Association between an intronic apolipoprotein E polymorphism and bone mineral density in Singaporean Chinese females

Bone

Volumn 47, Issue 3, 2010, Pages 503-510

  Tong, Terry Y Y ^a   Yong, Rita Y Y ^b   Goh, Victor H H ^c   Liang, Shen ^a   Chong, Alicia P L ^b   Mok, Helen P P ^a   Yong, Eu Leong ^a   Yap, Eric P H ^b   Moochhala, Shabbir ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b DSO NATIONAL LABORATORIES   (Singapore)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apolipoprotein E gene; Bone mineral density; Chinese; Intronic; Osteoporosis; Polymorphism

Indexed keywords

APOLIPOPROTEIN E; LIPID; PROSTAGLANDIN E2;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; BONE DENSITY; CHINESE; DEMOGRAPHY; DNA POLYMORPHISM; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; FRAGILITY FRACTURE; GENE FREQUENCY; GENOTYPE; HETEROZYGOSITY; HUMAN; INTRON; LIFESTYLE; LIPID BLOOD LEVEL; LUMBAR SPINE; MALE; NORMAL HUMAN; OSTEOPENIA; OSTEOPOROSIS; RISK FACTOR; SEX DIFFERENCE; SINGAPORE;

ABSORPTIOMETRY, PHOTON; ADULT; AGED; APOLIPOPROTEINS E; ASIAN CONTINENTAL ANCESTRY GROUP; BONE DENSITY; FEMALE; GENOTYPE; HUMANS; INTRONS; MALE; MIDDLE AGED; OSTEOPOROSIS; POLYMORPHISM, GENETIC; SINGAPORE;

EID: 77955845773     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.05.028     Document Type: Article

References (54)

