. et al. Unraveling the allosteric mechanism of serine protease inhibition by an antibody. Structure 17, 1614-1624 (2009).
-
(2009)
Structure
, vol.17
, pp. 1614-1624
-
-
Ganesan, R.1
-
26
-
-
79952009210
-
Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition
-
Oyen, D, Srinivasan, V, Steyaert, J. & Barlow, J. N. Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition. J Mol Biol 407, 138-148 (2011).
-
(2011)
J Mol Biol
, vol.407
, pp. 138-148
-
-
Oyen, D.1
Srinivasan, V.2
Steyaert, J.3
Barlow, J.N.4
-
27
-
-
84867762574
-
Generation and characterization of non-competitive furin-inhibiting nanobodies
-
Zhu, J. et al. Generation and characterization of non-competitive furin-inhibiting nanobodies. Biochem J 448, 73-82 (2012).
-
(2012)
Biochem J
, vol.448
, pp. 73-82
-
-
Zhu, J.1
-
28
-
-
13444307044
-
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions
-
Krissinel, E. & Henrick, K. Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D Biol Crystallogr 60, 2256-2268 (2004).
-
(2004)
Acta Crystallogr D Biol Crystallogr
, vol.60
, pp. 2256-2268
-
-
Krissinel, E.1
Henrick, K.2
-
29
-
-
0035955552
-
Degenerate interfaces in antigen-antibody complexes
-
Decanniere, K, Transue, T. R, Desmyter, A, Maes, D, Muyldermans, S. & Wyns, L. Degenerate interfaces in antigen-antibody complexes. J Mol Biol 313, 473-478 (2001).
-
(2001)
J Mol Biol
, vol.313
, pp. 473-478
-
-
Decanniere, K.1
Transue, T.R.2
Desmyter, A.3
Maes, D.4
Muyldermans, S.5
Wyns, L.6
-
30
-
-
0030794907
-
Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): Engineering of inhibitors with altered specificities
-
Scheidig, A. J, Hynes, T. R, Pelletier, L. A, Wells, J. A. & Kossiakoff, A. A. Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein science: a publication of the Protein Society 6, 1806-1824 (1997).
-
(1997)
Protein Science: A Publication of the Protein Society
, vol.6
, pp. 1806-1824
-
-
Scheidig, A.J.1
Hynes, T.R.2
Pelletier, L.A.3
Wells, J.A.4
Kossiakoff, A.A.5
-
31
-
-
84883257823
-
The activation peptide of coagulation factor IX and X serves as a high affinity receptor to cationic ligands
-
Griessner, A, Zögg, T. & Brandstetter, H. The activation peptide of coagulation factor IX and X serves as a high affinity receptor to cationic ligands. Thrombosis and Haemostasis 110, 620-622 (2013).
-
(2013)
Thrombosis and Haemostasis
, vol.110
, pp. 620-622
-
-
Griessner, A.1
Zögg, T.2
Brandstetter, H.3
-
32
-
-
0037423301
-
Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop
-
Sichler, K, Kopetzki, E, Huber, R, Bode, W, Hopfner, K. P. & Brandstetter, H. Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop. J Biol Chem 278, 4121-4126 (2003).
-
(2003)
J Biol Chem
, vol.278
, pp. 4121-4126
-
-
Sichler, K.1
Kopetzki, E.2
Huber, R.3
Bode, W.4
Hopfner, K.P.5
Brandstetter, H.6
-
33
-
-
33646581724
-
Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation
-
Johnson, D. J, Li, W, Adams, T. E. & Huntington, J. A. Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation. The EMBO journal 25, 2029-2037 (2006).
-
(2006)
The EMBO Journal
, vol.25
, pp. 2029-2037
-
-
Johnson, D.J.1
Li, W.2
Adams, T.E.3
Huntington, J.A.4
-
34
-
-
79952399087
-
Beyond natural antibodies: The power of in vitro display technologies
-
Bradbury, A. R, Sidhu, S, Dubel, S. & McCafferty, J. Beyond natural antibodies: the power of in vitro display technologies. Nature biotechnology 29, 245-254 (2011).
-
(2011)
Nature Biotechnology
, vol.29
, pp. 245-254
-
-
Bradbury, A.R.1
Sidhu, S.2
Dubel, S.3
McCafferty, J.4
-
35
-
-
84860129612
-
Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin
-
Mueller, U. et al. Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin. Journal of synchrotron radiation 19, 442-449 (2012).
-
(2012)
Journal of Synchrotron Radiation
, vol.19
, pp. 442-449
-
-
Mueller, U.1
-
37
-
-
79953737180
-
Overview of the CCP4 suite and current developments
-
Winn, M. D. et al. Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr 67, 235-242 (2011).
-
(2011)
Acta Crystallogr D Biol Crystallogr
, vol.67
, pp. 235-242
-
-
Winn, M.D.1
-
38
-
-
34447508216
-
Phaser crystallographic software
-
McCoy, A. J, Grosse-Kunstleve, R. W, Adams, P. D, Winn, M. D, Storoni, L. C. & Read, R. J. Phaser crystallographic software. Journal of applied crystallography 40, 658-674 (2007).
-
(2007)
Journal of Applied Crystallography
, vol.40
, pp. 658-674
-
-
McCoy, A.J.1
Grosse-Kunstleve, R.W.2
Adams, P.D.3
Winn, M.D.4
Storoni, L.C.5
Read, R.J.6
-
39
-
-
77949535720
-
Features and development of Coot
-
Emsley, P, Lohkamp, B, Scott, W. G. & Cowtan, K. Features and development of Coot. Acta Crystallogr D Biol Crystallogr 66, 486-501 (2010).
-
(2010)
Acta Crystallogr D Biol Crystallogr
, vol.66
, pp. 486-501
-
-
Emsley, P.1
Lohkamp, B.2
Scott, W.G.3
Cowtan, K.4
-
40
-
-
76449098262
-
PHENIX: A comprehensive Python-based system for macromolecular structure solution
-
Adams, P. D. et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr 66, 213-221 (2010).
-
(2010)
Acta Crystallogr D Biol Crystallogr
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
-
41
-
-
84881304302
-
MAIN software for density averaging, model building, structure refinement and validation
-
Turk, D. MAIN software for density averaging, model building, structure refinement and validation. Acta Crystallogr D Biol Crystallogr 69, 1342-1357 (2013).
-
(2013)
Acta Crystallogr D Biol Crystallogr
, vol.69
, pp. 1342-1357
-
-
Turk, D.1
|