Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

Nature Structural and Molecular Biology

Volumn 23, Issue 4, 2016, Pages 286-292

  Shukla, Siddharth ^a   Schmidt, Jens C ^a   Goldfarb, Katherine C ^a   Cech, Thomas R ^a   Parker, Roy ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYSKERIN; POLY(A) RNASE; RIBONUCLEASE; RNA; TELOMERASE; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; DKC1 PROTEIN, HUMAN; EXORIBONUCLEASE; EXOSC10 PROTEIN, HUMAN; EXOSOME MULTIENZYME RIBONUCLEASE COMPLEX; NUCLEAR PROTEIN; POLY(A)-SPECIFIC RIBONUCLEASE; PROTEIN BINDING; RNA POLYMERASE; TELOMERASE RNA; TRF4-2 PROTEIN, HUMAN;

ADENYLATION; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DEGRADATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; CELL LINE; GENETICS; HELA CELL LINE; METABOLISM; RNA STABILITY;

CELL CYCLE PROTEINS; CELL LINE; EXORIBONUCLEASES; EXOSOME MULTIENZYME RIBONUCLEASE COMPLEX; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; NUCLEAR PROTEINS; PROTEIN BINDING; RNA; RNA NUCLEOTIDYLTRANSFERASES; RNA STABILITY; TELOMERASE;

EID: 84960172419     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.3184     Document Type: Article

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