Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: A systematic review

Journal of Diabetes and Metabolic Disorders

Volumn 13, Issue 1, 2014, Pages

  Mohammadi, Zahra ^a   Fayyazbakhsh, Fateme ^b   Ebrahimi, Mehdi ^b   Amoli, Mahsa M ^b,c   Khashayar, Patricia ^b   Dini, Mahboubeh ^d   Zadeh, Reza Nezam ^a   Keshtkar, Abbasali ^b   Barikani, Hamid Reza ^e  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c Maziar University   (Iran)

^d MINISTRY OF HEALTH AND MEDICAL EDUCATION   (Iran)

^e TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Bone density; Bsm1; Fok1; Osteoporosis; Polymorphism; Vitamin D receptor gene

Indexed keywords

COLLAGEN TYPE 1; ESTROGEN RECEPTOR ALPHA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; VITAMIN D RECEPTOR;

ALLELE; BONE DENSITY; CALCIUM ABSORPTION; COLI1 GENE; ESR1 GENE; ETHNICITY; GENDER; GENE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; OSTEOPOROSIS; POSTMENOPAUSE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVIEW; SYSTEMATIC REVIEW; VITAMIN D RECEPTOR BSM1 GENE; VITAMIN D RECEPTOR FOK1 GENE;

EID: 84988838049     PISSN: None     EISSN: 22516581     Source Type: Journal    
DOI: 10.1186/s40200-014-0098-x     Document Type: Review

References (135)

1. Manolagas SC: Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis 1. Endocr Rev 2000, 21:115-137
2. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC: Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Investig 1998, 102:274
3. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA: Prediction of bone density from vitamin D receptor alleles. Nature 1994, 367:284-287
4. Barrett-Connor E, Siris ES, Wehren LE, Miller PD, Abbott TA, Berger ML, Santora AC, Sherwood LM: Osteoporosis and fracture risk in women of different ethnic groups. J Bone Miner Res 2005, 20:185-194
5. Looker AC, Orwoll ES, Johnston CC, Lindsay RL, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP: Prevalence of low femoral bone density in older US adults from NHANES III. J Bone Miner Res 1997, 12:1761-1768
6. Faucki A, Eugene B, Dennis L, Stephen L, Dan L, Jameson J: Harrison's Principles of Internal Medicine, Vol II. 17th edition. United States, New York: McGrow-Hill Medical; 2008
7. Zhang H, Tao G, Wu Q, Liu J, Gao Y, Chen R, Leng X: Vitamin D receptor gene polymorphism in postmenopausal women of the Han and Uygur nationalities in China. Chin Med J (Engl) 2000, 113:787-789
8. Lambrinoudaki I, Kung AWC: Absence of high-risk "s" allele associated with osteoporosis at the intronic SP1 binding-site of collagen Ia1 gene in Southern Chinese. J Endocrinol Investig 2001, 24:499-502
9. Lau EMC, Lam V, Li M, Ho K, Woo J: Vitamin D receptor start codon polymorphism (Fok I) and bone mineral density in Chinese men and women. Osteoporos Int 2002, 13:218-221
10. Li M, Meng X, Zhou X, Xing X, Yu W: Association of parathyroid hormone gene polymorphism with bone mineral density in Chinese women. Chin Med Sci J 2003, 18:222-225
11. Jiang DK, Shen H, Li MX, Jiang C, Yang N, Zhu J, Wu Y, Qin YJ, Zhou Q, Deng HW: No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women. Bone 2005, 36:694-699
12. Wang YB, Guo JJ, Liu YJ, Deng FY, Jiang DK, Deng HW: The Human Calcium-Sensing Receptor and Interleukin-6 Genes are Associated with Bone Mineral Density in Chinese. Acta Genetica Sin 2006, 33:870-880
13. Hong X, Hsu YH, Terwedow H, Tang G, Liu X, Jiang S, Xu X: Association of the methylenetetrahydrofolate reductase C677T polymorphism and fracture risk in Chinese postmenopausal women. Bone 2007, 40:737-742
