Association between Gene Polymorphisms and Pain Sensitivity Assessed in a Multi-Modal Multi-Tissue Human Experimental Model – An Explorative Study

Basic and Clinical Pharmacology and Toxicology

Volumn 119, Issue 4, 2016, Pages 360-366

  Nielsen, Lecia Møller ^a,b   Olesen, Anne Estrup ^a,b,d   Sato, Hiroe ^c   Christrup, Lona Louring ^b   Drewes, Asbjørn Mohr ^a,d  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c ROYAL BROMPTON HOSPITAL   (United Kingdom)

^d AALBORG UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; DELTA OPIATE RECEPTOR; DNA; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR;

ADULT; ALLELE; ARTICLE; COLD PRESSOR TEST; FEMALE; GENETIC ASSOCIATION; GENETIC VARIATION; HUMAN; HUMAN EXPERIMENT; MALE; NOCICEPTION; NORMAL HUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; SENSORY STIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN STIMULATION; VISCERAL PAIN;

EID: 84987814997     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12601     Document Type: Article

References (56)

1. Coghill RC. Individual differences in the subjective experience of pain: new insights into mechanisms and models. Headache 2010;50:1531–5.
2. Mogil JS. The genetic mediation of individual differences in sensitivity to pain and its inhibition. Proc Natl Acad Sci 1999;96:7744–51.
3. Fillingim RB, Kaplan L, Staud R, Ness TJ, Glover TL, Campbell CM et al. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J Pain 2005;6:159–67.
4. Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL. Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain 2009;10:447–85.
5. Edwards RR, Sarlani E, Wesselmann U, Fillingim RB. Quantitative assessment of experimental pain perception: multiple domains of clinical relevance. Pain 2005;114:315–9.
6. Arendt-Nielsen L, Yarnitsky D. Experimental and clinical applications of quantitative sensory testing applied to skin, Muscles and Viscera. J Pain 2009;10:556–72.
7. Seltzer Z. Nothing in pain makes sense except in the light of genetics. Pain 2014;155:841–2.
8. Smith MT, Muralidharan A. Pharmacogenetics of pain and analgesia. Clin Genet 2012;82:321–30.
9. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melén K, Julkunen I et al. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995;34:4202–10.
10. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996;6:243–50.
11. Kim H, Clark D, Dionne RA. Genetic contributions to clinical pain and analgesia: avoiding pitfalls in genetic research. J Pain 2009;10:663–93.
12. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci USA 1998;95:9608–13.
13. Sato H, Droney J, Ross J, Olesen AE, Staahl C, Andresen T et al. Gender, variation in opioid receptor genes and sensitivity to experimental pain. Mol Pain 2013;9:20.
14. Bravata DM, Olkin I. Versus combining. Heal San Fr 2001;24:218–30.
15. Olesen AE, Brock C, Sverrisdóttir E, Larsen IM, Drewes AM. Sensitivity of quantitative sensory models to morphine analgesia in humans. J Pain Res 2014;7:717–26.
16. Andresen T, Staahl C, Oksche A, Mansikka H, Arendt-Nielsen L, Drewes AM. Effect of transdermal opioids in experimentally induced superficial, deep and hyperalgesic pain. Br J Pharmacol 2011;164:934–45.
17. Andresen T, Pfeiffer-Jensen M, Brock C, Drewes AM, Arendt-Nielsen L. A human experimental bone pain model. Basic Clin Pharmacol Toxicol 2013;112:116–23.
18. Brock C, Nissen TD, Gravesen FH, Frøkjaer JB, Omar H, Gale J et al. Multimodal sensory testing of the rectum and rectosigmoid: development and reproducibility of a new method. Neurogastroenterol Motil 2008;20:908–18.
19. Droney JM, Gretton SK, Sato H, Ross JR, Branford R, Welsh KI et al. Analgesia and central side-effects: two separate dimensions of morphine response. Br J Clin Pharmacol 2013;75:1340–50.
20. Ross JR, Riley J, Taegetmeyer AB, Sato H, Gretton S, du Bois RM et al. Genetic variation and response to morphine in cancer patients: catechol-O-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects. Cancer 2008;112:1390–403.
21. Rakvåg TT, Ross JR, Sato H, Skorpen F, Kaasa S, Klepstad P. Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain. Mol Pain 2008;4:64.
22. De Gregori M, Garbin G, De Gregori S, Minella CE, Bugada D, Lisa A et al. Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain. Eur J Clin Pharmacol 2013;69:1651–8.
23. Diatchenko L, Nackley AG, Slade GD, Bhalang K, Belfer I, Max MB et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006;125:216–24.
24. Jensen KB, Lonsdorf TB, Schalling M, Kosek E, Ingvar M. Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism. PLoS ONE 2009;4:e6016.
25. Mobascher A, Brinkmeyer J, Thiele H, Toliat MR, Steffens M, Warbrick T et al. The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation. Mol Pain 2010;6:32.
