Vitamin D receptor gene allelic variants, bone density, and bone turnover in community-dwelling men

Bone

Volumn 31, Issue 5, 2002, Pages 631-637

  Van Pottelbergh, I ^a   Goemaere, S ^a   De Bacquer, D ^a   De Paepe, A ^a   Kaufman, M ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Bone markers; Male bone metabolism; Muscle strength; Vitamin D receptor (VDR) polymorphism

Indexed keywords

BIOCHEMICAL MARKER; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR;

ABSORPTIOMETRY; AGED; ALLELE; ARTICLE; BONE DENSITY; BONE TURNOVER; CALCANEUS; COHORT ANALYSIS; COMMUNITY; CONTROLLED STUDY; FEMUR NECK; FOREARM; FRACTURE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUSCLE STRENGTH; OSSIFICATION; POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; STATISTICAL SIGNIFICANCE; TIBIA; ULTRASOUND; X RAY ANALYSIS; ADULT; ANALYSIS OF VARIANCE; BELGIUM; BONE REMODELING; COMPARATIVE STUDY; GENETIC MARKER; GENETICS; LONGITUDINAL STUDY; MIDDLE AGED; NONPARAMETRIC TEST;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ANALYSIS OF VARIANCE; BELGIUM; BONE DENSITY; BONE REMODELING; GENETIC MARKERS; GENOTYPE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; RECEPTORS, CALCITRIOL; STATISTICS, NONPARAMETRIC; VARIATION (GENETICS);

EID: 0036862317     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(02)00867-0     Document Type: Article

References (35)