14. Jiang DK, Xu FX, Liu MY, Chen XD, Li MX, Liu YJ, Shen H, Deng HW: No evidence of association of the osteocalcin gene HindIII polymorphism with bone mineral density in Chinese women. JMNI 2007, 7:149-154
15. Cheung CL, Huang QY, Chan V, Kung AWC: Association of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese women. Hum Hered 2008, 65:232-239
16. Wang JT, Guo Y, Yang TL, Xu XH, Dong SS, Li M, Li TQ, Chen Y, Deng HW: Polymorphisms in the estrogen receptor genes are associated with hip fractures in Chinese. Bone 2008, 43:910-914
17. Zhou B, Wang XH, Wang ST, Guo LY, Xu C, Zhang Z, Kan ZY: Gene polymorphism in Cdx-2 binding sites of the vitamin D receptor and bone loss in the elderly in China. J Clin Rehab Tissue Eng Res 2008, 12:9130-9133
18. Huang QY, Li GHY, Kung AWC: Multiple osteoporosis susceptibility genes on chromosome 1p36 in Chinese. Bone 2009, 44:984-988
19. Liu JM, Zhang MJ, Zhao L, Cui B, Li ZB, Zhao HY, Sun LH, Tao B, Li M, Ning G: Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women. J Clin Endocrinol Metabol 2010, 95:E112-E120
20. Tong TYY, Yong RYY, Goh VHH, Liang S, Chong APL, Mok HPP, Yong EL, Yap EPH, Moochhala S: Association between an intronic apolipoprotein E polymorphism and bone mineral density in Singaporean Chinese females. Bone 2010, 47:503-510
21. Deng FY, Lei SF, Chen XD, Tan LJ, Zhu XZ, Deng HW: An integrative study ascertained SOD2 as a susceptibility gene for osteoporosis in Chinese. J Bone Miner Res 2011, 26:2695-2701
22. Hu WW, He JW, Zhang H, Wang C, Gu JM, Yue H, Ke YH, Hu YQ, Fu WZ, Li M, Liu YJ, Zhang ZL: No association between polymorphisms and haplotypes of COL1A1 and COL1A2 genes and osteoporotic fracture in postmenopausal Chinese women. Acta Pharmacol Sin 2011, 32:947-955
23. Li HYG, Kung WCA, Huang QY: Bone mineral density is linked to 1p36 and 7p15-13 in a southern Chinese population. J Bone Miner Metab 2011, 29:80-87
24. Li Y, Xi B, Li K, Wang C: Association between vitamin D receptor gene polymorphisms and bone mineral density in Chinese women. Mol Biol Rep 2012, 39:5709-5717
25. DeFrances CJ, Hall MJ, Podgornik MN: National Hospital Discharge Survey. Adv Data 2005, 2007(385):1-19
26. Hustmyer FG, Peacock M, Hui S, Johnston C, Christian J: Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus. J Clin Invest 1994, 94:2130
27. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 2007, 22:465-475
28. Ferrari S: Osteoporosis: a Complex Disorder of Aging with Multiple Genetic and Environmental Determinants. 2005
29. Labinson P, Taxel P, Gagel RF, Hoff AO: National Osteoporosis Foundation. 2006
30. van Leeuwen JP, Uitterlinden AG, Birkenhäger JC, Pols HA: Vitamin D receptor gene polymorphisms and osteoporosis. Steroids 1996, 61:154-156
31. Van Pottelbergh I, Goemaere S, Zmierczak H, De Bacquer D, Kaufman J: Deficient Acquisition of Bone During Maturation Underlies Idiopathic Osteoporosis in Men: Evidence From a Three-Generation Family Study. J Bone Miner Res 2003, 18:303-311
32. Slemenda CW, Christian JC, Williams CJ, Norton JA, Johnston CC: Genetic determinants of bone mass in adult women: a reevaluation of the twin model and the potential importance of gene interaction on heritability estimates. J Bone Miner Res 1991, 6:561-567
33. Nguyen T, Howard G, Kelly P, Eisman JA: Bone mass, lean mass, and fat mass: same genes or same environments? Am J Epidemiol 1998, 147:3-16
34. Harris M, Nguyen T, Howard G, Kelly P, Eisman J: Genetic and environmental correlations between bone formation and bone mineral density: a twin study. Bone 1998, 22:141-145
35. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S: Genetic determinants of bone mass in adults. A twin study. J Clin Invest 1987, 80:706
36. Williams F, Spector T: Recent advances in the genetics of osteoporosis. JMNI 2006, 6:27
37. Deng HW, Chen WM, Recker S, Stegman MR, Li JL, Davies KM, Zhou Y, Deng H, Heaney R, Recker RR: Genetic determination of Colles' fracture and differential bone mass in women with and without Colles' fracture. J Bone Miner Res 2000, 15:1243-1252
38. Li X-Q, Tembe V, Horwitz GM, Bushinsky DA, Favus MJ: Increased intestinal vitamin D receptor in genetic hypercalciuric rats. A cause of intestinal calcium hyperabsorption. J Clin Invest 1993, 91:661
39. Xue Y, Fleet JC: Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice. Gastroenterology 2009, 136:1317-1327. e2
40. Bland R: Steroid hormone receptor expression and action in bone. Clin Sci 2000, 98:217-240
41. Gennari L, Merlotti D, De Paola V, Calabro A, Becherini L, Martini G, Nuti R: Estrogen receptor gene polymorphisms and the genetics of osteoporosis: a HuGE review. Am J Epidemiol 2005, 161:307-320
42. Brandi ML, Gennari L, Cerinic MM, Becherini L, Falchetti A, Masi L, Gennari C, Reginster J-Y: Genetic markers of osteoarticular disorders: facts and hopes. Arthritis Res 2001, 3:270-280
43. Morrison NA, Yeoman R, Kelly PJ, Eisman JA: Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin. Proc Natl Acad Sci 1992, 89:6665-6669
44. Peacock M, Turner CH, Econs MJ, Foroud T: Genetics of osteoporosis. Endocr Rev 2002, 23:303-326
45. Hardy J, Singleton A: Genomewide association studies and human disease. New Engl J Med 2009, 360:1759-1768
46. Richards J, Rivadeneira F, Inouye M, Pastinen T, Soranzo N, Wilson S, Andrew T, Falchi M, Gwilliam R, Ahmadi K: Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 2008, 371:1505-1512
47. Richards JB, Zheng H-F, Spector TD: Genetics of osteoporosis from genome-wide association studies: advances and challenges. Nat Rev Genet 2012, 13:576-588
48. Ralston SH: Genetic control of susceptibility to osteoporosis. J Clin Endocrinol Metabol 2002, 87:2460-2466
49. Ralston S: The genetics of osteoporosis. QJM 1997, 90:247-251
50. Wood RJ, Fleet JC: The genetics of osteoporosis: vitamin D receptor polymorphisms. Annu Rev Nutr 1998, 18:233-258
51. Cantorna MT, Mahon BD: Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med 2004, 229:1136-1142
52. Nejentsev S, Godfrey L, Snook H, Rance H, Nutland S, Walker NM, Lam AC, Guja C, Ionescu-Tirgoviste C, Undlien DE: Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet 2004, 13:1633-1639
53. Ahn J, Albanes D, Berndt SI, Peters U, Chatterjee N, Freedman ND, Abnet CC, Huang W-Y, Kibel AS, Crawford ED: Vitamin D-related genes, serum vitamin D concentrations, and prostate cancer risk. Carcinogenesis 2009, 2009:bgp055
54. Taymans SE, Pack S, Pak E, Orban Z, Barsony J, Zhuang Z, Stratakis CA: The Human Vitamin D Receptor Gene (VDR) Is Localized to Region 12cen-q12 by Fluorescent In Situ Hybridization and Radiation Hybrid Mapping: Genetic and Physical VDR Map. J Bone Miner Res 1999, 14:1163-1166
55. Bai Y, Yu Y, Yu B, Ge J, Ji J, Lu H, Wei J, Weng Z, Tao Z, Lu J: Association of vitamin D receptor polymorphisms with the risk of prostate cancer in the Han population of Southern China. BMC Med Genet 2009, 10:125
56. Ferrari S, Rizzoli R, Chevalley T, Eisman J, Bonjour J, Slosman D: Vitamin-Dreceptor- gene polymorphisms and change in lumbar-spine bone mineral density. Lancet 1995, 345:423-424
57. Shahbazi S, Alavi S, Majidzadeh-A K, GhaffarPour M, Soleimani A, Mahdian R: BsmI but not FokI polymorphism of VDR gene is contributed in breast cancer. Med Oncol 2013, 30:1-6
