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Volumn 197, Issue 6, 2016, Pages 2509-2521

Immunotherapy expands and maintains the function of high-affinity tumor-infiltrating CD8 T cells in situ

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; CD69 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; GAMMA INTERFERON; GREEN FLUORESCENT PROTEIN; HERMES ANTIGEN; INTERFERON; INTERLEUKIN 10; MONOCLONAL ANTIBODY; NUCLEAR RECEPTOR NUR77; OX40 MONOCLONAL ANTIBODY; PROGRAMMED DEATH 1 LIGAND 1; PROSTAGLANDIN E2; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; CTLA4 PROTEIN, MOUSE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; LYMPHOCYTE ANTIGEN RECEPTOR; NR4A1 PROTEIN, MOUSE; PDCD1 PROTEIN, MOUSE; PROGRAMMED DEATH 1 RECEPTOR; TNFRSF4 PROTEIN, MOUSE;

EID: 84988978556     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1502659     Document Type: Article
Times cited : (28)

References (63)
  • 1
    • 62249131518 scopus 로고    scopus 로고
    • Complete but curtailed T-cell response to very low-affinity antigen
    • Zehn, D., S. Y. Lee, and M. J. Bevan. 2009. Complete but curtailed T-cell response to very low-affinity antigen. Nature 458: 211-214.
    • (2009) Nature , vol.458 , pp. 211-214
    • Zehn, D.1    Lee, S.Y.2    Bevan, M.J.3
  • 2
    • 84928770388 scopus 로고    scopus 로고
    • Neoantigens in cancer immunotherapy
    • Schumacher, T. N., and R. D. Schreiber. 2015. Neoantigens in cancer immunotherapy. Science 348: 69-74.
    • (2015) Science , vol.348 , pp. 69-74
    • Schumacher, T.N.1    Schreiber, R.D.2
  • 5
    • 0029125899 scopus 로고
    • A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma
    • Coulie, P. G., F. Lehmann, B. Lethé, J. Herman, C. Lurquin, M. Andrawiss, and T. Boon. 1995. A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma. Proc. Natl. Acad. Sci. USA 92: 7976-7980.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7976-7980
    • Coulie, P.G.1    Lehmann, F.2    Lethé, B.3    Herman, J.4    Lurquin, C.5    Andrawiss, M.6    Boon, T.7
  • 8
    • 84880276438 scopus 로고    scopus 로고
    • Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
    • Robbins, P. F., Y. C. Lu, M. El-Gamil, Y. F. Li, C. Gross, J. Gartner, J. C. Lin, J. K. Teer, P. Cliften, E. Tycksen, et al. 2013. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat. Med. 19: 747-752.
    • (2013) Nat. Med. , vol.19 , pp. 747-752
    • Robbins, P.F.1    Lu, Y.C.2    El-Gamil, M.3    Li, Y.F.4    Gross, C.5    Gartner, J.6    Lin, J.C.7    Teer, J.K.8    Cliften, P.9    Tycksen, E.10
  • 16
    • 33645289121 scopus 로고    scopus 로고
    • CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs
    • Shiow, L. R., D. B. Rosen, N. Brdicková, Y. Xu, J. An, L. L. Lanier, J. G. Cyster, and M. Matloubian. 2006. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440: 540-544.
    • (2006) Nature , vol.440 , pp. 540-544
    • Shiow, L.R.1    Rosen, D.B.2    Brdicková, N.3    Xu, Y.4    An, J.5    Lanier, L.L.6    Cyster, J.G.7    Matloubian, M.8
  • 17
    • 0032433054 scopus 로고    scopus 로고
    • Type i interferon-mediated stimulation of T cells by CpG DNA
    • Sun, S., X. Zhang, D. F. Tough, and J. Sprent. 1998. Type I interferon-mediated stimulation of T cells by CpG DNA. J. Exp. Med. 188: 2335-2342.