26. Zubieta J-K, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y et al. COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science 2003;299:1240–3.
27. Kim H, Mittal DP, Iadarola MJ, Dionne RA. Genetic predictors for acute experimental cold and heat pain sensitivity in humans. J Med Genet 2006;43:e40.
28. Kim H, Neubert JK, San Miguel A, Xu K, Krishnaraju RK, Iadarola MJ et al. Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain 2004;109:488–96.
29. Martínez-Jauand M, Sitges C, Rodríguez V, Picornell A, Ramon M, Buskila D et al. Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene. Eur J Pain 2013;17:16–27.
30. Josep García-Fructuoso F, Ignacio Lao-Villadóniga J, Beyer K, Santos C. Relationship between COMT gene genotypes and severity of fibromyalgia. Reumatol Clin 2006;2:168–72.
31. Finan PH, Zautra AJ, Davis MC, Lemery-Chalfant K, Covault J, Tennen H. COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia. Pain 2011;152:300–7.
32. Barbosa FR, Matsuda JB, Mazucato M, de Castro França S, Zingaretti SM, da Silva LM et al. Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromyalgia patients. Rheumatol Int 2012;32:427–30.
33. Cohen H, Neumann L, Glazer Y, Ebstein RP, Buskila D. The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia. Clin Exp Rheumatol 2009;27:S51–6.
34. Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I et al. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 2005;14:135–43.
35. Huang C-J, Liu H-F, Su N-Y, Hsu Y-W, Yang C-H, Chen C-C et al. Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*. Anaesthesia 2008;63:1288–95.
36. Belfer I, Wu T, Kingman A, Krishnaraju RK, Goldman D, Max MB. Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size. Anesthesiology 2004;100:1562–72.
37. Martin M, Matifas A, Maldonado R, Kieffer BL. Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones. Eur J Neurosci 2003;17:701–8.
38. Gavériaux-Ruff C, Kieffer BL. Opioid receptor genes inactivated in mice: the highlights. Neuropeptides 2002;36:62–71.
39. Simonin F, Valverde O, Smadja C, Slowe S, Kitchen I, Dierich A et al. Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. EMBO J 1998;17:886–97.
40. Nadal X, Baños J-E, Kieffer BL, Maldonado R. Neuropathic pain is enhanced in delta-opioid receptor knockout mice. Eur J Neurosci 2006;23:830–4.
41. Drewes AM, Gregersen H, Arendt-Nielsen L. Experimental pain in gastroenterology: a reappraisal of human studies. Scand J Gastroenterol 2003;38:1115–30.
42. Rainville P, Feine JS, Bushnell MC, Duncan GH. A psychophysical comparison of sensory and affective responses to four modalities of experimental pain. Somatosens Mot Res 1992;9:265–77.
43. Olesen AE, Andresen T, Staahl C, Drewes AM. Human experimental pain models for assessing the therapeutic efficacy of analgesic drugs. Pharmacol Rev 2012;64:722–79.
44. Birklein F, Depmeier C, Rolke R, Hansen C, Rautenstrauss B, Prawitt D et al. A family-based investigation of cold pain tolerance. Pain 2008;138:111–8.
45. Sindrup SH, Poulsen L, Brøsen K, Arendt-Nielsen L, Gram LF. Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers? Pain 1993;53:335–9.
46. Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M et al. Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl. Mol Pain 2014;10:75.
47. Cordell HJ. Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet 2002;11:2463–8.
48. Feldreich A, Ernberg M, Lund B, Rosén A. Increased β-endorphin levels and generalized decreased pain thresholds in patients with limited jaw opening and movement-evoked pain from the temporomandibular joint. J Oral Maxillofac Surg 2012;70:547–56.
49. Ghelardini C, Di Cesare Mannelli L, Bianchi E. The pharmacological basis of opioids. Clin Cases Miner Bone Metab 2015;12:219–21.
50. Sibille KT, Witek-Janusek L, Mathews HL, Fillingim RB. Telomeres and epigenetics: potential relevance to chronic pain. Pain 2012;153:1789–93.
51. Kristiansen FL, Olesen AE, Brock C, Gazerani P, Petrini L, Mogil JS et al. The role of pain catastrophizing in experimental pain perception. Pain Pract 2014;14:E136–45.
52. Drewes AM, Nielsen KD, Arendt-Nielsen L, Birket-Smith L, Hansen LM. The effect of cutaneous and deep pain on the electroencephalogram during sleep–an experimental study. Sleep 1997;20:632–40.
53. Chiu YH, Silman AJ, Macfarlane GJ, Ray D, Gupta A, Dickens C et al. Poor sleep and depression are independently associated with a reduced pain threshold. Results of a population based study. Pain 2005;115:316–21.
54. Gibson SJ, Farrell M. A review of age differences in the neurophysiology of nociception and the perceptual experience of pain. Clin J Pain 2004;20:227–39.
55. Herr KA, Garand L. Assessment and measurement of pain in older adults. Clin Geriatr Med 2001;17:457–78.
56. Innocenti F, Undevia SD, Iyer L, Chen PX, Das S, Kocherginsky M et al. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 2004;22:1382–8.