The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women

Journal of Bone and Mineral Research

Volumn 11, Issue 12, 1996, Pages 1850-1855

  Gross, Coleman ^a   Eccleshall, T Ross ^a   Malloy, Peter J ^a   Villa, Marie Luz ^a,b   Marcus, Robert ^a,b   Feldman, David ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; OSTEOCALCIN; PARATHYROID HORMONE; RESTRICTION ENDONUCLEASE; VITAMIN D; VITAMIN RECEPTOR;

ADULT; AMINO ACID SEQUENCE; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MINERAL; DNA FLANKING REGION; DNA POLYMORPHISM; FEMALE; FOLLOW UP; GENE TRANSLOCATION; GENETIC CODE; HUMAN; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; RISK FACTOR;

EID: 0030466997     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.5650111204     Document Type: Article

References (21)

1. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S 1987 Genetic determinants of bone mass in adults. J Clin Invest 80:706-710.
2. Christian JC, Yu P-L, Slemenda CW, Johnston CCJ 1989 Heritability of bone mass: A longitudinal study in aging male twins. Am J Hum Genet 44:429-433.
3. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA 1994 Prediction of bone density from vitamin D receptor alleles. Nature 367:284-287.
4. Eisman JA 1995 Vitamin D receptor gene alleles and osteoporosis: An affirmative view. J Bone Miner Res 10:1289-1293.
5. Peacock M 1995 Vitamin D receptor gene alleles and osteoporosis: A contrasting view. J Bone Miner Res 10:1294-1297.
6. Spector TD, Keen RW, Arden NK, Morrison NA, Major PJ, Nguyen TV, Kelly PJ, Baker JR, Sambrook PN, Lanchbury JS, Eisman JA 1995 Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: A twin study in Britain. Br Med J 310:1357-1360.
7. Baker AR, McDonnell DP, Hughes M, Crisp TM, Mangelsdorf DJ, Haussler MR, Pike JW, Shine J, O'Malley BW 1988 Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci USA 85:3294-3298.
8. Saijo T, Ito M, Takeda E, Huq AH, Naito E, Yokota I, Sone T, Pike JW, Kuroda Y 1991 A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin Ddependent rickets type II: Utility of single-strand conformation polymorphism analysis for heterozygous carrier detection. Am J Hum Genet 49:668-673.
9. Sturzenbecker L, Scardaville B, Kratzeisen C, Katz M, Abarzua P, McLane J 1994 Isolation and analysis of cDNA encoding a naturally-occurring truncated form of the human vitamin D receptor. In: Bouillon R, Norman AW, Thomasset M (eds.) Vitamin D: A PJuripotent Steroid Hormone: Structural Studies, Molecular Endocrinology, and Clinical Applications. W. de Gruyter, New York, NY, U.S.A., pp. 253-257.
10. Villa ML, Marcus R, Ramirez Delay R, Kelsey JL1995 Factors contributing to skeletal health of postmenopausal Mexican-American women. J Bone Miner Res 10:1233-1242.
11. Aguirre MA, Marcus R, Villa ML 1996 Relationship between bone mass and insulin resistance in two Caucasian ethnic groups. J Bone Miner Res 11 (Suppl 1):S326 (abstract).
12. Orwoll ES, Oviatt SK, Mann T 1990 The impact of osteophytic and vascular calcification on vertebral mineral density measurements in men. J Clin Endocrinol Metab 70:1202-1207.
13. Hughes MR, Malloy PJ, Kieback DK, Kesterson RA, Pike JW, Feldman D, O'Malley BW 1988 Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science 242:1702-1705.
14. McClure L, Eccleshall TR, Gross C, Villa ML, Lin N, Ramaswamy V, Kohlmeier L, Kelsey JL, Marcus R, Feldman D 1997 Vitamin D receptor polymorphisms, bone mineral density, and bone metabolism in post-menopausal Mexican-American women. J Bone Miner Res 12 (in press).
15. Slemenda CW, Johnston CC, Hui SL 1996 Assessing fracture risk. In: Marcus R, Feldman D, Kelsey J (eds.) Osteoporosis. Academic Press, San Diego, CA, U.S.A., pp. 623-633.
16. Kelly PJ, Morrison NA, Sambrook PN, Nguyen TV, Eisman JA 1995 Genetic influences on bone turnover, bone density and fracture. Eur J Endocrinol 133:265-271.
17. Krall EA, Parry P, Lichter JB, Dawson-Hughes B 1995 Vitamin D receptor alleles and rates of bone loss: Influences of years since the menopause and calcium intake. J Bone Miner Res 10:978-984.
18. Ferrari S, Rizzoli R, Chevalley T, Slosman D, Eisman JA, Bonjour JP 1995 Vitamin-D-receptor-gene polymorphisms and change in lumbar-spine bone mineral density. Lancet 345:423-424.
19. Ferrari SL, Rizzoli R, Chevalley T, Eisman J, Bonjour J-P 1995 Author's reply. Lancet 345:1239.
20. Miyamoto K, Taketani Y, Arai E, Yamamoto H, Iemori Y, Chikamori M, Morita K, Takeda E, Tohna T, Nishisho T 1996 A novel polymorphism in the vitamin D receptor gene and bone mineral density: Study of vitamin D receptor expression and function in COS-7 cells. J Bone Miner Res 11 (Suppl 1):S116 (abstract).
21. Gallagher JC, Riggs BL, Eisman J, Hamstra D, Arnaud SD, DeLuca HF 1979 Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: Effects of age and dietary calcium. J Clin Invest 64:729-736.