1. Arai H., Miyamoto K.I., Taketani Y., Yamamoto H., Iemori Y., Morita K., Tonai T., Nishisho T., Mori S., Takeda E. A vitamin D receptor gene polymorphism in the translation initiation codon Effect on protein activity and relation to bone mineral density in Japanese women . J Bone Miner Res. 12:1997;915-921.
2. Barger-Lux M.J., Heaney R.P., Hayes J., Deluca H.F., Johnson M.L., Gong G. Vitamin D receptor gene polymorphisms, bone mass, body size, and vitamin D receptor density. Calcif Tissue Int. 57:1995;161-162.
3. Berg J.P., Falch J.A., Haug E. Fracture rate, pre- and postmenopausal bone mass and early and late postmenopausal bone loss are not associated with vitamin D receptor genotype in a high-endemic area of osteoporosis. Eur J Endocrinol. 135:1996;96-100.
4. Center J.R., Nguyen T.V., Schneider D., Sambrook P.N., Eisman J.A. Mortality after all major types of osteoporotic fracture in men and women An observational study . Lancet. 353:1999;878-882.
5. Cooper G.S., Umbach D.M. Are vitamin D receptor polymorphisms associated with bone mineral density? A meta-analysis. J Bone Miner Res. 11:1996;1841-1849.
6. 3 receptors and hormonal responses in cloned human skeletal muscle cells. Endocrinology. 119:1986;2214-2220.
7. Csuka M., McCarty D.J. Simple method for measurement of lower extremity muscle strength. Am J Med. 78:1985;77-81.
8. Dukas L., Bischoff H.A., Michiels L., Geusens P., Thalmann B., Binder K., Monsch A.U., Boos G., Stähelin H.B. Vitamin D receptor genotype in community-dwelling elderly men and women Its relation to muscle strength results from cross-sectional analyses of the baseline measurements of the AIMS study . Abstract book of the 23rd annual meeting of the ASBMR. 2001;S353.
9. Ferrari S., Rizzoli R., Manen D., Slosman D., Bonjour J.-P. Vitamin D receptor gene start codon polymorphism (FokI) and bone mineral density Interaction with age, dietary calcium, and 3′-end region polymorphisms . J Bone Miner Res. 13:1998;925-930.
10. Francis R.M., Harrington F., Turner E., Papiha S.S., Datta H.K. Vitamin D receptor gene polymorphism in men and its effect on bone density and calcium absorption. Clin Endocrinol. 46:1997;83-86.
11. Garnero P., Borel O., Sornay-Rendu E., Delmas P.D. Vitamin D receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women. J Bone Miner Res. 10:1995;1283-1288.
12. Gennari L., Becherini L., Masi L., Mansani T., Gonnelli S., Cepollaro C., Martini S., Matagnani A., Lentini G., Becorpi A.M., Brandi M.L. Vitamin D and estrogen receptor allelic variants in Italian postmenopausal women Evidence of multiple gene contribution to bone mineral density . J Clin Endocrinol Metab. 83:1998;939-944.
13. Goemaere S., Van Pottelbergh I., Zmierczak H., Toye K., Daems M., Demuynck R., Myny H., De Bacquer D., Kaufman J.M. Inverse association between bone turnover rate and bone mineral density in community-dwelling men over 70 years of age No major role of sex steroid status . Bone. 29:2001;286-291.
14. Gómez C., Naves M.L., Barrios Y., Diáz J.B., Fernández J.L., Salido E., Torres A., Cannata J.B. Vitamin D receptor gene polymorphisms, bone mass, bone loss and prevalence of vertebral fracture Differences in postmenopausal women and men . Osteopor Int. 10:1999;175-182.
15. Gross C., Eccleshall T.R., Malloy P.J., Villa M.L., Marcus R., Feldman D. The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. J Bone Miner Res. 13:1998;925-930.
16. Gross C., Krishnan A.V., Malloy P.J., Eccleshall T.R., Zhao X.Y., Feldman D. The vitamin D receptor gene start codon polymorphism A functional analysis of FokI variants . J Bone Miner Res. 13:1998;1691-1699.
17. Haussler M.R., Whitfield G.K., Haussler C.A., Hsieh J.C., Thompson P.D., Selznick S.H., Dominguez C.E., Jurutka P.W. The nuclear vitamin D receptor Biological and molecular regulatory properties revealed . J Bone Miner Res. 13:1998;325-349.
18. Kanan R.M., Varanasi S.S., Francis R.M., Parker L., Datta H.K. Vitamin D receptor gene start codon polymorphism (FokI) and bone mineral density in healthy male subjects. Clin Endocrinol. 53:2000;93-98.
19. Keen R.W., Egger P., Fall C., Major P.J., Lanchbury J.S., Spector T.D., Cooper C. Polymorphisms of the vitamin D receptor, infant growth, and adult bone mass. Calcif Tissue Int. 60:1997;223-225.
20. Langdahl B.L., Gravholt C.H., Brixen K., Eriksen E.F. Polymorphisms in the vitamin D receptor gene and bone mass, bone turnover and osteoporotic fractures. Eur J Clin Invest. 30:2000;608-617.
21. Lorentzon M., Lorentzon R., Nordström P. Vitamin D receptor gene polymorphism is associated with birth height, growth to adolescence, and adult stature in healthy caucasian men A cross-sectional and longitudinal study . J Clin Endocrinol Metab. 85:2000;1666-1671.
22. Luukinen H., Koski K., Laippala P., Kiveläc S. Factors predicting fractures during falling impacts among home-dwelling older adults. J Am Geriatr Soc. 45:1997;1302-1309.
23. Mocharla H., Butch A.W., Pappas A.A., Flick J.T., Weinstein R.S., De Togni P., Jilka R.L., Roberson P.K., Parfitt A.M., Manolagas S.C. Quantification of vitamin D receptor mRNA by competitive polymerase chain reaction in PBMC Lack of correspondence with common allelic variants . J Bone Miner Res. 12:1997;726-733.
24. Morrison N.A., Qi J.C., Tokita A., Kelly P.J., Crofts L., Nguyen T.V., Sambrook P.N., Eisman J.A. Prediction of bone density from vitamin D receptor alleles. Nature. 367:1994;284-287.
25. Morrison N.A., Qi J.C., Tokita A., Kelly P.J., Crofts L., Nguyen T.V., Sambrook P.N., Eisman J.A. Correction Prediction of bone density from vitamin D receptor alleles . Nature. 387:1997;106.
26. Morrison N.A., Yeoman R., Kelly P.J., Eisman J.A. Contribution of trans-acting factor alleles to normal physiological variability Vitamin D receptor gene polymorphisms and circulating osteocalcin . Proc Natl Acad Sci USA. 89:1992;6665-6669.
27. Need A.G., Horowitz M., Stiliano A., Scopacasa F., Morris H.A., Chatterton B.E. Vitamin D receptor genotypes are related to bone size and bone density in men. Eur J Clin Invest. 26:1996;793-796.
28. Oden A., Dawson A., Dere W., Johnell O., Jonsson B., Kanis J.A. Lifetime risk of hip fractures is underestimated. Osteopor Int. 8:1998;599-603.
29. Poor G., Atkinson E.J., Lewallen D.G., O'Fallon W.M., Melton L.J. Age-related hip fractures in men Clinical spectrum and short-term outcomes . Osteopor Int. 5:1995;419-426.
30. Riggs B.L., Nguyen T.V., Melton L.J. III, Morrison N.A., O'Fallon W.M., Kelly P.J., Egan K.S., Sambrook P.N., Muhs J.M., Eisman J.A. The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res. 10:1995;991-996.
31. Uitterlinden A.G., Pols H.A.P., Burger H., Huang Q., Van Daele P.L.A., Van Duijn C.M., Hofman A., Birkenhäger J.C., Van Leeuwen J.P.T.M. A large-scale population-based study of the association of vitamin D receptor gene polymorphisms with bone mineral density. J Bone Miner Res. 11:1996;1241-1248.
32. Van Den Saffele J.K., Goemaere S., De Bacquer D., Kaufman J.M. Serum leptin levels in healthy ageing men Are decreased serum testosterone and increased adiposity in elderly men the consequence of leptin deficiency? Clin Endocrinol. 51:1999;81-88.
33. Van Pottelbergh I., Goemaere S., Lumbroso S., Sultan C., Kaufman J.M. Lack of influence of the androgen receptor gene CAG-repeat polymorphism on sex steroid status and bone metabolism in elderly men. Clin Endocrinol. 55:2001;659-666.
34. Viitanen A.M., Kärkkäinen M., Laitinen K., Lamberg-Allardt C., Kainulainene K., Räsänen L., Viikari J., Välimäki M.J., Kontula K. Common polymorphism of the vitamin D receptor gene is associated with variation of peak bone mass in young Finns. Calcif Tissue Int. 59:1996;231-234.
35. Wahner H.W., Looker A., Dunn W.L., Walters L.C., Hauser M.F., Novak C. Quality control of bone densitometry in a national health survey (NHANES III) using three mobile examination centers. J Bone Miner Res. 9:1994;951-960.