Anti-inflammatory and anticholinesterase activity of six flavonoids isolated from Polygonum and Dorstenia species

Archives of Pharmacal Research

Volumn 40, Issue 10, 2017, Pages 1129-1134

  Dzoyem, Jean Paul ^a,b   Nkuete, Antoine H L ^b   Ngameni, Barthelemy ^c   Eloff, Jacobus N ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b UNIVERSITY OF DSCHANG   (Cameroon)

^c UNIVERSITY OF YAOUNDÉ I   (Cameroon)

Author keywords

15 Lipoxygenase; Anticholinesterase; Flavonoids; Nitric oxide production inhibition

Indexed keywords

2',4' DIHYDROXY 3',6' DIMETHOXYCHALCONE; 4 HYDROXYLONCHOCARPIN; 6 8 DIPRENYLERIODICTYOL; 6 PRENYLAPIGENIN; ACETYLCHOLINESTERASE; ANTIINFLAMMATORY AGENT; FLAVONOID; INDOMETACIN; ISOBAVACHALCONE; PHYSOSTIGMINE; PINOSTROBIN; QUERCETIN; UNCLASSIFIED DRUG; CHOLINESTERASE INHIBITOR; NITRIC OXIDE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOSYNTHESIS; CELL VIABILITY; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DORSTENIA; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; IC50; MEDICINAL PLANT; MOUSE; NONHUMAN; POLYGONUM; STRUCTURE ACTIVITY RELATION; AFRICAN MEDICINE; ANIMAL; CAMEROON; CELL CULTURE TECHNIQUE; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; MACROPHAGE; METABOLISM; MORACEAE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CAMEROON; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; MACROPHAGES; MEDICINE, AFRICAN TRADITIONAL; MICE; MOLECULAR STRUCTURE; MORACEAE; NITRIC OXIDE; POLYGONUM;

EID: 84930536002     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-015-0612-9     Document Type: Article

References (29)