    • (1998) J. Exp. Med. , vol.188 , pp. 2335-2342
    • Sun, S.1    Zhang, X.2    Tough, D.F.3    Sprent, J.4
  • 18
    • 0028227874 scopus 로고
    • Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor
    • Godfrey, W. R., F. F. Fagnoni, M. A. Harara, D. Buck, and E. G. Engleman. 1994. Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor. J. Exp. Med. 180: 757-762.
    • (1994) J. Exp. Med. , vol.180 , pp. 757-762
    • Godfrey, W.R.1    Fagnoni, F.F.2    Harara, M.A.3    Buck, D.4    Engleman, E.G.5
  • 19
    • 34548724573 scopus 로고    scopus 로고
    • Transcriptional analysis of clonal deletion in vivo
    • Baldwin, T. A., and K. A. Hogquist. 2007. Transcriptional analysis of clonal deletion in vivo. J. Immunol. 179: 837-844.
    • (2007) J. Immunol. , vol.179 , pp. 837-844
    • Baldwin, T.A.1    Hogquist, K.A.2
  • 20
    • 0036238332 scopus 로고    scopus 로고
    • Nuclear hormone receptors in T lymphocytes
    • Winoto, A., and D. R. Littman. 2002. Nuclear hormone receptors in T lymphocytes. Cell 109(Suppl.): S57-S66.
    • (2002) Cell , vol.109 , pp. S57-S66
    • Winoto, A.1    Littman, D.R.2
  • 21
    • 84865721122 scopus 로고    scopus 로고
    • Endogenous antigen tunes the responsiveness of naive B cells but not T cells
    • Zikherman, J., R. Parameswaran, and A. Weiss. 2012. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature 489: 160-164.
    • (2012) Nature , vol.489 , pp. 160-164
    • Zikherman, J.1    Parameswaran, R.2    Weiss, A.3
  • 22
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran, A. E., K. L. Holzapfel, Y. Xing, N. R. Cunningham, J. S. Maltzman, J. Punt, and K. A. Hogquist. 2011. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208: 1279-1289.
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3    Cunningham, N.R.4    Maltzman, J.S.5    Punt, J.6    Hogquist, K.A.7
  • 23
    • 0023503073 scopus 로고
    • Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts
    • Paterson, D. J., W. A. Jefferies, J. R. Green, M. R. Brandon, P. Corthesy, M. Puklavec, and A. F. Williams. 1987. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol. Immunol. 24: 1281-1290.
    • (1987) Mol. Immunol. , vol.24 , pp. 1281-1290
    • Paterson, D.J.1    Jefferies, W.A.2    Green, J.R.3    Brandon, M.R.4    Corthesy, P.5    Puklavec, M.6    Williams, A.F.7
  • 26
    • 33846399187 scopus 로고    scopus 로고
    • Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses
    • Ruby, C. E., W. L. Redmond, D. Haley, and A. D. Weinberg. 2007. Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses. Eur. J. Immunol. 37: 157-166.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 157-166
    • Ruby, C.E.1    Redmond, W.L.2    Haley, D.3    Weinberg, A.D.4
  • 27
    • 70249141660 scopus 로고    scopus 로고
    • Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo
    • Redmond, W. L., M. J. Gough, and A. D. Weinberg. 2009. Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo. Eur. J. Immunol. 39: 2184-2194.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2184-2194
    • Redmond, W.L.1    Gough, M.J.2    Weinberg, A.D.3
  • 29
    • 33645048724 scopus 로고    scopus 로고
    • Deletion is neither sufficient nor necessary for the induction of peripheral tolerance in mature CD8+ T cells
    • Lees, J. R., B. Charbonneau, A. K. Swanson, R. Jensen, J. Zhang, R. Matusik, and T. L. Ratliff. 2006. Deletion is neither sufficient nor necessary for the induction of peripheral tolerance in mature CD8+ T cells. Immunology 117: 248-261.
    • (2006) Immunology , vol.117 , pp. 248-261
    • Lees, J.R.1    Charbonneau, B.2    Swanson, A.K.3    Jensen, R.4    Zhang, J.5    Matusik, R.6    Ratliff, T.L.7
  • 30
    • 84924386358 scopus 로고    scopus 로고
    • Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention
    • Mackay, L. K., A. Braun, B. L. Macleod, N. Collins, C. Tebartz, S. Bedoui, F. R. Carbone, and T. Gebhardt. 2015. Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention. J. Immunol. 194: 2059-2063.
