Lipid rafts are essential for peroxisome biogenesis in HepG2 cells

Hepatology

Volumn 52, Issue 2, 2010, Pages 623-633

  Woudenberg, Jannes ^a,d   Rembacz, Krzysztof P ^a   Hoekstra, Mark ^a   Pellicoro, Antonella ^a,e   Van Den Heuvel, Fiona A J ^a   Heegsma, Janette ^a   Van IJzendoorn, Sven C D ^a   Holzinger, Andreas ^b   Imanaka, Tsuneo ^c   Moshage, Han ^a   Faber, Klaas Nico ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF TOYAMA   (Japan)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CHOLESTEROL; CYCLOHEXIMIDE; GREEN FLUORESCENT PROTEIN; METHYL BETA CYCLODEXTRIN; MEVINOLIN; TRITON X 100;

ARTICLE; BIOGENESIS; CELL FUNCTION; CELL ISOLATION; CELL LYSATE; CELL SORTER; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISSOCIATION CONSTANT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; LIPID RAFT; PEROXISOME; PRIORITY JOURNAL; PROTEIN SYNTHESIS; WESTERN BLOTTING;

BIOLOGICAL PROCESSES; CHOLESTEROL; HEP G2 CELLS; HUMANS; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; PEROXISOMES;

EID: 77955685791     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.23684     Document Type: Article

References (43)

