The anti-arthritic, anti-inflammatory, antioxidant activity and relationships with total phenolics and total flavonoids of nine South African plants used traditionally to treat arthritis

BMC Complementary and Alternative Medicine

Volumn 16, Issue 1, 2016, Pages

  Elisha, Ishaku Leo ^a,b   Dzoyem, Jean Paul ^a,c   McGaw, Lyndy Joy ^a   Botha, Francien S ^a   Eloff, Jacobus Nicolaas ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b NATIONAL VETERINARY RESEARCH INSTITUTE   (Nigeria)

^c UNIVERSITY OF DSCHANG   (Cameroon)

Author keywords

Anti arthritic activity; Anti lipoxygenase; Antioxidant activity; Inhibition of nitric oxide production; Medicinal plants; Phytochemicals

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ARACHIDONATE 15 LIPOXYGENASE; ASCORBIC ACID; BOLUSANTHUS SPECIOSUS EXTRACT; CALPURNIA AUREA EXTRACT; CREMASPORA TRIFLORA EXTRACT; DICLOFENAC; ELAEODENDRON CROCEUM EXTRACT; FLAVONOID; HETEROMORPHA ARBORESCENS EXTRACT; HYPERICUM ROEPERIANUM EXTRACT; LIPOPOLYSACCHARIDE; MAESA LANCEOLATA EXTRACT; MORUS MESOZYGIA EXTRACT; NITRIC OXIDE; PHENOL DERIVATIVE; PITTOSPORUM VIRIDIFLORUM EXTRACT; PLANT EXTRACT; QUERCETIN; TROLOX C; UNCLASSIFIED DRUG;

ABTS RADICAL SCAVENGING ASSAY; ANTIARTHRITIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DPPH RADICAL SCAVENGING ASSAY; DRUG ACTIVITY; DRUG DETERMINATION; ENZYME INHIBITION; FERRIC REDUCING ANTIOXIDANT POWER ASSAY; IC50; INFLAMMATION; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; RAW 264.7 CELL LINE; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; MEDICINAL PLANT; MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; ARACHIDONATE 15-LIPOXYGENASE; ARTHRITIS; CELL LINE; CELL SURVIVAL; FLAVONOIDS; MICE; PHENOLS; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 84988416389     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-016-1301-z     Document Type: Article

References (45)