    • (2015) J. Immunol. , vol.194 , pp. 2059-2063
    • Mackay, L.K.1    Braun, A.2    Macleod, B.L.3    Collins, N.4    Tebartz, C.5    Bedoui, S.6    Carbone, F.R.7    Gebhardt, T.8
  • 31
    • 18644365244 scopus 로고    scopus 로고
    • Cutting edge: Re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections
    • Liu, F., and J. L. Whitton. 2005. Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections. J. Immunol. 174: 5936-5940.
    • (2005) J. Immunol. , vol.174 , pp. 5936-5940
    • Liu, F.1    Whitton, J.L.2
  • 32
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow
    • Balkwill, F., and A. Mantovani. 2001. Inflammation and cancer: back to Virchow? Lancet 357: 539-545.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 33
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens, L. M., and Z. Werb. 2002. Inflammation and cancer. Nature 420: 860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 34
    • 0023889012 scopus 로고
    • Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen
    • Lanier, L. L., D. W. Buck, L. Rhodes, A. Ding, E. Evans, C. Barney, and J. H. Phillips. 1988. Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen. J. Exp. Med. 167: 1572-1585.
    • (1988) J. Exp. Med. , vol.167 , pp. 1572-1585
    • Lanier, L.L.1    Buck, D.W.2    Rhodes, L.3    Ding, A.4    Evans, E.5    Barney, C.6    Phillips, J.H.7
  • 35
    • 0025288450 scopus 로고
    • Human T lymphocyte adhesion to endothelial cells and transendothelial migration. Alteration of receptor use relates to the activation status of both the T cell and the endothelial cell
    • Oppenheimer-Marks, N., L. S. Davis, and P. E. Lipsky. 1990. Human T lymphocyte adhesion to endothelial cells and transendothelial migration. Alteration of receptor use relates to the activation status of both the T cell and the endothelial cell. J. Immunol. 145: 140-148.
    • (1990) J. Immunol. , vol.145 , pp. 140-148
    • Oppenheimer-Marks, N.1    Davis, L.S.2    Lipsky, P.E.3
  • 37
    • 42149150398 scopus 로고    scopus 로고
    • SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade
    • Fasso, M., R. Waitz, Y. Hou, T. Rim, N. M. Greenberg, N. Shastri, L. Fong, and J. P. Allison. 2008. SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: a prostate tumor antigen identified by CTLA-4 blockade. Proc. Natl. Acad. Sci. USA 105: 3509-3514.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 3509-3514
    • Fasso, M.1    Waitz, R.2    Hou, Y.3    Rim, T.4    Greenberg, N.M.5    Shastri, N.6    Fong, L.7    Allison, J.P.8
  • 39
    • 0030001674 scopus 로고    scopus 로고
    • Immunological memory and protective immunity: Understanding their relation
    • Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272: 54-60.
    • (1996) Science , vol.272 , pp. 54-60
    • Ahmed, R.1    Gray, D.2
  • 40
    • 0033517288 scopus 로고    scopus 로고
    • Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells
    • Slifka, M. K., F. Rodriguez, and J. L. Whitton. 1999. Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells. Nature 401: 76-79.
    • (1999) Nature , vol.401 , pp. 76-79
    • Slifka, M.K.1    Rodriguez, F.2    Whitton, J.L.3
  • 41
    • 77955389719 scopus 로고    scopus 로고
    • Tumor masses support naive T cell infiltration, activation, and differentiation into effectors
    • Thompson, E. D., H. L. Enriquez, Y. X. Fu, and V. H. Engelhard. 2010. Tumor masses support naive T cell infiltration, activation, and differentiation into effectors. J. Exp. Med. 207: 1791-1804.
