Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease

Journal of Clinical Investigation

Volumn 126, Issue 9, 2016, Pages 3377-3382

  Boyraz, Baris ^a,b   Moon, Diane H ^a   Segal, Matthew ^a   Muosieyiri, Maud Z ^a   Aykanat, Asli ^a   Tai, Albert K ^c   Cahan, Patrick ^d   Agarwal, Suneet ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HACETTEPE UNIVERSITY   (Turkey)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LENTIVIRUS VECTOR; POLY(A) SPECIFIC RIBONUCLEASE; RIBONUCLEASE; SHORT HAIRPIN RNA; TELOMERASE; TELOMERASE RNA COMPONENT; UNCLASSIFIED DRUG; UNTRANSLATED RNA; COMPLEMENTARY DNA; EXORIBONUCLEASE; POLY(A)-SPECIFIC RIBONUCLEASE; RNA; RNA POLYMERASE; SMALL INTERFERING RNA; TELOMERASE RNA; TRF4-2 PROTEIN, HUMAN;

ADENYLATION; ARTICLE; CELL SELF-RENEWAL; CHROMOSOME DISORDER; EMBRYO; GENE MUTATION; GENE OVEREXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; TELOMERE; TELOMERE HOMEOSTASIS; TELOMERE LENGTH; DYSKERATOSIS CONGENITA; FIBROBLAST; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; LENTIVIRINAE; METABOLISM; MUTATION; PHENOTYPE; PROTEIN PROCESSING; RNA INTERFERENCE; SKIN; ULTRASTRUCTURE;

DNA, COMPLEMENTARY; DYSKERATOSIS CONGENITA; EXORIBONUCLEASES; FIBROBLASTS; GENE DELETION; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; LENTIVIRUS; MUTATION; PHENOTYPE; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA; RNA INTERFERENCE; RNA NUCLEOTIDYLTRANSFERASES; RNA, SMALL INTERFERING; SKIN; TELOMERASE; TELOMERE;

EID: 84987810657     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI87547     Document Type: Article

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