58. Naito M, Miyaki K, Naito T, Zhang L, Hoshi K, Hara A, Masaki K, Tohyama S, Muramatsu M, Hamajima N: Association between vitamin D receptor gene haplotypes and chronic periodontitis among Japanese men. Int J Med Sci 2007, 4:216
59. Brown MA, Duncan EL: Genetic studies of osteoporosis. Expert Rev Mol Med 1999, 1:1-18
60. Abbasi M, Hasani S, Sheikholeslami H, Alizadeh S, Rashvand Z, Yazdi Z, Najafipour R: Association between Vitamin D receptor Apa1 and Taq1 Genes Polymorphism and Osteoporosis in Postmenopausal Women. The Journal of Qazvin University of Medical Sciences 2012, 16:4-10
61. Thakkinstian A, D'Este C, Attia J: Haplotype analysis of VDR gene polymorphisms: a meta-analysis. Osteoporos Int 2004, 15:729-734
62. Riggs LB, Nguyen TV, Melton JL, Morrison NA, O'Fallon WM, Kelly PJ, Egan KS, Sambrook PN, Muhs JM, Eisman JA: The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res 1995, 10:991-996
63. Eisman JA: Vitamin D, receptor gene alleles and osteoporosis: an affirmative view. J Bone Miner Res 1995, 10:1289-1293
64. Arai H, Miyamoto KI, Taketani Y, Yamamoto H, Iemori Y, Morita K, Tonai T, Nishisho T, Mori S, Takeda E: A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res 1997, 12:915-921
65. Harris SS, Eccleshall T, Gross C, Dawson-Hughes B, Feldman D. The vitamin D receptor start codon polymorphism (FokI) and bone mineral density in premenopausal American black and white women. J Bone Miner Res 1997, 12:1043-1048
66. Gross C, Eccleshall TR, Malloy PJ, Villa ML, Marcus R, Feldman D: The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal mexican-American women. J Bone Miner Res 1996, 11:1850-1855
67. Ferrari S, Rizzoli R, Manen D, Slosman D, Bonjour JP: Vitamin D Receptor Gene Start Codon Polymorphisms (FokI) and Bone Mineral Density: Interaction with Age, Dietary Calcium, and 3'-End Region Polymorphisms. J Bone Miner Res 1998, 13:925-930
68. Eccleshall TR, Garnero P, Gross C, Delmas PD, Feldman D: Lack of correlation between start codon polymorphism of the vitamin D receptor gene and bone mineral density in premenopausal French women: the OFELY study. J Bone Miner Res 1998, 13:31-35
69. Ingles SA, Haile RW, Henderson BE, Kolonel LN, Nakaichi G, Shi C-Y, Yu MC, Ross RK, Coetzee GA: Strength of linkage disequilibrium between two vitamin D receptor markers in five ethnic groups: implications for association studies. Cancer Epidemiol Biomarkers Prev 1997, 6:93-98
70. Barr R, Macdonald H, Stewart A, McGuigan F, Rogers A, Eastell R, Felsenberg D, Glüer C, Roux C, Reid D: Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power: results from two independent studies (APOSS and OPUS). Osteoporos Int 2010, 21:457-466
71. Ames SK, Ellis KJ, Gunn SK, Copeland KC, Abrams SA: Vitamin D receptor gene Fok1 polymorphism predicts calcium absorption and bone mineral density in children. J Bone Miner Res 1999, 14:740-746
72. Wynne F, Drummond F, O'Sullivan K, Daly M, Shanahan F, Molloy MG, Quane KA: Investigation of the genetic influence of the OPG, VDR (Fok1), and COLIA1 Sp1 polymorphisms on BMD in the Irish population. Calcif Tissue Int 2002, 71:26-35
73. Van Pottelbergh I, Goemaere S, De Bacquer D, De Paepe A, Kaufman M: Vitamin D receptor gene allelic variants, bone density, and bone turnover in community-dwelling men. Bone 2002, 31:631-637
74. Tarner IH, Erkal MZ, Obermayer-Pietsch BM, Hofbauer LC, Bergmann S, Goettsch C, Madlener K, Muller-Ladner U, Lange U: Osteometabolic and osteogenetic pattern of Turkish immigrants in Germany. Exp Clin Endocrinol Diabetes 2012, 120:517-523
