The spleen contributes importantly to myocardial infarct exacerbation during post-ischemic reperfusion in mice via signaling between cardiac HMGB1 and splenic RAGE

Basic Research in Cardiology

Volumn 111, Issue 6, 2016, Pages

  Tian, Yikui ^a,b   Pan, Dongfeng ^c   Chordia, Mahendra D ^c   French, Brent A ^c,d   Kron, Irving L ^b   Yang, Zequan ^b,d  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d University of Virginia   (United States)

Author keywords

HMGB1 RAGE pathway; Myocardial ischemia; Neutrophils; Reperfusion injury; Spleen

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; CELL PROTEIN; FORMYL PEPTIDE RECEPTOR 1; HIGH MOBILITY GROUP B1 PROTEIN; UNCLASSIFIED DRUG; AGER PROTEIN, MOUSE; HMGB1 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE INJURY; HEART MUSCLE REPERFUSION; LEUKOCYTE ACTIVATION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SPLEEN; SPLENECTOMY; ANIMAL; C57BL MOUSE; DISEASE MODEL; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; METABOLISM; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR; ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; HMGB1 PROTEIN; IMMUNOPRECIPITATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPLEEN;

EID: 84988384020     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-016-0583-0     Document Type: Article

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