1. Gupta RK, Patel AK, Shah N, Chaudhary AK, Jha UK, Yadav UC, Gupta PK, Pakuwal U. Oxidative stress and antioxidants in disease and cancer: a review. Asian Pac J Cancer Prev. 2014;15:4405-9.
2. Fotina AA, Fisinin VI, Surai PF. Recent developments in usage of natural antioxidants to improve chicken meat production and quality. Bulg J Agric Sci. 2013;19:889-96.
3. Aust SD, Morehouse LA, Thomas CE. Role of metals in oxygen radical reactions. J Free Radic Biol Med. 1985;1:3-25.
4. Aruoma OI, Halliwell B, Dizdaroglu M. Iron ion-dependent modification of bases in DNA by the superoxide radical-generating system hypoxanthine/xanthine oxidase. J Biol Chem. 1989;264:13024-8.
5. Saeed N, Khan MR, Shabbir M. Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L. BMC Complement Altern Med. 2012;12:221.
6. Gülçin I. Antioxidant activity of food constituents: An overview. Arch Toxicol. 2012;86:345-91.
7. Zou Y, Chang SKC, Gu Y, Qian SY. Antioxidant activity and phenolic compositions of lentil (Lens culinaris var. Morton) extract and its fractions. J Agric Food Chem. 2011;59:2268-76.
8. Medzhitov R. Inflammation 2010: New Adventures of an Old Flame. Cell. 2010;140:771-6.
9. Calixto JB, Otuki MF, Santos ARS. Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB). Planta Med. 2003;69:973-83.
10. Boscá L, Zeini M, Través PG, Hortelano S. Nitric oxide and cell viability in inflammatory cells: A role for NO in macrophage function and fate. Toxicology. 2005;208:249-58.
11. Kroncke K-D, Fehsel K, Kolb-bachofen V. Nitric Oxide : Cytotoxicity versus Cytoprotection - How, Why, When, and Where ? Biol Chem. 1997;1:107-20.
12. Jang D, Murrell GAC. Nitric oxide in arthritis. Free Radic Biol Med. 1998;24:1511-9.
13. Qureshi AA, Guan X, Reis JC, Papasian CJ, Jabre S, Morrison DC, Qureshi N. Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor. Lipids Health Dis. 2012;11:76.
14. Evans CH, Stefanovic-Racic M. Nitric oxide in arthritis. A Companion to Methods Enzymol. 1996;10:34-8.
15. Wisastra R, Dekker FJ. Inflammation, cancer and oxidative lipoxygenase activity are intimately linked. Cancers (Basel). 2014;6:1500-21.
16. Brash AR. Functions, Catalysis, and Acquisition of Substrate J Biol Chem. 1999;274:23679-83.
17. Kumaraswamy MV, Satish S. Antioxidant and Anti-Lipoxygenase Activity of Thespesia lampas Dalz & Gibs. Adv Biol Res (Rennes). 2008;2:56-9.
18. Murugananthan G, Sudheer KG, Sathya CP, Mohan S. Anti-Arthritic and Anti-Inflammatory Constituents from Medicinal Plants. J Appl Pharm Sci. 2013;3:161-4.
19. Reddy VJS, Rao PGD, Lakshmi GR. A review on antiarthritic activity of some medicinal plaants. J Glob Trends Pharm Sci. 2014;5:2061-73.
20. Zubair M, Anwar F, Shahid SA. Effect of Extraction Solvents on Phenolics and Antioxidant Activity of Selected Varieties of Pakistani Rice (Oryza sativa). Int J Agric Biol. 2012;14:935-40.
21. Atawodi SE, Yakubu OE, Umar IA. Antioxidant and Hepatoprotective Effects of Parinari curatellifolia Root. Int J Agriculrure Biol. 2013;15:523-8.
22. Dzoyem JP, Kuete V, McGaw LJ, Eloff JN. The 15-lipoxygenase inhibitory, antioxidant, antimycobacterial activity and cytotoxicity of fourteen ethnomedicinally used African spices and culinary herbs. J Ethnopharmacol. 2014;156:1-8.
23. Elisha IL, Dzoyem J-P, Botha FS, Eloff JN. The efficacy and safety of nine South African medicinal plants in controlling Bacillus anthracis Sterne vaccine strain. BMC Complement Altern Med. 2016;16:5.
24. Kotze M, Eloff JN. Extraction of antibacterial compounds from Combretum microphyllum (Combretaceae). South African J Bot. 2002;68:62-7.
25. Eloff JN, Masoko P, Picard J. Resistance of animal fungal pathogens to solvents used in bioassays. South African J Bot. 2007;73:667-9.
26. Mu MM, Chakravortty D, Sugiyama T, Koide N, Takahashi K, Mori I, Yoshida T, Yokochi T. The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264. 7 macrophage cells. J Endotoxin Res. 2001;7:431-8.
27. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55-63.
28. Pinto MC, Tejeda A, Duque AL, Macias P. Determination of lipoxygenase activity in plant extracts using a modified ferrous oxidation. Xylenol orange assay. J Agric Food Chem. 2007;55:5956-9.
29. Sakat SS, Juvekar AR, Gambhire MN. In-vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharm Sci. 2010;2:146-55.
30. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999;26:1231-7.
31. Brand-Williams W, Cuvelier ME, Berset C. Use of a free radical method to evaluate antioxidant activity. LWT - Food Sci Technol. 1995;28:25-30.
32. Berker KI, Güçlü K, Tor I, Apak R. Comparative evaluation of Fe(III) reducing power-based antioxidant capacity assays in the presence of phenanthroline, batho-phenanthroline, tripyridyltriazine (FRAP), and ferricyanide reagents. Talanta. 2007;72:1157-65.
33. Zhang Q, Zhang J, Shen J, Silva A, Dennis DA, Barrow CJ. A Simple 96-Well Microplate Method for Estimation of Total Polyphenol Content in Seaweeds. J Appl Phycol. 2006;18:445-50.
34. Ordonez A, Gomez J, Vattuone M, Lsla M. Antioxidant activities of Sechium edule (Jacq.) Swartz extracts. Food Chem. 2006;97:452-8.
35. Paraskeva MP, van Vuuren SF, van Zyl RL, Davids H, Viljoen AM. The in vitro biological activity of selected South African Commiphora species. J Ethnopharmacol. 2008;119:673-9.
36. Liu S, Lin J, Wang C, Chen H, Yang D. Antioxidant properties of various solvent extracts from lychee (Litchi chinenesis Sonn.) flowers. Food Chem. 2009;114:577-81.
37. Do QD, Angkawijaya AE, Tran-Nguyen PL, Huynh LH, Soetaredjo FE, Ismadji S, Ju Y-H. Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica. J Food Drug Anal. 2014;22:296-302.
38. Hseu Y-C, Chang W-H, Chen C-S, Liao J-W, Huang C-J, Lu F-J, Chia Y-C, Hsu H-K, Wu J-J, Yang H-L. Antioxidant activities of Toona Sinensis leaves extracts using different antioxidant models. Food Chem Toxicol. 2008;46:105-14.
39. Hunter JA, Finkbeiner WE, Nadel JA, Goetzl EJ, Holtzman MJ. Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea. Proc Natl Acad Sci U S A. 1985;82:4633-7.
40. Bojase G, Wanjala CCW, Majinda RRT. Flavonoids from the stem bark of Bolusanthus speciosus. Phytochemistry. 2001;56:837-41.
41. Mulaudzi RB, Ndhlala AR, Kulkarni MG, Finnie JF, Van SJ. Anti-inflammatory and mutagenic evaluation of medicinal plants used by Venda people against venereal and related diseases. J Ethnopharmacol. 2013;146:173-9.
42. Dzoyem JP, Nkuete AHL, Ngameni B, Eloff JN. Anti-inflammatory and anticholinesterase activity of six flavonoids isolated from Polygonium and Dorstenia species. Arch Pharm Res 2015:1-6 doi: 10.1007/s12272-015-0612-9.
43. Cheeke PR, Piacente S, Oleszek W. Anti-inflammatory and anti-arthritic effects of Yucca schidigera: a review. J Inflamm (Lond). 2006;3:6.
44. Kishore G, Siva G, Sindhu ES. in Vitro Anti-Inflammatory and Anti-Arthritic Activity of Leaves of Physalis Angulata L. Int J Pharmacetical Ind Res. 2011;1:211-3.
45. Arya D, Meena M, Neha G, Vidya P. In vitro anti-inflammatory and anti-arthritic activity in methanolic extract of Cocculus hirsutus (L.) Diels. In vovo and In vitro. Int J Pharm Sci Res. 2014;5:1957-62.