Genetic ablation of smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia

Genes and Development

Volumn 30, Issue 17, 2016, Pages 1943-1955

  Liu, Xin ^a,b   Pitarresi, Jason R ^a,b   Cuitiño, Maria C ^a,b   Kladney, Raleigh D ^a,b   Woelke, Sarah A ^a   Sizemore, Gina M ^a,b   Nayak, Sunayana G ^a,b   Egriboz, Onur ^a,b   Schweickert, Patrick G ^c,d,e   Yu, Lianbo ^b   Trela, Stefan ^a,b   Schilling, Daniel J ^a,b   Halloran, Shannon K ^a,b   Li, Maokun ^a,b   Dutta, Shourik ^a,b   Fernandez, Soledad A ^b   Rosol, Thomas J ^a,b   Lesinski, Gregory B ^a,b   Shakya, Reena ^a   Ludwig, Thomas ^a,b   Konieczny, Stephen F ^c,d,e   Leone, Gustavo ^a,b   Wu, Jinghai ^a,b   Ostrowski, Michael C ^a,b   more..

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d Purdue University   (United States)

^e PURDUE UNIVERSITY   (United States)

Author keywords

Acinar to ductal metaplasia; AKT signaling; EGFR signaling; Hedgehog signaling; Stromal fibroblast

Indexed keywords

MESSENGER RNA; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; TRANSFORMING GROWTH FACTOR ALPHA; EGFR PROTEIN, MOUSE; EPIDERMAL GROWTH FACTOR RECEPTOR; KRUPPEL LIKE FACTOR; SMO PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; FIBROBLAST; GENE DISRUPTION; METAPLASIA; MOUSE; NONHUMAN; PANCREAS CANCER; PANCREATIC ACINAR TO DUCTAL METAPLASIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; EPITHELIUM CELL; GENE DELETION; GENETICS; METABOLISM; PANCREAS; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL CULTURE;

ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL PROLIFERATION; CELLS, CULTURED; EPITHELIAL CELLS; FIBROBLASTS; GENE DELETION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; METAPLASIA; MICE; MICE, INBRED C57BL; PANCREAS; PANCREATIC NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SMOOTHENED RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR CELLS, CULTURED;

EID: 84988842034     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.283499.116     Document Type: Article

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