75. Jakubowska-Pietkiewicz E, Mlynarski W, Klich I, Fendler W, Chlebna-Sokol D: Vitamin D receptor gene variability as a factor influencing bone mineral density in pediatric patients. Mol Biol Rep 2012, 39:6243-6250
76. Kanan RM: The effect of FokI vitamin D receptor polymorphism on bone mineral density in Jordanian perimenopausal women. Indian J Human Genet 2013, 19:233
77. Zhang HH, Hu YZ, Zhan ZW, Mu XF, Pei Y, Wu Q, Meng XM, Cui ZH, Tao GS: Relationship between vitamin D receptor gene (Fok 1) polymorphism and osteoporosis in the elderly men. Chin J Clin Rehabil 2006, 10:153-155
78. Kim JG, Lim KS, Kim EK, Choi YM, Lee JY: Association of vitamin D receptor and estrogen receptor gene polymorphisms with bone mass in postmenopausal Korean women. Menopause 2001, 8:222-228
79. Deng HW, Shen H, Xu FH, Deng HY, Conway T, Zhang HT, Recker RR: Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density. J Bone Miner Res 2002, 17:678-686
80. Chen HY, Chen WC, Hsu CD, Tsai FJ, Tsai CH: Relation of vitamin D receptor FokI start codon polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal women in Taiwan. Acta Obstet Gynecol Scand 2002, 81:93-98
81. Strandberg S, Nordström P, Lorentzon R, Lorentzon M: Vitamin D receptor start codon polymorphism (FokI) is related to bone mineral density in healthy adolescent boys. J Bone Miner Metab 2003, 21:109-113
82. Rabon-Stith KM, Hagberg JM, Phares DA, Kostek MC, Delmonico MJ, Roth SM, Ferrell RE, Conway JM, Ryan AS, Hurley BF: Vitamin D receptor FokI genotype influences bone mineral density response to strength training, but not aerobic training. Exp Physiol 2005, 90:653-661
83. Cusack S, Mølgaard C, Michaelsen KF, Jakobsen J, Lamberg-Allardt CJE, Cashman KD: Vitamin D and estrogen receptor-α genotype and indices of bone mass and bone turnover in Danish girls. J Bone Miner Metab 2006, 24:329-336
84. Terpstra L, Knol D, Van Coeverden S, Delemarre-van de Waal H: Bone metabolism markers predict increase in bone mass, height and sitting height during puberty depending on the VDR Fok1 genotype. Clin Endocrinol 2006, 64:625-631
85. Lau HH, Ng MY, Cheung WM, Paterson AD, Sham PC, Luk KD, Chan V, Kung AW: Assessment of linkage and association of 13 genetic loci with bone mineral density. J Bone Miner Metab 2006, 24:226-234
86. Falchetti A, Sferrazza C, Cepollaro C, Gozzini A, Del Monte F, Masi L, Napoli N, Di Fede G, Cannone V, Cusumano G: FokI polymorphism of the vitamin D receptor gene correlates with parameters of bone mass and turnover in a female population of the Italian island of Lampedusa. Calcif Tissue Int 2007, 80:15-20
87. Han X, Zhan ZW, Zhang HH, Pei Y, Hu YZ, Wang XR, Han ZT: Association between vitamin D receptor genetypes of Fok I polymorphism and bone mineral density in male of the Han nationality in Beijing area. J Clin Rehabil Tissue Eng Res 2009, 13:4763-4766
88. Hossein-Nezhad A, Ahangari G, Behzadi H, Maghbooli Z, Larijani B: Vitamin D receptor gene polymorphism may predict response to vitamin D intake and bone turnover. Daru 2009, 17:13-19
89. Hossein-nezhad A, Ahangari G, Larijani B: Evaluating of VDR gene variation and its interaction with Immune Regulatory Molecules in Osteoporosis. Iranian J Public Health 2009, 27-36
90. Ozaydin E, Dayangac-Erden D, Erdem-Yurter H, Derman O, Coskun T: The relationship between vitamin D receptor gene polymorphisms and bone density, osteocalcin level and growth in adolescents. J Pediatr Endocrinol Metabol 2010, 23:491-496
