Human myocardium releases heat shock protein 27 (HSP27) after global ischemia: The proinflammatory effect of extracellular HSP27 through toll-like receptor (TLR)-2 and TLR4

Molecular Medicine

Volumn 20, Issue 1, 2014, Pages 280-289

  Jin, Chunhua ^a,b   Cleveland, Joseph C ^a   Ao, Lihua ^a   Li, Jilin ^a,b   Zeng, Qingchun ^a,b   Fullerton, David A ^a   Meng, Xianzhong ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; HEAT SHOCK PROTEIN 27; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; HSPB1 PROTEIN, HUMAN; HSPB2 PROTEIN, MOUSE; TLR2 PROTEIN, HUMAN; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, HUMAN; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CORONARY BLOOD VESSEL; CORONARY SINUS BLOOD FLOW; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SPACE; HEART FUNCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN CELL; ISOLATED HEART; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR ENDOTHELIUM; CONTROLLED STUDY; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REPERFUSION INJURY; TISSUE LEVEL; ANIMAL; C3H MOUSE; C57BL MOUSE; CELL CULTURE; HEART MUSCLE; KNOCKOUT MOUSE; METABOLISM;

ANIMALS; CELLS, CULTURED; CYTOKINES; ENDOTHELIAL CELLS; HSP27 HEAT-SHOCK PROTEINS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NF-KAPPA B; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84904331738     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2014.00058     Document Type: Article

References (46)