1. Swertfeger D.K., Hui D.Y. Apolipoprotein E: a cholesterol transport protein with lipid transport-independent cell signaling properties. Front Biosci 2001, 6:D526-535.
2. Mahley R.W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988, 240:622-630.
3. Kowal R.C., Herz J., Weisgraber K.H., Mahley R.W., Brown M.S., Glodstein J.L. Opposing effects of lipoprotein E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem 1990, 265:10771-10779.
4. Rocchi A., Pellegrini S., Siciliano G., Murri L. Causative and susceptibility genes for Alzheimer's disease: a review. Brain Res Bull 2003, 61:1-24.
5. 1) by osteoblasts and osteoblast-like cells: role of heparin sulfate proteoglycans and apolipoprotein E. J Bone Miner Res 2002, 17:426-433.
6. Chanprasertyothin S., Ongphiphadhanakul B., Rajatanavin R., Piaseu N., Chailurkit L.O., Puavilai G. Correlation of apolipoprotein E gene polymorphism to serum lipid concentrations in healthy Thais. J Med Assoc Thai 2000, 83:1233-1239.
7. Tan C.E., Tai E.S., Tan C.S., Chia K.S., Lee J., Chew S.K., et al. APOE polymorphism and lipid profile in three ethnic groups in the Singapore population. Atherosclerosis 2003, 170:253-260.
8. Bennet A.M., Di Angelantonio E., Ye Z., Wensley F., Dahlin A., Ahlbom A., et al. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 2007, 298:1300-1311.
9. Adami S., Braga V., Zamboni M., Gatti D., Rossini M., Bakri J., et al. Relationship between lipids and bone mass in 2 cohorts of healthy women and men. Calcif Tissue Int 2004, 74:136-142.
10. Orozco P. Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women. Eur J Epidemiol 2004, 19:1105-1112.
11. Parhami F., Garfinkel A., Demel L.L. Role of lipids in osteoporosis. Arterioscler Thromb Vasc Biol 2000, 20:2346-2348.
12. Tanko L.B., Bagger Y.Z., Nielsen S.B., Christiansen C. Does serum cholesterol contribute to vertebral bone loss in postmenopausal women?. Bone 2003, 32:8-14.
13. Cauley J.A., Zmuda J.M., Yaffe K., Kuller L.H., Ferrell R.E., Cummings S.R. Allelic variation at the apolipoprotein E gene locus is associated with bone loss and hip fracture. J Bone Miner Res 1997, 12:P293.
14. Shiraki M., Shiraki Y., Aoki C., Hosoi T., Inoue S., Kaneki M., et al. Association of bone mineral density with apolipoprotein E phenotype. J Bone Miner Res 1997, 12:1438-1445.
15. Zajickova K., Zofkova I., Hill M., Horinek A., Novakova A. Apolipoprotein E 4 allele is associated with low bone mineral density in postmenopausal women. J Endocrinol Invest 2003, 26:312-315.
16. Salamone L.M., Cauley J.A., Zmuda J., Pasagian-Macaulay A., Epstein R.S., Ferrell R.E., et al. Apolipoprotein E gene polymorphism and bone loss: estrogen status modifies the influence of apolipoprotein E on bone loss. J Bone Miner Res 2000, 15:308-314.
17. Cauley J.A., Zmuda J.M., Yaffe K., Kuller L.H., Ferrell R.E., Wisniewski S.R., et al. Apolipoprotein E polymorphism: a new genetic marker of hip fracture risk-the study of osteoporosis fractures. J Bone Miner Res 1999, 14:1175-1181.
18. Feskanich D., Weber P., Willett W.C., Rockett H., Booth S.L., Colditz G.A. Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr 1999, 69:74-79.
19. Johnston J.M., Cauley J.A., Ganguli M. APOE4 and hip fracture risk in a community-based study of older adults. J Am Geriatr Soc 1999, 47:1342-1345.
20. Pluijm S.M.F., Dik M.G., Jonker C., Deeg D.J.H., van Kamp G.J., Lips P. Effects of gender and age on the association of apolipoprotein E ∈4 with bone mineral density, bone turnover and the risk of fractures in older people. Osteoporos Int 2002, 13:701-709.
21. Dick I.M., Devine A., Marangou A., Dhaliwal S.S., Laws S., Martins R.N., et al. Apolipoprotein E4 is associated with reduced calcaneal quantitative ultrasound measurements and bone mineral density in elderly women. Bone 2002, 31:497-502.
22. Gerdes L.U., Vestergaard P., Hermann A.P., Mosekilde L. Regional and hormone-dependent effects of apolipoprotein E genotype on changes in bone mineral in perimenopausal women. J Bone Miner Res 2001, 16:1906-1916.
23. Stulc T., Ceska R., Horinek A., Stepan J. Bone mineral density in patients with Apolipoprotein E type 2/2 and 4/4 genotype. Physiol Res 2000, 49:435-439.
24. Von Muhlen D.G., Barrett-Connor E., Schneider D.L., Morin P.A., Parry P. Osteoporosis and apolipoprotein E genotype in older adults: the Rancho Bernardo Study. Osteoporos Int 2001, 12:332-335.
25. Sennels H.P., Sand J.C., Madsen B., Lauritzen J.B., Fenger M., Jorgensen H.L. Association between polymorphisms of apolipoprotein E, bone mineral density of the lower forearm, quantitative ultrasound of the calcaneus and osteoporotic fractures in postmenopausal women with hip or lower forearm fracture. Scand J Clin Lab Invest 2003, 63:247-258.
26. Efstathiadou Z., Koukoulis G., Stakias N., Challa A., Tsatsoulis A. Apolipoprotein E polymorphism is not associated with spinal bone mineral density in peri- and postmenopausal Greek women. Maturitas 2004, 48:259-264.