91. Galbavỳ D, Omelka R, Bauerová M, Hunák O: ESR, CALCR and VDR gene polymorphisms and their relation to bone mineral density, bone turnover markers and incidence of fractures in Slovak osteoporotic women. Vzt'ah polymorfizmov v ESR, CALCR a VDR génoch k hustote kostného minerálu, markerom kostného obratu a vỳskytu fraktúr v populácii slovenskỳch osteoporotickỳch žien 2010, 15:156-164
92. Pérez A, Ulla M, García B, Lavezzo M, Elías E, Binci M, Rivoira M, Centeno V, Alisio A, De Talamoni NT: Genotypes and clinical aspects associated with bone mineral density in Argentine postmenopausal women. J Bone Miner Metab 2008, 26:358-365
93. Fontova Garrofé R, Gutiérrez Fornés C, Broch Montané M, Aguilar Crespillo C, Pujol Del Pozo A, Ortega JV, Jurado CR: Polymorphism of vitamin D receptor gene, bone mass, and bone turnover among women with postmenopausal osteoporosis. Journal of Revista clinica espanola 2000, 200:198-202
94. Uysal AR, Sahin M, Gursoy A, Gullu S: Vitamin D receptor gene polymorphism and osteoporosis in the Turkish population. Genet Test 2008, 12:591-594
95. Eckstein M, Vered I, Ish-Shalom S, Shlomo AB, Shtriker A, Koren-Morag N, Friedman E: Vitamin D and calcium-sensing receptor genotypes in men and premenopausal women with low bone mineral density. Isr Med Assoc J 2002, 4:340-344
96. Borjas-Fajardo L, Zambrano M, Fernández E, Pineda L, Machín A, De Romero P, Zabala W, Sánchez MA, Chacín JA, Delgado W: Analysis of Bsm I polymorphism of the Vitamin D receptor gen (VDR) in Venezuelan patients with osteoporosis. Análisis del polimorfismo Bsm I del gen receptor de la vitamina D (VDR) en pacientes venezolanas residentes del estado Zulia con osteoporosis 2003, 44:275-282
97. Durusu Tanriover M, Bora Tatar G, Uluturk TD, Dayangac Erden D, Tanriover A, Kilicarslan A, Oz SG, Erdem Yurter H, Sozen T, Sain Guven G: Evaluation of the effects of vitamin D receptor and estrogen receptor 1 gene polymorphisms on bone mineral density in postmenopausal women. Clin Rheumatol 2010, 29:1285-1293
98. Chen J, Zhang LP, Qiu JF, Peng H, Deng ZL, Wang YJ, Yan ZD: Studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in postmenopausal women. Chinese Journal of Medical Genetics 2003, 20:167-168
99. Tamulaitiene M, Marozik P, Alekna V, Mosse I, Strazdiene A, Mastaviciute A, Rudenko E, Piliciauskiene R, Ameliyanovich M: Association of VDR BsmI gene polymorphism, bone turnover markers and bone mineral density in severe postmenopausal osteoporosis. Gerontologija 2012, 13:206-213
100. Nelson DA, Vande Vord PJ, Wooley PH: Polymorphism in the vitamin D receptor gene and bone mass in African-American and white mothers and children: a preliminary report. Ann Rheum Dis 2000, 59:626-630
101. Sowinska-Przepiera E, Grys E: Polymorphism of vitamin D receptor Bsm I gene and of estrogen receptor Xba I and Pvu II gene in girls and women with low bone mass. Polimorfizm Bsm I genu receptora witaminy D oraz Xba I i Pvu II genu receptora estrogenow u dziewczat z niska masa kostna 2000, 71:673-679
102. Chen HY, Chen WC, Hsu CD, Tsai FJ, Tsai CH, Li CW: Relation of BsmI vitamin D receptor gene polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan. Osteoporos Int 2001, 12:1036-1041
103. Pollak RD, Blumenfeld A, Bejarano-Achache I, Idelson M, Hochner DC: The BsmI vitamin D receptor gene polymorphism in Israeli populations and in perimenopausal and osteoporotic Ashkenazi women. Am J Nephrol 2001, 21:185-188
104. Kubota M, Yoshida S, Ikeda M, Okada Y, Arai H, Miyamoto K, Takeda E: Association between two types of vitamin d receptor gene polymorphism and bone status in premenopausal Japanese women. Calcif Tissue Int 2001, 68:16-22