1. Wanders RJ, Waterham HR. Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem 2006;75:295-332.
2. Theodoulou FL, Holdsworth M, Baker A. Peroxisomal ABC transporters. FEBS Lett 2006;580:1139-1155.
3. Sundaram SS, Bove KE, Lovell MA, Sokol RJ. Mechanisms of disease: inborn errors of bile acid synthesis. Nat Clin Pract Gastroenterol Hepatol 2008;5:456-468.
4. Williams C, Distel B. Pex13p: docking or cargo handling protein? Biochim Biophys Acta 2006;1763:1585-1591.
5. Azevedo JE, Schliebs W. Pex14p, more than just a docking protein. Biochim Biophys Acta 2006;1763:1574-1584.
6. Berger J, Albet S, Bentejac M, Netik A, Holzinger A, Roscher AA, et al. The four murine peroxisomal ABC-transporter genes differ in constitutive, inducible and developmental expression. Eur J Biochem 1999;265:719-727.
7. Simons K, Ikonen E. Functional rafts in cell membranes. Nature 1997;387:569-572.
8. Brown DA. Lipid rafts, detergent-resistant membranes, and raft targeting signals. Physiology 2006;21:430-439.
9. Brown DA, London E. Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 1998;14:111-136.
10. Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000;1:31-39.
11. Rajendran L, Simons K. Lipid rafts and membrane dynamics. J Cell Sci 2005;118(pt 6):1099-1102.
12. Troost J, Lindenmaier H, Haefeli WE, Weiss J. Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells. Mol Pharmacol 2004;66:1332-1339. (Pubitemid 39411074)
13. Dos Santos SM, Weber CC, Franke C, Muller WE, Eckert GP. Cholesterol: coupling between membrane microenvironment and ABC transporter activity. Biochem Biophys Res Commun 2007;354:216-221.
14. Storch CH, Ehehalt R, Haefeli WE, Weiss J. Localization of the human breast cancer resistance protein (BCRP/ABCG2) in lipid rafts/caveolae and modulation of its activity by cholesterol in vitro. J Pharmacol Exp Ther 2007;323:257-264.
15. Kashiwayama Y, Asahina K, Shibata H, Morita M, Muntau AC, Roscher AA, et al. Role of Pex19p in the targeting of PMP70 to peroxisome. Biochim Biophys Acta 2005;1746:116-128.
16. Kashiwayama Y, Asahina K, Morita M, Imanaka T. Hydrophobic regions adjacent to transmembrane domains 1 and 5 are important for the targeting of the 70-kDa peroxisomal membrane protein. J Biol Chem 2007;282:33831-33844.
17. Landgraf P, Mayerhofer PU, Polanetz R, Roscher AA, Holzinger A. Targeting of the human adrenoleukodystrophy protein to the peroxisomal membrane by an internal region containing a highly conserved motif. Eur J Cell Biol 2003;82:401-410.
18. Blokzijl H, Vander Borght S, Bok LIH, Libbrecht L, Geuken M, Van den Heuvel FAJ, et al. Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels. Inflamm Bowel Dis 2007;13:710-720.
19. Pellicoro A, van den Heuvel FA, Geuken M, Moshage H, Jansen PL, Faber KN. Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport. HEPATOLOGY 2007;45:340-348.
20. Slimane TA, Trugnan G, van Ijzendoorn SCD, Hoekstra D. Raft-mediated trafficking of apical resident proteins occurs in both direct and transcytotic pathways in polarized hepatic cells: role of distinct lipid microdomains. Mol Biol Cell 2003;14:611-624.
21. Klein U, Gimpl G, Fahrenholz F. Alteration of the myometrial plasma membrane cholesterol content with beta-cyclodextrin modulates the binding affinity of the oxytocin receptor. Biochemistry 1995;34:13784-13793.
22. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-917.
23. Gamble W, Vaughan M, Kruth HS, Avigan J. Procedure for determination of free and total cholesterol in microgram or nanogram amounts suitable for studies with cultured-cells. J Lipid Res 1978;19:1068-1070.
24. Laliberte JP, McGinnes LW, Peeples ME, Morrison TG. Integrity of membrane lipid rafts is necessary for the ordered assembly and release of infectious Newcastle disease virus particles. J Virol 2006;80:10652-10662.
25. Foster LJ, De Hoog CL, Mann M. Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors. Proc Natl Acad Sci U S A 2003;100:5813-5818.
26. Shogomori H, Brown DA. Use of detergents to study membrane rafts: the good, the bad, and the ugly. Biol Chem 2003;384:1259-1263.
27. Chamberlain LH. Detergents as tools for the purification and classification of lipid rafts. FEBS Lett 2004;559:1-5.
28. Pike LJ. Lipid rafts: heterogeneity on the high seas. Biochem J 2004;378(pt 2):281-292.
29. Albertini M, Rehling P, Erdmann R, Girzalsky W, Kiel JA, Veenhuis M, et al. Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways. Cell 1997;89:83-92.
30. Fransen M, Terlecky SR, Subramani S. Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import. Proc Natl Acad Sci U S A 1998;95:8087-8092.
31. Schliebs W, Saidowsky J, Agianian B, Dodt G, Herberg FW, Kunau WH. Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14. J Biol Chem 1999;274:5666-5673.
32. Otera H, Harano T, Honsho M, Ghaedi K, Mukai S, Tanaka A, et al. The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p.PTS2 protein complex into peroxisomes via its initial docking site, Pex14p. J Biol Chem 2000;275:21703-21714.
33. Bottger G, Barnett P, Klein AT, Kragt A, Tabak HF, Distel B. Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner. Mol Biol Cell 2000;11:3963-3976.
34. Reguenga C, Oliveira ME, Gouveia AM, Sa-Miranda C, Azevedo JE. Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly. J Biol Chem 2001;276:29935-29942.
35. Lyons HT, Kharroubi A, Wolins N, Tenner S, Chanderbhan RF, Fiskum G, et al. Elevated cholesterol and decreased sterol carrier protein-2 in peroxisomes from AS-30D hepatoma compared to normal rat liver. Arch Biochem Biophys 1991;285:238-245.
36. Platta HW, Erdmann R. Peroxisomal dynamics. Trends Cell Biol 2007;17:474-484.
37. Boukh-Viner T, Guo T, Alexandrian A, Cerracchio A, Gregg C, Haile S, et al. Dynamic ergosterol- and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for peroxisome fusion. J Cell Biol 2005;168:761-773.
38. Gayet L, Dayan G, Barakat S, Labialle S, Michaud M, Cogne S, et al. Control of P-glycoprotein activity by membrane cholesterol amounts and their relation to multidrug resistance in human CEM leukemia cells. Biochemistry 2005;44:4499-4509.
39. Marbeuf-Gueye C, Stierle V, Sudwan P, Salerno M, Garnier-Suillerot A. Perturbation of membrane microdomains in GLC4 multidrug-resistant lung cancer cells - modification of ABCC1 (MRP1) localization and functionality. FEBS J 2007;274:1470-1480.
40. Pal A, Mehn D, Molnar E, Gedey S, Meszaros P, Nagy T, et al. Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2. J Pharmacol Exp Ther 2007;321:1085-1094.
41. Telbisz A, Muller M, Ozvegy-Laczka C, Homolya L, Szente L, Varadi A, et al. Membrane cholesterol selectively modulates the activity of the human ABCG2 multidrug transporter. Biochim Biophys Acta 2007;1768:2698-2713.
42. Di Biase A, Salvati S, Vari R, Avellino C, Sforza F, Cappa M, et al. Susceptibility to oxidation of plasma low-density lipoprotein in X-linked adrenoleukodystrophy: effects of simvastatin treatment. Mol Genet Metab 2000;71:651-655.
43. Pai GS, Khan M, Barbosa E, Key LL, Craver JR, Cure JK, et al. Lovastatin therapy for X-linked adrenoleukodystrophy: clinical and biochemical observations on 12 patients. Mol Genet Metab 2000;69:312-322.