1. Anselmi A, et al. (2004) Myocardial ischemia, stunning, inflammation, and apoptosis during cardiac surgery: a review of evidence. Eur. J. Cardiothorac. Surg. 25:304-11.
2. Valen G, Paulsson G, Vaage J. (2001) Induction of inflammatory mediators during reperfusion of the human heart. Ann. Thorac. Surg. 71:226-32.
3. Meldrum DR, et al. (1998) Human myocardial tissue TNFalpha expression following acute global ischemia in vivo. J. Mol. Cell. Cardiol. 30:1683-9.
4. Wan S, et al. (1996) Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 112:806-11.
5. Tomasdottir H, et al. (2003) Tumor necrosis factor gene polymorphism is associated with enhanced systemic inflammatory response and increased cardiopulmonary morbidity after cardiac surgery. Anesth. Analg. 97:944-9.
6. Cha J, et al. (2008) Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia. Ann. Thorac. Surg. 85:1678-85.
7. Zou N, et al. (2008) Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion. Am. J. Physiol. Heart Circ. Physiol. 294:H2805-13.
8. Oyama J, et al. (2004) Reduced myocardial ischemia-reperfusion injury in Toll-like receptor 4-deficient mice. Circulation. 109:784-9.
9. Chong AJ, et al. (2004) Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J. Thorac. Cardiovasc. Surg. 128:170-9.
10. Sakata Y, et al. (2007) Toll-like receptor 2 modulates left ventricular function following ischemiareperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 292:H503-9.
11. Li Y, et al. (2011) Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J. Biol. Chem. 286:31308-19.
12. Arslan F, de Kleijn DP, Pasterkamp G. (2011) Innate immune signaling in cardiac ischemia. Nat. Rev. Cardiol. 8:292-300.
13. Feng Y, Chao W. (2011) Toll-like receptors and myocardial inflammation. Int. J. Inflam. 2011:170352.
14. Lu C, et al. (2014) Toll-like receptor 3 plays a role in myocardial infarction and ischemia/reperfusion injury. Biochim. Biophys. Acta. 1842:22-31.
15. Chen C, et al. (2014) Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemiareperfusion injury. J. Am. Heart Assoc. 3:e000683.
16. Feng Y, et al. (2008) Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice. Am. J. Physiol. Heart Circ. Physiol. 295:H1311-8.
17. Fallach R, et al. (2010) Cardiomyocyte Toll-like receptor 4 is involved in heart dysfunction following septic shock or myocardial ischemia. J. Mol. Cell. Cardiol. 48:1236-44.
18. Hofmann U, Ertl G, Frantz S. (2011) Toll-like receptors as potential therapeutic targets in cardiac dysfunction. Expert Opin. Ther. Targets. 15:753-65.
19. Zhai Y, et al. (2004) Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J. Immunol. 173:7115-9.
20. Leemans JC, et al. (2005) Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J. Clin. Invest. 115:2894-903.
21. Altemeier WA, Liles WC, Villagra-Garcia A, Matute-Bello G, Glenny RW. (2013) Ischemiareperfusion lung injury is attenuated in MyD88-deficient mice. PLoS One. 8:e77123.
22. Caso JR, et al. (2007) Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation. 115:1599-608.
23. Kaczorowski DJ, et al. (2009) Mechanisms of Tolllike receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart. Transplantation. 87:1455-63.
24. Tian J, et al. (2013) Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Cardiovasc. Res. 98:391-401.
25. Saibil H. (2013) Chaperone machines for protein folding, unfolding and disaggregation. Nat. Rev. Mol. Cell. Biol. 14:630-42.
26. Asea A, et al. (2002) Novel signal transduction pathway utilized by extracellular HSP70: role of Toll-like receptor (TLR) 2 and TLR4. J. Biol. Chem. 277:15028-34.
27. Binder RJ, Vatner R, Srivastava P. (2004) The heat-shock protein receptors: some answers and more questions. Tissue Antigens. 64:442-51.
28. Dybdahl B, et al. (2002) Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through Toll-like receptor-4. Circulation. 105:685-90.
29. Ao L, Zou N, Cleveland JCJ, Fullerton DA, Meng X. (2009) Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70. Am. J. Physiol. Heart Circ. Physiol. 297:H21-8.
30. Su X, et al. (2010) Extracellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin: differential effect on TNF-alpha and ICAM-1 levels in heart tissue. Cytokine. 51:60-6.
31. Kostenko S, Moens U. (2009) Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology. Cell. Mol. Life Sci. 66:3289-307.
32. Acunzo J, Katsogiannou M, Rocchi P. (2012) Small heat shock proteins HSP27 (HspB1), alphaB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death. Int. J. Biochem. Cell Biol. 44:1622-31.
33. VanderHeide RS. (2002) Increased expression of HSP27 protects canine myocytes from simulated ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 282:H935-41.
34. National Research Council. (1996) Guide for the Care and Use of Laboratory Animals. 7th edition. Washington (DC): The National Academies Press. 125 pp.
35. Li J, Mullen AM, Shah AM. (2001) Phenotypic properties and characteristics of superoxide production by mouse coronary microvascular endothelial cells. J. Mol. Cell Cardiol. 33:1119-31.
36. Tynan GA, McNaughton A, Jarnicki A, Tsuji T, Lavelle EC. (2012) Polymyxin B inadequately quenches the effects of contaminating lipopolysaccharide on murine dendritic cells. PLoS One. 7:e37261.
37. Anand AR, Bradley R, Ganju RK. (2009) LPSinduced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway. Mol. Immunol. 46:962-8.
38. Vega VL, et al. (2008) Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membraneassociated form that activates macrophages. J. Immunol. 180:4299-307.
39. Salinthone S, Tyagi M, Gerthoffer WT. (2008) Small heat shock proteins in smooth muscle. Pharmacol. Ther. 119:44-54.
40. Alford KA, et al. (2007) Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling. J. Biol. Chem. 282:6232-41.
41. Sur R, Lyte PA, Southall MD. (2008) Hsp27 regulates pro-inflammatory mediator release in keratinocytes by modulating NF-kappaB signaling. J. Invest. Dermatol. 128:1116-22.
42. Miller-Graziano CL, De A, Laudanski K, Herrmann T, Bandyopadhyay S. (2008) HSP27: an anti-inflammatory and immunomodulatory stress protein acting to dampen immune function. Novartis Found. Symp. 291:196-208.
43. Yusuf N, et al. (2009) Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity. J. Immunol. 182:675-83.
44. Yang H, et al. (2010) A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc. Natl. Acad. Sci. U. S. A. 107:11942-7.
45. Qiang X, et al. (2013) Cold-inducible RNAbinding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. Nat. Med. 19:1489-95.
46. Zeytun A, Chaudhary A, Pardington P, Cary R, Gupta G. (2010) Induction of cytokines and chemokines by Toll-like receptor signaling: strategies for control of inflammation. Crit. Rev. Immunol. 30:53-67.