    • (2010) J. Exp. Med. , vol.207 , pp. 1791-1804
    • Thompson, E.D.1    Enriquez, H.L.2    Fu, Y.X.3    Engelhard, V.H.4
  • 43
    • 0035892124 scopus 로고    scopus 로고
    • Correlation of peripheral blood OX40+(CD134+) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation
    • Kotani, A., T. Ishikawa, Y. Matsumura, T. Ichinohe, H. Ohno, T. Hori, and T. Uchiyama. 2001. Correlation of peripheral blood OX40+(CD134+) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation. Blood 98: 3162-3164.
    • (2001) Blood , vol.98 , pp. 3162-3164
    • Kotani, A.1    Ishikawa, T.2    Matsumura, Y.3    Ichinohe, T.4    Ohno, H.5    Hori, T.6    Uchiyama, T.7
  • 44
    • 65249117082 scopus 로고    scopus 로고
    • Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands
    • Klinger, M., J. K. Kim, S. A. Chmura, A. Barczak, D. J. Erle, and N. Killeen. 2009. Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands. J. Immunol. 182: 4581-4589.
    • (2009) J. Immunol. , vol.182 , pp. 4581-4589
    • Klinger, M.1    Kim, J.K.2    Chmura, S.A.3    Barczak, A.4    Erle, D.J.5    Killeen, N.6
  • 45
    • 0035348175 scopus 로고    scopus 로고
    • Memory CD8+ T cell differentiation: Initial antigen encounter triggers a developmental program in naïve cells
    • Kaech, S. M., and R. Ahmed. 2001. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat. Immunol. 2: 415-422.
    • (2001) Nat. Immunol. , vol.2 , pp. 415-422
    • Kaech, S.M.1    Ahmed, R.2
  • 46
    • 0034663776 scopus 로고    scopus 로고
    • Cutting edge: Naive T cells masquerading as memory cells
    • Murali-Krishna, K., and R. Ahmed. 2000. Cutting edge: naive T cells masquerading as memory cells. J. Immunol. 165: 1733-1737.
    • (2000) J. Immunol. , vol.165 , pp. 1733-1737
    • Murali-Krishna, K.1    Ahmed, R.2
  • 47
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel, T. R., S. E. Henrickson, and U. H. Von Andrian. 2004. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427: 154-159.
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    Von Andrian, U.H.3
  • 48
    • 24744454592 scopus 로고    scopus 로고
    • OX40 and Bcl-xL promote the persistence of CD8 T cells to recall tumor-associated antigen
    • Song, A., X. Tang, K. M. Harms, and M. Croft. 2005. OX40 and Bcl-xL promote the persistence of CD8 T cells to recall tumor-associated antigen. J. Immunol. 175: 3534-3541.
    • (2005) J. Immunol. , vol.175 , pp. 3534-3541
    • Song, A.1    Tang, X.2    Harms, K.M.3    Croft, M.4
  • 49
    • 0027966029 scopus 로고
    • Activation markers on T cells infiltrating melanoma metastases after therapy with dinitrophenyl-conjugated vaccine
    • Berd, D., H. C. Maguire, Jr., M. J. Mastrangelo, and G. Murphy. 1994. Activation markers on T cells infiltrating melanoma metastases after therapy with dinitrophenyl-conjugated vaccine. Cancer Immunol. Immunother. 39: 141-147.
    • (1994) Cancer Immunol. Immunother. , vol.39 , pp. 141-147
    • Berd, D.1    Maguire, H.C.2    Mastrangelo, M.J.3    Murphy, G.4
  • 50
    • 58149191881 scopus 로고    scopus 로고
    • The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
    • Kinter, A. L., E. J. Godbout, J. P. McNally, I. Sereti, G. A. Roby, M. A. O'Shea, and A. S. Fauci. 2008. The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J. Immunol. 181: 6738-6746.
    • (2008) J. Immunol. , vol.181 , pp. 6738-6746
    • Kinter, A.L.1    Godbout, E.J.2    McNally, J.P.3    Sereti, I.4    Roby, G.A.5    O'Shea, M.A.6    Fauci, A.S.7
  • 51
    • 33646891251 scopus 로고    scopus 로고
    • Estrogenmediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway
    • Polanczyk, M. J., C. Hopke, A. A. Vandenbark, and H. Offner. 2006. Estrogenmediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway. J. Neurosci. Res. 84: 370-378.
