PGE2/EP4 Signaling Controls the Transfer of the Mammary Stem Cell State by Lipid Rafts in Extracellular Vesicles

Stem Cells

Volumn 35, Issue 2, 2017, Pages 425-444

  Lin, Meng Chieh ^a   Chen, Shih Yin ^a   Tsai, Ho Min ^a   He, Pei Lin ^a   Lin, Yen Chun ^a,b   Herschman, Harvey ^c   Li, Hua Jung ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

EP4 receptor; Exosome; Extracellular vesicle; Lipid raft; PGE2; Stem cell homeostasis

Indexed keywords

ANTIBODY; CELL SURFACE MARKER; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; INTEGRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROTEIN KINASE B; RAB PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN; BIOLOGICAL MARKER; NEUTRALIZING ANTIBODY; PROSTAGLANDIN E SYNTHASE; PTGES PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST EPITHELIUM CELL; CAVEOLA; CELL MOTILITY; CELL STRUCTURE; CONTROLLED STUDY; ENZYME INHIBITION; EXOSOME; FEMALE; HUMAN; HUMAN CELL; LIPID RAFT; MAMMARY GLAND; MAMMARY STEM CELL; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; STEM CELL; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL ADHESION; CELL LINE; CELL MOTION; CELL SHAPE; CYTOLOGY; EPITHELIUM CELL; MEMBRANE MICRODOMAIN; METABOLISM; MULTICELLULAR SPHEROID; ULTRASTRUCTURE;

ANIMALS; ANTIBODIES, NEUTRALIZING; BIOMARKERS; CAVEOLAE; CELL ADHESION; CELL LINE; CELL MOVEMENT; CELL SHAPE; CYCLOOXYGENASE 2; DINOPROSTONE; EPITHELIAL CELLS; EXTRACELLULAR VESICLES; FEMALE; HUMANS; INTEGRINS; MAMMARY GLANDS, HUMAN; MEMBRANE MICRODOMAINS; MICE, INBRED C57BL; PROSTAGLANDIN-E SYNTHASES; RAB GTP-BINDING PROTEINS; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; STEM CELLS;

EID: 84987910488     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2476     Document Type: Article

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