Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component

Nature Genetics

Volumn 47, Issue 12, 2015, Pages 1482-1488

  Moon, Diane H ^a,b,c,d   Segal, Matthew ^a,b,c,d   Boyraz, Baris ^a,b,c,d,e   Guinan, Eva ^b   Hofmann, Inga ^a,c,d   Cahan, Patrick ^a   Tai, Albert K ^f   Agarwal, Suneet ^a,b,c,d  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e HACETTEPE UNIVERSITY   (Turkey)

^f TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYSKERIN; MESSENGER RNA; NUCLEAR RNA; POLYADENYLIC ACID; POLYADENYLIC ACID SPECIFIC RIBONUCLEASE; RIBONUCLEASE; RNA POLYMERASE II; SMALL NUCLEOLAR RNA; TELOMERASE; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; EXORIBONUCLEASE; POLY(A)-SPECIFIC RIBONUCLEASE; RNA; TELOMERASE RNA;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; BIOGENESIS; CELL MATURATION; CELL RENEWAL; CONTROLLED STUDY; DYSKERATOSIS CONGENITA; GENE SEQUENCE; HAPLOINSUFFICIENCY; HETEROZYGOSITY; HUMAN; HUMAN CELL; IMMORTALIZED CELL LINE; LOSS OF FUNCTION MUTATION; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RNA DEGRADATION; RNA INTERFERENCE; RNA STRUCTURE; SKIN FIBROBLAST; SOMATIC CELL; TELOMERASE RNA COMPONENT; TELOMERE HOMEOSTASIS; 3' UNTRANSLATED REGION; CELL CULTURE; CYTOLOGY; FEMALE; FIBROBLAST; GENETICS; INDUCED PLURIPOTENT STEM CELL; MALE; METABOLISM; MUTATION; PEDIGREE; TELOMERE;

3' UNTRANSLATED REGIONS; CELLS, CULTURED; DYSKERATOSIS CONGENITA; EXORIBONUCLEASES; FEMALE; FIBROBLASTS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MUTATION; PEDIGREE; RNA; TELOMERASE; TELOMERE;

EID: 84949101798     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3423     Document Type: Article

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