    • (2006) J. Neurosci. Res. , vol.84 , pp. 370-378
    • Polanczyk, M.J.1    Hopke, C.2    Vandenbark, A.A.3    Offner, H.4
  • 52
    • 79952767536 scopus 로고    scopus 로고
    • IFN-A directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity
    • Terawaki, S., S. Chikuma, S. Shibayama, T. Hayashi, T. Yoshida, T. Okazaki, and T. Honjo. 2011. IFN-A directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity. J. Immunol. 186: 2772-2779.
    • (2011) J. Immunol. , vol.186 , pp. 2772-2779
    • Terawaki, S.1    Chikuma, S.2    Shibayama, S.3    Hayashi, T.4    Yoshida, T.5    Okazaki, T.6    Honjo, T.7
  • 53
    • 84880651129 scopus 로고    scopus 로고
    • Cutting edge: IL-12 and type i IFN differentially program CD8 T cells for programmed death 1 re-expression levels and tumor control
    • Gerner, M. Y., L. M. Heltemes-Harris, B. T. Fife, and M. F. Mescher. 2013. Cutting edge: IL-12 and type I IFN differentially program CD8 T cells for programmed death 1 re-expression levels and tumor control. J. Immunol. 191: 1011-1015.
    • (2013) J. Immunol. , vol.191 , pp. 1011-1015
    • Gerner, M.Y.1    Heltemes-Harris, L.M.2    Fife, B.T.3    Mescher, M.F.4
  • 56
    • 66149123225 scopus 로고    scopus 로고
    • Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection
    • Blattman, J. N., E. J. Wherry, S. J. Ha, R. G. van der Most, and R. Ahmed. 2009. Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. J. Virol. 83: 4386-4394.
    • (2009) J. Virol. , vol.83 , pp. 4386-4394
    • Blattman, J.N.1    Wherry, E.J.2    Ha, S.J.3    Van Der Most, R.G.4    Ahmed, R.5
  • 58
    • 0030036342 scopus 로고    scopus 로고
    • Induction of bystander T cell proliferation by viruses and type i interferon in vivo
    • Tough, D. F., P. Borrow, and J. Sprent. 1996. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272: 1947-1950.
    • (1996) Science , vol.272 , pp. 1947-1950
    • Tough, D.F.1    Borrow, P.2    Sprent, J.3
  • 59
    • 0027935476 scopus 로고
    • Antigen-independent activation of naive and memory resting T cells by a cytokine combination
    • Unutmaz, D., P. Pileri, and S. Abrignani. 1994. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J. Exp. Med. 180: 1159-1164.
    • (1994) J. Exp. Med. , vol.180 , pp. 1159-1164
    • Unutmaz, D.1    Pileri, P.2    Abrignani, S.3
  • 60
    • 0034812971 scopus 로고    scopus 로고
    • OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells
    • Rogers, P. R., J. Song, I. Gramaglia, N. Killeen, and M. Croft. 2001. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 15: 445-455.
    • (2001) Immunity , vol.15 , pp. 445-455
    • Rogers, P.R.1    Song, J.2    Gramaglia, I.3    Killeen, N.4    Croft, M.5
  • 61
    • 84937596884 scopus 로고    scopus 로고
    • Quiescence of memory CD8(+) T cells is mediated by regulatory T cells through inhibitory receptor CTLA-4
    • Kalia, V., L. A. Penny, Y. Yuzefpolskiy, F. M. Baumann, and S. Sarkar. 2015. Quiescence of memory CD8(+) T cells is mediated by regulatory T cells through inhibitory receptor CTLA-4. Immunity 42: 1116-1129.
    • (2015) Immunity , vol.42 , pp. 1116-1129
    • Kalia, V.1    Penny, L.A.2    Yuzefpolskiy, Y.3    Baumann, F.M.4    Sarkar, S.5


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