105. Laaksonen M, Kärkkäinen M, Outila T, Vanninen T, Ray C, Lamberg-Allardt C: Vitamin D receptor gene BsmI-polymorphism in Finnish premenopausal and postmenopausal women: Its association with bone mineral density, markers of bone turnover, and intestinal calcium absorption, with adjustment for lifestyle factors. J Bone Miner Metab 2002, 20:383-390
106. van der Sluis IM, de Muinck Keizer-Schrama SM, Krenning EP, Pols HA, Uitterlinden AG: Vitamin D receptor gene polymorphism predicts height and bone size, rather than bone density in children and young adults. Calcif Tissue Int 2003, 73:332-338
107. Grundberg E, Brändström H, Ribom E, Ljunggren O, Kindmark A, Mallmin H: A poly adenosine repeat in the human vitamin D receptor gene is associated with bone mineral density in young Swedish women. Calcif Tissue Int 2003, 73:455-462
108. Kammerer CM, Dualan AA, Samollow PB, Périssé ARS, Bauer RL, MacCluer JW, O'Leary DH, Mitchell BD: Bone mineral density, carotid artery intimal medial thickness, and the vitamin D receptor BsmI polymorphism in Mexican American women. Calcif Tissue Int 2004, 75:292-298
109. Seremak-Mrozikiewicz A, Drews K, Danska A, Spaczynski M, Opala T, Mrozikiewicz PM: Vitamin D receptor polymorphism in the group of postmenopausal women with low bone mineral density. Ginekol Pol 2004, 75:367-372
110. Palomba S, Numis FG, Mossetti G, Rendina D, Vuotto P, Russo T, Zullo F, Nappi C, Nunziata V: Raloxifene administration in post-menopausal women with osteoporosis: effect of different BsmI vitamin D receptor genotypes. Hum Reprod 2003, 18:192-198
111. Dong J, Huang ZW, Piao JH, Gong J: Association of bone mineral density with gene polymorphisms and environmental factors in Chinese postmenopausal women. Wei sheng yan jiu =Journal of hygiene research 2006, 35:196-200
112. Bernardes M, Pires A, Bernardo A, Alves H, Simoes-Ventura F: Bone Mass in postmenopausal Portuguese Women: Interaction between BSMI Vitamin D Receptor gene and PVUII Estrogen Receptor Gene polymorphisms. Annals of the Rheumatic Diseases. London WC1H 9JR, England: BMJ Publishing Group British Med Assoc House, Tavistock Square; 2005:119-120
113. Mitra S, Desai M, Ikram KM: Vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Indian women. Maturitas 2006, 55:27-35
114. Bezerra FF, Cabello GM, Mendonca LM, Donangelo CM: Bone mass and breast milk calcium concentration are associated with vitamin D receptor gene polymorphisms in adolescent mothers. J Nutr 2008, 138:277-281
115. Musumeci M, Vadalà G, Tringali G, Insirello E, Roccazzello AM, Simpore J, Musumeci S: Genetic and environmental factors in human osteoporosis from Sub-Saharan to Mediterranean areas. J Bone Miner Metab 2009, 27:424-434
116. Stathopoulou MG, Dedoussis GV, Trovas G, Theodoraki EV, Katsalira A, Dontas IA, Hammond N, Deloukas P, Lyritis GP: The role of vitamin D receptor gene polymorphisms in the bone mineral density of Greek postmenopausal women with low calcium intake. J Nutr Biochem2011, 22:752-757
117. Pouresmaeili F, Jamshidi J, Azargashb E, Samangouee S: Association between vitamin D receptor gene BsmI polymorphism and bone mineral density in a population of 146 Iranian women. Cell J 2013, 15:75-82
118. Horst-Sikorska W, Kalak R, Wawrzyniak A, Marcinkowska M, Celczynska-Bajew L, Slomski R: Association analysis of the polymorphisms of the VDR gene with bone mineral density and the occurrence of fractures. J Bone Miner Metab 2007, 25:310-319
