The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody

Biochemical Journal

Volumn 472, Issue 2, 2015, Pages 169-181

  Ciferri, Claudio ^a   Lipari, Michael T ^a   Liang, Wei Ching ^a   Estevez, Alberto ^a   Hang, Julie ^a   Stawicki, Scott ^a   Wu, Yan ^a   Moran, Paul ^a   Elliott, Mike ^a   Eigenbrot, Charles ^a   Katschke, Kenneth J ^a   Van Lookeren Campagne, Menno ^a   Kirchhofer, Daniel ^a  

^a GENENTECH INC   (United States)

Author keywords

Age related macular degeneration; Antibody; HtrA1; Phage display; Serine protease

Indexed keywords

HIGH TEMPERATURE REQUIREMENT A1; IMMUNOGLOBULIN F(AB) FRAGMENT; SERINE PROTEINASE; TRYPSIN; UNCLASSIFIED DRUG; ANTIGEN ANTIBODY COMPLEX; ANTINEOPLASTIC AGENT; HTRA1 PROTEIN, HUMAN; IMMUNOGLOBULIN G; MUTANT PROTEIN; NEUTRALIZING ANTIBODY; PEPTIDE FRAGMENT; PROTEIN SUBUNIT; PROTEINASE INHIBITOR; PRSS11 PROTEIN, MOUSE; RECOMBINANT PROTEIN; TUMOR PROTEIN;

ANTIBODY COMBINING SITE; ANTIBODY LIBRARY; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EPITOPE MAPPING; HUMAN; MACROMOLECULE; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; ALLOSTERISM; AMINO ACID SUBSTITUTION; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; CHEMISTRY; COMPARATIVE STUDY; ENZYMOLOGY; GENETICS; MELANOMA; METABOLISM; PROTEIN SUBUNIT; TUMOR CELL LINE;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY COMPLEX; ANTINEOPLASTIC AGENTS; BINDING SITES, ANTIBODY; CATALYTIC DOMAIN; CELL LINE, TUMOR; EPITOPE MAPPING; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; MELANOMA; MICE; MUTANT PROTEINS; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES;

EID: 84955478819     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150601     Document Type: Article

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