27. Schoofs M.W., van der Klift M., Hofman A., van Duijn C.M., Stricker B.H., Pols H.A., et al. ApoE gene polymorphisms, BMD, and fracture risk in elderly men and women: the Rotterdam study. J Bone Miner Res 2004, 19:1490-1496.
28. Artiga M.J., Bullido M.J., Sastre I., Recuero M., Garcia M.A., Aldudo J., et al. Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E. FEBS Letters 1998, 421:105-108.
29. Mui S., Briggs M., Chung H., Wallace R.B., Gomez-Isla T., Rebeck G.W., et al. A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the ∈4 allele. Neurology 1996, 47:196-201.
30. Laws S.M., Hone E., Gandy S., Martins R.N. Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. J Neurochemistry 2003, 84:1215-1236.
31. Viiri L.E., Viiri K.M., Ilveskoski E., Huhtala H., Maki M., Tienari P.J., et al. Interactions of functional apolipoprotein E gene promoter polymorphisms with smoking on aortic atherosclerosis. Circ Cardiovasc Genet 2008, 1:107-116.
32. Viiri L.E., Loimaala A., Nenonen A., Islam S., Vuori I., Karhunen P.J., et al. The association of the apolipoprotein E gene promoter polymorphisms and haplotypes with serum lipid and lipoprotein concentrations. Atherosclerosis 2005, 179:161-167.
33. WHO Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organization Technical Report Series 1994, 843:1-129.
34. Goh V.H.H., Tong T.Y.Y., Mok H.P.P., Said B. Differential impact of aging and gender on lipid and lipoprotein profiles in a cohort of healthy Chinese Singaporeans. Asian J Andrology 2007, 9:787-794.
35. Goh V.H.H., Tong T.Y.Y., Mok H.P.P., Said B. Interactions among age, adiposity, bodyweight, lifestyle factors and sex steroid hormones in healthy Singaporean Chinese men. Asian J Andrology 2007, 9:611-621.
36. Singapore Health Promotion Board Food-Based Dietary Guidelines for Adults 2003, Available at: http://www.hpb.gov.sg/foodforhealth/article.aspx?id=2758. Accessed September 2009.
37. Minelli C., Thompson J.R., Abrams K.R., Thakkinstian A., Attia J. The choice of a genetic model in the meta-analysis of molecular association studies. Int J Epidemiol 2005, 34:1319-1328.
38. Comings D.E., MacMurray J.P. Molecular heterosis: a review. Mol Genet Metab 2000, 71:19-31.
39. Burr D.B. Bone quality: understanding what matters. J Musculoskelet Neuronal Interact 2004, 4:184-186.
40. Blouin S., Thaler H.W., Korninger C., Schmid R., Hofstaetter J.G., Zoehrer R., et al. Bone matrix quality and plasma homocysteine levels. Bone 2009, 44:959-964.
41. Paik Y.K., Chang D.J., Reardon C.A., Walker M.D., Taxman E., Taylor J.M. Identification and characterization of transcriptional regulatory regions associated with expression of the human apolipoprotein E gene. J Biol Chem 1988, 263:13340-13349.
42. Bullido M.J., Valdivieso F. Apolipoprotein E gene promoter polymorphisms in Alzheimer's disease. Microsc Res Tech 2000, 50:261-267.
43. Poli A., Bruschi F., Cesana B., Rossi M., Paoletti R., Crosignani P.G. Plasma low-density lipoprotein cholesterol and bone mass densitometry in postmenopausal women. Obstet Gynecol 2003, 102:922-926.
44. Yamaguchi T., Sugimoto T., Yano S., Yamauchi M., Sowa H., Chen Q., et al. Plasma lipids and osteoporosis in postmenopausal women. Endocr J 2002, 49:211-217.
45. Virii L.E., Raitakari O.T., Huhtala H., Kahonen M., Rontu R., Juonala M., et al. Relations of APOE promoter polymorphisms to LDL cholesterol and markers of subclinical atherosclerosis in young adults. J Lipid Res 2006, 47:1298-1306.
46. Hefferan T.E., Maran A., Lotinum S., Zhang M., Turner R.T. The apolipoprotein E gene is expressed in the skeleton and is differentially regulated by estrogen and parathyroid hormone. J Bone Miner Res 2000, 15:F366. (abstract).
47. Andreotti G., Chen J., Gao Y.-T., Rashid A., Chen B.E., Rosenberg P., et al. Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. Cancer Epidemiol Biomarkers Prev 2008, 17:525-533.
48. Takei N., Miyashita A., Tsukie T., Arai H., Asada T., Imagawa M., et al. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics 2009, 93:441-448.
49. Rebeck G.W., Cheung B.S., Growdon W.B., Deng A., Akuthota P., Locascio J., et al. Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease. Neurosci Lett 1999, 272:155-158.
50. He L.-N., Recker R.R., Deng H.-W., Dvornyk V. A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females. Maturitas 2009, 62:37-41.
51. Koch W., Ehrenhaft A., Griesser K., Pfeufer A., Muller J., Schomig A., et al. TaqMan systems for genotyping of disease-related polymorphisms present in the gene encoding apolipoprotein E. Clin Chem Lab Med 2002, 40:1123-1131.
52. Lambert J.C., Pasquier F., Cottel D., Frigard B., Amouyel P., Chartier-Harlin M.C. A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease. Hum Mol Genet 1988, 7:533-540.
53. Capurso C., Solfrizzi V., D'Introno A., Colacicco A.M., Capurso S.A., Capurso A., et al. Interleukin 6 -174 G/C promoter gene polymorphism and sporadic Alzheimer's disease: geographic allele and genotype variations in Europe. Exp Gerontol 2004, 39:1567-1573.
54. Singh P.P., Singh M., Mastana S.S. APOE distribution in world populations with new data from India and the UK. Ann of Hum Biol 2006, 33:279-308.