119. Gonzalez-Mercado A, Sanchez-Lopez JY, Regla-Nava JA, Gamez-Nava JI, Gonzalez-Lopez L, Duran-Gonzalez J, Celis A, Perea-Diaz FJ, Salazar-Paramo M, Ibarra B: Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women. Genet Mol Res 2013, 12:2755-2763
120. Kanan RM, Mesmar M: The effect of vitamin D receptor and estrogen receptor gene polymorphisms on bone mineral density in healthy and osteoporotic postmenopausal Jordanian women. Int J Integr Biol 2008, 4:67-71
121. Lisker R, López MA, Jasqui S, De León Rosales SP, Correa-Rotter R, Sánchez S, Mutchinick OM: Association of Vitamin D receptor polymorphisms with osteoporosis in Mexican postmenopausal women. Hum Biol 2003, 75:399-403
122. Mansour L, Sedky M, AbdelKhader M, Sabry R, Kamal M, El-Sawah H: The role of vitamin D receptor genes (FOKI and BSMI) polymorphism in osteoporosis. Middle East Fertil Soc J 2010, 15:79-83
123. Rogers A, Hannon R, Lambert H, Barker M, Sorrell J, Eastell R: A novel approach to examining VDR polymorphisms (BsmI and Fokl) and the risk of osteoporosis. Calcif Tissue Int 2000, 67:488
124. Lorentzon M, Lorentzon R, Nordstrom P: Vitamin D receptor gene polymorphism is related to bone density, circulating osteocalcin, and parathyroid hormone in healthy adolescent girls. J Bone Miner Metab 2001, 19:302-307
125. Zajícková K, Žofková I: Polymorphisms in osteoporosis-related candidate genes and their associations not only with bone metabolism. Polymorfizmy v kandidátních genech pro osteoporózu a jejich asociace nejen s kostním metabolismem 2007, 10:84-88
126. Vidal C, Grima C, Brincat M, Megally N, Xuereb-Anastasi A: Associations of polymorphisms in the vitamin D receptor gene (Bsml and Fokl) with bone mineral density in postmenopausal women in Malta. Osteoporos Int 2003, 14:923-928
127. Bandrés E, Pombo I, González-Huarriz M, Rebollo A, López G, García- Foncillas J: Association between bone mineral density and polymorphisms of the VDR, ERa, COL1A1 and CTR genes in Spanish postmenopausal women. J Endocrinol Invest 2005, 28:312-321
128. Ivanova J, Doukova P, Boyanov M, Popivanov P: FokI and BsmI polymorphisms of the vitamin D receptor gene and bone mineral density in a random Bulgarian population sample. Endocrine 2006, 29:413-418
129. Macdonald HM, McGuigan FE, Stewart A, Black AJ, Fraser WD, Ralston S, Reid DM: Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women. J Bone Miner Res 2006, 21:151-162
130. Yavuz DG, Yuksel M, Tarcin O, Yazici D, Telli A, Sancak S, Deyneli O, Aydin H, Haklar G, Akalin S: Vitamin D receptor Gene Bsm1 and Fok1 Polymorphisms and Indices of Bone Mass and Bone Turnover in Healty young Turkish Men and Women. ; 2007
131. Sanwalka N, Khadilkar A, Chiplonkar S, Khatod K, Phadke N, Khadilkar V: Vitamin D receptor gene polymorphisms and bone mass indices in postmenarchal Indian adolescent girls. J Bone Miner Metab 2013, 31:108-115
132. Organization WH: Assessment of Fracture Risk and its Application to Screening for Postmenopausal Osteoporosis: Report of a WHO Study Group [Meeting Held in Rome from 22 to 25 June 1992]. ; 1994
133. Anderson JJ, Pollitzer WS: Ethnic and Genetic Differences in Susceptibility to Osteoporotic Fractures. Nutrition and Osteoporosis. New York City: Springer; 1994:129-149
134. Cauley JA, Lui L-Y, Ensrud KE, Zmuda JM, Stone KL, Hochberg MC, Cummings SR: Bone mineral density and the risk of incident nonspinal fractures in black and white women. JAMA 2005, 293:2102-2108
135. Fleet JC, Harris SS, Wood RJ, Dawson-Hughes B: The BsmI vitamin D receptor restriction fragment length polymorphism (BB) predicts low bone density in premenopausal black and white women. J Bone Miner Res 1995, 10:985-990