1. Adjanohoun, J.E., N. Aboubakar, K. Dramane, M.E. Ebot, J.A. Ekpere, E.G. Enow-Orock, D. Focho, Z.E. Gbile, A. Kamanyi, K.J. Kamsu, A. Keita, T. Mbenkum, C.N. Mbi, A.L. Mbiele, I.L. Mbome, N.K. Miburu, W.L. Nancy, B. Nkongmeneck, B. Satabie, A. Sofowora, V. Tamze, and C.K. Wirmum. 1996. Traditional medicine and pharmacopoeia: contribution to ethnopharmacological and floristic studies in Cameroon. Lagos: OUA/ST&RC.
2. Akiyama, H., S. Barger, S. Barnum, B. Bradt, J. Bauer, G.M. Cole, N.R. Cooper, P. Eikelenboom, M. Emmerling, B.L. Fiebich, C.E. Finch, S. Frautschy, W.S.T. Griffin, H. Hampel, M. Hull, G. Landreth, L. Lue, R. Mrak, I.R. Mackenzie, P.L. McGeer, M.K. O’Banion, J. Pachter, G. Pasinetti, C. Plata-Salaman, J. Rogers, R. Rydel, Y. Shen, W. Streit, R. Strohmeyer, I. Tooyoma, F.L. Van Muiswinkel, R. Veerhuis, D. Walker, S. Webster, B. Wegrzyniak, G. Wenk, and T. Wyss-Coray. 2000. Inflammation and Alzheimer’s disease. Neurobiology of Aging 21: 383–421.
3. Ayaz, M., M. Junaid, J. Ahmed, F. Ullah, A. Sadiq, S. Ahmad, and M. Imran. 2014. Phenolic contents, antioxidant and anticholinesterase potentials of crude extract, subsequent fractions and crude saponins from Polygonum hydropiper L. BMC Complementary and Alternative Medicine 14: 145.
4. Bakthir, H., N.A.A. Ali, N. Arnoldc, A. Teichertc, and L. Wessjohannc. 2011. Anticholinesterase activity of endemic plant extracts from Soqotra. African Journal of Traditional, Complementary and Alternative Medicines 8: 296–299.
5. Black, S., C.C. Brideau, M. Cirino, M. Belley, J. Bosquet, C.C. Chan, and I.W. Rodger. 1998. Differential effect of a selective cyclooxygenase-2 inhibitor versus indomethacin on renal blood flow in conscious volume-depleted dogs. Journal of Cardiovascular Pharmacology 32: 686–694.
6. Bouquet, A. 1969. Feticheurs et medecines traditionnelles du Congo Brazaville. Memoires ORSTOM 366: 295.
7. Brain, S.D., and T.J. Williams. 1990. Leukotrienes and inflammation. Pharmacology & Therapeutic 46: 57–66.
8. Chen, Y.-C., S.-C. Shen, W.-R. Lee, W.-C. Hou, L.-L. Yang, and T.J.F. Lee. 2001. Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages. Journal of Cellular Biochemistry 82: 537–548.
9. del Carmen Pinto, M., A. Tejeda, A.L. Duque, and P. Macias. 2007. Determination of lipoxygenase activity in plant extracts using a modified ferrous oxidation-xylenol orange assay. Journal of Agricultural and Food Chemistry 55: 5956–5959.
10. Di Carlo, G., N. Mascolo, A.A. Izzo, and F. Capasso. 1999. Flavonoids: Old and new aspects of a class of natural therapeutic drugs. Life Sciences 65: 337–353.
11. Dzoyem, J.P., A.H.L. Nkuete, V. Kuete, M.F. Tala, H.K. Wabo, S.K. Guru, V.S. Rajput, S. Akash, P. Tane, I.A. Khan, A.K. Saxena, H. Laatsch, and N.H. Tan. 2012. Cytotoxicity and antimicrobial activity of the methanol extract and compounds from Polygonum limbatum. Planta Medica 78: 787–792.
12. Ellman, G.L., K.D. Courtney, V. Andres Jr, and R.M. Featherstone Jr. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology 7: 88–95.
13. Guzik, T.J., R. Korbut, and T. Adamek-Guzik. 2003. Nitric oxide and superoxide in inflammation and immune regulation. Journal of Physiology and Pharmacology 54: 469–487.
14. Ji, H.F., and H.-Y. Zhang. 2006. Theoretical evaluation of flavonoids as multipotent agents to combat Alzheimer’s disease. Journal of Molecular Structure: THEOCHEM 767: 3–9.
15. Kim, Y.H., J. Kim, H. Park, and H.P. Kim. 2007. Anti-inflammatory activity of the synthetic chalcone derivatives: Inhibition of inducible nitric oxide synthase-catalyzed nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells. Biological and Pharmaceutical Bulletin 30: 1450–1455.
16. Kumar, S., and A.K. Pandey. 2013. Chemistry and biological activities of flavonoids: An overview. The Scientific World Journal 2013: 162750.
17. Mazid, M.A., B.K. Datta, S.C. Bachar, S.A.M.K. Bashar, L. Nahar, and S.D. Sarker. 2010. Analgesic and anti-inflammatory activities of Polygonum stagninum. Pharmaceutical Biology 48: 770–774.
18. Min, H.-Y., S.Y. Song, B. Lee, S. Kim, and S.K. Lee. 2010. Inhibition of lipopolysaccharide-induced nitric oxide production by antofine and its analogues in RAW 264.7 macrophage cells. Chemistry & Biodiversity 7: 409–414.
19. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods 65: 55–63.
20. Mu, M.M., D. Chakravortty, T. Sugiyama, N. Koide, K. Takahashi, I. Mori, T. Yoshida, and T. Yokochi. 2001. The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. Journal of Endotoxin Research 7: 431–438.
21. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB Journal 6: 3051–3064.
22. Ngadjui, B.T., S.F. Kouam, E. Dongo, G.W.F. Kapche, and B.M. Abegaz. 2000. Prenylated flavonoids from the aerial parts of Dorstenia mannii. Phytochemistry 55: 915–919.
23. Ngadjui, B.T., E. Dongo, B.M. Abegaz, S. Fotso, and H. Tamboue. 2002. Dinklagins A, B and C: three prenylated flavonoids and other constituents from the twigs of Dorstenia dinklagei. Phytochemistry 61: 99–104.
24. Ngameni, B., M. Touaibia, A. Belkaid, P. Ambassa, J. Watchueng, R. Patnam, B.T. Ngadjui, B. Annabi, and R. Roy. 2007. Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau. Arkivoc 2007: 91–103.
25. Omisore, N.O.A., C.O. Adewunmi, E.O. Iwalewa, B.T. Ngadjui, J. Watchueng, B.M. Abegaz, and J.A.O. Ojewole. 2004. Antinociceptive and anti-inflammatory effects of Dorstenia barteri (Moraceae) leaf and twig extracts in mice. Journal of Ethnopharmacology 95: 7–12.
26. Ramassamy, C. 2006. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets. European Journal of Pharmacology 545: 51–64.
27. Sadik, C.D., H. Sies, and T. Schewe. 2003. Inhibition of 15-lipoxygenases by flavonoids: Structure–activity relations and mode of action. Biochemical Pharmacology 65: 773–781.
28. Shin, H.J., D.H. Shon, and H.S. Youn. 2013. Isobavachalcone suppresses expression of inducible nitric oxide synthase induced by toll-like receptor agonists. International Immunopharmacology 15: 38–41.
29. Tabet, N. 2006. Acetylcholinesterase inhibitors for Alzheimer’s disease: Anti-inflammatories in acetylcholine clothing! Age and Ageing 35: 336–338.